메뉴 건너뛰기




Volumn 47, Issue 6, 2013, Pages 828-840

Dabigatran: Is there a role for coagulation assays in guiding therapy?;Dabigatran: ¿tienen las pruebas de coagulación algún papel en guiar la terapia?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDOTE; DABIGATRAN ETEXILATE; ECARIN; ENOXAPARIN; PHYTOMENADIONE; THROMBIN; THROMBIN INHIBITOR; WARFARIN;

EID: 84881221868     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1R720     Document Type: Article
Times cited : (9)

References (100)
  • 1
    • 84856699090 scopus 로고    scopus 로고
    • Executive summary: Antithrombotic therapy and prevention of thrombosis
    • 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, doi: 10.1378/chest.1412S3
    • Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuunemann HJ. Executive summary: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012;141:7S-47S. doi: 10.1378/chest.1412S3
    • (2012) Chest , vol.141 , pp. 7-47
    • Guyatt, G.H.1    Akl, E.A.2    Crowther, M.3    Gutterman, D.D.4    Schuunemann, H.J.5
  • 2
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • doi:10.1056/NEJMoa0905561
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361:1139-1151.doi: 10.1056/NEJMoa0905561
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 3
    • 84878661546 scopus 로고    scopus 로고
    • Product information, Ridgefield, CT:, Boehringer Ingelheim Pharmaceuticals, Inc., December
    • Product information. Pradaxa (dabigatran etexilate mesylate). Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc., December 2012.
    • (2012) Pradaxa (dabigatran Etexilate Mesylate)
  • 4
    • 41949116970 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
    • doi:10.2165/00003088-200847050-00001
    • Stangier J. Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clin Pharmacokinet 2008;47:285-295. doi: 10.2165/00003088-200847050-00001
    • (2008) Clin Pharmacokinet , vol.47 , pp. 285-295
    • Stangier, J.1
  • 5
    • 77952167209 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics, and pharmacody-namics of dabigatran etexilate, an oral direct thrombin inhibitor
    • doi:10.1177/1076029609343004
    • Stangier J, Clemens A. Pharmacology, pharmacokinetics, and pharmacody-namics of dabigatran etexilate, an oral direct thrombin inhibitor. Clin Appl Thromb Hemost 2009;15(suppl 1):9S-16S.doi: 10.1177/1076029609343004
    • (2009) Clin Appl Thromb Hemost , vol.15 , Issue.1 , pp. 9-16
    • Stangier, J.1    Clemens, A.2
  • 6
    • 17644400166 scopus 로고    scopus 로고
    • Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement
    • doi:10.1177/0091270005274550
    • Stangier J, Eriksson BI, Dahl OE, et al. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. J Clin Pharmacol 2005;45:555-563. doi: 10.1177/0091270005274550
    • (2005) J Clin Pharmacol , vol.45 , pp. 555-563
    • Stangier, J.1    Eriksson, B.I.2    Dahl, O.E.3
  • 7
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacoki-netics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • doi:10.1111/j.1365-2125.2007.02899.x
    • Stangier J, Rathgen K, Stahle H, Gansser D, Roth W. The pharmacoki-netics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007;64:292-303. doi: 10.1111/j.1365-2125.2007.02899.x
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 8
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabiga-tran, in humans
    • doi:10.1124/dmd.107.019083
    • Blech S, Ebner T, Ludwig-Schwellinger E, Stangier J, Roth W. The metabolism and disposition of the oral direct thrombin inhibitor, dabiga-tran, in humans. Drug Metab Dispos 2008;36:386-399.doi: 10.1124/dmd.107.019083
    • (2008) Drug Metab Dispos , vol.36 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3    Stangier, J.4    Roth, W.5
  • 9
    • 84867357013 scopus 로고    scopus 로고
    • Perspective on dabi- gatran etexilate dosing: Why not follow standard pharmacological principles?
    • doi:10.1111/j.1365-2125.2012.04266.x
    • Chin PK, Vella-Brincat JW, Barclay ML, Begg EJ. Perspective on dabi- gatran etexilate dosing: why not follow standard pharmacological principles? Br J Clin Pharmacol 2012;74:734-740. doi: 10.1111/j.1365-2125.2012.04266.x
    • (2012) Br J Clin Pharmacol , vol.74 , pp. 734-740
    • Chin, P.K.1    Vella-Brincat, J.W.2    Barclay, M.L.3    Begg, E.J.4
  • 10
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate: A novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity
    • doi:10.1160/TH09-11-0758
    • VanRyn J, Stangier J, Haertter S, et al. Dabigatran etexilate: a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010;103: 1116-1127. doi: 10.1160/TH09-11-0758
    • (2010) Thromb Haemost , vol.103 , pp. 1116-1127
    • VanRyn, J.1    Stangier, J.2    Haertter, S.3
  • 11
    • 84894653205 scopus 로고    scopus 로고
    • Dabigatran anticoagulant activity is neutralized by an antibody selective to dabigatran in in vitro and in vivo models
    • VanRyn J, Litzenberger T, Waterman A, et al. Dabigatran anticoagulant activity is neutralized by an antibody selective to dabigatran in in vitro and in vivo models. J Am Coll Cardiol 2011;57:E1130.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 11-30
    • VanRyn, J.1    Litzenberger, T.2    Waterman, A.3
  • 12
    • 34548575058 scopus 로고    scopus 로고
    • Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomised, double-blind, non-inferiority trial
    • doi:10.1016/S0140-6736(07)61445-7
    • Eriksson BI, Dahl OE, Rosencher N, et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet 2007;370:949-956. doi: 10.1016/S0140-6736(07)61445-7
    • (2007) Lancet , vol.370 , pp. 949-956
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 13
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • doi:10.1056/NEJMoa0906598
    • Schulman S, Kearon C, Kakkar AK, et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009; 361:2342-2352. doi: 10.1056/NEJMoa0906598
    • (2009) N Engl J Med , vol.361 , pp. 2342-2352
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 14
    • 57649123692 scopus 로고    scopus 로고
    • Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery
    • doi:10.1016/j.arth.2008.01.132
