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Volumn 8, Issue 3, 2013, Pages 165-169

Where does HIV hide? A focus on the central nervous system

Author keywords

astrocytes; brain; dementia; HIV; microglia; mutations; reservoirs; viral evolution

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CELL CONTACT; CELL POPULATION; CYTOPATHOLOGY; CYTOTOXIC T LYMPHOCYTE; ENDOTHELIUM CELL; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; MACROPHAGE; MICROGLIA; NEUROPATHOLOGY; PRIORITY JOURNAL; RESERVOIR; REVIEW; VIRUS DETECTION; VIRUS ENTRY; VIRUS MUTATION;

EID: 84876410605     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0b013e32835fc601     Document Type: Review
Times cited : (120)

References (44)
  • 1
    • 84860263679 scopus 로고    scopus 로고
    • HIV compartmentalization: A review on a clinically important phenomenon
    • Blackard JT. HIV compartmentalization: a review on a clinically important phenomenon. Curr HIV Res 2012; 10:133-142.
    • (2012) Curr HIV Res , vol.10 , pp. 133-142
    • Blackard, J.T.1
  • 2
    • 79952921819 scopus 로고    scopus 로고
    • HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: Differences in rates, nature, and predictors
    • Heaton RK, Franklin DR, Ellis RJ, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol 2011;17:3-16.
    • (2011) J Neurovirol , vol.17 , pp. 3-16
    • Heaton, R.K.1    Franklin, D.R.2    Ellis, R.J.3
  • 3
    • 80051726729 scopus 로고    scopus 로고
    • Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden
    • Spudich S, Gisslen M, Hagberg L, et al. Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden. J Infect Dis 2011; 204:753-760.
    • (2011) J Infect Dis , vol.204 , pp. 753-760
    • Spudich, S.1    Gisslen, M.2    Hagberg, L.3
  • 4
    • 78650338104 scopus 로고    scopus 로고
    • HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment
    • Eden A, Fuchs D, Hagberg L, et al. HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment. J Infect Dis 2010; 202:1819-1825.
    • (2010) J Infect Dis , vol.202 , pp. 1819-1825
    • Eden, A.1    Fuchs, D.2    Hagberg, L.3
  • 5
    • 79953117041 scopus 로고    scopus 로고
    • Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation
    • Allers K, Hutter G, Hofmann J, et al. Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 2011; 117:2791-2799.
    • (2011) Blood , vol.117 , pp. 2791-2799
    • Allers, K.1    Hutter, G.2    Hofmann, J.3
  • 6
    • 79952455592 scopus 로고    scopus 로고
    • Eradication of HIV from the brain: Reasons for pause
    • Nath A, Clements JE. Eradication of HIV from the brain: reasons for pause. AIDS 2011; 25:577-580.
    • (2011) AIDS , vol.25 , pp. 577-580
    • Nath, A.1    Clements, J.E.2
  • 7
    • 84862885694 scopus 로고    scopus 로고
    • Central nervous system viral invasion and inflammation during acute HIV infection
    • Valcour V, Chalermchai T, Sailasuta N, et al. Central nervous system viral invasion and inflammation during acute HIV infection. J Infect Dis 2012; 206:275-282.
    • (2012) J Infect Dis , vol.206 , pp. 275-282
    • Valcour, V.1    Chalermchai, T.2    Sailasuta, N.3
  • 8
    • 72549114622 scopus 로고    scopus 로고
    • Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia
    • Zhou L, Rua R, Ng T, et al. Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia. BMC Infect Dis 2009; 9:192.
    • (2009) BMC Infect Dis , vol.9 , pp. 192
    • Zhou, L.1    Rua, R.2    Ng, T.3
  • 9
    • 0027433852 scopus 로고
    • Frequency and topographical distribution of CD68-positive macrophages and HIV-1 core proteins in HIV-associated brain lesions
    • Neuen-Jacob E, Arendt G, Wendtland B, et al. Frequency and topographical distribution of CD68-positive macrophages and HIV-1 core proteins in HIV-associated brain lesions. Clin Neuropathol 1993; 12:315-324.
    • (1993) Clin Neuropathol , vol.12 , pp. 315-324
    • Neuen-Jacob, E.1    Arendt, G.2    Wendtland, B.3
  • 10
    • 78650222420 scopus 로고    scopus 로고
    • HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues
    • Lamers SL, Gray RR, Salemi M, et al. HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues. Infect Genet Evol 2011; 11:31-37.
    • (2011) Infect Genet Evol , vol.11 , pp. 31-37
