Direct renal effects of a fructose-enriched diet: Interaction with high salt intake

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 309, Issue 9, 2015, Pages R1078-R1081

  Ares, Gustavo R ^a   Ortiz, Pablo A ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fructose; NKCC2; Renal function; Salt sensitivity

Indexed keywords

DRINKING WATER; FRUCTOSE; CARBOHYDRATE DIET; SALT INTAKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD PRESSURE REGULATION; CALORIC INTAKE; CARBOHYDRATE DIET; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE ASSOCIATION; HYPERTENSION; ION TRANSPORT; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; LIPID STORAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SALT INTAKE; WEIGHT GAIN; ADVERSE EFFECTS; ANIMAL; BIOLOGICAL MODEL; BLOOD PRESSURE; HUMAN; KIDNEY; METABOLIC CLEARANCE RATE; METABOLISM; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PHYSIOLOGY;

ADMINISTRATION, ORAL; ANIMALS; BLOOD PRESSURE; DIETARY CARBOHYDRATES; FRUCTOSE; HUMANS; HYPERTENSION; KIDNEY; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; SODIUM CHLORIDE, DIETARY;

EID: 84946075410     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00156.2015     Document Type: Review

References (52)

1. Ares GR, Ortiz PA. Fructose potently stimulates NKCC2 trafficking in rat thick ascending limbs. Council Of High Blood Pressure (Abstract). Hypertension 62: A639, 2013.
2. Beck-Nielsen H, Pedersen O, Lindskov HO. Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects. Am J Clin Nutr 33: 273-278, 1980.
3. Bray GA, Popkin BM. Calorie-sweetened beverages and fructose: what have we learned 10 years later. Pediatr Obes 8: 242-248, 2013.
4. Brown CM, Dulloo AG, Yepuri G, Montani JP. Fructose ingestion acutely elevates blood pressure in healthy young humans. Am J Physiol Regul Integr Comp Physiol 294: R730-R737, 2008.
5. Brown IJ, Stamler J, Van HL, Robertson CE, Chan Q, Dyer AR, Huang CC, Rodriguez BL, Zhao L, Daviglus ML, Ueshima H, Elliott P. Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure. Hypertension 57: 695-701, 2011.
6. Cabral PD, Hong NJ, Hye Khan MA, Ortiz PA, Beierwaltes WH, Imig JD, Garvin JL. Fructose stimulates Na/H exchange activity and sensitizes the proximal tubule to angiotensin II. Hypertension 63: e68-e73, 2014.
7. Cha SH, Wolfgang M, Tokutake Y, Chohnan S, Lane MD. Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci USA 105: 16871-16875, 2008.
8. Cohen L, Curhan G, Forman J. Association of sweetened beverage intake with incident hypertension. J Gen Intern Med 27: 1127-1134, 2012.
9. Dai S, McNeill JH. Fructose-induced hypertension in rats is concentration- and duration-dependent. J Pharmacol Toxicol Methods 33: 101-107, 1995.
10. Douard V, Ferraris RP. Regulation of the fructose transporter GLUT5 in health and disease. Am J Physiol Endocrinol Metab 295: E227-E237, 2008.
11. Douard V, Ferraris RP. The role of fructose transporters in diseases linked to excessive fructose intake. J Physiol 591: 401-414, 2013.
12. Drewnowski A, Bellisle F. Liquid calories, sugar, and body weight. Am J Clin Nutr 85: 651-661, 2007.
13. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76: 911-922, 2002.
14. Gersch MS, Mu W, Cirillo P, Reungjui S, Zhang L, Roncal C, Sautin YY, Johnson RJ, Nakagawa T. Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am J Physiol Renal Physiol 293: F1256-F1261, 2007.
15. Ha V, Sievenpiper JL, de Souza RJ, Chiavaroli L, Wang DD, Cozma AI, Mirrahimi A, Yu ME, Carleton AJ, Dibuono M, Jenkins AL, Leiter LA, Wolever TM, Beyene J, Kendall CW, Jenkins DJ. Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials. Hypertension 59: 787-795, 2012.
16. Haley S,. Jane Reed, Biing-Hwan Lin, Annetta Cook. Sweetener sonsumption in the United States. In: Electronic Outlook Report from the Economic Research Service. Washington DC: USDA. http://www. ers.usda.gov/media/326278/sss24301_002.pdf, 2015.
17. Havel PJ. Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 63: 133-157, 2005.
18. He FJ, Marrero NM, MacGregor GA. Salt intake is related to soft drink consumption in children and adolescents: a link to obesity? Hypertension 51: 629-634, 2008.
19. Huang DY, Boini KM, Friedrich B, Metzger M, Just L, Osswald H, Wulff P, Kuhl D, Vallon V, Lang F. Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1. Am J Physiol Regul Integr Comp Physiol 290: R935-R944, 2006.
20. Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension 10: 512-516, 1987.
21. Johnson RJ, Lanaspa MA, Roncal-Jimenez C, Sanchez-Lozada LG. Effects of excessive fructose intake on health. Ann Intern Med 156: 905-906, 2012.
22. Johnson RJ, Sanchez-Lozada LG, Nakagawa T. The effect of fructose on renal biology and disease. J Am Soc Nephrol 21: 2036-2039, 2010.
23. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sanchez-Lozada LG. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 86: 899-906, 2007.
24. Kawasaki T, Akanuma H, Yamanouchi T. Increased fructose concentrations in blood and urine in patients with diabetes. Diabetes Care 25: 353-357, 2002.
25. Kawasaki T, Igarashi K, Koeda T, Sugimoto K, Nakagawa K, Hayashi S, Yamaji R, Inui H, Fukusato T, Yamanouchi T. Rats fed fructoseenriched diets have characteristics of nonalcoholic hepatic steatosis. J Nutr 139: 2067-2071, 2009.
26. Le KA, Ith M, Kreis R, Faeh D, Bortolotti M, Tran C, Boesch C, Tappy L. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr 89: 1760-1765, 2009.
27. Le MT, Frye RF, Rivard CJ, Cheng J, McFann KK, Segal MS, Johnson RJ, Johnson JA. Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism 61: 641-651, 2012.
28. Livesey G. Fructose ingestion: dose-dependent responses in health research. J Nutr 139: 1246S-1252S, 2009.
29. Lustig RH. Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc 110: 1307-1321, 2010.
30. Madero M, Perez-Pozo SE, Jalal D, Johnson RJ, Sanchez-Lozada LG. Dietary fructose and hypertension. Curr Hypertens Rep 13: 29-35, 2011.
31. Manolescu AR, Witkowska K, Kinnaird A, Cessford T, Cheeseman C. Facilitated hexose transporters: new perspectives on form and function. Physiology (Bethesda) 22: 234-240, 2007.
32. Marshall RO, Kooi ER. Enzymatic conversion of D-glucose to D-fructose. Science 125: 648-649, 1957.
33. Melanson KJ, Zukley L, Lowndes J, Nguyen V, Angelopoulos TJ, Rippe JM. Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition 23: 103-112, 2007.
34. Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, Ouyang X, Feig DI, Block ER, Herrera-Acosta J, Patel JM, Johnson RJ. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 290: F625-F631, 2006.
35. Nishimoto Y, Tomida T, Matsui H, Ito T, Okumura K. Decrease in renal medullary endothelial nitric oxide synthase of fructose-fed, saltsensitive hypertensive rats. Hypertension 40: 190-194, 2002.
36. Page KA, Chan O, Arora J, Belfort-Deaguiar R, Dzuira J, Roehmholdt B, Cline GW, Naik S, Sinha R, Constable RT, Sherwin RS. Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. JAMA 309: 63-70, 2013.
37. Park SH, Lee YJ, Lim MJ, Kim EJ, Lee JH, Han HJ. High glucose inhibits fructose uptake in renal proximal tubule cells: involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2. J Cell Physiol 200: 407-416, 2004.
38. Perez-Pozo SE, Schold J, Nakagawa T, Sanchez-Lozada LG, Johnson RJ, Lillo JL. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes (Lond) 34: 454-461, 2010.
39. Petersen A, Kappler F, Szwergold BS, Brown TR. Fructose metabolism in the human erythrocyte. Phosphorylation to fructose 3-phosphate. Biochem J 284: 363-366, 1992.
40. Queiroz-Leite GD, Crajoinas RO, Neri EA, Bezerra CN, Girardi AC, Reboucas NA, Malnic G. Fructose acutely stimulates NHE3 activity in kidney proximal tubule. Kidney Blood Press Res 36: 320 -334, 2012.
41. Reed MJ, Ho H, Donnelly R, Reaven GM. Salt-sensitive and carbohydrate- sensitive rodent hypertension: evidence of strain differences. Blood Press 3: 197-201, 1994.
42. Samuel VT. Fructose induced lipogenesis: from sugar to fat to insulin resistance. Trends Endocrinol Metab 22: 60-65, 2011.
43. Sanchez-Lozada LG, Tapia E, Jimenez A, Bautista P, Cristobal M, Nepomuceno T, Soto V, vila-Casado C, Nakagawa T, Johnson RJ, Herrera-Acosta J, Franco M. Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol 292: F423-F429, 2007.
44. Sharma N, Li L, Ecelbarger CM. Sex differences in renal and metabolic responses to a high-fructose diet in mice. Am J Physiol Renal Physiol 308: F400-F410, 2015.
45. Singh AK, Amlal H, Haas PJ, Dringenberg U, Fussell S, Barone SL, Engelhardt R, Zuo J, Seidler U, Soleimani M. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int 74: 438-447, 2008.
46. Song J, Hu X, Shi M, Knepper MA, Ecelbarger CA. Effects of dietary fat, NaCl, and fructose on renal sodium and water transporter abundances and systemic blood pressure. Am J Physiol Renal Physiol 287: F1204- F1212, 2004.
47. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ. Consuming fructose-sweetened, not glucosesweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119: 1322-1334, 2009.
48. Sugawara-Yokoo M, Suzuki T, Matsuzaki T, Naruse T, Takata K. Presence of fructose transporter GLUT5 in the S3 proximal tubules in the rat kidney. Kidney Int 56: 1022-1028, 1999.
49. Tappy L, Le KA. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 90: 23-46, 2010.
50. Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 89: 2963-2972, 2004.
51. Vos MB, Lavine JE. Dietary fructose in nonalcoholic fatty liver disease. Hepatology 57: 2525-2531, 2013.
52. Yang Q, Zhang Z, Gregg EW, Flanders WD, Merritt R, Hu FB. Added sugar intake and cardiovascular diseases mortality among US adults. JAMA Intern Med 10, 2014.