Physiology and pathophysiology of IGFBP-1 and IGFBP-2 - Consensus and dissent on metabolic control and malignant potential

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 29, Issue 5, 2015, Pages 685-700

  Hoeflich, Andreas ^a   Russo, Vincenzo C ^b  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

AKT; cancer; diabetes; IGFBP 1; IGFBP 2; metabolism; obesity; PTEN; steroids

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; ESTROGEN; GLUCOSE; GROWTH HORMONE; INSULIN; INTEGRIN; LEPTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SEX HORMONE; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN C; SOMATOMEDIN;

BREAST CANCER; CANCER RISK; CELL DIFFERENTIATION; CONSENSUS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HORMONAL REGULATION; HORMONE RELEASE; HUMAN; INSULIN SENSITIVITY; LIPID METABOLISM; METABOLIC REGULATION; NEOPLASM; NONHUMAN; OBESITY; OVARY CANCER; PATHOPHYSIOLOGY; PROADIPOCYTE; PROSTATE CANCER; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; GENETICS; METABOLIC DISORDER; METABOLISM;

ANIMALS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; METABOLIC DISEASES; NEOPLASMS; SIGNAL TRANSDUCTION; SOMATOMEDINS;

EID: 84946486122     PISSN: 1521690X     EISSN: 15321908     Source Type: Journal    
DOI: 10.1016/j.beem.2015.07.002     Document Type: Review

References (105)

1. S.M. Firth, and R.C. Baxter Cellular actions of the insulin-like growth factor binding proteins Endocr Rev 23 2002 824 854
2. D.O. Daza, G. Sundström, C.A. Bergqvist, and et al. Evolution of the insulin-like growth factor binding protein (IGFBP) family Endocrinology 152 2011 2278 2289
3. R.C. Baxter Insulin-like growth factor (IGF) binding proteins: the role of serum IGFBPs in regulating IGF availability Acta Paediatr Scand 372 1991 107 114
4. S.M. Twigg, M.C. Kiefer, J. Zapf, and et al. A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit Endocrinology 141 2000 454 457
5. S. Hardouin, M. Gourmelen, P. Noguiez, and et al. Molecular forms of serum insulin-like growth factor (IGF)- binding proteins in man: relationships with growth hormone and IGFs and physiological significance J Clin Endo Metab 69 1989 1291 1301
6. J.B. Pucilowska, M.L. Davenport, I. Kabir, and et al. The effect of dietary protein supplementation on insulin-like growth factors (IGFs) and IGF-binding proteins in children with shigellosis J Clin Endo Metab 77 1993 1516 1521
7. B. Strasser-Vogel, W.F. Blum, R. Past, and et al. Insulin-like growth factor (IGF)-I and -II and IGF-binding proteins-1, -2, and -3 in children and adolescents with diabetes mellitus: correlation with metabolic control and height attainment J Clin Endocrinol Metab 80 1995 1207 1213
8. S. Rajaram, D.J. Baylink, and S. Mohan Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions Endocr Rev 18 1997 801 831
9. V.C. Russo, P. Gluckman, E.L. Feldman, and et al. The insulin-like growth factor system and its pleiotropic functions in brain Endocr Rev 26 2005 916 943
10. H. Bohn, W. Kraus, and W. Winckler New soluble placental tissue proteins: their isolation, characterization, localization and quantification Placenta Suppl 4 1982 67 81
11. M.L. Huhtala, R. Koistinen, P. Palomaki, and et al. Biologically active domain in somatomedin-binding protein Biochem Biophys Res Commun 141 1986 263 270
12. P.D. Lee, C.A. Conover, and D.R. Powell Regulation and function of insulin-like growth factor-binding protein-1 Proc Soc Exp Biol Med 204 1993 4 29