    • Ginsberg JS, Davidson BL, Comp PC, et al. Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty 2009;24:1-9. doi: 10.1016/j.arth.2008.01.132
    • (2009) J Arthroplasty , vol.24 , pp. 1-9
    • Ginsberg, J.S.1    Davidson, B.L.2    Comp, P.C.3
  • 15
    • 79953836474 scopus 로고    scopus 로고
    • Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NO-VATE II): A randomised, double-blind, non-inferiority trial
    • doi:10.1160/TH10-10-0679
    • Eriksson BI, Dahl OE, Huo MH, et al. Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NO-VATE II): a randomised, double-blind, non-inferiority trial. Thromb Haemost 2011;105:721-729. doi: 10.1160/TH10-10-0679
    • (2011) Thromb Haemost , vol.105 , pp. 721-729
    • Eriksson, B.I.1    Dahl, O.E.2    Huo, M.H.3
  • 16
    • 35449007749 scopus 로고    scopus 로고
    • Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: The RE-MODEL randomized trial
    • doi:10.1111/j.1538-7836.2007.02748.x
    • Eriksson BI, Dahl OE, Rosencher N, et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost 2007;5:2178-2185. doi: 10.1111/j.1538-7836.2007.02748.x
    • (2007) J Thromb Haemost , vol.5 , pp. 2178-2185
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 17
    • 84865045736 scopus 로고    scopus 로고
    • Fatal gastrointestinal hemorrhage after a single dose of dabigatran
    • doi:10.3109/15563650.2012.705290
    • Kernan L, Ito S, Shirazi F, Boesen K. Fatal gastrointestinal hemorrhage after a single dose of dabigatran. Clin Toxicol 2012;50:571-573. doi: 10.3109/15563650.2012.705290
    • (2012) Clin Toxicol , vol.50 , pp. 571-573
    • Kernan, L.1    Ito, S.2    Shirazi, F.3    Boesen, K.4
  • 18
    • 84857853180 scopus 로고    scopus 로고
    • Bleeding risk with dabigatran in the frail elderly
    • doi:10.1056/NEJMc1112874
    • Harper P, Young L, Merriman E. Bleeding risk with dabigatran in the frail elderly. N Engl J Med 2012;366:864-866. doi: 10.1056/NEJMc1112874
    • (2012) N Engl J Med , vol.366 , pp. 864-866
    • Harper, P.1    Young, L.2    Merriman, E.3
  • 19
    • 84881262489 scopus 로고    scopus 로고
    • QuarterWatch (first quarter 2011), ISMP medication safety alert, 17(1), January
    • QuarterWatch (first quarter 2011). Signals for dabigatran and metoclo-pramide. ISMP medication safety alert, 17(1), January 12, 2012.
    • (2012) Signals For Dabigatran and Metoclo-pramide , pp. 12
  • 20
    • 79960955075 scopus 로고    scopus 로고
    • The use of dabigatran in elderly patients
    • doi: 10.1001/archinternmed.2011.314
    • Legrand M, Mateo J, Aribaud A, et al. The use of dabigatran in elderly patients. Arch Intern Med 2011;171:1285-1286. doi: 10.1001/archinternmed.2011.314
    • (2011) Arch Intern Med , vol.171 , pp. 1285-1286
    • Legrand, M.1    Mateo, J.2    Aribaud, A.3
  • 21
    • 84863660210 scopus 로고    scopus 로고
    • Dabigatran: Uncharted waters and potential harms
    • doi: 10.7326/0003-4819-157-1-201207030-00467
    • Radecki RP. Dabigatran: uncharted waters and potential harms. Ann Intern Med 2012;157:66-68. doi: 10.7326/0003-4819-157-1-201207030-00467
    • (2012) Ann Intern Med , vol.157 , pp. 66-68
    • Radecki, R.P.1
  • 22
    • 84862243930 scopus 로고    scopus 로고
    • Rectal bleeding and hemostatic disorders induced by dabigatran etexilate in 2 elderly patients
    • doi: 10.1345/aph.1Q705
    • Bene J, Said W, Rannou M, Deheul S, Coupe P, Gautier S. Rectal bleeding and hemostatic disorders induced by dabigatran etexilate in 2 elderly patients. Ann Pharmacother 2012;46:e14. doi: 10.1345/aph.1Q705
    • (2012) Ann Pharmacother , vol.14 , pp. 46
    • Bene, J.1    Said, W.2    Rannou, M.3    Deheul, S.4    Coupe, P.5    Gautier, S.6
  • 23
    • 84865041123 scopus 로고    scopus 로고
    • Stroke and bleeding in atrial fibrillation with chronic kidney disease
    • doi: 10.1056/NEJMoa1105594
    • Olesen JB, Lip GY, Kamper AL, et al. Stroke and bleeding in atrial fibrillation with chronic kidney disease. N Engl J Med 2012;367:625-635. doi: 10.1056/NEJMoa1105594
    • (2012) N Engl J Med , vol.367 , pp. 625-635
    • Olesen, J.B.1    Lip, G.Y.2    Kamper, A.L.3
  • 24
    • 77955801264 scopus 로고    scopus 로고
    • Systemic anticoagulation considerations in chronic kidney disease
    • doi: 10.1053/j.ackd.2010.06.002
    • Dager WE, Kiser TH. Systemic anticoagulation considerations in chronic kidney disease. Adv Chronic Kidney Dis 2010;17:420-427. doi: 10.1053/j.ackd.2010.06.002
    • (2010) Adv Chronic Kidney Dis , vol.17 , pp. 420-427
    • Dager, W.E.1    Kiser, T.H.2
  • 25
    • 66249097380 scopus 로고    scopus 로고
    • Use of anticoagulants in elderly patients: Practical recommendations
    • Robert-Ebadi H, Le Gal G, Righini M. Use of anticoagulants in elderly patients: practical recommendations. Clin Interv Aging 2009;4:165-177.
    • (2009) Clin Interv Aging , vol.4 , pp. 165-177
    • Robert-Ebadi, H.1    Le, G.G.2    Righini, M.3
  • 26
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etex-ilate: An open-label, parallel-group, single-centre study
    • doi: 10.2165/11318170-000000000-00000
    • Stangier J, Rathgen K, Stahle H, Mazur D. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etex-ilate: an open-label, parallel-group, single-centre study. Clin Pharma-cokinet 2010;49:259-268. doi: 10.2165/11318170-000000000-00000
    • (2010) Clin Pharma-cokinet , vol.49 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Mazur, D.4
  • 27
    • 79958126202 scopus 로고    scopus 로고
    • Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (Re-LY) trial
    • doi: 10.1161/CIRCULATIONAHA.110.004747
    • Eikelboom JW, Wallentin L, Connolly SJ, et al. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (Re-LY) trial. Circulation 2011;123: 2363-2372. doi: 10.1161/CIRCULATIONAHA.110.004747
    • (2011) Circulation , vol.123 , pp. 2363-2372
    • Eikelboom, J.W.1    Wallentin, L.2    Connolly, S.J.3
  • 28
    • 84873611970 scopus 로고    scopus 로고
    • Prescribing information, European Medicines Agency.(accessed 2012 Oct 1)
    • Prescribing information. Pradaxa (dabigatran etexilate). European Medicines Agency. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_Product_Information/human/000829/WC500041059.pdf (accessed 2012 Oct 1).
