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Volumn 99, Issue 11, 2015, Pages 2258-2268

A rationale for age-adapted immunosuppression in organ transplantation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIMETABOLITE; BELATACEPT; BIOLOGICAL MARKER; CALCINEURIN INHIBITOR; CORTICOSTEROID; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; IMMUNOSUPPRESSIVE AGENT;

EID: 84945954234     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0000000000000842     Document Type: Review
Times cited : (89)

References (139)
  • 1
    • 84893262380 scopus 로고    scopus 로고
    • OPTN/SRTR 2012 Annual Data Report: Kidney
    • Matas AJ, Smith JM, Skeans MA, et al. OPTN/SRTR 2012 Annual Data Report: Kidney. Am J Transplant. 2014;14(S1):11-44.
    • (2014) Am J Transplant. , vol.14 S1 , pp. 11-44
    • Matas, A.J.1    Smith, J.M.2    Skeans, M.A.3
  • 2
    • 84945910714 scopus 로고    scopus 로고
    • Eurotransplant International Foundation. Annual Report 2013
    • Eurotransplant International Foundation. Annual Report 2013; 2013.
    • (2013)
  • 3
    • 16244395140 scopus 로고    scopus 로고
    • Current status of kidney and pancreas transplantation in the United States, 1994-2003
    • Danovitch GM, Cohen DJ, Weir MR, et al. Current status of kidney and pancreas transplantation in the United States, 1994-2003. Am J Transplant. 2005;5(4 Pt 2):904-915.
    • (2005) Am J Transplant. , vol.5 , Issue.4 , pp. 904-915
    • Danovitch, G.M.1    Cohen, D.J.2    Weir, M.R.3
  • 4
    • 70649096162 scopus 로고    scopus 로고
    • Long-term probability of and mortality from de novo malignancy after liver transplantation
    • Watt KD, Pedersen RA, Kremers WK, et al. Long-term probability of and mortality from de novo malignancy after liver transplantation. Gastroen-terology. 2009;137:2010-2017.
    • (2009) Gastroen-terology. , vol.137 , pp. 2010-2017
    • Watt, K.D.1    Pedersen, R.A.2    Kremers, W.K.3
  • 5
    • 84899487686 scopus 로고    scopus 로고
    • Recipient age and risk for mortality after kidney transplantation in England
    • Karim A, Farrugia D, Cheshire J, et al. Recipient age and risk for mortality after kidney transplantation in England. Transplantation. 2014;97:832-838.
    • (2014) Transplantation. , vol.97 , pp. 832-838
    • Karim, A.1    Farrugia, D.2    Cheshire, J.3
  • 6
    • 0035070003 scopus 로고    scopus 로고
    • Exponentially increased risk of infectious death in older renal transplant recipients
    • Meier-Kriesche HU, Ojo AO, Hanson JA, et al. Exponentially increased risk of infectious death in older renal transplant recipients. Kidney Int. 2001;59:1539-1543.
    • (2001) Kidney Int. , vol.59 , pp. 1539-1543
    • Meier-Kriesche, H.U.1    Ojo, A.O.2    Hanson, J.A.3
  • 7
    • 84870507915 scopus 로고    scopus 로고
    • Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs
    • Jacobson PA, Schladt D, Oetting WS, et al. Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs. Am J Transplant. 2012;12:3326-3336.
    • (2012) Am J Transplant. , vol.12 , pp. 3326-3336
    • Jacobson, P.A.1    Schladt, D.2    Oetting, W.S.3
  • 8
    • 79953798838 scopus 로고    scopus 로고
    • Kidney allocation and the aging immune response
    • Tullius SG, Milford E. Kidney allocation and the aging immune response. N Engl J Med. 2011;364:1369-1370.
    • (2011) N Engl J Med. , vol.364 , pp. 1369-1370
    • Tullius, S.G.1    Milford, E.2
  • 9
    • 0032572694 scopus 로고    scopus 로고
    • Age and liver transplantation: A report of the Liver Transplantation Database
    • Zetterman RK, Belle SH, Hoofnagle JH, et al. Age and liver transplantation: a report of the Liver Transplantation Database. Transplantation. 1998;66:500-506.
    • (1998) Transplantation. , vol.66 , pp. 500-506
    • Zetterman, R.K.1    Belle, S.H.2    Hoofnagle, J.H.3
  • 10
    • 27844569484 scopus 로고    scopus 로고
    • The need for a tailored im-munosuppression in older heart transplant recipients
    • Kaczmarek I, Sadoni S, Schmoeckel M, et al. The need for a tailored im-munosuppression in older heart transplant recipients. J Heart Lung Transplant. 2005;24:1965-1968.
