메뉴 건너뛰기




Volumn 472, Issue 1, 2015, Pages 55-69

Manipulating Cx43 expression triggers gene reprogramming events in dermal fibroblasts from oculodentodigital dysplasia patients

Author keywords

Collagen; Connexin43; Extracellularmatrix; Fibroblast; Gap junctional intercellular communication; Oculodentodigital dysplasia

Indexed keywords

COLLAGEN TYPE 1; CONNEXIN 43; LAMININ; MATRIX METALLOPROTEINASE; VERY LATE ACTIVATION ANTIGEN 5;

EID: 84945966507     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150652     Document Type: Article
Times cited : (13)

References (85)
  • 1
    • 0141426742 scopus 로고    scopus 로고
    • Transfer of biologically important molecules between cells through gap junction channels
    • CrossRef PubMed
    • Alexander, D.B. and Goldberg, G.S. (2003) Transfer of biologically important molecules between cells through gap junction channels. Curr. Med. Chem. 10, 2045-2058 CrossRef PubMed
    • (2003) Curr. Med. Chem. , vol.10 , pp. 2045-2058
    • Alexander, D.B.1    Goldberg, G.S.2
  • 2
    • 0030013202 scopus 로고    scopus 로고
    • Connexins, connexons, and intercellular communication
    • CrossRef PubMed
    • Goodenough, D.A., Goliger, J.A. and Paul, D.L. (1996) Connexins, connexons, and intercellular communication. Annu. Rev. Biochem. 65, 475-502 CrossRef PubMed
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 475-502
    • Goodenough, D.A.1    Goliger, J.A.2    Paul, D.L.3
  • 4
    • 84861625594 scopus 로고    scopus 로고
    • Gap junctions in inherited human disorders of the central nervous system
    • CrossRef PubMed
    • Abrams, C.K. and Scherer, S.S. (2012) Gap junctions in inherited human disorders of the central nervous system. Biochim. Biophys. Acta 1818, 2030-2047 CrossRef PubMed
    • (2012) Biochim. Biophys. Acta , vol.1818 , pp. 2030-2047
    • Abrams, C.K.1    Scherer, S.S.2
  • 5
    • 41249084806 scopus 로고    scopus 로고
    • Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease
    • CrossRef PubMed
    • Laird, D.W. (2008) Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease. J. Biol. Chem. 283, 2997-3001 CrossRef PubMed
    • (2008) J. Biol. Chem. , vol.283 , pp. 2997-3001
    • Laird, D.W.1
  • 6
    • 0036985324 scopus 로고    scopus 로고
    • Physical map of the chromosome 6q22 region containing the oculodentodigital dysplasia locus: Analysis of thirteen candidate genes and identification of novel ESTs and DNA polymorphisms
    • CrossRef PubMed
    • Boyadjiev, S.A., Chowdry, A.B., Shapiro, R.E., Paznekas, W.A., Wandstrat, A.E., Choi, J.W., Kasch, L., Zhang, G., Wollnik, B., Burgess, C.E. et al. (2002) Physical map of the chromosome 6q22 region containing the oculodentodigital dysplasia locus: analysis of thirteen candidate genes and identification of novel ESTs and DNA polymorphisms. Cytogenet. Genome Res. 98, 29-37 CrossRef PubMed
    • (2002) Cytogenet. Genome Res. , vol.98 , pp. 29-37
    • Boyadjiev, S.A.1    Chowdry, A.B.2    Shapiro, R.E.3    Paznekas, W.A.4    Wandstrat, A.E.5    Choi, J.W.6    Kasch, L.7    Zhang, G.8    Wollnik, B.9    Burgess, C.E.10
  • 8
    • 23744507557 scopus 로고    scopus 로고
    • Functional characterization of connexin43 mutations found in patients with oculodentodigital dysplasia
    • CrossRef PubMed
    • Shibayama, J., Paznekas, W., Seki, A., Taffet, S., Jabs, E.W., Delmar, M. and Musa, H. (2005) Functional characterization of connexin43 mutations found in patients with oculodentodigital dysplasia. Circ. Res. 96, e83-91 CrossRef PubMed
    • (2005) Circ. Res. , vol.96 , pp. e83-91
    • Shibayama, J.1    Paznekas, W.2    Seki, A.3    Taffet, S.4    Jabs, E.W.5    Delmar, M.6    Musa, H.7
  • 10
    • 1642324567 scopus 로고    scopus 로고
    • A homozygous GJA1 gene mutation causes a Hallermann-Streiff/ODDD spectrum phenotype
    • CrossRef PubMed
    • Pizzuti, A., Flex, E., Mingarelli, R., Salpietro, C., Zelante, L. and Dallapiccola, B. (2004) A homozygous GJA1 gene mutation causes a Hallermann-Streiff/ODDD spectrum phenotype. Hum. Mutat. 23, 286 CrossRef PubMed
    • (2004) Hum. Mutat. , vol.23 , pp. 286
    • Pizzuti, A.1    Flex, E.2    Mingarelli, R.3    Salpietro, C.4    Zelante, L.5    Dallapiccola, B.6
  • 11
    • 0036255381 scopus 로고    scopus 로고
    • Neurological manifestations of the oculodentodigital dysplasia syndrome
    • CrossRef PubMed
    • Loddenkemper, T., Grote, K., Evers, S., Oelerich, M. and Stogbauer, F. (2002) Neurological manifestations of the oculodentodigital dysplasia syndrome. J. Neurol. 249, 584-595 CrossRef PubMed
    • (2002) J. Neurol. , vol.249 , pp. 584-595
    • Loddenkemper, T.1    Grote, K.2    Evers, S.3    Oelerich, M.4    Stogbauer, F.5
  • 12
    • 84885344514 scopus 로고    scopus 로고
    • Neurological manifestations of oculodentodigital dysplasia: A Cx43 channelopathy of the central nervous system?
