-
3
-
-
77952167209
-
Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
-
Stangier J, Clemens A,. Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor. Clin Appl Thromb Hemost. 2009; 15 (suppl 1): 9S-16S.
-
(2009)
Clin Appl Thromb Hemost
, vol.15
, pp. 9S-16S
-
-
Stangier, J.1
Clemens, A.2
-
4
-
-
79954520954
-
Dabigatran inhibits both clot-bound and fluid-phase thrombin in vitro: Comparison to heparin and hirudin
-
van Ryn J, Hauel N, Waldmann L, Wienen W,. Dabigatran inhibits both clot-bound and fluid-phase thrombin in vitro: comparison to heparin and hirudin. Arterioscler Thromb Vasc Biol. 2008; 28: e136-e137.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. e136-e137
-
-
Van Ryn, J.1
Hauel, N.2
Waldmann, L.3
Wienen, W.4
-
5
-
-
79954456496
-
Dabigatran etexilate: A new oral thrombin inhibitor
-
Hankey GJ, Eikelboom JW,. Dabigatran etexilate: a new oral thrombin inhibitor. Circulation. 2011; 123 (13): 1436-1450.
-
(2011)
Circulation
, vol.123
, Issue.13
, pp. 1436-1450
-
-
Hankey, G.J.1
Eikelboom, J.W.2
-
6
-
-
34548031359
-
The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
-
Stangier J, Rathgen K, Stähle H, Gansser D, Roth W,. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol. 2007; 64 (3): 292-303.
-
(2007)
Br J Clin Pharmacol
, vol.64
, Issue.3
, pp. 292-303
-
-
Stangier, J.1
Rathgen, K.2
Stähle, H.3
Gansser, D.4
Roth, W.5
-
7
-
-
70349306707
-
Dabigatran versus warfarin in patients with atrial fibrillation
-
Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009; 361 (12): 1139-1151.
-
(2009)
N Engl J Med
, vol.361
, Issue.12
, pp. 1139-1151
-
-
Connolly, S.J.1
Ezekowitz, M.D.2
Yusuf, S.3
-
8
-
-
77953168824
-
Dabigatran etexilate - A novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity
-
van Ryn J, Stangier J, Haertter S, et al. Dabigatran etexilate - a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost. 2010; 103 (6): 1116-1127.
-
(2010)
Thromb Haemost
, vol.103
, Issue.6
, pp. 1116-1127
-
-
Van Ryn, J.1
Stangier, J.2
Haertter, S.3
-
9
-
-
84870924316
-
Emergency management of bleeding associated with old and new oral anticoagulants
-
Peacock WF, Gearhart MM, Mills RM,. Emergency management of bleeding associated with old and new oral anticoagulants. Clin Cardiol. 2012; 35 (12): 730-737.
-
(2012)
Clin Cardiol
, vol.35
, Issue.12
, pp. 730-737
-
-
Peacock, W.F.1
Gearhart, M.M.2
Mills, R.M.3
-
10
-
-
80052232522
-
Dabigatran vs. Placebo in patients with acute coronary syndromes on dual antiplatelet therapy: A randomized, double-blind, phase II trial
-
Oldgren J, Budaj A, Granger CB, et al. Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial. Eur Heart J. 2011; 32 (22): 2781-2789.
-
(2011)
Eur Heart J
, vol.32
, Issue.22
, pp. 2781-2789
-
-
Oldgren, J.1
Budaj, A.2
Granger, C.B.3
-
11
-
-
84873569160
-
Concomitant use of antiplatelet therapy with dabigatran or warfarin in the randomized evaluation of long-term anticoagulation therapy (RE-LY) trial
-
Dans AL, Connolly SJ, Wallentin L, et al. Concomitant use of antiplatelet therapy with dabigatran or warfarin in the randomized evaluation of long-term anticoagulation therapy (RE-LY) trial. Circulation. 2013; 127 (5): 634-640.
-
(2013)
Circulation
, vol.127
, Issue.5
, pp. 634-640
-
-
Dans, A.L.1
Connolly, S.J.2
Wallentin, L.3
-
12
-
-
77953880514
-
Overview of platelet transfusion
-
McCullough J,. Overview of platelet transfusion. Semin Hematol. 2010; 47 (3): 235-242.