13. A. Brinkman, D.J. Kortleve, E.C. Zwarthoff, and et al. Mutations in the C-terminal part of insulin-like growth factor (IGF)-binding protein-1 result in dimer formation and loss of IGF binding capacity Mol Endocrinol 5 1991 987 994
14. E. Ruoslahti, and M.D. Pierschbacher New perspectives in cell adhesion: RGD and integrins Science 238 1987 491 497
15. P.J. Ho, and R.C. Baxter Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia Clin Endocrinol 46 1997 333 342
16. V.C. Russo, G. Rekaris, N.L. Baker, and et al. Basic fibroblast growth factor induces proteolysis of secreted and cell membrane-associated insulin-like growth factor binding protein-2 in human neuroblastoma cells Endocrinology 140 1999 3082 3090
17. M.E. Graham, D.M. Kilby, S.M. Firth, and et al. The in vivo phosphorylation and glycosylation of human insulin-like growth factor-binding Protein-5 Mol Cell Proteomics 6 2007 1392 1405
18. J.J. Pereira, T. Meyer, S.E. Docherty, and et al. Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alphavbeta3 negatively modulates IGF-I-mediated migration and tumor growth Cancer Res 64 2004 977 984
19. V.C. Russo, B.S. Schutt, E. Andaloro, and et al. Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell proliferation, migration, and invasion Endocrinology 146 2005 4445 4455
20. X. Shen, G. Xi, L.A. Maile, and et al. Insulin-like growth factor binding protein-2 functions coordinately with receptor protein tyrosine phosphatase beta and the IGF-I receptor to regulate IGF-I-stimulated signaling Mol Cell Biol 32 2012 4116 4130
21. Z. Kuang, S. Yao, D.W. Keizer, and et al. Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2) J Mol Biol 364 2006 690 704
22. W.J. Azar, S.H. Azar, S. Higgins, and et al. IGFBP-2 enhances VEGF gene promoter activity and consequent promotion of angiogenesis by neuroblastoma cells Endocrinology 152 2011 3332 3342
23. W.J. Azar, S. Zivkovic, G.A. Werther, and et al. IGFBP-2 nuclear translocation is mediated by a functional NLS sequence and is essential for its pro-tumorigenic actions in cancer cells Oncogene 33 2014 578 588
24. C. Iosef, T. Gkourasas, C.Y. Jia, and et al. A functional nuclear localization signal in insulin-like growth factor binding protein-6 mediates its nuclear import Endocrinology 149 2008 1214 1226
25. T. Alitalo, K. Kontula, R. Koistinen, and et al. The gene encoding human low-molecular weight insulin-like growth- factor binding protein (IGF-BP25): regional localization to 7p12- p13 and description of a DNA polymorphism Hum Gen 83 1989 335 338
26. M.L. Cubbage, A. Suwanichkul, and D.R. Powell Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein Mol Endocrinol 3 1989 846 851
27. L. Tseng, J.G. Gao, R. Chen, and et al. Effect of progestin, antiprogestin, and relaxin on the accumulation of prolactin and insulin-like growth factor-binding protein-1 messenger ribonucleic acid in human endometrial stromal cells Biol Reprod 47 1992 441 450
28. S. Babajko, F. Tronche, and A. Groyer Liver-specific expression of human insulin-like growth factor binding protein 1: functional role of transcription factor HNF1 in vivo Proc Natl Acad Sci USA 90 1993 272 276
29. C.A. Conover, P.D. Lee, B.L. Riggs, and et al. Insulin-like growth factor-binding protein-1 expression in cultured human bone cells: regulation by insulin and glucocorticoid Endocrinology 137 1996 3295 3301
30. C. Binkert, J.B. Margot, J. Landwehr, and et al. Structure of the human insulin-like growth factor binding protein-2 gene Mol Endocrinol 6 1992 826 836