    • CrossRef PubMed
    • De Bock, M., Kerrebrouck, M., Wang, N. and Leybaert, L. (2013) Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system? Front. Pharmacol 4, 120 CrossRef PubMed
    • (2013) Front. Pharmacol , vol.4 , pp. 120
    • De Bock, M.1    Kerrebrouck, M.2    Wang, N.3    Leybaert, L.4
  • 14
    • 36649026454 scopus 로고    scopus 로고
    • Some oculodentodigital dysplasia-associated Cx43 mutations cause increased hemichannel activity in addition to deficient gap junction channels
    • CrossRef PubMed
    • Dobrowolski, R., Sommershof, A. and Willecke, K. (2007) Some oculodentodigital dysplasia-associated Cx43 mutations cause increased hemichannel activity in addition to deficient gap junction channels. J. Membr. Biol. 219, 9-17 CrossRef PubMed
    • (2007) J. Membr. Biol. , vol.219 , pp. 9-17
    • Dobrowolski, R.1    Sommershof, A.2    Willecke, K.3
  • 16
    • 34547131839 scopus 로고    scopus 로고
    • Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia
    • CrossRef PubMed
    • Gong, X.Q., Shao, Q., Langlois, S., Bai, D. and Laird, D.W. (2007) Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia. J. Biol. Chem. 282, 19190-19202 CrossRef PubMed
    • (2007) J. Biol. Chem. , vol.282 , pp. 19190-19202
    • Gong, X.Q.1    Shao, Q.2    Langlois, S.3    Bai, D.4    Laird, D.W.5
  • 17
    • 33845977738 scopus 로고    scopus 로고
    • Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma
    • CrossRef PubMed
    • Gong, X.Q., Shao, Q., Lounsbury, C.S., Bai, D. and Laird, D.W. (2006) Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma. J. Biol. Chem. 281, 31801-31811 CrossRef PubMed
    • (2006) J. Biol. Chem. , vol.281 , pp. 31801-31811
    • Gong, X.Q.1    Shao, Q.2    Lounsbury, C.S.3    Bai, D.4    Laird, D.W.5
  • 18
    • 84892162489 scopus 로고    scopus 로고
    • Myogenic bladder defects in mouse models of human oculodentodigital dysplasia
    • CrossRef PubMed
    • Huang, T., Shao, Q., Barr, K., Simek, J., Fishman, G.I. and Laird, D.W. (2014) Myogenic bladder defects in mouse models of human oculodentodigital dysplasia. Biochem. J. 457, 441-449 CrossRef PubMed
    • (2014) Biochem. J. , vol.457 , pp. 441-449
    • Huang, T.1    Shao, Q.2    Barr, K.3    Simek, J.4    Fishman, G.I.5    Laird, D.W.6
  • 19
    • 84880681669 scopus 로고    scopus 로고
    • Autosomal recessive GJA1 (Cx43) gene mutations cause oculodentodigital dysplasia by distinct mechanisms
    • CrossRef PubMed
    • Huang, T., Shao, Q., MacDonald, A., Xin, L., Lorentz, R., Bai, D. and Laird, D.W. (2013) Autosomal recessive GJA1 (Cx43) gene mutations cause oculodentodigital dysplasia by distinct mechanisms. J. Cell Sci. 126, 2857-2866 CrossRef PubMed
    • (2013) J. Cell Sci. , vol.126 , pp. 2857-2866
    • Huang, T.1    Shao, Q.2    MacDonald, A.3    Xin, L.4    Lorentz, R.5    Bai, D.6    Laird, D.W.7
  • 20
    • 33644979261 scopus 로고    scopus 로고
    • Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells
    • CrossRef PubMed
    • Lai, A., Le, D.N., Paznekas, W.A., Gifford, W.D., Jabs, E.W. and Charles, A.C. (2006) Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells. J. Cell Sci. 119, 532-541 CrossRef PubMed
    • (2006) J. Cell Sci. , vol.119 , pp. 532-541
    • Lai, A.1    Le, D.N.2    Paznekas, W.A.3    Gifford, W.D.4    Jabs, E.W.5    Charles, A.C.6
  • 21
    • 84898888299 scopus 로고    scopus 로고
    • Syndromic and non-syndromic disease-linked Cx43 mutations
    • CrossRef PubMed
    • Laird, D.W. (2014) Syndromic and non-syndromic disease-linked Cx43 mutations. FEBS Lett. 588, 1339-1348 CrossRef PubMed
    • (2014) FEBS Lett. , vol.588 , pp. 1339-1348
    • Laird, D.W.1
  • 22
    • 84864331377 scopus 로고    scopus 로고
    • Characterization of gap junction proteins in the bladder of Cx43 mutant mouse models of oculodentodigital dysplasia
    • CrossRef PubMed
    • Lorentz, R., Shao, Q., Huang, T., Fishman, G.I. and Laird, D.W. (2012) Characterization of gap junction proteins in the bladder of Cx43 mutant mouse models of oculodentodigital dysplasia. J. Membr. Biol. 245, 345-355 CrossRef PubMed
    • (2012) J. Membr. Biol. , vol.245 , pp. 345-355