    • (2005) J Heart Lung Transplant. , vol.24 , pp. 1965-1968
    • Kaczmarek, I.1    Sadoni, S.2    Schmoeckel, M.3
  • 11
    • 33847722694 scopus 로고    scopus 로고
    • Risk factors for hospitalization for bacterial or viral infection in renal transplant recipients-an analysis of USRDS data
    • Dharnidharka VR, Agodoa LY, Abbott KC. Risk factors for hospitalization for bacterial or viral infection in renal transplant recipients-an analysis of USRDS data. Am J Transplant. 2007;7:653-661.
    • (2007) Am J Transplant. , vol.7 , pp. 653-661
    • Dharnidharka, V.R.1    Agodoa, L.Y.2    Abbott, K.C.3
  • 12
    • 84908085323 scopus 로고    scopus 로고
    • Bloodstream infections among solid organ transplant recipients: Epidemiology, microbiology, associated risk factors for morbidity and mortality
    • Shao M, Wan Q, Xie W, et al. Bloodstream infections among solid organ transplant recipients: epidemiology, microbiology, associated risk factors for morbidity and mortality. Transplant Rev (Orlando). 2014;28:176-181.
    • (2014) Transplant Rev (Orlando). , vol.28 , pp. 176-181
    • Shao, M.1    Wan, Q.2    Xie, W.3
  • 13
    • 29544441906 scopus 로고    scopus 로고
    • Bacteremia and septic shock after solid-organ transplantation
    • Candel FJ, Grima E, Matesanz M, et al. Bacteremia and septic shock after solid-organ transplantation. Transplant Proc. 2005;37:4097-4099.
    • (2005) Transplant Proc. , vol.37 , pp. 4097-4099
    • Candel, F.J.1    Grima, E.2    Matesanz, M.3
  • 14
    • 33745479157 scopus 로고    scopus 로고
    • Infection frequency and profile in different age groups of kidney transplant recipients
    • Dharnidharka VR, Caillard S, Agodoa LY, et al. Infection frequency and profile in different age groups of kidney transplant recipients. Transplantation. 2006;81:1662-1667.
    • (2006) Transplantation. , vol.81 , pp. 1662-1667
    • Dharnidharka, V.R.1    Caillard, S.2    Agodoa, L.Y.3
  • 15
    • 84888865862 scopus 로고    scopus 로고
    • Cytomegalovirus & Epstein Barr Virus serostatus as a predictor of the long-term outcome of kidney transplantation
    • Page Le, Amelia K, Mackie FE, et al. Cytomegalovirus & Epstein Barr Virus serostatus as a predictor of the long-term outcome of kidney transplantation. Nephrology (Carlton, Vic.). 2013;18:813-819.
    • (2013) Nephrology (Carlton, Vic.). , vol.18 , pp. 813-819
    • Page Le Amelia, K.1    Mackie, F.E.2
  • 16
    • 34249701218 scopus 로고    scopus 로고
    • Fungal infections in solid organ transplantation
    • Silveira FP, Husain S. Fungal infections in solid organ transplantation. Med Mycol. 2007;45:305-320.
    • (2007) Med Mycol. , vol.45 , pp. 305-320
    • Silveira, F.P.1    Husain, S.2
  • 17
    • 84897456258 scopus 로고    scopus 로고
    • Invasive fungal infections in liver transplant recipients
    • Ok Atilgan A, Özdemir BH, Kirnap M, et al. Invasive fungal infections in liver transplant recipients. Exp Clin Transplant. 2014;12(Suppl 1): 110-116.
    • (2014) Exp Clin Transplant. , vol.12 , pp. 110-116
    • Ok Atilgan, A.1    Özdemir, B.H.2    Kirnap, M.3
  • 18
    • 0035882402 scopus 로고    scopus 로고
    • Fungal infections in older adults
    • Kauffman CA. Fungal infections in older adults. Clin Infect Dis. 2001;33: 550-555.
    • (2001) Clin Infect Dis. , vol.33 , pp. 550-555
    • Kauffman, C.A.1
  • 19
    • 84897032631 scopus 로고    scopus 로고
    • Malignancies: Pre and post transplantation strategies
    • AlBugami M, Kiberd B. Malignancies: pre and post transplantation strategies. Transplant Rev (Orlando). 2014;28:76-83.
    • (2014) Transplant Rev (Orlando). , vol.28 , pp. 76-83
    • AlBugami, M.1    Kiberd, B.2
  • 20
  • 21
    • 84859853106 scopus 로고    scopus 로고
    • New onset diabetes after transplantation (NODAT): An overview
    • Pham PT, Pham PT, Pham SV, et al. New onset diabetes after transplantation (NODAT): an overview. Diabetes Metab Syndr Obes. 2011;4: 175-186.
    • (2011) Diabetes Metab Syndr Obes. , vol.4 , pp. 175-186
    • Pham, P.T.1    Pham, P.T.2    Pham, S.V.3
  • 22
    • 84931576100 scopus 로고    scopus 로고
    • Effect of pretransplant diabetes on short-term outcomes after liver transplantation: A national cohort study
    • Hoehn RS, Singhal A, Wima K, et al. Effect of pretransplant diabetes on short-term outcomes after liver transplantation: a national cohort study. Liver Int. 2015;35:1902-1909.
