Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies

PLoS Pathogens

Volumn 11, Issue 10, 2015, Pages

  Ciferri, Claudio ^a,g   Chandramouli, Sumana ^a   Leitner, Alexander ^b   Donnarumma, Danilo ^c   Cianfrocco, Michael A ^d,e   Gerrein, Rachel ^a   Friedrich, Kristian ^a   Aggarwal, Yukti ^a   Palladino, Giuseppe ^a,h   Aebersold, Ruedi ^b,f   Norais, Nathalie ^c   Settembre, Ethan C ^a,h   Carfi, Andrea ^a  

^a GLAXOSMITHKLINE   (United States)

^b ETH ZURICH   (Switzerland)

^c GSK   (Italy)

^d HARVARD UNIVERSITY   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF ZURICH   (Switzerland)

^g GENENTECH INC   (United States)

^h NVS Influenza Vaccines   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; EPITOPE; VIRUS ANTIGEN; VIRUS FUSION PROTEIN;

ANIMAL CELL; ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN CYTOMEGALOVIRUS; MASS SPECTROMETRY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; SIZE EXCLUSION CHROMATOGRAPHY; SURFACE PLASMON RESONANCE; BINDING SITE; CELL LINE; CYTOMEGALOVIRUS; GENETIC TRANSFECTION; HUMAN; IMMUNOLOGY; LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; VIRUS ENTRY;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIGENS, VIRAL; BINDING SITES; CELL LINE; CHROMATOGRAPHY, LIQUID; CYTOMEGALOVIRUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, B-LYMPHOCYTE; HUMANS; SURFACE PLASMON RESONANCE; TANDEM MASS SPECTROMETRY; TRANSFECTION; VIRAL FUSION PROTEINS; VIRUS INTERNALIZATION;

EID: 84946023846     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005230     Document Type: Article

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