    • Pradaxa (dabigatran Etexilate)
  • 29
    • 84873611970 scopus 로고    scopus 로고
    • Prescribing information, Health Canada, accessed 2012 Oct 1
    • Prescribing information. Pradaxa (dabigatran etexilate). Health Canada. http://www.boehringer-ingelheim.ca/en/Home/Human_Health/Our_Prod-ucts/Product_Monographs/Pradax-pm.pdf (accessed 2012 Oct 1)
    • Pradaxa (dabigatran Etexilate)
  • 30
    • 84864288063 scopus 로고    scopus 로고
    • The food and drug administration decision not to approve the 110 mg dose of dabigatran: Give us a way out
    • doi: 10.1016/j.amjmed.2011.10.035
    • Kowey PR, Naccarelli G V. The food and drug administration decision not to approve the 110 mg dose of dabigatran: Give us a way out. Am J Med 2012;125:732. doi: 10.1016/j.amjmed.2011.10.035
    • (2012) Am J Med , vol.125 , pp. 732
    • Kowey, P.R.1    Naccarelli, G.V.2
  • 31
    • 79955480110 scopus 로고    scopus 로고
    • Coagulation parameters in patients receiving dabigatran etexilate or rivaroxaban: Two observational studies in patients undergoing total hip or total knee replacement
    • doi: 10.1016/j.thromres.2011.01.001
    • Freyburger G, Macouillard G, Labrouche S, Sztark F. Coagulation parameters in patients receiving dabigatran etexilate or rivaroxaban: Two observational studies in patients undergoing total hip or total knee replacement. Thromb Res 2011;127:457-465. doi: 10.1016/j.thromres.2011.01.001
    • (2011) Thromb Res , vol.127 , pp. 457-465
    • Freyburger, G.1    Macouillard, G.2    Labrouche, S.3    Sztark, F.4
  • 32
    • 84857015053 scopus 로고    scopus 로고
    • Laboratory testing of anticoagulants: The present and the future
    • doi: 10.1097/PAT.0b013e32834bf5f4
    • Favaloro EJ, Lippi G, Koutts J. Laboratory testing of anticoagulants: the present and the future. Pathology 2011;43:682-692. doi: 10.1097/PAT.0b013e32834bf5f4
    • (2011) Pathology , vol.43 , pp. 682-692
    • Favaloro, E.J.1    Lippi, G.2    Koutts, J.3
  • 34
    • 37149005153 scopus 로고    scopus 로고
    • Pharmacokinetics and pharma-codynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
    • doi: 10.2165/00003088-200847010-00005
    • Stangier J, Stahle H, Rathgen K, Fuhr R. Pharmacokinetics and pharma-codynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet 2008;47:47-59. doi: 10.2165/00003088-200847010-00005
    • (2008) Clin Pharmacokinet , vol.47 , pp. 47-59
    • Stangier, J.1    Stahle, H.2    Rathgen, K.3    Fuhr, R.4
  • 35
    • 84856593171 scopus 로고    scopus 로고
    • Using the Hemoclot direct thrombin inhibitor assay to determine plasma concentrations of dabigatran
    • doi: 10.1097/MBC.0b013e32834f1b0c
    • Stangier J, Feuring M. Using the Hemoclot direct thrombin inhibitor assay to determine plasma concentrations of dabigatran. Blood Coagul Fib-rinolysis 2012;23:138-143. doi: 10.1097/MBC.0b013e32834f1b0c
    • (2012) Blood Coagul Fib-rinolysis , vol.23 , pp. 138-143
    • Stangier, J.1    Feuring, M.2
  • 36
    • 84860528205 scopus 로고    scopus 로고
    • Impact of dabigatran on a large panel of routine or specific coagulation assays: Laboratory recommendations for monitoring of dabigatran etexi-late
    • doi: 10.1160/TH11-11-0804
    • Douxfils J, Mullier F, Robert S, Chatelain C, Chatelain B, Dogne JM. Impact of dabigatran on a large panel of routine or specific coagulation assays: laboratory recommendations for monitoring of dabigatran etexi-late. Thromb Haemost 2012;107:985-997. doi: 10.1160/TH11-11-0804
    • (2012) Thromb Haemost , vol.107 , pp. 985-997
    • Douxfils, J.1    Mullier, F.2    Robert, S.3    Chatelain, C.4    Chatelain, B.5    Dogne, J.M.6
  • 37
    • 84860548394 scopus 로고    scopus 로고
    • Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran etexilate therapy
    • doi: 10.1309/AJCPAU7OQM0SRPZQ
    • Avecilla ST, Ferrell C, Chandler WL, Reyes M. Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran etexilate therapy. Am J Clin Pathol 2012;137:572-574. doi: 10.1309/AJCPAU7OQM0SRPZQ
    • (2012) Am J Clin Pathol , vol.137 , pp. 572-574
    • Avecilla, S.T.1    Ferrell, C.2    Chandler, W.L.3    Reyes, M.4
  • 38
    • 84866008554 scopus 로고    scopus 로고
    • Dabigatran etexilate in atrial fibrillation patients with severe renal impairment: Dose identification using pharmacokinetic modeling and simulation
    • doi: 10.1177/0091270011417716
    • Lehr T, Haertter S, Liesenfeld KH, et al. Dabigatran etexilate in atrial fibrillation patients with severe renal impairment: dose identification using pharmacokinetic modeling and simulation. J Clin Pharmacol 2011;52: 1373-1378. doi: 10.1177/0091270011417716
    • (2011) J Clin Pharmacol , vol.52 , pp. 1373-1378
    • Lehr, T.1    Haertter, S.2    Liesenfeld, K.H.3
  • 39
  • 40
    • 84860531800 scopus 로고    scopus 로고
    • Monitoring new oral anticoagulants, managing thrombosis, or both?