31. Y.R. Boisclair, A.L. Brown, S. Casola, and et al. Three clustered Sp1 sites are required for efficient transcription of the TATA-less promoter of the gene for insulin- like growth factor-binding protein-2 from the rat J Biol Chem 268 1993 24892 24901
32. G.P. Cardona-Gomez, J.A. Chowen, and L.M. Garcia-Segura Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats J Neurobiol 43 2000 269 281
33. L. Badinga, S. Song, R.C. Simmen, and et al. A distal regulatory region of the insulin-like growth factor binding protein-2 (IGFBP-2) gene interacts with the basic helix-loop-helix transcription factor, AP-4 Endocrine 8 1998 281 289
34. E. Kutoh, J. Margot, and J. Schwander Cell-density (cycle) dependent silencer of the rat insulin-like growth factor binding protein-2 (IGFBP-2) gene Growth Factors 16 1999 217 223
35. V. Cazals, E. Nabeyrat, S. Corroyer, and et al. Role for NF-kappa B in mediating the effects of hyperoxia on IGF- binding protein 2 promoter activity in lung alveolar epithelial cells Biochim Biophys Acta 1448 1999 349 362
36. A.M. Cotterill, C.T. Cowell, and M. Silink Insulin and variation in glucose levels modify the secretion rates of the growth hormone-independent insulin-like growth factor binding protein-1 in the human hepatoblastoma cell line Hep G2 J Endocrinol 123 1989 R17 R20
37. A. Hilding, K. Brismar, M. Thoren, and et al. Glucagon stimulates insulin-like growth factor binding protein-1 secretion in healthy subjects, patients with pituitary insufficiency, and patients with insulin-dependent diabetes mellitus J Clin Endocrinol Metab 77 1993 1142 1147
38. J.M. Holly, D.B. Dunger, J.A. Edge, and et al. Insulin-like growth factor binding protein-1 levels in diabetic adolescents and their relationship to metabolic control Diabet Med 7 1990 618 623
39. J.U. Weaver, J.M. Holly, P.G. Kopelman, and et al. Decreased sex hormone binding globulin (SHBG) and insulin-like growth factor binding protein (IGFBP-1) in extreme obesity Clin Endocrinol Oxf 33 1990 415 422
40. D.R. Counts, H. Gwirtsman, L.M. Carlsson, and et al. The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins J Clin Endocrinol Metab 75 1992 762 767
41. R.J. Ross, J.P. Miell, J.M. Holly, and et al. Levels of GH binding activity, IGFBP-1, insulin, blood glucose and cortisol in intensive care patients Clin Endocrinol (Oxf) 35 1991 361 367
42. D.K. Snyder, and D.R. Clemmons Insulin-dependent regulation of insulin-like growth factor-binding protein-1 J Clin Endocrinol Metab 71 1990 1632 1636
43. M.S. Lewitt, and R.C. Baxter Inhibitors of glucose uptake stimulate the production of insulin-like growth factor-binding protein (IGFBP-1) by human fetal liver Endocrinology 126 1990 1527 1533
44. M.S. Lewitt, G.S. Denyer, G.J. Cooney, and et al. Insulin-like growth factor-binding protein-1 modulates blood glucose levels Endocrinology 129 1991 2254 2256
45. H. Norrelund, S. Fisker, N. Vahl, and et al. Evidence supporting a direct suppressive effect of growth hormone on serum IGFBP-1 levels. Experimental studies in normal, obese and GH-deficient adults Growth Horm IGF Res 9 1999 52 60
46. J.O. Jorgensen, N. Moller, J. Moller, and et al. Insulin-like growth factors (IGF)-I and -II and IGF binding protein-1, -2, and -3 in patients with acromegaly before and after adenomectomy Metabolism 43 1994 579 583
47. N.E. Allen, P.N. Appleby, G.K. Davey, and et al. The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans Cancer Epidemiol Biomarkers Prev 11 2002 1441 1448
48. S.B. Wheatcroft, and M.T. Kearney IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis Trends Endocrinol Metab 20 2009 153 162