-
(2010)
Semin Hematol
, vol.47
, Issue.3
, pp. 235-242
-
-
McCullough, J.1
-
13
-
-
77949421739
-
Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: An open-label, parallel-group, single-centre study
-
Stangier J, Rathgen K, Stähle H, Mazur D,. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet. 2010; 49 (4): 259-268.
-
(2010)
Clin Pharmacokinet
, vol.49
, Issue.4
, pp. 259-268
-
-
Stangier, J.1
Rathgen, K.2
Stähle, H.3
Mazur, D.4
-
14
-
-
77952118055
-
-
E.M.A. EU. Accessed September 15, 2013
-
E.M.A. EU. Summary of Product Characteristic: PRADAXA. http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Product-Information/human/000829/WC500041059.pdf. Accessed September 15, 2013.
-
Summary of Product Characteristic: PRADAXA
-
-
-
15
-
-
84946138107
-
-
Health Canada. Boehringer Ingelheim Canada Ltd. Accessed September 15, 2013
-
Health Canada. Boehringer Ingelheim Canada Ltd. PRADAXA Product Monograph. Date of Revision: May 14, 2013. http://www.boehringer-ingelheim.ca/content/dam/internet/opu/ca-EN/documents/humanhealth/product-monograph/PradaxaPMEN0513.pdf. Accessed September 15, 2013.
-
PRADAXA Product Monograph. Date of Revision: May 14, 2013
-
-
-
16
-
-
84860528205
-
Impact of dabigatran on a large panel of routine or specific coagulation assays: Laboratory recommendations for monitoring of dabigatran etexilate
-
Douxfils J, Mullier F, Robert S, Chatelain C, Chatelain B, Dogné JM,. Impact of dabigatran on a large panel of routine or specific coagulation assays: laboratory recommendations for monitoring of dabigatran etexilate. Thromb Haemost. 2012; 107 (5): 985-997.
-
(2012)
Thromb Haemost
, vol.107
, Issue.5
, pp. 985-997
-
-
Douxfils, J.1
Mullier, F.2
Robert, S.3
Chatelain, C.4
Chatelain, B.5
Dogné, J.M.6
-
17
-
-
84881221868
-
Dabigatran: Is there a role for coagulation assays in guiding therapy?
-
Brunetti L, Bandali F,. Dabigatran: is there a role for coagulation assays in guiding therapy? Ann Pharmacother. 2013; 47 (6): 828-840.
-
(2013)
Ann Pharmacother
, vol.47
, Issue.6
, pp. 828-840
-
-
Brunetti, L.1
Bandali, F.2
-
18
-
-
84883668874
-
Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: A single center experience
-
Singh T, Maw TT, Henry BL, et al. Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013; 8 (9): 1533-1539.
-
(2013)
Clin J Am Soc Nephrol
, vol.8
, Issue.9
, pp. 1533-1539
-
-
Singh, T.1
Maw, T.T.2
Henry, B.L.3
-
19
-
-
84858966373
-
Interpretation of point-of-care INR results in patients treated with dabigatran
-
van Ryn J, Baruch L, Clemens A., van Ryn J, Baruch L, Clemens A,. Interpretation of point-of-care INR results in patients treated with dabigatran. Am J Med. 2012; 125 (4): 417-420.
-
(2012)
Am J Med
, vol.125
, Issue.4
, pp. 417-420
-
-
Van Ryn, J.1
Baruch, L.2
Clemens, A.3
Van Ryn, J.4
Baruch, L.5
Clemens, A.6
-
20
-
-
37149005153
-
Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
-
Stangier J, Stahle H, Rathgen K, et al. Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet. 2008; 47 (1): 47-59.
-
(2008)
Clin Pharmacokinet
, vol.47
, Issue.1
, pp. 47-59
-
-
Stangier, J.1
Stahle, H.2
Rathgen, K.3
-
22
-
-
84871744380
-
The effect of dabigatran on select specialty coagulation assays
-
Adcock DM, Gosselin R, Kitchen S, Dwyre DM,. The effect of dabigatran on select specialty coagulation assays. Am J Clin Pathol. 2013; 139 (1): 102-109.