    • Lorentz, R.1    Shao, Q.2    Huang, T.3    Fishman, G.I.4    Laird, D.W.5
  • 23
    • 56549116154 scopus 로고    scopus 로고
    • Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant
    • CrossRef PubMed
    • Manias, J.L., Plante, I., Gong, X.Q., Shao, Q., Churko, J., Bai, D. and Laird, D.W. (2008) Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant. Cardiovasc. Res. 80, 385-395 CrossRef PubMed
    • (2008) Cardiovasc. Res. , vol.80 , pp. 385-395
    • Manias, J.L.1    Plante, I.2    Gong, X.Q.3    Shao, Q.4    Churko, J.5    Bai, D.6    Laird, D.W.7
  • 25
    • 44449137493 scopus 로고    scopus 로고
    • ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation
    • CrossRef PubMed
    • McLachlan, E., Plante, I., Shao, Q., Tong, D., Kidder, G.M., Bernier, S.M. and Laird, D.W. (2008) ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation. J. Bone Miner. Res. 23, 928-938 CrossRef PubMed
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 928-938
    • McLachlan, E.1    Plante, I.2    Shao, Q.3    Tong, D.4    Kidder, G.M.5    Bernier, S.M.6    Laird, D.W.7
  • 26
    • 84865709980 scopus 로고    scopus 로고
    • Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia
    • CrossRef PubMed
    • Shao, Q., Liu, Q., Lorentz, R., Gong, X.Q., Bai, D., Shaw, G.S. and Laird, D.W. (2012) Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia. Mol. Biol. Cell 23, 3312-3321 CrossRef PubMed
    • (2012) Mol. Biol. Cell , vol.23 , pp. 3312-3321
    • Shao, Q.1    Liu, Q.2    Lorentz, R.3    Gong, X.Q.4    Bai, D.5    Shaw, G.S.6    Laird, D.W.7
  • 27
    • 58149092631 scopus 로고    scopus 로고
    • Connexin-caused genetic diseases and corresponding mouse models
    • CrossRef PubMed
    • Dobrowolski, R. and Willecke, K. (2009) Connexin-caused genetic diseases and corresponding mouse models. Antioxid. Redox Signal. 11, 283-295 CrossRef PubMed
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 283-295
    • Dobrowolski, R.1    Willecke, K.2
  • 29
    • 79952749525 scopus 로고    scopus 로고
    • Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects
    • CrossRef PubMed
    • Churko, J.M., Shao, Q., Gong, X.Q., Swoboda, K.J., Bai, D., Sampson, J. and Laird, D.W. (2011) Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects. Hum. Mutat. 32, 456-466 CrossRef PubMed
    • (2011) Hum. Mutat. , vol.32 , pp. 456-466
    • Churko, J.M.1    Shao, Q.2    Gong, X.Q.3    Swoboda, K.J.4    Bai, D.5    Sampson, J.6    Laird, D.W.7
  • 31
    • 0029071158 scopus 로고
    • Oculodentodigital dysplasia with cerebral white matter abnormalities in a two-generation family
    • CrossRef PubMed
    • Norton, K.K., Carey, J.C. and Gutmann, D.H. (1995) Oculodentodigital dysplasia with cerebral white matter abnormalities in a two-generation family. Am. J. Med. Genet. 57, 458-461 CrossRef PubMed
    • (1995) Am. J. Med. Genet. , vol.57 , pp. 458-461
    • Norton, K.K.1    Carey, J.C.2    Gutmann, D.H.3
  • 32
    • 84898627374 scopus 로고    scopus 로고
    • Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation
    • CrossRef PubMed
    • Batra, N., Riquelme, M.A., Burra, S., Kar, R., Gu, S. and Jiang, J.X. (2014) Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation. J. Biol. Chem. 289, 10582-10591 CrossRef PubMed
    • (2014) J. Biol. Chem. , vol.289 , pp. 10582-10591
    • Batra, N.1    Riquelme, M.A.2    Burra, S.3    Kar, R.4    Gu, S.5    Jiang, J.X.6
  • 33
    • 33745598855 scopus 로고    scopus 로고
    • Gap junction communications influence upon fibroblast synthesis of type i collagen and fibronectin
    • CrossRef PubMed
    • Ehrlich, H.P., Sun, B., Saggers, G.C. and Kromath, F. (2006) Gap junction communications influence upon fibroblast synthesis of type I collagen and fibronectin. J. Cell. Biochem. 98, 735-743 CrossRef PubMed
    • (2006) J. Cell. Biochem. , vol.98 , pp. 735-743
    • Ehrlich, H.P.1    Sun, B.2    Saggers, G.C.3    Kromath, F.4
  • 34
    • 0031963247 scopus 로고    scopus 로고
    • Chronology of events accompanying follicular atresia in hypophysectomized ewes. Changes in levels of steroidogenic enzymes, connexin 43, insulin-like growth factor II/mannose 6 phosphate receptor, extracellular matrix components, and matrix metalloproteinases