    • Lamers, S.L.1    Gray, R.R.2    Salemi, M.3
  • 11
    • 0036795863 scopus 로고    scopus 로고
    • Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis
    • Cosenza MA, Zhao ML, Si Q, Lee SC. Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis. Brain Pathol 2002; 12:442-455.
    • (2002) Brain Pathol , vol.12 , pp. 442-455
    • Cosenza, M.A.1    Zhao, M.L.2    Si, Q.3    Lee, S.C.4
  • 12
    • 0029945512 scopus 로고    scopus 로고
    • Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocyto-chemistry
    • Takahashi K, Wesselingh SL, Griffin DE, et al. Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocyto-chemistry. Ann Neurol 1996; 39:705-711.
    • (1996) Ann Neurol , vol.39 , pp. 705-711
    • Takahashi, K.1    Wesselingh, S.L.2    Griffin, D.E.3
  • 13
    • 0000969952 scopus 로고
    • Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients
    • Wiley CA, Schrier RD, Nelson JA, et al. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci USA 1986; 83:7089-7093.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 7089-7093
    • Wiley, C.A.1    Schrier, R.D.2    Nelson, J.A.3
  • 14
    • 33644519960 scopus 로고    scopus 로고
    • Astrocyte dysfunction in neurological disorders: A molecular perspective
    • Seifert G, Schilling K, Steinhauser C. Astrocyte dysfunction in neurological disorders: a molecular perspective. Nat Rev Neurosci 2006; 7:194-206.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 194-206
    • Seifert, G.1    Schilling, K.2    Steinhauser, C.3
  • 15
    • 0028057831 scopus 로고
    • Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes
    • Tornatore C, Meyers K, Atwood W, et al. Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes. J Virol 1994; 68:93-102.
    • (1994) J Virol , vol.68 , pp. 93-102
    • Tornatore, C.1    Meyers, K.2    Atwood, W.3
  • 16
    • 2142708770 scopus 로고    scopus 로고
    • Astrocyte infection by HIV-1: Mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia
    • Gorry PR, Ong C, Thorpe J, et al. Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia. Curr HIV Res 2003; 1:463-473.
    • (2003) Curr HIV Res , vol.1 , pp. 463-473
    • Gorry, P.R.1    Ong, C.2    Thorpe, J.3
  • 18
    • 0026041114 scopus 로고
    • Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta
    • Tornatore C, Nath A, Amemiya K, Major EO. Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta. J Virol 1991; 65:6094-6100.
    • (1991) J Virol , vol.65 , pp. 6094-6100
    • Tornatore, C.1    Nath, A.2    Amemiya, K.3    Major, E.O.4
  • 19
    • 0034991252 scopus 로고    scopus 로고
    • Correlation between neurological progression and astrocyte apoptosis in HIV-associated dementia
    • Thompson KA, McArthur JC, Wesselingh SL. Correlation between neurological progression and astrocyte apoptosis in HIV-associated dementia. Ann Neurol 2001; 49:745-752.
    • (2001) Ann Neurol , vol.49 , pp. 745-752
    • Thompson, K.A.1    McArthur, J.C.2    Wesselingh, S.L.3
  • 20
    • 33646064691 scopus 로고    scopus 로고
    • Novel pathway of human immunodeficiency virus type 1 uptake and release in astrocytes
    • Clarke JN, Lake JA, Burrell CJ, et al. Novel pathway of human immunodeficiency virus type 1 uptake and release in astrocytes. Virology 2006; 348:141-155.
    • (2006) Virology , vol.348 , pp. 141-155
    • Clarke, J.N.1    Lake, J.A.2    Burrell, C.J.3
  • 21
    • 0029070088 scopus 로고
    • Infection of human fetal astrocytes with HIV-1: Viral tropism and the role of cell to cell contact in viral transmission
    • Nath A, Hartloper V, Furer M, Fowke KR. Infection of human fetal astrocytes with HIV-1: viral tropism and the role of cell to cell contact in viral transmission. J Neuropathol Exp Neurol 1995; 54:320-330.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 320-330
    • Nath, A.1    Hartloper, V.2    Furer, M.3    Fowke, K.R.4
  • 22
    • 33746901642 scopus 로고    scopus 로고
    • Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues
    • Churchill MJ, Gorry PR, Cowley D, et al. Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues. J Neurovirol 2006; 12:146-152.
    • (2006) J Neurovirol , vol.12 , pp. 146-152
    • Churchill, M.J.1    Gorry, P.R.2    Cowley, D.3
  • 23
    • 0028230433 scopus 로고
    • Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues
    • Saito Y, Sharer LR, Epstein LG, et al. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 1994; 44:474-481.
    • (1994) Neurology , vol.44 , pp. 474-481
    • Saito, Y.1    Sharer, L.R.2    Epstein, L.G.3
  • 24
    • 70149099556 scopus 로고    scopus 로고
    • Extensive astrocyte infection is prominent inhuman immunodeficiency virus-associated dementia
    • Churchill MJ, Wesselingh SL, Cowley D, et al. Extensive astrocyte infection is prominent inhuman immunodeficiency virus-associated dementia. Ann Neurol 2009; 66:253-258.
    • (2009) Ann Neurol , vol.66 , pp. 253-258
    • Churchill, M.J.1    Wesselingh, S.L.2    Cowley, D.3
  • 25
    • 0027082508 scopus 로고
    • Cellular localization of Nef expressed in persistently HIV-1-infected low-producer astrocytes
    • Kohleisen B, Neumann M, Herrmann R, et al. Cellular localization of Nef expressed in persistently HIV-1-infected low-producer astrocytes. AIDS 1992; 6:1427-1436.
    • (1992) AIDS , vol.6 , pp. 1427-1436
    • Kohleisen, B.1    Neumann, M.2    Herrmann, R.3
  • 26
    • 12144291605 scopus 로고    scopus 로고
    • Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: Potential role in neuropathogenesis
    • Wang Z, Trillo-Pazos G, Kim SY, et al. Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis. J Neurovirol 2004; 10 (Suppl 1):25-32.
    • (2004) J Neurovirol , vol.10 , Issue.SUPPL. 1 , pp. 25-32
    • Wang, Z.1    Trillo-Pazos, G.2    Kim, S.Y.3
  • 27
    • 0036176509 scopus 로고    scopus 로고
    • The challenge of viral reservoirs in HIV-1 infection
    • Blankson JN, Persaud D, Siliciano RF. The challenge of viral reservoirs in HIV-1 infection. Annu Rev Med 2002; 53:557-593.
    • (2002) Annu Rev Med , vol.53 , pp. 557-593
    • Blankson, J.N.1    Persaud, D.2    Siliciano, R.F.3
  • 28
    • 0027254101 scopus 로고
    • Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia
    • Wesselingh SL, Power C, Glass JD, et al. Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann Neurol 1993; 33:576-582.
    • (1993) Ann Neurol , vol.33 , pp. 576-582
    • Wesselingh, S.L.1    Power, C.2    Glass, J.D.3
  • 29
    • 0034025075 scopus 로고    scopus 로고
    • Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues
    • Hudson L, Liu J, Nath A, et al. Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues. J Neurovirol 2000; 6:145-155.
    • (2000) J Neurovirol , vol.6 , pp. 145-155
    • Hudson, L.1    Liu, J.2    Nath, A.3
  • 30
    • 0037631328 scopus 로고    scopus 로고
    • Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport
    • Chauhan A, Turchan J, Pocernich C, et al. Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport. J Biol Chem 2003; 278:13512-13519.
    • (2003) J Biol Chem , vol.278 , pp. 13512-13519
    • Chauhan, A.1    Turchan, J.2    Pocernich, C.3
  • 31
    • 0027427274 scopus 로고
    • HIV-1 mRNA transcripts from persistently infected human fetal astrocytes
    • Atwood WJ, Tornatore CS, Meyers K, Major EO. HIV-1 mRNA transcripts from persistently infected human fetal astrocytes. Ann N Y Acad Sci 1993; 693:324-325.
    • (1993) Ann N y Acad Sci , vol.693 , pp. 324-325
    • Atwood, W.J.1    Tornatore, C.S.2    Meyers, K.3    Major, E.O.4
  • 32
    • 70349900678 scopus 로고    scopus 로고
    • Role of Tat protein in HIV neuropathogenesis
    • Li W, Li G, Steiner J, Nath A. Role of Tat protein in HIV neuropathogenesis. Neurotox Res 2009; 16:205-220.
    • (2009) Neurotox Res , vol.16 , pp. 205-220
    • Li, W.1    Li, G.2    Steiner, J.3    Nath, A.4
  • 33
    • 79952904381 scopus 로고    scopus 로고
    • CD4 and MHC class 1 down-modulation activities of nef alleles from brain-and lymphoid tissue-derived primary HIV-1 isolates
    • Gray LR, Gabuzda D, Cowley D, et al. CD4 and MHC class 1 down-modulation activities of nef alleles from brain-and lymphoid tissue-derived primary HIV-1 isolates. J Neurovirol 2011; 17:82-91.
    • (2011) J Neurovirol , vol.17 , pp. 82-91
    • Gray, L.R.1    Gabuzda, D.2    Cowley, D.3
  • 34
    • 84858113500 scopus 로고    scopus 로고
    • Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue
    • Gonzalez-Perez MP, O'Connell O, Lin R, et al. Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue. Retrovirology 2012; 9:20.
