Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Grimm, Alizée J ^a   Kontos, Stephan ^a,b,c   Diaceri, Giacomo ^a   Quaglia Thermes, Xavier ^a   Hubbell, Jeffrey A ^a,b,c,d  

^a EPFL   (Switzerland)

^b Anokion SA   (Switzerland)

^c Kanyos Bio Inc   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN;

ANIMAL; CD8+ T LYMPHOCYTE; ERYTHROCYTE; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MOUSE; REGULATORY T LYMPHOCYTE;

ANIMALS; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; ERYTHROCYTES; IMMUNE TOLERANCE; IMMUNOLOGIC MEMORY; MICE; T-LYMPHOCYTES, REGULATORY;

EID: 84946135560     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep15907     Document Type: Article

References (40)

1. Michael, M., Shimoni, A. & Nagler, A. Recent compounds for immunosuppression and experimental therapies for acute graftversus- host disease. Isr. Med. Assoc. J. 15, 44-50 (2013).
2. Herold, K. C. et al. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes 62, 3766-74 (2013).
3. Pescovitz, M. D. et al. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N. Engl. J. Med. 361, 2143-52 (2009).
4. Kontos, S., Grimm, A. J. & Hubbell, J. A. Engineering Antigen-Specific Immunological Tolerance. Curr. Opin. Immunol. 35, (2015).
5. Akdis, C. A. & Akdis, M. Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens. World Allergy Organ. J. 8, 17 (2015).
6. Makharia, G. K. Current and emerging therapy for celiac disease. Front. Med. 1, 6 (2014).
7. Walczak, A., Siger, M., Ciach, A., Szczepanik, M. & Selmaj, K. Transdermal application of myelin peptides in multiple sclerosis treatment. JAMA Neurol. 70, 1105-9 (2013).
8. Bar-Or, A. et al. Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial. Arch. Neurol. 64, 1407-15 (2007).
9. Roep, B. O. et al. Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8+ T cells in type 1 diabetes. Sci. Transl. Med. 5, 191ra82 (2013).
10. Akbarpour, M. et al. Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs. Sci. Transl. Med. 7, 289ra81 (2015).
11. Getts, D. R., McCarthy, D. P. & Miller, S. D. Exploiting apoptosis for therapeutic tolerance induction. J. Immunol. 191, 5341-6 (2013).
12. Fife, B. T. et al. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J. Exp. Med. 203, 2737-47 (2006).
13. Lutterotti, A. et al. Antigen-specific tolerance by autologous myelin peptide-coupled cells: a phase 1 trial in multiple sclerosis. Sci. Transl. Med. 5, 188ra75 (2013).
14. Smarr, C. B., Hsu, C.-L., Byrne, A. J., Miller, S. D. & Bryce, P. J. Antigen-fixed leukocytes tolerize Th2 responses in mouse models of allergy. J. Immunol. 187, 5090-8 (2011).
15. Luo, X. et al. ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms. Proc. Natl. Acad. Sci. USA. 105, 14527-32 (2008).
16. Kontos, S., Kourtis, I. C., Dane, K. Y. & Hubbell, J. A. Engineering antigens for in situ erythrocyte binding induces T-cell deletion. Proc. Natl. Acad. Sci. USA. 110, E60-8 (2013).
17. De Back, D. Z., Kostova, E. B., van Kraaij, M., van den Berg, T. K. & van Bruggen, R. Of macrophages and red blood cells; a complex love story. Front. Physiol. 5, 9 (2014).
18. Lorentz, K. M., Kontos, S., Diaceri, G., Henry, H. & Hubbell, J. A. Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase. Sci. Adv. 1, e1500112-e1500112 (2015).
19. Kina, T. et al. The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br. J. Haematol. 109, 280-7 (2000).
20. Rotzschke, O. et al. Exact prediction of a natural T cell epitope. Eur. J. Immunol. 21, 2891-4 (1991).
21. Parish, I. A. et al. The molecular signature of CD8+ T cells undergoing deletional tolerance. Blood 113, 4575-85 (2009).
22. Wherry, E. J. T cell exhaustion. Nat. Immunol. 12, 492-9 (2011).
23. Jellison, E. R. et al. Distinct mechanisms mediate naive and memory CD8 T-cell tolerance. Proc. Natl. Acad. Sci. USA. 109, 21438-43 (2012).
24. Redmond, W. L. & Sherman, L. A. Peripheral tolerance of CD8 T lymphocytes. Immunity 22, 275-84 (2005).
25. Xing, Y. & Hogquist, K. A. T-cell tolerance: central and peripheral. Cold Spring Harb. Perspect. Biol. 4, (2012).
26. Shevach, E. M. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30, 636-45 (2009).
27. Dejaco, C., Duftner, C., Grubeck-Loebenstein, B. & Schirmer, M. Imbalance of regulatory T cells in human autoimmune diseases. Immunology 117, 289-300 (2006).
28. Bennett, C. L. & Ochs, H. D. IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena. Curr. Opin. Pediatr. 13, 533-8 (2001).
29. Frisullo, G. et al. CD8(+ )Foxp3(+ ) T cells in peripheral blood of relapsing-remitting multiple sclerosis patients. Hum. Immunol. 71, 437-41 (2010).
30. Beres, A. J. et al. CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity. J. Immunol. 189, 464-74 (2012).
31. Chen, Z. et al. CD11c(high)CD8+ regulatory T cell feedback inhibits CD4 T cell immune response via Fas ligand-Fas pathway. J. Immunol. 190, 6145-54 (2013).
32. Carrette, F. & Surh, C. D. IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis. Semin. Immunol. 24, 209-17 (2012).
33. Liu, W. et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203, 1701-11 (2006).
34. Fife, B. T. & Bluestone, J. A. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol. Rev. 224, 166-82 (2008).
35. Getts, D. R. et al. Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. J. Immunol. 187, 2405-17 (2011).
36. Parry, R. V et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell. Biol. 25, 9543-53 (2005).
37. Buchwald, Z. S., Kiesel, J. R., DiPaolo, R., Pagadala, M. S. & Aurora, R. Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro. PLoS One 7, e38199 (2012).
38. Kapp, J. A. et al. TCR transgenic CD8+ T cells activated in the presence of TGFbeta express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int. Immunol. 18, 1549-62 (2006).
39. Tarbell, K. V et al. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J. Exp. Med. 204, 191-201 (2007).
40. Smith, N. H., Hod, E. A., Spitalnik, S. L., Zimring, J. C. & Hendrickson, J. E. Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs. Transfus. Med. 119, 1566-1569 (2012).