    • doi: 10.1160/TH12-03-0130
    • Ten CH. Monitoring new oral anticoagulants, managing thrombosis, or both? Thromb Haemost 2012;107:803-805. doi: 10.1160/TH12-03-0130
    • (2012) Thromb Haemost , vol.107 , pp. 803-805
    • Ten, C.H.1
  • 41
    • 79954534386 scopus 로고    scopus 로고
    • Laboratory assessment of new anticoagulants
    • doi: 10.1515/CCLM.2011.134
    • Samama MM, Guinet C. Laboratory assessment of new anticoagulants. Clin Chem Lab Med 2011;49:761-772. doi: 10.1515/CCLM.2011.134
    • (2011) Clin Chem Lab Med , vol.49 , pp. 761-772
    • Samama, M.M.1    Guinet, C.2
  • 42
    • 84859788384 scopus 로고    scopus 로고
    • Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: Resolving uncertainties in routine practic
    • doi: 10.1160/TH11-10-0718
    • Huisman MV, Lip GY, Diener HC, Brueckmann M, van Ryn J, Clemens A. Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: resolving uncertainties in routine practice. Thromb Haemost 2012;107:838-847. doi: 10.1160/TH11-10-0718
    • (2012) Thromb Haemos , vol.107 , pp. 838-847
    • Huisman, M.V.1    Lip, G.Y.2    Diener, H.C.3    Brueckmann, M.4    van Ryn, J.5    Clemens, A.6
  • 43
    • 35348879239 scopus 로고    scopus 로고
    • Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonval -vular atrial fibrillation (PETRO study)
    • doi: 10.1016/j.amjcard.2007.06.034
    • Ezekowitz MD, Reilly PA, Nehmiz G, et al. Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonval -vular atrial fibrillation (PETRO study). Am J Cardiol 2007;100:1419-1426. doi: 10.1016/j.amjcard.2007.06.034
    • (2007) Am J Cardiol , vol.100 , pp. 1419-1426
    • Ezekowitz, M.D.1    Reilly, P.A.2    Nehmiz, G.3
  • 44
    • 84858966373 scopus 로고    scopus 로고
    • Interpretation of point-of-care INR results in patients treated with dabigatran
    • doi: 10.1016/j.amjmed.2011.10.017
    • Van Ryn J, Baruch L, Clemens A. Interpretation of point-of-care INR results in patients treated with dabigatran. Am J Med 2012;125:417-420. doi: 10.1016/j.amjmed.2011.10.017
    • (2012) Am J Med , vol.125 , pp. 417-420
    • van Ryn, J.1    Baruch, L.2    Clemens, A.3
  • 45
    • 10844233894 scopus 로고    scopus 로고
    • The ecarin clotting time, a universal method to quantify direct thrombin inhibitors
    • doi: 10.1159/000081505
    • Nowak G. The ecarin clotting time, a universal method to quantify direct thrombin inhibitors. Pathophysiol Haemost Thromb 2003;33:173-183. doi: 10.1159/000081505
    • (2003) Pathophysiol Haemost Thromb , vol.33 , pp. 173-183
    • Nowak, G.1
  • 46
    • 79851482951 scopus 로고    scopus 로고
    • Effects of the oral, direct throm-bin inhibitor dabigatran on five common coagulation assays
    • doi: 10.1160/TH10-06-0342
    • Lindahl TL, Baghaei F, Blixter IF, et al. Effects of the oral, direct throm-bin inhibitor dabigatran on five common coagulation assays. Thromb Haemost 2011;105:371-378. doi: 10.1160/TH10-06-0342
    • (2011) Thromb Haemost , vol.105 , pp. 371-378
    • Lindahl, T.L.1    Baghaei, F.2    Blixter, I.F.3
  • 47
    • 34347359499 scopus 로고    scopus 로고
    • How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults
    • doi: 10.4065/82.7.864
    • Kamal AH, Tefferi A, Pruthi RK. How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults. Mayo Clin Proc 2007;82:864-873. doi: 10.4065/82.7.864
    • (2007) Mayo Clin Proc , vol.82 , pp. 864-873
    • Kamal, A.H.1    Tefferi, A.2    Pruthi, R.K.3
  • 48
    • 84863811351 scopus 로고    scopus 로고
    • Dabigatran falsely elevates point of care international normalized ratio results
    • doi: 10.1016/j.amjmed.2011.02.009
    • DeRemer CE, Gujral JS, Thornton JW, Sorrentino RA. Dabigatran falsely elevates point of care international normalized ratio results. Am J Med 2011;124:e5-6. doi: 10.1016/j.amjmed.2011.02.009
    • (2011) Am J Med , vol.124
    • Deremer, C.E.1    Gujral, J.S.2    Thornton, J.W.3    Sorrentino, R.A.4
  • 49
    • 84876398583 scopus 로고    scopus 로고
    • Treatment of dabigatran-associat-ed bleeding: Case report and review of the literature
    • Nov 16, (epub ahead of print)
    • Harinstein LM, Morgan JW, Russo N. Treatment of dabigatran-associat-ed bleeding: case report and review of the literature. J Pharm Pract 2012. Nov 16. (epub ahead of print)
    • (2012) J Pharm Pract
    • Harinstein, L.M.1    Morgan, J.W.2    Russo, N.3
  • 50
    • 84858164255 scopus 로고    scopus 로고
    • US Food and Drug Administration, Center for Drug Evaluation and Research, deputy office director decisional memo application 22-512., October 19, accessed 2012 Nov 1
    • US Food and Drug Administration, Center for Drug Evaluation and Research. Dabigatran etexilate; deputy office director decisional memo application 22-512. October 19, 2010. http://www.Accessdata.Fda.Gov/drugsatfda_docs/nda/2010/022512orig1s000sumr.pdf (accessed 2012 Nov 1).