    • (2012) Retrovirology , vol.9 , pp. 20
    • Gonzalez-Perez, M.P.1    O'Connell, O.2    Lin, R.3
  • 35
    • 33750036975 scopus 로고    scopus 로고
    • The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia
    • Dunfee RL, Thomas ER, Gorry PR, et al. The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia. Proc Natl Acad Sci USA 2006; 103:15160-15165.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15160-15165
    • Dunfee, R.L.1    Thomas, E.R.2    Gorry, P.R.3
  • 36
    • 79952958942 scopus 로고    scopus 로고
    • Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia
    • Cowley D, Gray LR, Wesselingh SL, et al. Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia. J Neurovirol 2011; 17:70-81.
    • (2011) J Neurovirol , vol.17 , pp. 70-81
    • Cowley, D.1    Gray, L.R.2    Wesselingh, S.L.3
  • 37
    • 58149393846 scopus 로고    scopus 로고
    • NMDA receptor activation by HIV-Tat protein is clade dependent
    • Li W, Huang Y, Reid R, et al. NMDA receptor activation by HIV-Tat protein is clade dependent. J Neurosci 2008; 28:12190-12198.
    • (2008) J Neurosci , vol.28 , pp. 12190-12198
    • Li, W.1    Huang, Y.2    Reid, R.3
  • 38
    • 79951801671 scopus 로고    scopus 로고
    • HIV-1 nef protein structures associated with brain infection and dementia pathogenesis
    • Lamers SL, Poon AF, McGrath MS. HIV-1 nef protein structures associated with brain infection and dementia pathogenesis. PLoS One 2011; 6:e16659.
    • (2011) PLoS One , vol.6
    • Lamers, S.L.1    Poon, A.F.2    McGrath, M.S.3
  • 39
    • 77951819905 scopus 로고    scopus 로고
    • Evidence for adaptive evolution at the divergence between lymphoid and brain HIV-1 nef genes
    • Olivieri KC, Agopian KA, Mukerji J, Gabuzda D. Evidence for adaptive evolution at the divergence between lymphoid and brain HIV-1 nef genes. AIDS Res Hum Retroviruses 2010; 26:495-500.
    • (2010) AIDS Res Hum Retroviruses , vol.26 , pp. 495-500
    • Olivieri, K.C.1    Agopian, K.A.2    Mukerji, J.3    Gabuzda, D.4
  • 40
    • 9644302671 scopus 로고    scopus 로고
    • Astrocyte specific viral strains in HIV dementia
    • Thompson KA, Churchill MJ, Gorry PR, et al. Astrocyte specific viral strains in HIV dementia. Ann Neurol 2004; 56:873-877.
    • (2004) Ann Neurol , vol.56 , pp. 873-877
    • Thompson, K.A.1    Churchill, M.J.2    Gorry, P.R.3
  • 41
    • 78649995429 scopus 로고    scopus 로고
    • HIV Brain SeqDB: A database of annotated HIV envelope sequences from brain and other anatomical sites
    • Holman AG, Mefford ME, O'Connor N, Gabuzda D. HIV Brain SeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites. AIDS Res Ther 2010; 7:43.
    • (2010) AIDS Res Ther , vol.7 , pp. 43
    • Holman, A.G.1    Mefford, M.E.2    O'Connor, N.3    Gabuzda, D.4
  • 42
    • 78149497205 scopus 로고    scopus 로고
    • Could differential virological characteristics account for ongoing viral replication and insidious damage of the brain during HIV 1 infection of the central nervous system?
    • Vissers M, Stelma FF, Koopmans PP. Could differential virological characteristics account for ongoing viral replication and insidious damage of the brain during HIV 1 infection of the central nervous system? J Clin Virol 2010; 49:231-238.
    • (2010) J Clin Virol , vol.49 , pp. 231-238
    • Vissers, M.1    Stelma, F.F.2    Koopmans, P.P.3
  • 43
    • 77953208580 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 evolutionary patterns associated with pathogenic processes in the brain
    • Lamers SL, Salemi M, Galligan DC, et al. Human immunodeficiency virus-1 evolutionary patterns associated with pathogenic processes in the brain. J Neurovirol 2010; 16:230-241.
    • (2010) J Neurovirol , vol.16 , pp. 230-241
    • Lamers, S.L.1    Salemi, M.2    Galligan, D.C.3
  • 44
    • 77949886626 scopus 로고    scopus 로고
    • Neurological complications of immune reconstitution in HIV-infected populations
    • Johnson T, Nath A. Neurological complications of immune reconstitution in HIV-infected populations. Ann N Y Acad Sci 2010; 1184:106-120.
    • (2010) Ann N y Acad Sci , vol.1184 , pp. 106-120
    • Johnson, T.1    Nath, A.2


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