A Citrus extract containing flavanones represses plasminogen activator inhibitor-1 (PAl-1) expression and regulates multiple inflammatory, tissue repair, and fibrosis genes in human colon fibroblasts

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 19, 2009, Pages 9305-9315

  Giménez Bastida, Juan A ^a   Martínez Florensa, Mario ^a   Espín, Juan Carlos ^a   Tomás BARBERÁN, Francisco A ^a   García Conesa, María Teresa ^a  

^a CSIC   (Spain)

Author keywords

In vitro digestion; Intestinal stability; Microarrays; Migration; MMP 12; Monocytes adhesion

Indexed keywords

ANTIINFLAMMATORY AGENT; FLAVANONE DERIVATIVE; MACROPHAGE ELASTASE; MESSENGER RNA; PLANT EXTRACT; PLASMINOGEN ACTIVATOR INHIBITOR 1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL ADHESION; CELL LINE; CELL MOTION; CHEMISTRY; CITRUS FRUIT; COLON; DIGESTION; DRUG EFFECT; FIBROBLAST; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; HUMAN;

ANTI-INFLAMMATORY AGENTS; CELL ADHESION; CELL LINE; CELL MOVEMENT; CITRUS; COLON; DIGESTION; FIBROBLASTS; FIBROSIS; FLAVANONES; GENE EXPRESSION REGULATION; HUMANS; MATRIX METALLOPROTEINASE 12; PLANT EXTRACTS; PLASMINOGEN ACTIVATOR INHIBITOR 1; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

CITRUS; CITRUS AURANTIUM;

EID: 70349925317     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf901983g     Document Type: Article

References (43)