    • CrossRef PubMed
    • Huet, C., Monget, P., Pisselet, C., Hennequet, C., Locatelli, A. and Monniaux, D. (1998) Chronology of events accompanying follicular atresia in hypophysectomized ewes. Changes in levels of steroidogenic enzymes, connexin 43, insulin-like growth factor II/mannose 6 phosphate receptor, extracellular matrix components, and matrix metalloproteinases. Biol. Reprod. 58, 175-185 CrossRef PubMed
    • (1998) Biol. Reprod. , vol.58 , pp. 175-185
    • Huet, C.1    Monget, P.2    Pisselet, C.3    Hennequet, C.4    Locatelli, A.5    Monniaux, D.6
  • 35
    • 33748482385 scopus 로고    scopus 로고
    • Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cells
    • CrossRef PubMed
    • Isakson, B.E., Olsen, C.E. and Boitano, S. (2006) Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cells. Respir. Res. 7, 105 CrossRef PubMed
    • (2006) Respir. Res. , vol.7 , pp. 105
    • Isakson, B.E.1    Olsen, C.E.2    Boitano, S.3
  • 36
    • 84865455412 scopus 로고    scopus 로고
    • Contractility in type III cochlear fibrocytes is dependent on non-muscle myosin II and intercellular gap junctional coupling
    • CrossRef PubMed
    • Kelly, J.J., Forge, A. and Jagger, D.J. (2012) Contractility in type III cochlear fibrocytes is dependent on non-muscle myosin II and intercellular gap junctional coupling. J. Assoc. Res. Otolaryngol. 13, 473-484 CrossRef PubMed
    • (2012) J. Assoc. Res. Otolaryngol. , vol.13 , pp. 473-484
    • Kelly, J.J.1    Forge, A.2    Jagger, D.J.3
  • 37
    • 0032517773 scopus 로고    scopus 로고
    • Cellular interaction of integrin alpha3beta1 with laminin 5 promotes gap junctional communication
    • CrossRef PubMed
    • Lampe, P.D., Nguyen, B.P., Gil, S., Usui, M., Olerud, J., Takada, Y. and Carter, W.G. (1998) Cellular interaction of integrin alpha3beta1 with laminin 5 promotes gap junctional communication. J. Cell Biol. 143, 1735-1747 CrossRef PubMed
    • (1998) J. Cell Biol. , vol.143 , pp. 1735-1747
    • Lampe, P.D.1    Nguyen, B.P.2    Gil, S.3    Usui, M.4    Olerud, J.5    Takada, Y.6    Carter, W.G.7
  • 38
    • 33846142148 scopus 로고    scopus 로고
    • Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration
    • CrossRef PubMed
    • Mori, R., Power, K.T., Wang, C.M., Martin, P. and Becker, D.L. (2006) Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration. J. Cell Sci. 119, 5193-5203 CrossRef PubMed
    • (2006) J. Cell Sci. , vol.119 , pp. 5193-5203
    • Mori, R.1    Power, K.T.2    Wang, C.M.3    Martin, P.4    Becker, D.L.5
  • 39
    • 33847288186 scopus 로고    scopus 로고
    • Hepatic granulomas induced by Schistosoma mansoni in mice deficient for connexin 43 present lower cell proliferation and higher collagen content
    • CrossRef PubMed
    • Oloris, S.C., Mesnil, M., Reis, V.N., Sakai, M., Matsuzaki, P., Fonseca Ede, S., da Silva, T.C., Avanzo, J.L., Sinhorini, I.L., Guerra, J.L. et al. (2007) Hepatic granulomas induced by Schistosoma mansoni in mice deficient for connexin 43 present lower cell proliferation and higher collagen content. Life Sci. 80, 1228-1235 CrossRef PubMed
    • (2007) Life Sci. , vol.80 , pp. 1228-1235
    • Oloris, S.C.1    Mesnil, M.2    Reis, V.N.3    Sakai, M.4    Matsuzaki, P.5    Fonseca Ede, S.6    Da Silva, T.C.7    Avanzo, J.L.8    Sinhorini, I.L.9    Guerra, J.L.10
  • 40
    • 84863940824 scopus 로고    scopus 로고
    • Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex
    • CrossRef PubMed
    • Suh, H.N., Kim, M.O. and Han, H.J. (2012) Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex. Stem Cells Dev. 21, 2058-2070 CrossRef PubMed
    • (2012) Stem Cells Dev. , vol.21 , pp. 2058-2070
    • Suh, H.N.1    Kim, M.O.2    Han, H.J.3
  • 41
    • 84921047224 scopus 로고    scopus 로고
    • Expression and function of connexin 43 in human gingival wound healing and fibroblasts
    • CrossRef PubMed
    • Tarzemany, R., Jiang, G., Larjava, H. and Hakkinen, L. (2015) Expression and function of connexin 43 in human gingival wound healing and fibroblasts. PLoS One 10, e0115524 CrossRef PubMed
    • (2015) PLoS One , vol.10