    • (2010) Dabigatran Etexilate
  • 51
    • 80255134514 scopus 로고    scopus 로고
    • UPLC MS/MS assay for routine quantification of dabigatran, a direct thrombin inhibitor, in human plasma
    • doi: 10.1016/j.jpba.2011.09.018
    • Delavenne X, Moracchini J, Laporte S, Mismetti P, Basset T. UPLC MS/MS assay for routine quantification of dabigatran, a direct thrombin inhibitor, in human plasma. J Pharm Biomed Anal 2012;58:152-156.doi: 10.1016/j.jpba.2011.09.018
    • (2012) J Pharm Biomed Anal , vol.58 , pp. 152-156
    • Delavenne, X.1    Moracchini, J.2    Laporte, S.3    Mismetti, P.4    Basset, T.5
  • 52
    • 78649980897 scopus 로고    scopus 로고
    • Pharmacologic properties of the new oral anticoagulants: A clinician-oriented review with a focus on perioperative management
    • doi: 10.2174/138161210793563338
    • Douketis JD. Pharmacologic properties of the new oral anticoagulants: a clinician-oriented review with a focus on perioperative management. Curr Pharm Des 2010;16:3436-3441. doi: 10.2174/138161210793563338
    • (2010) Curr Pharm Des , vol.16 , pp. 3436-3441
    • Douketis, J.D.1
  • 53
    • 84869189977 scopus 로고    scopus 로고
    • Periprocedural management and approach to bleeding in patients taking dabigatran
    • doi: 10.1161/CIRCULATIONAHA.112.123224
    • Weitz JI, Quinlan DJ, Eikelboom JW. Periprocedural management and approach to bleeding in patients taking dabigatran. Circulation 2012;126:2428-2432. doi: 10.1161/CIRCULATIONAHA.112.123224
    • (2012) Circulation , vol.126 , pp. 2428-2432
    • Weitz, J.I.1    Quinlan, D.J.2    Eikelboom, J.W.3
  • 54
    • 84863989146 scopus 로고    scopus 로고
    • Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: Results from the randomized evaluation of long-term anticoagulation therapy (RE-LY) randomized trial
    • doi: 10.1161/CIRCULATIONAHA.111.090464
    • Healey JS, Eikelboom J, Douketis J, et al. Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the randomized evaluation of long-term anticoagulation therapy (RE-LY) randomized trial. Circulation 2012;126:343-348.doi: 10.1161/CIRCULATIONAHA.111.090464
    • (2012) Circulation , vol.126 , pp. 343-348
    • Healey, J.S.1    Eikelboom, J.2    Douketis, J.3
  • 55
    • 84857759555 scopus 로고    scopus 로고
    • Recombinant factor VIIa (rfVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding
    • doi: 10.1182/blood-2011-11-393587
    • Warkentin TE, Margetts P, Connolly SJ, Lamy A, Ricci C, Eikelboom JW. Recombinant factor VIIa (rfVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding. Blood 2012; 119:2172-2174. doi: 10.1182/blood-2011-11-393587
    • (2012) Blood , vol.119 , pp. 2172-2174
    • Warkentin, T.E.1    Margetts, P.2    Connolly, S.J.3    Lamy, A.4    Ricci, C.5    Eikelboom, J.W.6
  • 56
    • 79954456496 scopus 로고    scopus 로고
    • Dabigatran etexilate: A new oral thrombin inhibitor
    • doi: 10.1161/CIRCULATIONAHA.110.004424
    • Hankey GJ, Eikelboom JW. Dabigatran etexilate: a new oral thrombin inhibitor. Circulation 2011;123:1436-1450.doi: 10.1161/CIRCULATIONAHA.110.004424
    • (2011) Circulation , vol.123 , pp. 1436-1450
    • Hankey, G.J.1    Eikelboom, J.W.2
  • 57
    • 84865851374 scopus 로고    scopus 로고
    • Safe use of hemodialysis for dabigatran removal before cardiac surgery
    • doi: 10.1345/aph.1R081
    • Wanek MR, Horn ET, Elapavaluru S, Baroody SC, Sokos G. Safe use of hemodialysis for dabigatran removal before cardiac surgery. Ann Phar-macother 2012;46:e21. doi: 10.1345/aph.1R081
    • (2012) Ann Phar-macother , vol.e21 , pp. 46
    • Wanek, M.R.1    Horn, E.T.2    Elapavaluru, S.3    Baroody, S.C.4    Sokos, G.5
  • 58
    • 34247844511 scopus 로고    scopus 로고
    • Guidelines for the early management of adults with ischemic stroke: A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups
    • doi: 10.1161/STROKEAHA.107.181486, The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
    • Adams HP Jr., del ZG, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007;38:1655-1711.doi: 10.1161/STROKEAHA.107.181486
    • (2007) Stroke , vol.38 , pp. 1655-1711
    • Adams Jr., H.P.1    Del, Z.G.2    Alberts, M.J.3
  • 59
    • 68749100878 scopus 로고    scopus 로고
    • Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: A science advisory from the American Heart As sociation/American Stroke Association
    • doi: 10.1161/STROKEAHA.109.192535
    • Del Zoppo GJ, Saver JL, Jauch EC, Adams HP Jr. Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American Heart As sociation/American Stroke Association. Stroke 2009;40:2945-2948.doi: 10.1161/STROKEAHA.109.192535
    • (2009) Stroke , vol.40 , pp. 2945-2948
    • Del Zoppo, G.J.1    Saver, J.L.2    Jauch, E.C.3    Adams Jr., H.P.4
  • 60
    • 52649165720 scopus 로고    scopus 로고
    • Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    • doi: 10.1056/NEJMoa0804656
    • Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317-29. doi: 10.1056/NEJMoa0804656
    • (2008) N Engl J Med , vol.359 , pp. 1317-1329
    • Hacke, W.1    Kaste, M.2    Bluhmki, E.3
  • 61
    • 84860222458 scopus 로고    scopus 로고
    • Thrombolysis with re-combinant tissue plasminogen activator under dabigatran anticoagulation in experimental stroke
    • doi: 10.1002/ana.23558
    • Pfeilschifter W, Bohmann F, Baumgarten P, et al. Thrombolysis with re-combinant tissue plasminogen activator under dabigatran anticoagulation in experimental stroke. Ann Neurol 2012;71:624-633. doi: 10.1002/ana.23558
    • (2012) Ann Neurol , vol.71 , pp. 624-633
    • Pfeilschifter, W.1    Bohmann, F.2    Baumgarten, P.3
  • 62
    • 84866702670 scopus 로고    scopus 로고