-
(2013)
Am J Clin Pathol
, vol.139
, Issue.1
, pp. 102-109
-
-
Adcock, D.M.1
Gosselin, R.2
Kitchen, S.3
Dwyre, D.M.4
-
23
-
-
10844269522
-
Ecarin chromogenic assay - A new method for quantitative determination of direct thrombin inhibitors like hirudin
-
Lange U, Nowak G, Bucha E,. Ecarin chromogenic assay - a new method for quantitative determination of direct thrombin inhibitors like hirudin. Pathophysiol Haemost Thromb. 2003; 33 (4): 184-191.
-
(2003)
Pathophysiol Haemost Thromb
, vol.33
, Issue.4
, pp. 184-191
-
-
Lange, U.1
Nowak, G.2
Bucha, E.3
-
24
-
-
84881474743
-
Measuring the anticoagulant effects of target specific oral anticoagulants-reasons, methods and current limitations
-
Mani H, Kasper A, Lindhoff-Last E,. Measuring the anticoagulant effects of target specific oral anticoagulants-reasons, methods and current limitations. J Thromb Thrombolysis. 2013; 36 (2): 187-194.
-
(2013)
J Thromb Thrombolysis
, vol.36
, Issue.2
, pp. 187-194
-
-
Mani, H.1
Kasper, A.2
Lindhoff-Last, E.3
-
25
-
-
84886792146
-
Evaluation of coagulation assays versus LC-MS/MS for determinations of dabigatran concentrations in plasma
-
Antovic JP, Skeppholm M, Eintrei J, et al. Evaluation of coagulation assays versus LC-MS/MS for determinations of dabigatran concentrations in plasma. Eur J Clin Pharmacol. 2013; 69 (11): 1875-1881.
-
(2013)
Eur J Clin Pharmacol
, vol.69
, Issue.11
, pp. 1875-1881
-
-
Antovic, J.P.1
Skeppholm, M.2
Eintrei, J.3
-
26
-
-
84856784474
-
American college of chest physicians. Oral anticoagulant therapy: Antithrombotic therapy and prevention of Thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines
-
S
-
Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G,. American college of chest physicians. Oral anticoagulant therapy: antithrombotic therapy and prevention of Thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2012; 141 (2 suppl): e44S-e88 S.
-
(2012)
Chest
, vol.141
, Issue.2
, pp. e44S-e88
-
-
Ageno, W.1
Gallus, A.S.2
Wittkowsky, A.3
Crowther, M.4
Hylek, E.M.5
Palareti, G.6
-
27
-
-
79958844941
-
Adsorption of dabigatran etexilate in water or dabigatran in pooled human plasma by activated charcoal in vitro [Abstract no. 1065]
-
New Orleans (LA): American Society of Hematology
-
van Ryn J, Sieger P, Kink-Eiband M, et al. Adsorption of dabigatran etexilate in water or dabigatran in pooled human plasma by activated charcoal in vitro [Abstract no. 1065]. 51st ASH Annual Meeting and Exposition. New Orleans (LA): American Society of Hematology. 2009.
-
(2009)
51st ASH Annual Meeting and Exposition
-
-
Van Ryn, J.1
Sieger, P.2
Kink-Eiband, M.3
-
28
-
-
84859971855
-
Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors
-
Kaatz S, Kouides PA, Garcia DA, et al. Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. Am J Hematol. 2012; 87 (suppl 1): S141-S145.
-
(2012)
Am J Hematol
, vol.87
, pp. S141-S145
-
-
Kaatz, S.1
Kouides, P.A.2
Garcia, D.A.3
-
29
-
-
84874114340
-
Removal of dabigatran by hemodialysis
-
Chang DN, Dager WE, Chin AI,. Removal of dabigatran by hemodialysis. Am J Kidney Dis. 2013; 61 (3): 487-489.
-
(2013)
Am J Kidney Dis
, vol.61
, Issue.3
, pp. 487-489
-
-
Chang, D.N.1
Dager, W.E.2
Chin, A.I.3
-
30
-
-
84857759555
-
Recombinant factor VIIa (rhFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding
-
Warkentin TE, Margetts P, Connolly SJ, Lamy A, Ricci C, Eikelboom JW,. Recombinant factor VIIa (rhFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding. Blood. 2012; 119: 2172-2174.