    • Tarzemany, R.1    Jiang, G.2    Larjava, H.3    Hakkinen, L.4
  • 42
    • 33749661874 scopus 로고    scopus 로고
    • Connexin 32 and 43 gap junctions differentially modulate tenocyte response to cyclic mechanical load
    • CrossRef PubMed
    • Waggett, A.D., Benjamin, M. and Ralphs, J.R. (2006) Connexin 32 and 43 gap junctions differentially modulate tenocyte response to cyclic mechanical load. Eur. J. Cell Biol. 85, 1145-1154 CrossRef PubMed
    • (2006) Eur. J. Cell Biol. , vol.85 , pp. 1145-1154
    • Waggett, A.D.1    Benjamin, M.2    Ralphs, J.R.3
  • 43
    • 84930170671 scopus 로고    scopus 로고
    • Cardiomyoblast (H9c2) differentiation on tunable extracellular matrix microenvironment
    • CrossRef PubMed
    • Suhaeri, M., Subbiah, R., Van, S.Y., Du, P., Kim, I.G., Lee, K. and Park, K. (2015) Cardiomyoblast (H9c2) differentiation on tunable extracellular matrix microenvironment. Tissue Eng. Part A 21, 1940-1951 CrossRef PubMed
    • (2015) Tissue Eng. Part A , vol.21 , pp. 1940-1951
    • Suhaeri, M.1    Subbiah, R.2    Van, S.Y.3    Du, P.4    Kim, I.G.5    Lee, K.6    Park, K.7
  • 44
    • 84929494344 scopus 로고    scopus 로고
    • The role of gap junctions and mechanical loading on mineral formation in a collagen-I scaffold seeded with osteoprogenitor cells
    • CrossRef PubMed
    • Damaraju, S., Matyas, J.R., Rancourt, D.E. and Duncan, N.A. (2015) The role of gap junctions and mechanical loading on mineral formation in a collagen-I scaffold seeded with osteoprogenitor cells. Tissue Eng. Part A 21, 1720-1732 CrossRef PubMed
    • (2015) Tissue Eng. Part A , vol.21 , pp. 1720-1732
    • Damaraju, S.1    Matyas, J.R.2    Rancourt, D.E.3    Duncan, N.A.4
  • 47
    • 36048938981 scopus 로고    scopus 로고
    • The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells
    • CrossRef PubMed
    • Ito, T.K., Ishii, G., Chiba, H. and Ochiai, A. (2007) The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells. Oncogene 26, 7194-7203 CrossRef PubMed
    • (2007) Oncogene , vol.26 , pp. 7194-7203
    • Ito, T.K.1    Ishii, G.2    Chiba, H.3    Ochiai, A.4
  • 48
    • 84887373594 scopus 로고    scopus 로고
    • Laminin production and basement membrane deposition by mesenchymal stem cells upon adipogenic differentiation
    • CrossRef PubMed
    • Noro, A., Sillat, T., Virtanen, I., Ingerpuu, S., Back, N., Konttinen, Y.T. and Korhonen, M. (2013) Laminin production and basement membrane deposition by mesenchymal stem cells upon adipogenic differentiation. J. Histochem. Cytochem. 61, 719-730 CrossRef PubMed
    • (2013) J. Histochem. Cytochem. , vol.61 , pp. 719-730
    • Noro, A.1    Sillat, T.2    Virtanen, I.3    Ingerpuu, S.4    Back, N.5    Konttinen, Y.T.6    Korhonen, M.7
  • 50
    • 0030611991 scopus 로고    scopus 로고
    • Reduced expression of the P2 form of the gap junction protein connexin43 in malignant meningiomas
    • CrossRef PubMed
    • Sato, K., Gratas, C., Lampe, J., Biernat, W., Kleihues, P., Yamasaki, H. and Ohgaki, H. (1997) Reduced expression of the P2 form of the gap junction protein connexin43 in malignant meningiomas. J. Neuropathol. Exp. Neurol. 56, 835-839 CrossRef PubMed
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 835-839
    • Sato, K.1    Gratas, C.2    Lampe, J.3    Biernat, W.4    Kleihues, P.5    Yamasaki, H.6    Ohgaki, H.7
  • 51
    • 21344438851 scopus 로고    scopus 로고
    • Role for beta1 integrin and its associated alpha3, alpha5, and alpha6 subunits in development of the human fetal pancreas
    • CrossRef PubMed
    • Wang, R., Li, J., Lyte, K., Yashpal, N.K., Fellows, F. and Goodyer, C.G. (2005) Role for beta1 integrin and its associated alpha3, alpha5, and alpha6 subunits in development of the human fetal pancreas. Diabetes 54, 2080-2089 CrossRef PubMed
    • (2005) Diabetes , vol.54 , pp. 2080-2089
    • Wang, R.1    Li, J.2    Lyte, K.3    Yashpal, N.K.4    Fellows, F.5    Goodyer, C.G.6
  • 52
    • 80054094641 scopus 로고    scopus 로고
    • Reference gene validation for qPCR on normoxia-and hypoxia-cultured human dermal fibroblasts exposed to UVA: Is beta-actin a reliable normalizer for photoaging studies?
