Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 8, 2009, Pages 2880-2885

  Backovic, Marija ^a,c   Longnecker, Richard ^b   Jardetzky, Theodore S ^a,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c INSTITUT PASTEUR   (France)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Entry; Fusion; Herpesvirus

Indexed keywords

GLYCOPROTEIN B; VIRUS ENVELOPE PROTEIN; VIRUS FUSION PROTEIN;

ARTICLE; CELL FUSION; CRYSTAL STRUCTURE; EPSTEIN BARR VIRUS; HOST CELL; MEMBRANE FUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; VESICULAR STOMATITIS VIRUS; VIRUS ENTRY;

BIOPOLYMERS; CRYSTALLIZATION; GLYCOPROTEINS; HERPESVIRUS 4, HUMAN; MEMBRANE FUSION; MODELS, MOLECULAR; PROTEIN CONFORMATION;

HERPESVIRIDAE; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 4; VESICULAR STOMATITIS VIRUS;

EID: 62449188223     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810530106     Document Type: Article

References (36)

1. Pellet PE, Roizman B (2007) in Fields Virology, eds Knipe DM, Howley PM (Lippincott Williams and Wilkins, New York), pp 2479-2499.
2. Heldwein EE, Krummenacher C (2008) Entry of herpesviruses into mammalian cells. Cell Mol Life Sci 65:1653-1668.
3. Spear PG, Longnecker R (2003) Herpesvirus entry: An update. J Virol 77:10179-10185.
4. Rey FA (2006) Molecular gymnastics at the herpesvirus surface. EMBO reports 7:1000-1005.
5. Haan KM, Kwok WW, Longnecker R, Speck P (2000) Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor. J Virol 74:2451-2454.
6. Li Q, et al. (1997) Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes. J Virol 71:4657-4662.
7. Maurer UE, Sodeik B, Grunewald K (2008) Native 3D intermediates of membrane fusion in herpes simplex virus 1 entry. Proc Natl Acad Sci USA 105:10559-10564.
8. Carfi A, et al. (2001) Herpes simplex virus glycoprotein D bound to the human receptor Hve A. Mol Cell 8:169-179.
9. Krummenacher C, et al. (2005) Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry. EMBO J 24:4144-4153.
10. Kirschner AN, Sorem J, Longnecker R, Jardetzky TS (2009) Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor activated virus entry. Structure, in press.
11. Mullen MM, Haan KM, Longnecker R, Jardetzky TS (2002) Structure of the Epstein-Barr virus gp42 protein bound to the MHCclassll receptor HLA-DR1. Mol Cell 9:375-385.
12. Heldwein EE, et al. (2006) Crystal structure of glycoprotein B from herpes simplex virus 1. Science 313:217-220.
13. Roche S, Bressanelli S, Rey FA, Gaudin Y (2006) Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G. Science 313:187-191.
14. Gong M, Kieff E (1990) Intracellular trafficking of two major Epstein-Barr virus glycoproteins, gp350/220 and gp110. J Virol 64:1507-1516.
15. Papworth MA, et al. (1997) The processing, transport and heterologous expression of Epstein-Barr virus gp110. J Gen Virol 78:2179-2189.
16. Herrold RE, Marchini A, Fruehling S, Longnecker R (1996) Glycoprotein 110, the Epstein-Barr virus homolog of herpes simplex virus glycoprotein B, is essential for Epstein-Barr virus replication in vivo. J Virol 70:2049-2054.
17. Farnsworth A, et al. (2007) Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane. Proc Natl Acad Sci USA 104:10187-10192.
18. Backovic M, Jardetzky TS, Longnecker R (2007) Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity. J Virol 81:9596-9600.
19. Backovic M, Leser GP, Lamb RA, Longnecker R, Jardetzky TS (2007) Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins. Virology 368:102-113.
20. Steven AC, Spear PG (2006) Biochemistry. Viral glycoproteins and an evolutionary conundrum. Science 313:177-178.
21. Kadlec J, Loureiro S, Abrescia NG, Stuart Dl, Jones IM (2008) The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines. Nat Struct Mol Biol 15:1024-1030.
22. Johannsen E, et al. (2004) Proteins of purified Epstein-Barr virus. Proc Natl Acad Sci USA 101:16286 -16291.
23. Reimer JJ, Backovic M, Deshpande CG, Jardetzky T, Longnecker R (2009) Analysis of Epstein-Barr Virus Glycoprotein B Functional Domains Via Linker Insertion Mutagenesis. J Virol 83:743-747.
24. Lemmon MA (2004) Pleckstrin homology domains: Not just for phosphoinositides. Biochem Soc T 32:707-711.
25. Hannah BP, Heldwein EE, Bender FC, Cohen GH, Eisenberg RJ (2007) Mutational evidence of internal fusion loops in herpes simplex virus glycoprotein B. J Virol 81:4858-4865.
26. Roche S, Rey FA, Gaudin Y, Bressanelli S (2007) Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G. Science 315:843-848.
27. Lopper M, Compton T (2004) Coiled-coil domains in glycoproteins B and H are involved in human cytomegalovirus membrane fusion. J Virol 78:8333-8341.
28. Jeetendra E, Robison CS, Albritton LM, Whitt MA (2002) The membrane-proximal domain of vesicular stomatitis virus G protein functions as a membrane fusion potentiator and can induce hemifusion. J Virol 76:12300-12311.
29. Subramanian RP, Geraghty RJ (2007) Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B. Proc Natl Acad Sci USA 104:2903-2908.
30. Atanasiu D, et al. (2007) Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplexvirus interact with each other during cell fusion. Proc Natl Acad Sci USA 104:18718-18723.
31. Avitabile E, Forghieri C, Campadelli-Fiume G (2007) Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein. J Virol 81:11532-11537.
32. Roche S, Albertini AA, Lepault J, Bressanelli S, Gaudin Y (2008) Structures of vesicular stomatitis virus glycoprotein: Membrane fusion revisited. Cell Mol Life Sci 65:1716-1728.
33. Mueller DS, et al. (2008) Histidine protonation and the activation of viral fusion proteins. Biochem Soc T 36:43-45.
34. Collaborative Computational Project (1994) The CCP4 suite: Programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 50:760-763.
35. Brunger AT, et al. (1998) Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr 54:905-921.
36. Emsley P, Cowtan K (2004) Coot: Model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60:2126 -2132.