1. (1) Ardizzone, S.; Bianchi-Porro, G. Biologic therapy for inflammatory bowel disease. Drugs 2005, 65, 2253-2286 (Pubitemid 41571985)
2. Benavente-García, O.; Castillo, J. Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity. J. Agric. Food Chem, 2008, 56, 6185-6205.
3. (3) Merken, H. M.; Beecher, G. R. Measurement of food flavonoids by high-performance liquid chromatography: A review. J. Agric. Food Chem. 2000, 48, 577-599. (Pubitemid 30193975)
4. Garg, A.; Garg, S.; Zaneveld, L. J. D.; Singla, A. K. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother. Res. 2001, 15, 655-669.
5. (5) Yeh, C. C.; Kao, S. J.; Lin, C. C.; Wang, S. D.; Liu, C. J.; Kao, S. T. The inmunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro. Life Sci. 2007, 80, 1821-1831. (Pubitemid 46560728)
6. (6) Kawaguchi, K.; Kikuchi, S.; Hasunuma, R.; Maruyama, H.; Yoshikawa, T.; Kumazawa, Y. A citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice. Biol. Pharm. Bull, 2004, 27, 679-683. (Pubitemid 41694670)
7. (7) Li, R.; Li, J.; Cai, L; Hu, C. M.; Zhang, L. Suppression of adjuvant arthritis by hespedirin in rats and its mechanisms. J. Pharm. Pharmacol. 2008, 60, 221-228. (Pubitemid 351211838)
8. Kawaguchi, K.; Maruyama, H.; Kometani, T.; Kumazawa, Y. Suppression of collagen-induced arthritis by oral administration of the citrus flavonid hesperidin. Planta Med. 2006, 72, 477-479.
9. (9) Koyuncu, H.; Berkarda, B.; Baykut, F.; Soybir, G.; Alatli, C.; GUI, H.; Altun, M. Preventive effect of hesperidin against inflammation in CD-1 mouse skin caused by tumor promoter. Anticancer Res. 1999, 19, 3237-3241. (Pubitemid 30042615)
10. (10) Kanno, S.; Shouji, A.; Tomizawa, A.; Hiura, T.; Osanai, Y.; Ujibe, M.; Obara, Y.; Nakahata, N.; Ishikawa, M. Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. Life Sci. 2006, 78, 673-681. (Pubitemid 41821123)
11. (11) Kawaguchi, K.; Kikuchi, S.; Hasunuma, R.; Maruyama, H.; Ryll, R.; Kumazawa, Y. Suppression of infection-induced endotoxin shock in mice by a citrus flavanone naringin. Planta Med. 2004, 70, 17-22. (Pubitemid 38233907)
12. Bodet, C.; La, V. D.; Epifanio, F.; Grenier, D. Naringenin has antiinflammatory properties in macrophage and ex vivo human wholeblood models. J. Periodont. Res. 2008, 43, 400-407.
13. (13) Crespo, M. E.; Gálvez, J.; Cruz, T.; Ocete, M. A.; Zarzuelo, A. Antiinflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS. Planta Med. 1999, 65, 651-653. (Pubitemid 29503234)
14. Lei, X.; Zhong-lin, Y.; Ping, L.; Yong-qiang, Z. Modulating effect of hesperidin on experimental murine colitis induced by dextran sulphate sodium. Phytomedicine [Online early access]. DOI: 10.1016/ jphymed.2009.02.021.
15. Andoh, A.; Bamba, S.; Brittan, M; Fujiyama, Y.; Wright, N. A. Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut. Pharmacol. Ther. 2007, 114, 94-106.
16. (16) Bermudez-Soto, M. J.; Tomás-Barberán, F. A.; Garcia-Conesa, M. T. Stability of polyphenols in chokeberry (Aronia melanocarpa) subjected to in vitro gastric and pancreatic digestion. Food Chem. 2007, 102, 865-874. (Pubitemid 46108292)
17. (17) Rios, L. Y.; Bennett, R. N.; Lazarus, S. A.; Rémésy, C.; Scalbert, A.; Williamson, G. Cocoa procyanidins are stable during gastric transit in humans. Am. J. Clin. Nutr. 2002, 76, 1106-1110 (Pubitemid 35244685)
18. Espin, J. C.; González-Barrio, R.; Cerdá, B.; López-Bote, C.; Rey, A. I.; Tomás-Barberán, F. A. Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans. J. Agric. Food Chem. 2007, 55, 10476-10485.
19. http://gepas.bioinfo.cipf.es/ (accessed Jul 30, 2009).
20. http://www.ingenuity.com (accessed Jul 30, 2009).
21. http://www.ncbi.nlm.nih.gov/geo/ (accessed Jul 30, 2009).
22. Espin, J. C.; Garcia-Conesa, M. T.; Tomás-Barberán, F. A. Nutraceuticals: facts and fiction. Phytochemistry 2007, 68, 2986-3008.
23. Rechner, A. R.; Smith, M. A.; Kuhnle, G; Gibson, G. R.; Debnam, E. S.; Srai, S. K. S.; Moore, K. P.; Rice-Evans, C. A. Colonic metabolism of dieraty polyphenols influence of structure on microbial fermentation products. Free Radical Biol. Med. 2004, 36, 212-225.
