Single-nucleotide polymorphisms in cytochrome P450 2E1 (CYP2E1) 3′-Untranslated Region Affect the Regulation of CYP2E1 by miR-570

Drug Metabolism and Disposition

Volumn 43, Issue 10, 2015, Pages 1450-1457

  Nakano, Masataka ^a   Mohri, Takuya ^b   Fukami, Tatsuki ^a   Takamiya, Masataka ^a   Aoki, Yasuhiro ^b,d   McLeod, Howard L ^c,e   Nakajima, Miki ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

^c WASHINGTON UNIVERSITY   (United States)

^d NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^e H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2E1; MICRORNA; MICRORNA 570; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MIRN570 MICRORNA, HUMAN; PROTEIN BINDING;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE OVEREXPRESSION; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUCIFERASE ASSAY; MICROSOME; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DENATURATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RNA BINDING; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; GENETICS; HEK293 CELL LINE; LIVER MICROSOME; METABOLISM; PHYSIOLOGY;

3' UNTRANSLATED REGIONS; CYTOCHROME P-450 CYP2E1; HEK293 CELLS; HUMANS; MICRORNAS; MICROSOMES, LIVER; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING;

EID: 84946215164     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.065664     Document Type: Article

References (19)

1. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
2. Bolt HM, Roos PH, and Thier R (2003) The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine. Int Arch Occup Environ Health 76:174-185.
3. ∗. Proc Natl Acad Sci USA 109:15330-15335.
4. Chen K, Song F, Calin G.A., Wei Q., Hao X, and Zhang W (2008) Polymorphisms in microRNA targets: a gold mine for molecular epidemiology. Carcinogenesis 29:1306-1311.
5. Cicatiello L, Mutarelli M, Grober O.M., Paris O., Ferraro L, Ravo M, Tarallo R., Luo S, Schroth GP, and Seifert M, et al. (2010) Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. Am J Pathol 176: 2113-2130.
6. ∗ mediates metabolic shift in breast cancer cells via the PGC-1b/ERRg transcriptional pathway. Cell Metab 12:352-361 DOI: 10.1016/j.cmet.2010.09.002.
7. Friedman RC, Farh KK, Burge C.B., and Bartel DP (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19:92-105.
8. Liao LH, Zhang H, Lai M.P., Chen SL, Wu M, and Shen N (2011) Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population. Arthritis Res Ther 13:R11.
9. Liu Y, Chen SH, Jin X, and Li YM (2013) Analysis of differentially expressed genes and microRNAs in alcoholic liver disease. Int J Mol Med 31:547-554.
10. Lu Y and Cederbaum AI (2008) CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 44:723-738.
11. Mohri T, Nakajima M, Fukami T., Takamiya M, Aoki Y, and Yokoi T (2010) Human CYP2E1 is regulated by miR-378. Biochem Pharmacol 79:1045-1052.
12. Nakano M, Fukushima Y, Yokota S., Fukami T, Takamiya M, Aoki Y., Yokoi T, and Nakajima M (2015) CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126. Drug Metab Dispos 43:703-712.
13. Ramamoorthy A and Skaar TC (2011) In silico identification of microRNAs predicted to regulate the drug metabolizing cytochrome P450 genes. Drug Metab Lett 5:126-131.
14. Roberts BJ, Song BJ, Soh Y, Park S.S., and Shoaf SE (1995) Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. J Biol Chem 270:29632-29635.
15. Song BJ, Gelboin HV, Park S.S., Yang CS, and Gonzalez FJ (1986) Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. J Biol Chem 261:16689-16697.
16. Sumida A, Kinoshita K, Fukuda T., Matsuda H, Yamamoto I, Inaba T., and Azuma J (1999) Relationship between mRNA levels quantified by reverse transcription-competitive PCR and metabolic activity of CYP3A4 and CYP2E1 in human liver. Biochem Biophys Res Commun 262:499-503.
17. Tsuchiya Y, Nakajima M, Kyo S., Kanaya T, Inoue M, and Yokoi T (2004) Human CYP1B1 is regulated by estradiol via estrogen receptor. Cancer Res 64:3119-3125.
18. Tsuchiya Y, Nakajima M, Takagi S., Taniya T, and Yokoi T (2006) MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res 66:9090-9098.
19. Zhang SY, Surapureddi S, Coulter S., Ferguson SS, and Goldstein JA (2012) Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver. Mol Pharmacol 82:529-540.