    • Thrombolysis in an ischemic stroke patient on dabigatran anticoagulation: A case report
    • doi: 10.1159/000342307
    • Marrone LC, Marrone AC. Thrombolysis in an ischemic stroke patient on dabigatran anticoagulation: a case report. Cerebrovasc Dis 2012;34: 246-247. doi: 10.1159/000342307
    • (2012) Cerebrovasc Dis , vol.34 , pp. 246-247
    • Marrone, L.C.1    Marrone, A.C.2
  • 63
    • 79960101903 scopus 로고    scopus 로고
    • Thrombolysis treatment for acute ischaemic stroke in a patient on treatment with dabigatran
    • doi: 10.1160/TH11-01-0042
    • Matute MC, Guillan M, Garcia-Caldentey J, et al. Thrombolysis treatment for acute ischaemic stroke in a patient on treatment with dabigatran. Thromb Haemost 2011;106:178-179 doi: 10.1160/TH11-01-0042
    • (2011) Thromb Haemost , vol.106 , pp. 178-179
    • Matute, M.C.1    Guillan, M.2    Garcia-Caldentey, J.3
  • 64
    • 77957126877 scopus 로고    scopus 로고
    • Intravenous thrombolysis with recombinant tissue plasminogen activator in a stroke patient treated with dabigatran
    • doi:10.1159/000319886
    • De Smedt A, De Raedt S, Nieboer K, De Keyser J, Brouns R. Intravenous thrombolysis with recombinant tissue plasminogen activator in a stroke patient treated with dabigatran. Cerebrovasc Dis 2010;30:533-534. doi:10.1159/000319886
    • (2010) Cerebrovasc Dis , vol.30 , pp. 533-534
    • de Smedt, A.1    de Raedt, S.2    Nieboer, K.3    de Keyser, J.4    Brouns, R.5
  • 65
    • 84868356598 scopus 로고    scopus 로고
    • Acute ischemic stroke treated with intravenous tissue plasminogen activator in a patient taking dabigatran with radiographic evidence of recanalization
    • doi: 10.1016/j.jstrokecerebrovasdis.2012.05.003
    • Sangha N, El Khoury R, Misra V, Lopez G. Acute ischemic stroke treated with intravenous tissue plasminogen activator in a patient taking dabigatran with radiographic evidence of recanalization. J Stroke Cerebrovasc Dis 2012; 21:917.e5-8. doi: 10.1016/j.jstrokecerebrovasdis.2012.05.003
    • (2012) J Stroke Cerebrovasc Dis , vol.21 , Issue.917
    • Sangha, N.1    El, K.R.2    Misra, V.3    Lopez, G.4
  • 66
    • 82355164327 scopus 로고    scopus 로고
    • Fatal intracerebral hemorrhage associated with administration of recombinant tissue plasminogen activator in a stroke patient on treatment with dabigatran
    • doi: 10.1159/000334578
    • Casado Naranjo I, Portilla-Cuenca JC, Jimenez Caballero PE, Calle Escobar ML, Romero Sevilla RM. Fatal intracerebral hemorrhage associated with administration of recombinant tissue plasminogen activator in a stroke patient on treatment with dabigatran. Cerebrovasc Dis 2011;32: 614-615. doi: 10.1159/000334578
    • (2011) Cerebrovasc Dis , vol.32 , pp. 614-615
    • Casado, N.I.1    Portilla-Cuenca, J.C.2    Jimenez, C.P.E.3    Calle, E.M.L.4    Romero, S.R.M.5
  • 67
    • 84860217742 scopus 로고    scopus 로고
    • Using dabigatran in patients with stroke: A practical guide for clinicians
    • Letter by Casado-Naranjo et al. regarding article, doi: 10.1161/STROKEAHA.111.648212
    • Casado-Naranjo I, Portilla-Cuenca JC, Jimenez-Caballero PE. Letter by Casado-Naranjo et al. regarding article, "Using dabigatran in patients with stroke: a practical guide for clinicians." Stroke 2012;43:e45. doi: 10.1161/STROKEAHA.111.648212
    • (2012) Stroke , vol.e45 , pp. 43
    • Casado-Naranjo, I.1    Portilla-Cuenca, J.C.2    Jimenez-Caballero, P.E.3
  • 68
    • 84861143612 scopus 로고    scopus 로고
    • Endovascu-lar therapy after stroke in a patient treated with dabigatran
    • Moey AW, Koblar SA, Chryssidis S, Robinson M, Jannes J. Endovascu-lar therapy after stroke in a patient treated with dabigatran. Med J Aust 2012;196:469-471.
    • (2012) Med J Aust , vol.196 , pp. 469-471
    • Moey, A.W.1    Koblar, S.A.2    Chryssidis, S.3    Robinson, M.4    Jannes, J.5
  • 69
    • 84855359475 scopus 로고    scopus 로고
    • Using dabigatran in patients with stroke: A practical guide for clinicians
    • doi: 10.1161/STROKEAHA.111.622498
    • Alberts MJ, Bernstein RA, Naccarelli GV, Garcia DA. Using dabigatran in patients with stroke: a practical guide for clinicians. Stroke 2012;43: 271-279. doi: 10.1161/STROKEAHA.111.622498
    • (2012) Stroke , vol.43 , pp. 271-279
    • Alberts, M.J.1    Bernstein, R.A.2    Naccarelli, G.V.3    Garcia, D.A.4
  • 70
    • 84876734450 scopus 로고    scopus 로고
    • Micromedex 2.0 (electronic version), Greenwood Village, CO, accessed 2012 Oct 6
    • Micromedex 2.0 (electronic version). Thomson Reuters (Healthcare), Greenwood Village, CO. http://www.thomsonhc.com (accessed 2012 Oct 6).
    • Thomson Reuters (Healthcare)
  • 71
    • 84864808150 scopus 로고    scopus 로고
    • Decrease in the oral bioavailability of dabigatran etexilate after co-medication with rifampicin
    • . doi: 10.1111/j.1365-2125.2012.04218.x
    • Hartter S, Koenen-Bergmann M, Sharma A, et al. Decrease in the oral bioavailability of dabigatran etexilate after co-medication with rifampicin. Br J Clin Pharmacol 2012. doi: 10.1111/j.1365-2125.2012.04218.x
    • (2012) Br J Clin Pharmacol
    • Hartter, S.1    Koenen-Bergmann, M.2    Sharma, A.3
  • 72
    • 84875071896 scopus 로고    scopus 로고
    • Oral bioavailability of dabiga-tran etexilate (Pradaxa) after co-medication with verapamil in healthy subjects
    • doi: 10.1111/j.1365-2125.2012.04453.x
    • Hartter S, Sennewald R, Nehmiz G, Reilly P. Oral bioavailability of dabiga-tran etexilate (Pradaxa) after co-medication with verapamil in healthy subjects. Br J Clin Pharmacol 2012. doi: 10.1111/j.1365-2125.2012.04453.x
    • (2012) Br J Clin Pharmacol
    • Hartter, S.1    Sennewald, R.2    Nehmiz, G.3    Reilly, P.4
  • 73