24. Mullen, W.; Archeveque, M.-A.; Edwards, C. A.; Matsumoto, H.; Crozier, A. Bioavailability and metabolism of orange juice flavanones in humans: Impact of a full-fat yogurt. J. Agric. Food Chem. 2008, 56, 11157-11164.
25. Kahle, K.; Kraus, M.; Scheppach, W.; Ackermann, M.; Ridder, F.; Richling, E. Studies on apple and blueberry fruit constituents: do the polyphenols reach the colon after ingestion? Mol. Nutr. Food Res. 2006, 50, 418-423
26. Scalbert, A.; Williamson, G. Dietary intake and bioavailability of polyphenols. J. Nutr. 2000, 130, 2073S-2085S.
27. (27) Snoeck, V.; Goddeeris, B.; Cox, E. The role of enterocytes in the intestinal barrier function and antigen uptake. Microbes Infect. 2005, 7, 997-1004. (Pubitemid 40982667)
28. Powell, D. W.; Adegboyega, P. A.; Di Mari, J. F.; Mifflin, R. C. Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289, G2-G7.
29. Nicholl, S. M.; Roztocil, E.; Davies, M. G. Plasminogen activator system and vascular disease. Curr. Vase. Pharmacol. 2006, 4, 101-116.
30. Pender, S. L. F.; Li, C. K. F.; Sabatino, A. D. I.; Macdonald, T. T.; Buckley, M. G. Role of macrophage matalloelastase in gut inflammation. Ann. N. Y. Acad. Sci. 2006, 1072, 386-388.
31. (31) Renckens, R.; Roelofs, J. J. T. H.; De Waard, V.; Florquin, S.; Lijnen, H. R.; Canneliet, P.; Poll, T. The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury.J. Thromb. Haemost. 2005, 3, 1018-1025. (Pubitemid 41632834)
32. (32) Friedl, P.; Bröcker, E.-B. The biology of cell locomotion within three-dimensional extracellular matrix. Cell. Mol. Life Sci. 2000, 57, 41-64. (Pubitemid 30105329)
33. Cale, J. M.; Lawrence, D. A. Structure-function relationships of plaminogen activator inhibitor-1 and its potential as a therapeutic agent. Curr. Drug Targets 2007, 8, 971-981.
34. (34) Nénan, S.; Boichot, E.; Lagente, V.; Bertrand, C. P. Macrophage elastase (MMP-12): a pro-inflammatory mediator? Mem. Inst. Oswaldo Cruz. 2005, 100, 167-172. (Pubitemid 40685458)
35. (35) Macfelda, K.; Weiss, T. W.; Kaun, C.; Breuss, J. M.; Zorn, G.; Oberndorfer, U.; Voegele-Kadletz, M.; Huber-Beckmann, R.; Ullrich, R.; Binder, B. R.; Losert, U. M.; Maurer, G.; Pacher, R.; Huber, K.; Wojta, J. Plasminogen activator inhibitor 1 expression is regulated by the inflammatory mediators intelukin-1β, tumor necrosis factor-α, transforming growth factor-β and oncostatin M in human cardiac myocytes. J. Mol. Cell Cardiol. 2002, 34, 1681-1691. (Pubitemid 35454482)
36. Barrientes, S.; Stojadinovic, O.; Golinko, M. S.; Brem, H.; TomicCanic, M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008, 16, 585-601.
37. Witkowski, J.; Yang, L.; Wood, D. J.; Sung, Paul K.-L. Migration and healing of ligament cells under inflammatory conditions. J. Orthoped. Res. 1997, 15, 269-277.
38. Chetty, A.; Davis, P.; Infeld, M. Effect of elastase on the directional migration of lung fibroblasts within a three-dimensional collagen matrix. Exp. Lung. Res. 1995, 21, 889-899.
39. Ugwu, F.; Lemmens, G.; Collen, D.; Lijnen, R. Matrix metalloproteinase deficiencies do not impair cell-associated fibrinolytic activity. Thromb. Res. 2001, 102, 61-69.
40. (40) Buchwalter, G.; Gross, C.; Wasylyk, B. The ternary complex factor net regulates cell migration through inhibition of PAI-I expression. Mol. Cell. Biol. 2005, 25, 10853-10862. (Pubitemid 41747130)
41. Nizamutdinova, I. T.; Jeong, J. J.; Xu, G. H.; Lee, S. H.; Kang, S. S.; Kim, Y. S.; Chang, K. C.; Kim, H. J. Hesperidin, hesperidin methyl chalcone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells. Int. Immunopharmacol. 2008, 8, 670-678
42. (42) Liu, X.; Wang, W.; Hu, H.; Tang, N.; Zhang, C.; Liang, W.; Wang, M. Smad3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-/β1 in cultured rat hepatic stellate cells. Pharm. Res. 2006, 23, 82-89 (Pubitemid 43214663)
43. Manthey, J. A.; Bendele, P. Anti-inflammatory activity of an orange peel polymcthoxylated flavone, 3′, 4′, 3, 5, 6, 7, 8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharidechallenge assays. J. Agric. Food Chem. 2008, 56, 9399-9403.