49. M.A. Sabin, V.C. Russo, W.J. Azar, and et al. IGFBP-2 at the interface of growth and metabolism-implications for childhood obesity Pediatr Endocrinol Rev 8 2011 382 393
50. A.H. Heald, K. Kaushal, K.W. Siddals, and et al. Insulin-like growth factor binding Protein-2 (IGFBP-2) is a marker for the metabolic syndrome Exp Clin Endocrinol Diabetes 114 2006 371 376
51. C. Rehfeldt, U. Renne, M. Sawitzky, and et al. Increased fat mass, decreased myofiber size, and a shift to glycolytic muscle metabolism in adolescent male transgenic mice overexpressing IGFBP-2 Am J Physiol Endocrinol Metab 299 2010 E287 E298
52. P. Wiedmer, F. Schwarz, B. Große, and et al. Gender-specific effects on food intake but no inhibition of age-related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif J Cell Commun Signal 9 2015 143 150
53. A. Hoeflich, M. Wu, S. Mohan, and et al. Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain Endocrinology 140 1999 5488 5496
54. S.B. Wheatcroft, M.T. Kearney, A.M. Shah, and et al. IGF-binding Protein-2 protects against the development of obesity and insulin resistance Diabetes 56 2007 285 294
55. Z. Li, and F. Picard Modulation of IGFBP2 mRNA expression in white adipose tissue upon aging and obesity Horm Metab Res 42 2010 787 791
56. S.Y. Nam, E.J. Lee, K.R. Kim, and et al. Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone Int J Obes Relat Metab Disord 21 1997 355 359
57. J. Frystyk, C. Skjaerbaek, E. Vestbo, and et al. Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes Diabetes Metab Res Rev 15 1999 314 322
58. A. Bereket, C.H. Lang, and T.A. Wilson Alterations in the growth hormone-insulin-like growth factor axis in insulin dependent diabetes mellitus Horm Metab Res 31 1999 172 181
59. J. Frystyk, T. Bek, A. Flyvbjerg, and et al. The relationship between the circulating IGF system and the presence of retinopathy in type 1 diabetic patients Diabet Med 20 2003 269 276
60. M.G. Ballerini, M.G. Ropelato, H.M. Domene, and et al. Differential impact of simple childhood obesity on the components of the growth hormone-insulin-like growth factor (IGF)-IGF binding proteins axis J Pediatr Endocrinol Metab 17 2004 749 757
61. A. Smerieri, M. Petraroli, M.A. Ziveri, and et al. Effects of cord serum insulin, IGF-II, IGFBP-2, IL-6 and cortisol concentrations on human birth weight and length: pilot study PLoS One 6 2011 e29562
62. J.M. Ko, H.K. Park, S. Yang, and et al. Influence of catch-up growth on IGFBP-2 levels and association between IGFBP-2 and cardiovascular risk factors in Korean children born SGA Endocr J 59 2012 725 733
63. S.W. de Kort, J. van Doorn, A.G. van de Sande, and et al. Serum insulin-like growth factor-binding protein-2 levels and metabolic and cardiovascular risk factors in young adults and children born small for gestational age J Clin Endocrinol Metab 95 2010 864 871
64. K. Hedbacker, K. Birsoy, R.W. Wysocki, and et al. Antidiabetic effects of IGFBP2, a leptin-regulated gene Cell Metab 11 2010 11 22
65. J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 1998 763 770
66. S.W. Yau, B.A. Henry, V.C. Russo, and et al. Leptin enhances insulin sensitivity by direct and sympathetic nervous system regulation of muscle Igfbp-2 expression - evidence from non-rodent models Endocrinology 2014 en20132099
67. G. Xi, M.A. Solum, C. Wai, and et al. The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice Endocrinology 154 2013 4146 4157
