Chemotherapy promotes tumour cell hybridization in vivo

Tumor Biology

Volumn 37, Issue 4, 2016, Pages 5025-5030

  Yan, Bingyu ^a   Wang, Jianguo ^a   Liu, Li ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cell fusion; Chemotherapy resistance; In vivo; Poor prognosis

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; EPIRUBICIN; RED FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER CELL LINE; CANCER PROGNOSIS; CELL ASSAY; CELL FUSION; CELL HETEROGENEITY; CELL HYBRIDIZATION; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; ANIMAL; BREAST NEOPLASMS; CARCINOGENESIS; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; FEMALE; GENETICS; HYBRID CELL; METASTASIS; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CARCINOGENESIS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; EPIRUBICIN; FEMALE; HUMANS; HYBRID CELLS; MICE; NEOPLASM METASTASIS; PROGNOSIS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84946130492     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-4337-7     Document Type: Article

References (36)

1. Chen EH, Olson EN. Unveiling the mechanisms of cell-cell fusion. Science. 2005;308(5720):369–73.
2. Ogle BM, Cascalho M, Platt JL. Biological implications of cell fusion. Nat Rev Mol Cell Biol. 2005;6(7):567–75.
3. Oren-Suissa M, Podbilewicz B. Cell fusion during development. Trends Cell Biol. 2007;17(11):537–46.
4. Shilagardi K, Li S, Luo F, Marikar F, Duan R, Jin P, et al. Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion. Science. 2013;340(6130):359–63.
5. Aichel O. Über Zellverschmelzung mit qualitativ abnormer Chromosomenverteilung als Ursache der Geschwulstbildung. vol 13. W. Engelmann; 1911.
6. Pawelek JM. Tumour-cell fusion as a source of myeloid traits in cancer. Lancet Oncol. 2005;6(12):988–93.
7. Pawelek JM, Chakraborty AK. The cancer cell–leukocyte fusion theory of metastasis. Adv Cancer Res. 2008;101:397–444.
8. Miller FR, Mohamed AN, McEachern D. Production of a more aggressive tumor cell variant by spontaneous fusion of two mouse tumor subpopulations. Cancer Res. 1989;49(15):4316–21.
9. Miller FR, McInerney D, Rogers C, Miller BE. Spontaneous fusion between metastatic mammary tumor subpopulations. J Cell Biochem. 1988;36(2):129–36.
10. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860–7.
11. Pawelek JM, Chakraborty AK. Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis. Nat Rev Cancer. 2008;8(5):377–86.
12. Dittmar T, Nagler C, Schwitalla S, Reith G, Niggemann B, Zänker KS. Recurrence cancer stem cells—made by cell fusion? Med Hypotheses. 2009;73(4):542–7.
13. Dexter DL, Leith JT. Tumor heterogeneity and drug resistance. J Clin Oncol. 1986;4(2):244–57.
14. Marusyk A, Almendro V, Polyak K. Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer. 2012;12(5):323–34.
15. Baylin SB, Jones PA. A decade of exploring the cancer epigenome—biological and translational implications. Nat Rev Cancer. 2011;11(10):726–34.
16. Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012;21(3):283–96.
17. Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366(10):883–92.
18. Rappa G, Mercapide J, Lorico A. Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity. Am J Pathol. 2012;180(6):2504–15.
19. Duelli D, Lazebnik Y. Cell fusion: a hidden enemy? Cancer Cell. 2003;3(5):445–8.
20. Yu Z, Pestell TG, Lisanti MP, Pestell RG. Cancer stem cells. Int J Biochem Cell Biol. 2012;44(12):2144–51.
21. Pawelek J. Tumour cell hybridization and metastasis revisited. Melanoma Res. 2000;10(6):507–14.
22. Kerbel RS, Lagarde A, Dennis J, Donaghue T. Spontaneous fusion in vivo between normal host and tumor cells: possible contribution to tumor progression and metastasis studied with a lectin-resistant mutant tumor. Mol Cell Biol. 1983;3(4):523–38.
23. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007;131(6):1109–23.
24. Naito S, Von Eschenbach AC, Giavazzi R, Fidler IJ. Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res. 1986;46(8):4109–15.
25. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci. 2003;100(7):3983–8.
26. Fortuna M, Dewey M, Furmanski P. Cell fusion in tumor development and progression: occurrence of cell fusion in primary methylcholanthrene‐induced tumorigenesis. Int J Cancer. 1989;44(4):731–7.
27. Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell. 2004;6(1):17–32.
28. Trédan O, Galmarini CM, Patel K, Tannock IF. Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst. 2007;99(19):1441–54.
29. Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA, Kinzler KW. Cancer genome landscapes. Science. 2013;339(6127):1546–58.
30. Li F, Tiede B, Massagué J, Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res. 2007;17(1):3–14.
31. Nowell PC. The clonal evolution of tumor cell populations. Science. 1976;194(4260):23–8.
32. Lu X, Kang Y. Cell fusion as a hidden force in tumor progression. Cancer Res. 2009;69(22):8536–9.
33. Goldenberg DM, Rooney RJ, Loo M, Liu D, Chang C-H. In-vivo fusion of human cancer and hamster stromal cells permanently transduces and transcribes human DNA. PLoS One. 2014;9(9):e107927.
34. Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science. 2005;309(5739):1369–73.
35. Lu X, Kang Y. Cell fusion hypothesis of the cancer stem cell. Cell Fusion in Health and Disease. Springer; 2011. p. 129–40.
36. Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer. 2007;7(3):169–81.