The in vivo phosphorylation and glycosylation of human insulin-like growth factor-binding protein-5

Molecular and Cellular Proteomics

Volumn 6, Issue 8, 2007, Pages 1392-1405

  Graham, Mark E ^a   Kilby, Dean M ^b   Firth, Sue M ^b   Robinson, Phillip J ^a   Baxter, Robert C ^b  

^a CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE DERIVATIVE; CASEIN KINASE II; GLYCAN DERIVATIVE; HEPARIN; HEXOSAMINE; HEXOSE; N ACETYLNEURAMINIC ACID; PEPTIDE DERIVATIVE; SERINE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 5;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; CASEIN KINASE II; CELL LINE, TUMOR; GLYCOSYLATION; HEPARIN; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; POLYSACCHARIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 34548456934     PISSN: 15359476     EISSN: None     Source Type: Journal    
DOI: 10.1074/mcp.M700027-MCP200     Document Type: Article

References (41)

1. Baxter, R. C. (2000) Insulin-like growth factor (IGF) binding proteins: Interactions with IGFs and intrinsic bioactivities. Am. J. Physiol. 278, E967-E976
2. Firth, S. M., and Baxter, R. C. (2002) Cellular actions of the insulin-like growth factor binding proteins. Endocr. Rev. 23, 824-854
3. Marshman, E., Green, K. A., Flint, D. J., White, A., Streuli, C. H., and Westwood, M. (2003) Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells. J. Cell Sci. 116, 675-682
4. Andress, D. L., and Birnbaum, R. S. (1992) Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. J. Biol. Chem. 267, 22467-22472
5. Miyakoshi, N., Richman, C., Kasukawa, Y., Linkhart, T. A., Baylink, D. J., and Mohan, S. (2001) Evidence that IGF-binding protein-5 functions as a growth factor. J. Clin. Investig. 107, 73-81
6. Coverley, J. A., Martin, J. L., and Baxter, R. C. (2000) The effect of phosphorylation by casein kinase 2 on the activity of insulin-like growth factor binding protein. Endocrinology 141, 564-570
7. Schedlich, L. J., Nilsen, T., John, A. P., Jans, D. A., and Baxter, R. C. (2003) Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation. Endocrinology 144, 1984-1993
8. Cobb, L. J., Liu, B., Lee, K. W., and Cohen, P. (2006) Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. Cancer Res. 66, 10878-10884
9. Jones, J. I., and Clemmons, D. R. (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16, 3-34
10. Firth, S. M., and Baxter, R. C. (1995) The role of glycosylation in the action of IGFBP-3. Prog. Growth Factor Res. 6, 223-229
11. Chelius, D., Wu, S. L., and Bondarenko, P. V. (2002) Identification of N-linked oligosaccharides of rat insulin-like growth factor binding protein-4. Growth Horm. IGF Res. 12, 169-177
12. Ständker, L., Wobst, P., Mark, S., and Forssmann, W. G. (1998) Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5. FEBS Lett. 441, 281-286
13. Marinaro, J. A., Neumann, G. M., Russo, V. C., Leeding, K. S., and Bach, L. A. (2000) O-Glycosylation of insulin-like growth factor (IGF) binding protein-6 maintains high IGF-II binding affinity by decreasing binding to glycosaminoglycans and susceptibility to proteolysis. Eur. J. Biochem. 267, 5378-5386
14. Bohn, H., and Kraus, W. (1980) Isolation and characterization of a new placenta specific protein (PP12). Arch. Gynecol. 229, 279-291
15. Firth, S. M., and Baxter, R. C. (1999) Characterisation of recombinant glycosylation variants of insulin-like growth factor binding protein-3. J. Endocrinol. 160, 379-387
16. Kalus, W., Zweckstetter, M., Renner, C., Sanchez, Y., Georgescu, J., Grol, M., Demuth, D., Schumacher, R., Dony, C., Lang, K., and Holak, T. A. (1998) Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. EMBO J. 17, 6558-6572
17. Pattison, S. T., Fanayan, S., and Martin, J. L. (1999) Insulin-like growth factor binding protein-3 is secreted as a phosphoprotein by human breast cancer cells. Mol. Cell. Endocrinol. 156, 131-139
18. Firth, S. M., Clemmons, D. R., and Baxter, R. C. (2001) Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding. Endocrinology 142, 2147-2150
19. Graham, M. E., Ruma-Haynes, P., Capes-Davis, A. G., Dunn, J. M., Tan, T. C., Valova, V. A., Robinson, P. J., and Jeffrey, P. L. (2004) Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5. Biochem. J. 381, 471-481
20. Fernandez-Patron, C., Castellanos-Serra, L., and Rodriguez, P. (1992) Reverse staining of sodium dodecyl sulfate polyacrylamide gels by imidazole-zinc salts: sensitive detection of unmodified proteins. BioTechniques 12, 564-573