68. S.W. Yau, V.C. Russo, I.J. Clarke, and et al. IGFBP-2 inhibits adipogenesis and lipogenesis in human visceral, but not subcutaneous, adipocytes Int J Obes Lond 39 2014 770 781
69. D.R. Clemmons, C. Camacho-Hubner, E. Coronado, and et al. Insulin-like growth factor binding protein secretion by breast carcinoma cell lines: correlation with estrogen receptor status Endocrinology 127 1990 2679 2686
70. P.E. Lonning, K. Hall, A. Aakvaag, and et al. Influence of tamoxifen on plasma levels of insulin-like growth factor I and insulin-like growth factor binding protein I in breast cancer patients Cancer Res 52 1992 4719 4723
71. F. Pekonen, T. Nyman, V. Ilvesmaki, and et al. Insulin-like growth factor binding proteins in human breast cancer tissue Cancer Res 52 1992 5204 5207
72. J.A. Figueroa, J. Sharma, J.G. Jackson, and et al. Recombinant insulin-like growth factor binding protein-1 inhibits IGF-I, serum, and estrogen-dependent growth of MCF-7 human breast cancer cells J Cell Physiol 157 1993 229 236
73. C.M. Perks, P.V. Newcomb, M.R. Norman, and et al. Effect of insulin-like growth factor binding protein-1 on integrin signalling and the induction of apoptosis in human breast cancer cells J Mol Endocrinol 22 1999 141 150
74. D. Yee, J.G. Jackson, T.W. Kozelsky, and et al. Insulin-like growth factor binding protein 1 expression inhibits insulin-like growth factor I action in MCF-7 breast cancer cells Cell Growth Differ 5 1994 73 77
75. P.J. Goodwin, M. Ennis, K.I. Pritchard, and et al. Insulin-like growth factor binding proteins 1 and 3 and breast cancer outcomes Breast Cancer Res Treat 74 2002 65 76
76. E.S. Schernhammer, J.M. Holly, M.N. Pollak, and et al. Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk Cancer Epidemiol Biomarkers Prev 14 2005 699 704
77. I. Cheng, K.L. Penney, D.O. Stram, and et al. Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort Cancer Epidemiol Biomarkers Prev 15 2006 1993 1997
78. A. Hoeflich, R. Reisinger, H. Lahm, and et al. Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter? Cancer Res 61 2001 8601 8610
79. H. Wang, B.K. Arun, H. Wang, and et al. IGFBP2 and IGFBP5 overexpression correlates with the lymph node metastasis in T1 breast carcinomas Breast J 14 2008 261 267
80. K.W. Frommer, K. Reichenmiller, B.S. Schutt, and et al. IGF-independent effects of IGFBP-2 on the human breast cancer cell line Hs578T J Mol Endocrinol 37 2006 13 23
81. A. Juncker-Jensen, A.E. Lykkesfeldt, J. Worm, and et al. Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator Growth Horm IGF Res 16 2006 224 239
82. J. Sohn, K.A. Do, S. Liu, and et al. Functional proteomics characterization of residual triple-negative breast cancer after standard neoadjuvant chemotherapy Ann Oncol 24 2013 2522 2526
83. E.J. Foulstone, L. Zeng, C.M. Perks, and et al. Insulin-like growth factor binding protein 2 (IGFBP-2) promotes growth and survival of breast epithelial cells: novel regulation of the estrogen receptor Endocrinology 154 2013 1780 1793
84. C.M. Perks, E.G. Vernon, A.H. Rosendahl, and et al. IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells Oncogene 26 2007 5966 5972
85. M. Mireuta, A. Darnel, and M. Pollak IGFBP-2 expression in MCF-7 cells is regulated by the PI3K/AKT/mTOR pathway through Sp1-induced increase in transcription Growth Factors 28 2010 243 255
86. S.J.R. Dean, C.M. Perks, J.M.P. Holly, and et al. Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer Am J Clin Pathol 141 2014 323 333