    • 79958077792 scopus 로고    scopus 로고
    • Drug and dietary interactions of warfarin and novel oral anticoagulants: An update
    • doi: 10.1007/s11239-011-0561-1
    • Nutescu E, Chuatrisorn I, Hellenbart E. Drug and dietary interactions of warfarin and novel oral anticoagulants: an update. J Thromb Thromboly-sis 2011;31:326-343. doi: 10.1007/s11239-011-0561-1
    • (2011) J Thromb Thromboly-sis , vol.31 , pp. 326-343
    • Nutescu, E.1    Chuatrisorn, I.2    Hellenbart, E.3
  • 74
    • 84873114043 scopus 로고    scopus 로고
    • The laboratory and the new oral anticoagulants
    • doi: 10.1373/clinchem.2012.189704
    • Tripodi A. The laboratory and the new oral anticoagulants. Clin Chem 2013;59:353-3562. doi: 10.1373/clinchem.2012.189704
    • (2013) Clin Chem , vol.59 , pp. 353-3562
    • Tripodi, A.1
  • 75
    • 84865862471 scopus 로고    scopus 로고
    • Position paper on laboratory testing for patients taking new oral anticoagulants. Consensus document of FCSA, SIMEL, SIBIOC and CISMEL
    • doi: 10.1515/cclm-2012-0327
    • Tripodi A, Di Iorio G, Lippi G, Testa S, Manotti C. Position paper on laboratory testing for patients taking new oral anticoagulants. Consensus document of FCSA, SIMEL, SIBIOC and CISMEL. Clin Chem Lab Med 2012. doi: 10.1515/cclm-2012-0327
    • (2012) Clin Chem Lab Med
    • Tripodi, A.1    Di, I.G.2    Lippi, G.3    Testa, S.4    Manotti, C.5
  • 76
    • 84859800192 scopus 로고    scopus 로고
    • Clinical pharmacology basis of deriving dosing recommendations for dabigatran in patients with severe renal impairment
    • doi:10.1177/0091270011415527
    • Hariharan S, Madabushi R. Clinical pharmacology basis of deriving dosing recommendations for dabigatran in patients with severe renal impairment. J Clin Pharmacol 2012;52:119S-1125S. doi:10.1177/0091270011415527
    • (2012) J Clin Pharmacol , vol.52
    • Hariharan, S.1    Madabushi, R.2
  • 77
    • 84864769237 scopus 로고    scopus 로고
    • Pharmacokinetic and clinical implications of dabiga-tran use in severe renal impairment for stroke prevention in nonvalvular atrial fibrillation
    • doi: 10.1345/aph.1R057
    • Mack DR, Kim JJ. Pharmacokinetic and clinical implications of dabiga-tran use in severe renal impairment for stroke prevention in nonvalvular atrial fibrillation. Ann Pharmacother 2012;46:1105-1110.doi: 10.1345/aph.1R057
    • (2012) Ann Pharmacother , vol.46 , pp. 1105-1110
    • Mack, D.R.1    Kim, J.J.2
  • 78
    • 84867699158 scopus 로고    scopus 로고
    • Hemorrhagic complications asso ciated with dabigatran use
    • doi: 10.3109/15563650.2012.721888
    • Chen BC, Viny AD, Garlich FM, et al. Hemorrhagic complications asso ciated with dabigatran use. Clin Toxicol 2012;50:854-857.doi: 10.3109/15563650.2012.721888
    • (2012) Clin Toxicol , vol.50 , pp. 854-857
    • Chen, B.C.1    Viny, A.D.2    Garlich, F.M.3
  • 79
    • 80155206426 scopus 로고    scopus 로고
    • Questions and answers on the use of dabigatran and perspectives on the use of other new oral anticoagulants in patients with atrial fibrillation: A consensus document of the Italian Federation of Thrombosis Centers (FCSA)
    • doi: 10.1160/TH11-05-0358
    • Pengo V, Crippa L, Falanga A, et al. Questions and answers on the use of dabigatran and perspectives on the use of other new oral anticoagulants in patients with atrial fibrillation: a consensus document of the Italian Federation of Thrombosis Centers (FCSA). Thromb Haemost 2011;106: 868-876. doi: 10.1160/TH11-05-0358
    • (2011) Thromb Haemost , vol.106 , pp. 868-876
    • Pengo, V.1    Crippa, L.2    Falanga, A.3
  • 80
    • 0037228105 scopus 로고    scopus 로고
    • Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    • doi: 10.1053/ajkd.2003.50007
    • Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;41:1-12. doi: 10.1053/ajkd.2003.50007
    • (2003) Am J Kidney Dis , vol.41 , pp. 1-12
    • Coresh, J.1    Astor, B.C.2    Greene, T.3    Eknoyan, G.4    Levey, A.S.5
  • 82
    • 76749163232 scopus 로고    scopus 로고
    • Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: The Euro Heart Sur vey on Atrial Fibrillation
    • doi: 10.1378/chest.09-1584
    • Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: The Euro Heart Sur vey on Atrial Fibrillation. Chest 2010;137:263-272.doi: 10.1378/chest.09-1584
    • (2010) Chest , vol.137 , pp. 263-272
    • Lip, G.Y.1    Nieuwlaat, R.2    Pisters, R.3    Lane, D.A.4    Crijns, H.J.5
  • 83
    • 80053574509 scopus 로고    scopus 로고
    • Anticoagulating obese patients in the modern era
    • doi: 10.1111/j.1365-2141.2011.08826.x
    • Patel JP, Roberts LN, Arya R. Anticoagulating obese patients in the modern era. Br J Haematol 2011;155:137-149.doi: 10.1111/j.1365-2141.2011.08826.x
    • (2011) Br J Haematol , vol.155 , pp. 137-149
    • Patel, J.P.1    Roberts, L.N.2    Arya, R.3
  • 84
    • 84867577674 scopus 로고    scopus 로고
    • Dabigatran is effective with a favourable safety profile in normal and overweight patients undergoing major orthopaedic surgery: A pooled analysis
    • doi: 10.1016/j.thromres.2012.07.004
    • Eriksson BI, Dahl OE, Feuring M, et al. Dabigatran is effective with a favourable safety profile in normal and overweight patients undergoing major orthopaedic surgery: a pooled analysis. Thromb Res 2012;130: 818-820. doi: 10.1016/j.thromres.2012.07.004
    • (2012) Thromb Res , vol.130 , pp. 818-820
    • Eriksson, B.I.1    Dahl, O.E.2    Feuring, M.3
  • 85
    • 0036862025 scopus 로고    scopus 로고
    • Coagulation and fibrinolysis abnormalities in obesity
    • De Pergola G, Pannacciulli N. Coagulation and fibrinolysis abnormalities in obesity. J Endocrinol Invest 2002;25:899-904.