    • CrossRef PubMed
    • Bruge, F., Venditti, E., Tiano, L., Littarru, G.P. and Damiani, E. (2011) Reference gene validation for qPCR on normoxia-and hypoxia-cultured human dermal fibroblasts exposed to UVA: is beta-actin a reliable normalizer for photoaging studies? J. Biotechnol. 156, 153-162 CrossRef PubMed
    • (2011) J. Biotechnol. , vol.156 , pp. 153-162
    • Bruge, F.1    Venditti, E.2    Tiano, L.3    Littarru, G.P.4    Damiani, E.5
  • 53
    • 16844375853 scopus 로고    scopus 로고
    • Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype
    • CrossRef PubMed
    • Shao, Q., Wang, H., McLachlan, E., Veitch, G.I. and Laird, D.W. (2005) Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. Cancer Res. 65, 2705-2711 CrossRef PubMed
    • (2005) Cancer Res. , vol.65 , pp. 2705-2711
    • Shao, Q.1    Wang, H.2    McLachlan, E.3    Veitch, G.I.4    Laird, D.W.5
  • 56
    • 84880776742 scopus 로고    scopus 로고
    • MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts
    • CrossRef PubMed
    • Curcio, A., Torella, D., Iaconetti, C., Pasceri, E., Sabatino, J., Sorrentino, S., Giampa, S., Micieli, M., Polimeni, A., Henning, B.J. et al. (2013) MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts. PLoS One 8, e70158 CrossRef PubMed
    • (2013) PLoS One , vol.8
    • Curcio, A.1    Torella, D.2    Iaconetti, C.3    Pasceri, E.4    Sabatino, J.5    Sorrentino, S.6    Giampa, S.7    Micieli, M.8    Polimeni, A.9    Henning, B.J.10
  • 57
    • 84881236735 scopus 로고    scopus 로고
    • SiRNA design principles and off-target effects
    • CrossRef PubMed
    • Petri, S. and Meister, G. (2013) siRNA design principles and off-target effects. Methods Mol. Biol. 986, 59-71 CrossRef PubMed
    • (2013) Methods Mol. Biol. , vol.986 , pp. 59-71
    • Petri, S.1    Meister, G.2
  • 61
    • 84878529977 scopus 로고    scopus 로고
    • Gap junction remodeling in skin repair following wounding and disease
    • CrossRef PubMed
    • Churko, J.M. and Laird, D.W. (2013) Gap junction remodeling in skin repair following wounding and disease. Physiology 28, 190-198 CrossRef PubMed
    • (2013) Physiology , vol.28 , pp. 190-198
    • Churko, J.M.1    Laird, D.W.2
  • 62
    • 4344678168 scopus 로고    scopus 로고
    • Redefining the structure of the mouse connexin43 gene: Selective promoter usage and alternative splicing mechanisms yield transcripts with different translational efficiencies
    • CrossRef PubMed
    • Pfeifer, I., Anderson, C., Werner, R. and Oltra, E. (2004) Redefining the structure of the mouse connexin43 gene: selective promoter usage and alternative splicing mechanisms yield transcripts with different translational efficiencies. Nucleic Acids Res. 32, 4550-4562 CrossRef PubMed
    • (2004) Nucleic Acids Res. , vol.32 , pp. 4550-4562
    • Pfeifer, I.1    Anderson, C.2    Werner, R.3    Oltra, E.4
  • 63
    • 84870057902 scopus 로고    scopus 로고
    • Regulation of connexin expression by transcription factors and epigenetic mechanisms
    • CrossRef PubMed
    • Oyamada, M., Takebe, K. and Oyamada, Y. (2013) Regulation of connexin expression by transcription factors and epigenetic mechanisms. Biochim. Biophys. Acta 1828, 118-133 CrossRef PubMed
    • (2013) Biochim. Biophys. Acta , vol.1828 , pp. 118-133
    • Oyamada, M.1    Takebe, K.2    Oyamada, Y.3
  • 65
    • 0035099870 scopus 로고    scopus 로고
    • Parathyroid hormone-induced up-regulation of connexin-43 messenger ribonucleic acid (mRNA) is mediated by sequences within both the promoter and the 3'untranslated region of the mRNA
    • PubMed
    • Mitchell, J.A., Ou, C., Chen, Z., Nishimura, T. and Lye, S.J. (2001) Parathyroid hormone-induced up-regulation of connexin-43 messenger ribonucleic acid (mRNA) is mediated by sequences within both the promoter and the 3'untranslated region of the mRNA. Endocrinology 142, 907-915 PubMed
