Production of 3-hydroxypropionic acid from glucose and xylose by metabolically engineered Saccharomyces cerevisiae

Metabolic Engineering Communications

Volumn 2, Issue , 2015, Pages 132-136

  Kildegaard, Kanchana R ^a   Wang, Zheng ^b,c   Chen, Yun ^b   Nielsen, Jens ^a,b   Borodina, Irina ^a  

^a Chalmers University of Technology   (Denmark)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

3 hydroxypropionic acid; Biorefineries; Metabolic engineering; Saccharomyces cerevisiae; Xylose utilization

Indexed keywords

3 HYDROXY 2 METHYLPROPIONIC ACID; ACETIC ACID; ACETYL COENZYME A CARBOXYLASE; ALCOHOL; ALDEHYDE DEHYDROGENASE; BETA ALANINE; BETA ALANINE PYRUVATE AMINOTRANSFERASE; GLUCOSE; GLYCEROL; HYDRACRYLIC ACID; MALONYL COENZYME A; PYRUVATE CARBOXYLASE; PYRUVATE DECARBOXYLASE; SUCCINIC ACID; XYLOSE;

ARTICLE; BIOMASS; BIOSYNTHESIS; FERMENTATION; FUNGAL STRAIN; FUNGUS GROWTH; GENE CASSETTE; GENETIC TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLIC ENGINEERING; NONHUMAN; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST;

EID: 84946089934     PISSN: None     EISSN: 22140301     Source Type: Journal    
DOI: 10.1016/j.meteno.2015.10.001     Document Type: Article

References (12)

1. Borodina I., Kildegaard K.R., Jensen N.B., Blicher T.H., Maury J., Sherstyk S., Schneider K., Lamosa P., Herrgård M.J., Rosenstand I., Öberg F., Forster J., Nielsen J. Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine. Metab. Eng. 2015, 27:57-64. 10.1016/j.ymben. 2014.10.003.
2. Borodina I., Nielsen J. Advances in metabolic engineering of yeast Saccharomyces cerevisiae for production of chemicals. Biotechnol. J. 2014, 9:609-620. 10.1002/biot. 201300445.
3. Chen Y., Bao J., Kim I.-K., Siewers V., Nielsen J. Coupled incremental precursor and co-factor supply improves 3-hydroxypropionic acid production in Saccharomyces cerevisiae. Metab. Eng. 2014, 22:104-109. 10.1016/j.ymben.2014.01.005.
4. Gietz R.D., Schiestl R.H. High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat. Protoc. 2007, 2:31-34. 10.1038/nprot.2007.13.
5. Jensen, N., Borodina, I., Chen, Y., Maury, J., Kildegaard, K., Forster, J., Nielsen, J., 2014a. Microbial production of 3-hydroxypropionic acid. WO Patent Application, 2014/198831 A1.
6. Jensen N.B., Strucko T., Kildegaard K.R., David F., Maury J., Mortensen U.H., Forster J., Nielsen J., Borodina I. EasyClone: method for iterative chromosomal integration of multiple genes in Saccharomyces cerevisiae. FEMS Yeast Res. 2014, 14:238-248. 10.1111/1567-1364.12118.
7. Kildegaard K.R., Hallström B.M., Blicher T.H., Sonnenschein N., Jensen N.B., Sherstyk S., Harrison S.J., Maury J., Herrgård M.J., Juncker A.S., Forster J., Nielsen J., Borodina I. Evolution reveals a glutathione-dependent mechanism of 3-hydroxypropionic acid tolerance. Metab. Eng. 2014, 26:57-66. 10.1016/j.ymben.2014.09.004.
8. Kumar V., Ashok S., Park S. Recent advances in biological production of 3-hydroxypropionic acid. Biotechnol. Adv. 2013, 31:945-961. 10.1016/j.biotechadv. 2013.02.008.
9. Li M., Borodina I. Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2014, 15:1-12. 10.1111/1567-1364.12213.
10. Scalcinati G., Otero J.M., Van Vleet J.R.H., Jeffries T.W., Olsson L., Nielsen J. Evolutionary engineering of Saccharomyces cerevisiae for efficient aerobic xylose consumption. FEMS Yeast Res. 2012, 12:582-597. 10.1111/j.1567-1364.2012.00808.x.
11. Van Dien S. From the first drop to the first truckload: commercialization of microbial processes for renewable chemicals. Curr. Opin. Biotechnol. 2013, 24:1061-1068. 10.1016/j.copbio.2013.03.002.
12. Verduyn C., Postma E., Scheffers W.A., Van Dijken J.P. Effect of benzoic acid on metabolic fluxes in yeasts: a continuous-culture study on the regulation of respiration and alcoholic fermentation. Yeast 1992, 8:501-517. 10.1002/yea.320080703.