21. Larsen, M. R., Graham, M. E., Robinson, P. J., and Roepstorff, P. (2004) Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence for in vivo doubly phosphorylated dynamin I and dynamin III. Mol. Cell. Proteomics 3, 456-465
22. Craig, A. G., Hoeger, C. A., Miller, C. L., Goedken, T., Rivier, J. E., and Fischer, W. H. (1994) Monitoring protein kinase and phosphatase reactions with matrix-assisted laser desorption/ionization mass spectrometry and capillary zone electrophoresis: comparison of the detection efficiency of peptide-phosphopeptide mixtures. Biol. Mass Spectrom. 23, 519-528
23. Graham, M. E., Dickson, P. W., Dunkley, P. R., and von Nagy-Felsobuki, E. I. (2000) Determination of phosphorylation levels of tyrosine hydroxylase by electrospray mass spectrometry. Anal. Biochem. 281, 98-104
24. Zhu, K., Zhao, J., Lubman, D. M., Miller, F. R., and Barder, T. J. (2005) Protein pl shifts due to posttranslational modifications in the separation and characterization of proteins. Anal. Chem. 77, 2745-2755
25. Jones, J. I., Busby, W. J., Wright, G., Smith, C. E., Kimack, N. M., and Clemmons, D. R. (1993) Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101. J. Biol. Chem. 268, 1125-1131
26. Hoeck, W. G., and Mukku, V. R. (1994) Identification of the major sites of phosphorylation in IGF binding protein-3. J. Cell. Biochem. 56, 262-273
27. Xu, Q., Yan, B., Li, S., and Duan, C. (2004) Fibronectin binds insulin-like growth factor-binding protein 5 and abolishes its ligand-dependent action on cell migration. J. Biol. Chem. 279, 4269-4277
28. Schedlich, L. J., O'Han, M. K., Leong, G. M., and Baxter, R. C. (2004) Insulin-like growth factor binding protein-3 prevents retinoid receptor heterodimerization: implications for retinoic acid-sensitivity in human breast cancer cells. Biochem. Biophys. Res. Commun. 314, 83-88
29. Amaar, Y. G., Baylink, D. J., and Mohan, S. (2005) Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. J. Bone Miner. Res. 20, 1430-1439
30. Amaar, Y. G., Thompson, G. R., Linkhart, T. A., Chen, S. T., Baylink, D. J., and Mohan, S. (2002) Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2). J. Biol. Chem. 277, 12053-12060
31. Ankrapp, D. P., Jones, J. I., and Clemmons, D. R. (1996) Characterization of insulin-like growth factor binding protein-1 kinases from human hepatoma cells. J. Cell. Biochem. 60, 387-399
32. Imai, Y., Busby, W. H., Jr., Smith, C. E., Clarke, J. B., Garmong, A. J., Horwitz, G. D., Rees, C., and Clemmons, D. R. (1997) Protease-resistant form of insulin-like growth factor-binding protein 5 is an inhibitor of insulin-like growth factor-I actions on porcine smooth muscle cells in culture. J. Clin. Investig. 100, 2596-2605
33. Overgaard, M. T., Boldt, H. B., Laursen, L. S., Sottrup-Jensen, L., Conover, C. A., and Oxvig, C. (2001) Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase. J. Biol. Chem. 276, 21849-21853
34. Andress, D. L., Loop, S. M., Zapf, J., and Kiefer, M. C. (1993) Carboxy-truncated insulin-like growth factor binding protein-5 stimulates mitogenesis in osteoblast-like cells. Biochem. Biophys. Res. Commun. 195, 25-30
35. Campbell, P. G., and Andress, D. L. (1997) Plasmin degradation of insulin-like growth factor-binding protein-5 (IGFBP-5): regulation by IGFBP-5-(201-218). Am. J. Physiol. 273, E996-E1004
36. Burchell, J. M., Mungul, A., and Taylor-Papadimitriou, J. (2001) O-Linked glycosylation in the mammary gland: changes that occur during malignancy. J. Mammary Gland Biol. Neoplasia 6, 355-364
37. Conover, C. A., and Kiefer, M. C. (1993) Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteo-blastic cells. J. Clin. Endocrinol. Metab. 76, 1153-1159
38. Arai, T., Parker, A., Busby, W., Jr., and Clemmons, D. R. (1994) Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes. J. Biol. Chem. 269, 20388-20393
39. Parker, A., Rees, C., Clarke, J., Busby, W. H., Jr., and Clemmons, D. R. (1998) Binding of insulin-like growth factor (IGF)-binding protein-5 to smooth-muscle cell extracellular matrix is a major determinant of the cellular response to IGF-I. Mol. Biol. Cell 9, 2383-2392
40. Baxter, R. C., Meka, S., and Firth, S. M. (2002) Molecular distribution of lGF binding protein-5 in human serum. J. Clin. Endocrinol. Metab. 87, 271-276
41. Sala, A., Capaldi, S., Campagnoli, M., Faggion, B., Labò, S., Perduca, M., Romano, A., Carrizo, M. E., Valli, M., Visai, L., Minchiotti, L., Galliano, M., and Monaco, H. L. (2005) Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid. J. Biol. Chem. 280, 29812-29819