    • (2001) Endocrinology , vol.142 , pp. 907-915
    • Mitchell, J.A.1    Ou, C.2    Chen, Z.3    Nishimura, T.4    Lye, S.J.5
  • 66
    • 0031464587 scopus 로고    scopus 로고
    • Evidence for a posttranscriptional effect of retinoic acid on connexin43 gene expression via the 3'-untranslated region
    • CrossRef PubMed
    • Clairmont, A. and Sies, H. (1997) Evidence for a posttranscriptional effect of retinoic acid on connexin43 gene expression via the 3'-untranslated region. FEBS Lett. 419, 268-270 CrossRef PubMed
    • (1997) FEBS Lett. , vol.419 , pp. 268-270
    • Clairmont, A.1    Sies, H.2
  • 67
    • 84861643461 scopus 로고    scopus 로고
    • Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues
    • CrossRef PubMed
    • Marquez-Rosado, L., Solan, J.L., Dunn, C.A., Norris, R.P. and Lampe, P.D. (2012) Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues. Biochim. Biophys. Acta 1818, 1985-1992 CrossRef PubMed
    • (2012) Biochim. Biophys. Acta , vol.1818 , pp. 1985-1992
    • Marquez-Rosado, L.1    Solan, J.L.2    Dunn, C.A.3    Norris, R.P.4    Lampe, P.D.5
  • 68
    • 64249170988 scopus 로고    scopus 로고
    • Connexin43 phosphorylation: Structural changes and biological effects
    • CrossRef PubMed
    • Solan, J.L. and Lampe, P.D. (2009) Connexin43 phosphorylation: structural changes and biological effects. Biochem. J. 419, 261-272 CrossRef PubMed
    • (2009) Biochem. J. , vol.419 , pp. 261-272
    • Solan, J.L.1    Lampe, P.D.2
  • 70
    • 0026025267 scopus 로고
    • Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes
    • CrossRef PubMed
    • Laird, D.W., Puranam, K.L. and Revel, J.P. (1991) Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes. Biochem. J. 273, 67-72 CrossRef PubMed
    • (1991) Biochem. J. , vol.273 , pp. 67-72
    • Laird, D.W.1    Puranam, K.L.2    Revel, J.P.3
  • 71
    • 44349184836 scopus 로고    scopus 로고
    • Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia
    • CrossRef PubMed
    • Plante, I. and Laird, D.W. (2008) Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia. Dev. Biol. 318, 312-322 CrossRef PubMed
    • (2008) Dev. Biol. , vol.318 , pp. 312-322
    • Plante, I.1    Laird, D.W.2
  • 74
    • 80054951128 scopus 로고    scopus 로고
    • The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitro
    • CrossRef PubMed
    • Wright, C.S., Pollok, S., Flint, D.J., Brandner, J.M. and Martin, P.E. (2012) The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitro. J. Cell Physiol. 227, 77-87 CrossRef PubMed
    • (2012) J. Cell Physiol. , vol.227 , pp. 77-87
    • Wright, C.S.1    Pollok, S.2    Flint, D.J.3    Brandner, J.M.4    Martin, P.E.5
  • 75
    • 78649739295 scopus 로고    scopus 로고
    • Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells
    • CrossRef PubMed
    • Pollok, S., Pfeiffer, A.C., Lobmann, R., Wright, C.S., Moll, I., Martin, P.E. and Brandner, J.M. (2011) Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells. J. Cell. Mol. Med. 15, 861-873 CrossRef PubMed
    • (2011) J. Cell. Mol. Med. , vol.15 , pp. 861-873
    • Pollok, S.1    Pfeiffer, A.C.2    Lobmann, R.3    Wright, C.S.4    Moll, I.5    Martin, P.E.6    Brandner, J.M.7
  • 77
    • 0026664282 scopus 로고
    • Regulation of fibroblast-mediated collagen gel contraction by platelet-derived growth factor, interleukin-1 alpha and transforming growth factor-beta 1
    • PubMed
    • Tingstrom, A., Heldin, C.H. and Rubin, K. (1992) Regulation of fibroblast-mediated collagen gel contraction by platelet-derived growth factor, interleukin-1 alpha and transforming growth factor-beta 1. J. Cell Sci. 102, 315-322 PubMed
    • (1992) J. Cell Sci. , vol.102 , pp. 315-322
    • Tingstrom, A.1    Heldin, C.H.2    Rubin, K.3
