No cure of HIV infection in a child despite early treatment and apparent viral clearance

The Lancet

Volumn 384, Issue 9950, 2014, Pages 1320-

  Giacomet, Vania ^a   Trabattoni, Daria ^a   Zanchetta, Nadia ^a   Biasin, Mara ^a   Gismondo, Mariarita ^a   Clerici, Mario ^b,c   Zuccotti, Gianvincenzo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIVUDINE; LOPINAVIR; NEVIRAPINE; RITONAVIR; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIVIRAL THERAPY; BIRTH; BONE MARROW TRANSPLANTATION; CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE; DONOR; EARLY INTERVENTION; GESTATIONAL AGE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INTRAVENOUS DRUG ABUSE; LOW BIRTH WEIGHT; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY T LYMPHOCYTE; NEWBORN; NOTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROPHYLAXIS; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL FOR DATE INFANT; TREATMENT DURATION; VAGINAL DELIVERY; VIRAL CLEARANCE; VIREMIA; VIRUS LOAD; VIRUS REPLICATION; VIRUS RESISTANCE; WESTERN BLOTTING; FEMALE; FOLLOW UP; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; ISOLATION AND PURIFICATION; PREGNANCY; PREGNANCY COMPLICATION; PROCEDURES; RECURRENT DISEASE; SECONDARY PREVENTION; TRANSMISSION; VERTICAL TRANSMISSION; VIROLOGY;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HIV-1; HUMANS; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RECURRENCE; SECONDARY PREVENTION; VIRAL LOAD;

EID: 84915800900     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(14)61405-7     Document Type: Article

References (5)

1. Yukl SA, Boritz E, Bush M, et al. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog 2013; 9: e1003347.
2. Persaud D, Gay H, Ziemniak C, et al. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med 2013; 369: 1828-35.
3. Piconi S, Trabattoni D, Gori A, et al. Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4(+) T-cell counts during antiretroviral therapy. AIDS 2010; 24: 1991-2000.
4. Deeks SG. HIV infection, infl ammation, immunosenescence, and aging. Annu Rev Med 2011; 62: 141-55.
5. Paiardini M, Muller-Trutwin M. HIV-associated chronic immune activation. Immunol Rev 2013; 254: 78-101.