-
(2012)
Blood
, vol.119
, pp. 2172-2174
-
-
Warkentin, T.E.1
Margetts, P.2
Connolly, S.J.3
Lamy, A.4
Ricci, C.5
Eikelboom, J.W.6
-
31
-
-
84875926001
-
Effective elimination of dabigatran by haemodialysis: A phase i single-centre study in patients with end-stage renal disease
-
Khadzhynov D, Wagner F, Formella S, et al. Effective elimination of dabigatran by haemodialysis: a phase I single-centre study in patients with end-stage renal disease. Thromb Haemost. 2013; 109 (4): 596-605.
-
(2013)
Thromb Haemost
, vol.109
, Issue.4
, pp. 596-605
-
-
Khadzhynov, D.1
Wagner, F.2
Formella, S.3
-
32
-
-
9644254211
-
Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage
-
Freeman WD, Brott TG, Barrett KM, et al. Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage. Mayo Clin Proc. 2004; 79 (12): 1495-1500.
-
(2004)
Mayo Clin Proc
, vol.79
, Issue.12
, pp. 1495-1500
-
-
Freeman, W.D.1
Brott, T.G.2
Barrett, K.M.3
-
33
-
-
46249125890
-
Recombinant factor VIIa for warfarin-associated intracranial bleeding
-
Ilyas C, Beyer GM, Dutton RP, et al. Recombinant factor VIIa for warfarin-associated intracranial bleeding. J Clin Anesth. 2008; 20 (4): 276-279.
-
(2008)
J Clin Anesth
, vol.20
, Issue.4
, pp. 276-279
-
-
Ilyas, C.1
Beyer, G.M.2
Dutton, R.P.3
-
34
-
-
84864370719
-
Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: A randomised crossover ex vivo study in healthy volunteers
-
Marlu R, Hodaj E, Paris A, Albaladejo P, Cracowski JL, Pernod G,. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb Haemost. 2012; 108 (2): 217-224.
-
(2012)
Thromb Haemost
, vol.108
, Issue.2
, pp. 217-224
-
-
Marlu, R.1
Hodaj, E.2
Paris, A.3
Albaladejo, P.4
Cracowski, J.L.5
Pernod, G.6
-
35
-
-
67849124919
-
Reversibility of the anticoagulant effect of high doses of the direct thrombin inhibitor dabigatran, by recombinant factor VIIa or activated prothrombin complex concentrate
-
van Ryn J, Ruehl D, Priepke H, Hauel N, Wienen W,. Reversibility of the anticoagulant effect of high doses of the direct thrombin inhibitor dabigatran, by recombinant factor VIIa or activated prothrombin complex concentrate. Haematologica. 2008; 93 (s1): 148.
-
(2008)
Haematologica
, vol.93
, Issue.S1
, pp. 148
-
-
Van Ryn, J.1
Ruehl, D.2
Priepke, H.3
Hauel, N.4
Wienen, W.5
-
36
-
-
78049498149
-
Safety of recombinant activated factor VII in randomized clinical trials
-
Levi M, Levy JH, Andersen HF, Truloff D,. Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med. 2010; 363 (19): 1791-1800.
-
(2010)
N Engl J Med
, vol.363
, Issue.19
, pp. 1791-1800
-
-
Levi, M.1
Levy, J.H.2
Andersen, H.F.3
Truloff, D.4
-
37
-
-
34547436844
-
Coagulation factor concentrates: Past, present, and future
-
Key NS, Negrier C,. Coagulation factor concentrates: past, present, and future. Lancet. 2007; 370 (9585): 439-448.
-
(2007)
Lancet
, vol.370
, Issue.9585
, pp. 439-448
-
-
Key, N.S.1
Negrier, C.2
-
38
-
-
84856214360
-
Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran
-
Zhou W, Schwarting S, Illanes S, et al. Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran. Stroke. 2011; 42 (12): 3594-3599.
-
(2011)
Stroke
, vol.42
, Issue.12
, pp. 3594-3599
-
-
Zhou, W.1
Schwarting, S.2
Illanes, S.3
-
39
-
-
80053571188
-
Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
-
Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M,. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011; 124 (14): 1573-1579.