87. N. Inaba, H. Ishige, M. Ijichi, and et al. Immunohistochemical detection of pregnancy-specific protein (SP1) and placenta-specific tissue proteins (PP5, PP10, PP11 and PP12) in ovarian adenocarcinomas Oncodev Biol Med 3 1982 379 389
88. S. Sugita, Y. Morishita, J. Kano, and et al. IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma Histopathology 58 2011 729 738
89. M. Seppala, and G. Than Insulin-like growth factor-binding protein PP12 in ovarian cyst fluid Arch Gynecol Obstet 241 1987 33 35
90. A. Lukanova, E. Lundin, A. Micheli, and et al. Risk of ovarian cancer in relation to prediagnostic levels of C-peptide, insulin-like growth factor binding proteins-1 and -2 (USA, Sweden, Italy) Cancer Causes Control 14 2003 285 292
91. D. Yee, F.R. Morales, T.C. Hamilton, and et al. Expression of insulin-like growth factor I, its binding proteins, and its receptor in ovarian cancer Cancer Res 51 1991 5107 5112
92. H. Kanety, M. Kattan, I. Goldberg, and et al. Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid Br J Cancer 73 1996 1069 1073
93. A. Karasik, J. Menczer, C. Pariente, and et al. Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer J Clin Endocrinol Metab 78 1994 271 276
94. H. Wang, D.G. Rosen, H. Wang, and et al. Insulin-like growth factor-binding protein 2 and 5 are differentially regulated in ovarian cancer of different histologic types Mod Pathol 19 2006 1149 1156
95. E.J. Lee, C. Mircean, I. Shmulevich, and et al. Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion Mol Cancer 4 2005 7
96. A. Flyvbjerg, O. Mogensen, B. Mogensen, and et al. Elevated serum insulin-like growth factor-binding protein 2 (IGFBP-2) and decreased IGFBP-3 in epithelial ovarian cancer: correlation with cancer antigen 125 and tumor-associated trypsin inhibitor J Clin Endocrinol Metab 82 1997 2308 2313
97. S. Baron-Hay, F. Boyle, A. Ferrier, and et al. Elevated serum insulin-like growth factor binding protein-2 as a prognostic marker in patients with ovarian cancer Clin Cancer Res 10 2004 1796 1806
98. Y. Cao, K. Nimptsch, I.M. Shui, and et al. Prediagnostic plasma IGFBP-1, IGF-1 and risk of prostate cancer Int J Cancer 136 2015 2418 2426
99. G. Kimura, J. Kasuya, S. Giannini, and et al. Insulin-like growth factor (IGF) system components in human prostatic cancer cell-lines: LNCaP, DU145, and PC-3 cells Int J Urol 3 1996 39 46
100. P. Cohen, D.M. Peehl, T.A. Stamey, and et al. Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients J Clin Endocrinol Metab 76 1993 1031 1035
101. M.K. Tennant, J.B. Thrasher, P.A. Twomey, and et al. Insulin-like growth factor-binding protein-2 and -3 expression in benign human prostate epithelium, prostate intraepithelial neoplasia, and adenocarcinoma of the prostate J Clin Endocrinol Metab 81 1996 411 420
102. D.J. Degraff, A.A. Aguiar, and R.A. Sikes Disease evidence for IGFBP-2 as a key player in prostate cancer progression and development of osteosclerotic lesions Am J Transl Res 1 2009 115 130
103. D.J. DeGraff, M. Malik, Q. Chen, and et al. Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model J Cell Physiol 213 2007 261 268
104. C.C. Uzoh, J.M. Holly, K.M. Biernacka, and et al. Insulin-like growth factor-binding protein-2 promotes prostate cancer cell growth via IGF-dependent or -independent mechanisms and reduces the efficacy of docetaxel Br J Cancer 104 2011 1587 1593
105. G. Mesotten DvdB Changes within the GH/IGF-I/IGFBP Axis in critical illness Berghe GVd, Contemporary endocrinology: acute cause to consequence 2008 Humana Press New York, NY 181 199