    • (2002) J Endocrinol Invest , vol.25 , pp. 899-904
    • de Pergola, G.1    Pannacciulli, N.2
  • 87
    • 84865977200 scopus 로고    scopus 로고
    • Newer oral anticoagulants: A review of laboratory monitoring options and reversal agents in the hemorrhagic patient
    • doi: 10.2146/ajhp110725
    • Miyares MA, Davis K. Newer oral anticoagulants: a review of laboratory monitoring options and reversal agents in the hemorrhagic patient. Am J Health Syst Pharm 2012;69:1473-1484. doi: 10.2146/ajhp110725
    • (2012) Am J Health Syst Pharm , vol.69 , pp. 1473-1484
    • Miyares, M.A.1    Davis, K.2
  • 88
    • 84874251027 scopus 로고    scopus 로고
    • Acute management of bleeding in patients on novel oral anticoagulants
    • doi: 10.1093/eurheartj/ehs408
    • Siegal DM, Crowther MA. Acute management of bleeding in patients on novel oral anticoagulants. Eur Heart J 2013;34:489-498b.doi: 10.1093/eurheartj/ehs408
    • (2013) Eur Heart J , vol.34
    • Siegal, D.M.1    Crowther, M.A.2
  • 89
    • 84859971855 scopus 로고    scopus 로고
    • Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors
    • doi: 10.1002/ajh.23202
    • Kaatz S, Kouides PA, Garcia DA, et al. Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. Am J Hematol 2012;87(suppl 1): 141-145. doi: 10.1002/ajh.23202
    • (2012) Am J Hematol , vol.87 , Issue.SUPPL. 1 , pp. 141-145
    • Kaatz, S.1    Kouides, P.A.2    Garcia, D.A.3
  • 90
    • 84861616750 scopus 로고    scopus 로고
    • Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: The RELY trial
    • doi: 10.1161/STROKEAHA.112.650614
    • Hart RG, Diener HC, Yang S, et al. Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: The RELY trial. Stroke 2012;43:1511-1517. doi: 10.1161/STROKEAHA.112.650614
    • (2012) Stroke , vol.43 , pp. 1511-1517
    • Hart, R.G.1    Diener, H.C.2    Yang, S.3
  • 91
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • doi: 10.1161/CIRCULATIONAHA.111.029017
    • Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011;124:1573-1579.doi: 10.1161/CIRCULATIONAHA.111.029017
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 92
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: A randomised crossover ex vivo study in healthy volunteers
    • doi: 10.1160/TH12-03-0179
    • Marlu R, Hodaj E, Paris A, Albaladejo P, Crackowski JL, Pernod G. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb Haemost 2012;108:217-224. doi: 10.1160/TH12-03-0179
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3    Albaladejo, P.4    Crackowski, J.L.5    Pernod, G.6
  • 93
    • 11044228152 scopus 로고    scopus 로고
    • FEIBA safety profile in multiple modes of clinical and home-therapy application
    • doi: 10.1111/j.1365-2516.2004.00935.x
    • Luu H, Ewenstein B. FEIBA safety profile in multiple modes of clinical and home-therapy application. Haemophilia 2004;10(suppl 2):10-16. doi: 10.1111/j.1365-2516.2004.00935.x
    • (2004) Haemophilia , vol.10 , Issue.SUPPL. 2 , pp. 10-16
    • Luu, H.1    Ewenstein, B.2
  • 94
    • 84865856473 scopus 로고    scopus 로고
    • Reversing dabigatran with FEIBA in a patient with transseptal perforation during cardiac ablation
    • Dager W, Roberts A. Reversing dabigatran with FEIBA in a patient with transseptal perforation during cardiac ablation. Crit Care Med 2011;39: 243.
    • (2011) Crit Care Med , vol.39 , pp. 243
    • Dager, W.1    Roberts, A.2
  • 95
    • 84874114340 scopus 로고    scopus 로고
    • Removal of dabigatran by hemodialy-sis
    • doi: 10.1053/j.ajkd.2012.08.047
    • Chang DN, Dager WE, Chin AI. Removal of dabigatran by hemodialy-sis. Am J Kidney Dis 2013;61:487-489.doi: 10.1053/j.ajkd.2012.08.047
    • (2013) Am J Kidney Dis , vol.61 , pp. 487-489
    • Chang, D.N.1    Dager, W.E.2    Chin, A.I.3
  • 96
    • 84881218703 scopus 로고    scopus 로고
    • New Zealand Pharmaceutical Management Agency, accessed 2013 Jan 25
    • New Zealand Pharmaceutical Management Agency. Guidelines for testing and perioperative management of dabigatran. http://www.Pharmac.Govt. Nz/2011/06/13/dabigatran testing AND perioperative management.pdf (accessed 2013 Jan 25).
    • Guidelines For Testing and Perioperative Management of Dabigatran
  • 97
    • 84858755308 scopus 로고    scopus 로고
    • The successful reversal of dabigatran-induced bleeding by coagulation factor concentrates in a rat tail bleeding model do not correlate with ex vivo markers of anticoagulation (abstract 2316)
    • Van Ryn J, Schurer J, Kink-Eiband M, Clemens A. The successful reversal of dabigatran-induced bleeding by coagulation factor concentrates in a rat tail bleeding model do not correlate with ex vivo markers of anticoagulation (abstract 2316). Blood 2011;118:2316.
    • (2316) Blood , vol.2011 , pp. 118
    • van Ryn, J.1    Schurer, J.2    Kink-Eiband, M.3    Clemens, A.4
  • 98
    • 84875053456 scopus 로고    scopus 로고
    • The use of FEIBA in the correction of coagulation abnormalities induced by dabigatran
    • doi: 10.1111/ijlh.12005
    • Khoo TL, Weatherburn C, Kershaw G, Reddel CJ, Curnow J, Dunkley S. The use of FEIBA in the correction of coagulation abnormalities induced by dabigatran. Int J Lab Hematol 2013;35:222-224.doi: 10.1111/ijlh.12005
    • (2013) Int J Lab Hematol , vol.35 , pp. 222-224
    • Khoo, T.L.1    Weatherburn, C.2    Kershaw, G.3    Reddel, C.J.4    Curnow, J.5    Dunkley, S.6
  • 99
    • 84866977076 scopus 로고    scopus 로고
    • Do new oral anticoagulants re quire laboratory monitoring? The clinician point of view
    • doi: 10.1016/j.thromres.2012.08.286
    • Samama MM, Guinet C, Le Flem L. Do new oral anticoagulants re quire laboratory monitoring? The clinician point of view. Thromb Res 2012;130(suppl 1):88-89. doi: 10.1016/j.thromres.2012.08.286
    • (2012) Thromb Res , vol.130 , Issue.SUPPL. 1 , pp. 88-89
    • Samama, M.M.1    Guinet, C.2    Le, F.L.3
  • 100
    • 84858164255 scopus 로고    scopus 로고
    • US Food and Drug Administration, Center for Drug Evaluation and Research, Advisory comittee briefing document, August 27, accessed 2012 Nov 1
    • US Food and Drug Administration, Center for Drug Evaluation and Research. Dabigatran etexilate. Advisory comittee briefing document, August 27, 2010. http://www.Fda.Gov/downloads/advisorycommittees/committeesmeetingmaterials/drugs/cardiovascularandrenaldrugsadviso-ry committee/ucm226009.pdf (accessed 2012 Nov 1).
    • (2010) Dabigatran Etexilate


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.