-
(2011)
Circulation
, vol.124
, Issue.14
, pp. 1573-1579
-
-
Eerenberg, E.S.1
Kamphuisen, P.W.2
Sijpkens, M.K.3
Meijers, J.C.4
Buller, H.R.5
Levi, M.6
-
40
-
-
84869189977
-
Periprocedural management and approach to bleeding in patients taking dabigatran
-
Weitz JI, Quinlan DJ, Eikelboom JW,. Periprocedural management and approach to bleeding in patients taking dabigatran. Circulation. 2012; 126 (20): 2428-2432.
-
(2012)
Circulation
, vol.126
, Issue.20
, pp. 2428-2432
-
-
Weitz, J.I.1
Quinlan, D.J.2
Eikelboom, J.W.3
-
41
-
-
84876666915
-
Reversing dabigatran in life-threatening bleeding occurring during cardiac ablation with factor eight inhibitor bypassing activity
-
Dager WE, Gosselin RC, Roberts AJ,. Reversing dabigatran in life-threatening bleeding occurring during cardiac ablation with factor eight inhibitor bypassing activity. Crit Care Med. 2013; 41 (5): e42-e46.
-
(2013)
Crit Care Med
, vol.41
, Issue.5
, pp. e42-e46
-
-
Dager, W.E.1
Gosselin, R.C.2
Roberts, A.J.3
-
42
-
-
80052332326
-
Safety of prothrombin complex concentrates for rapid anticoagulation reversal of Vitamin K antagonists. A meta-analysis
-
Dentali F, Marchesi C, Pierfranceschi MG, et al. Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis. Thromb Haemost. 2011; 106 (3): 429-438.
-
(2011)
Thromb Haemost
, vol.106
, Issue.3
, pp. 429-438
-
-
Dentali, F.1
Marchesi, C.2
Pierfranceschi, M.G.3
-
43
-
-
84859648812
-
-
Preparation and clinical use of plasma and plasma fractions. In: eds. New York, NY: McGraw-Hill
-
Friedman KD, Menitove JE,. Preparation and clinical use of plasma and plasma fractions. In: Beutler E, Lichtman MA, Coller BS, et al.eds. Williams' Hematology, 6th ed. New York, NY: McGraw-Hill; 2001: 1917.
-
(2001)
Williams' Hematology, 6th Ed
, pp. 1917
-
-
Friedman, K.D.1
Menitove, J.E.2
Beutler, E.3
Lichtman, M.A.4
Coller, B.S.5
-
44
-
-
21644434986
-
Fresh frozen plasma is ineffective for correcting minimally elevated international normalized ratios
-
Holland LL, Foster TM, Marlar RA, Brooks JP,. Fresh frozen plasma is ineffective for correcting minimally elevated international normalized ratios. Transfusion. 2005; 45 (7): 1234-1235.
-
(2005)
Transfusion
, vol.45
, Issue.7
, pp. 1234-1235
-
-
Holland, L.L.1
Foster, T.M.2
Marlar, R.A.3
Brooks, J.P.4
-
45
-
-
0026584690
-
Desmopressin (d-DAVP) effects on platelet rheology and von Willebrand factor activities in uremia
-
Zeigler ZR, Megaludis A, Fraley DS,. Desmopressin (d-DAVP) effects on platelet rheology and von Willebrand factor activities in uremia. Am J Hematol. 1992; 39 (2): 90-95.
-
(1992)
Am J Hematol
, vol.39
, Issue.2
, pp. 90-95
-
-
Zeigler, Z.R.1
Megaludis, A.2
Fraley, D.S.3
-
46
-
-
0020672461
-
Deamino-8-D-Arginine vasopressin shortens the bleeding time in uremia
-
Mannucci PM, Remuzzi G, Pusineri F, et al. Deamino-8-D-Arginine vasopressin shortens the bleeding time in uremia. N Engl J Med. 1983; 308 (1): 8-12.
-
(1983)
N Engl J Med
, vol.308
, Issue.1
, pp. 8-12
-
-
Mannucci, P.M.1
Remuzzi, G.2
Pusineri, F.3
|