  • 78
    • 0037813105 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1-mediated collagen gel contraction by cardiac fibroblasts
    • CrossRef PubMed
    • Lijnen, P., Petrov, V. and Fagard, R. (2003) Transforming growth factor-beta 1-mediated collagen gel contraction by cardiac fibroblasts. J. Renin Angiotensin Aldosterone Syst. 4, 113-118 CrossRef PubMed
    • (2003) J. Renin Angiotensin Aldosterone Syst. , vol.4 , pp. 113-118
    • Lijnen, P.1    Petrov, V.2    Fagard, R.3
  • 79
    • 0037356909 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 promotes contraction of collagen gel by cardiac fibroblasts through their differentiation into myofibroblasts
    • CrossRef PubMed
    • Lijnen, P., Petrov, V., Rumilla, K. and Fagard, R. (2003) Transforming growth factor-beta 1 promotes contraction of collagen gel by cardiac fibroblasts through their differentiation into myofibroblasts. Methods Find. Exp. Clin. Pharmacol. 25, 79-86 CrossRef PubMed
    • (2003) Methods Find. Exp. Clin. Pharmacol. , vol.25 , pp. 79-86
    • Lijnen, P.1    Petrov, V.2    Rumilla, K.3    Fagard, R.4
  • 80
    • 0344196791 scopus 로고    scopus 로고
    • Demonstration of altered fibroblast contractile activity in hypertensive heart disease
    • CrossRef PubMed
    • Marganski, W.A., De Biase, V.M., Burgess, M.L. and Dembo, M. (2003) Demonstration of altered fibroblast contractile activity in hypertensive heart disease. Cardiovasc. Res. 60, 547-556 CrossRef PubMed
    • (2003) Cardiovasc. Res. , vol.60 , pp. 547-556
    • Marganski, W.A.1    De Biase, V.M.2    Burgess, M.L.3    Dembo, M.4
  • 81
    • 0842310833 scopus 로고    scopus 로고
    • A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1
    • CrossRef PubMed
    • Takamiya, K., Kostourou, V., Adams, S., Jadeja, S., Chalepakis, G., Scambler, P.J., Huganir, R.L. and Adams, R.H. (2004) A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat. Genet. 36, 172-177 CrossRef PubMed
    • (2004) Nat. Genet. , vol.36 , pp. 172-177
    • Takamiya, K.1    Kostourou, V.2    Adams, S.3    Jadeja, S.4    Chalepakis, G.5    Scambler, P.J.6    Huganir, R.L.7    Adams, R.H.8
  • 82
    • 0037872680 scopus 로고    scopus 로고
    • Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein
    • CrossRef PubMed
    • McGregor, L., Makela, V., Darling, S.M., Vrontou, S., Chalepakis, G., Roberts, C., Smart, N., Rutland, P., Prescott, N., Hopkins, J. et al. (2003) Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein. Nat. Genet. 34, 203-208 CrossRef PubMed
    • (2003) Nat. Genet. , vol.34 , pp. 203-208
    • McGregor, L.1    Makela, V.2    Darling, S.M.3    Vrontou, S.4    Chalepakis, G.5    Roberts, C.6    Smart, N.7    Rutland, P.8    Prescott, N.9    Hopkins, J.10
  • 84
    • 84881411006 scopus 로고    scopus 로고
    • Overexpression of CXCL12 chemokine up-regulates connexin and integrin expression in mesenchymal stem cells through PI3K/Akt pathway
    • CrossRef PubMed
    • Xiaowei, C., Jia, M., Xiaowei, W. and Yina, Z. (2013) Overexpression of CXCL12 chemokine up-regulates connexin and integrin expression in mesenchymal stem cells through PI3K/Akt pathway. Cell Commun. Adhes. 20, 67-72 CrossRef PubMed
    • (2013) Cell Commun. Adhes. , vol.20 , pp. 67-72
    • Xiaowei, C.1    Jia, M.2    Xiaowei, W.3    Yina, Z.4
  • 85
    • 84891403754 scopus 로고    scopus 로고
    • 14-3-3theta facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels
    • CrossRef PubMed
    • Batra, N., Riquelme, M.A., Burra, S. and Jiang, J.X. (2014) 14-3-3theta facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels. J. Cell Sci. 127, 137-146 CrossRef PubMed
    • (2014) J. Cell Sci. , vol.127 , pp. 137-146
    • Batra, N.1    Riquelme, M.A.2    Burra, S.3    Jiang, J.X.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.