    • (2015) Liver Int. , vol.35 , pp. 1902-1909
    • Hoehn, R.S.1    Singhal, A.2    Wima, K.3
  • 25
    • 67649396090 scopus 로고    scopus 로고
    • Thymic involution and immune reconstitution
    • Lynch HE, Goldberg GL, Chidgey A, et al. Thymic involution and immune reconstitution. Trends Immunol. 2009;30:366-373.
    • (2009) Trends Immunol. , vol.30 , pp. 366-373
    • Lynch, H.E.1    Goldberg, G.L.2    Chidgey, A.3
  • 26
    • 21044451726 scopus 로고    scopus 로고
    • The influence of age on Tcell generation and TCR diversity
    • Naylor K, Li G, Vallejo AN, et al. The influence of age on Tcell generation and TCR diversity. J Immunol. 2005;174:7446-7452.
    • (2005) J Immunol. , vol.174 , pp. 7446-7452
    • Naylor, K.1    Li, G.2    Vallejo, A.N.3
  • 27
    • 5644279200 scopus 로고    scopus 로고
    • Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells
    • Hong MS, Dan JM, Choi J, et al. Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells. Mech Ageing Dev. 2004;125:615-618.
    • (2004) Mech Ageing Dev. , vol.125 , pp. 615-618
    • Hong, M.S.1    Dan, J.M.2    Choi, J.3
  • 28
    • 32244433673 scopus 로고    scopus 로고
    • Accumulation of memory T cells from childhood to old age: Central and effector memory cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+) compartment
    • Saule P, Trauet J, Dutriez V, et al. Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+) compartment. Mech Ageing Dev. 2006;127:274-281.
    • (2006) Mech Ageing Dev. , vol.127 , pp. 274-281
    • Saule, P.1    Trauet, J.2    Dutriez, V.3
  • 29
    • 18744422561 scopus 로고    scopus 로고
    • Proliferation and apoptosis of human CD8(+)CD28(+) and CD8(+)CD28(-) lymphocytes during aging
    • Brzezinska A, Magalska A, Szybinska A, et al. Proliferation and apoptosis of human CD8(+)CD28(+) and CD8(+)CD28(-) lymphocytes during aging. Exp Gerontol. 2004;39:539-544.
    • (2004) Exp Gerontol. , vol.39 , pp. 539-544
    • Brzezinska, A.1    Magalska, A.2    Szybinska, A.3
  • 30
    • 84863641682 scopus 로고    scopus 로고
    • Collapse of telomere homeosta-sis in hematopoietic cells caused by heterozygous mutations in telome-rase genes
    • Aubert G, Baerlocher GM, Vulto I, et al. Collapse of telomere homeosta-sis in hematopoietic cells caused by heterozygous mutations in telome-rase genes. PLoS Genet. 2012;8:e1002696.
    • (2012) PLoS Genet. , vol.8 , pp. e1002696
    • Aubert, G.1    Baerlocher, G.M.2    Vulto, I.3
  • 31
    • 84876732591 scopus 로고    scopus 로고
    • T cell replicative senescence in human aging
    • Chou JP, Effros RB. T cell replicative senescence in human aging. Curr Pharm Des. 2013;19:1680-1698.
    • (2013) Curr Pharm Des. , vol.19 , pp. 1680-1698
    • Chou, J.P.1    Effros, R.B.2
  • 32
    • 74149086692 scopus 로고    scopus 로고
    • Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation
    • Larbi A, Cabreiro F, Zelba H, et al. Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. Free Radic Biol Med. 2010;48:26-34.
    • (2010) Free Radic Biol Med. , vol.48 , pp. 26-34
    • Larbi, A.1    Cabreiro, F.2    Zelba, H.3
  • 33
    • 79955964506 scopus 로고    scopus 로고
    • Age effects on B cells and humoral immunity in humans
    • Frasca D, Diaz A, Romero M, et al. Age effects on B cells and humoral immunity in humans. Ageing Res Rev. 2011;10:330-335.
    • (2011) Ageing Res Rev. , vol.10 , pp. 330-335
    • Frasca, D.1    Diaz, A.2    Romero, M.3
  • 34
    • 0035116898 scopus 로고    scopus 로고
    • IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice
    • Herrero C, Marqués L, Lloberas J, et al. IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice. J Clin Invest. 2001;107:485-493.
    • (2001) J Clin Invest. , vol.107 , pp. 485-493
    • Herrero, C.1    Marqués, L.2    Lloberas, J.3
  • 35
    • 84937549200 scopus 로고    scopus 로고
    • CD11c+ DCs Accelerate the Rejection of Older Cardiac Transplants via IL-17A
    • May 8, 2015 [Epub ahead of print]
    • Oberhuber R, Heinbokel T, Rodriguez Cetina Biefer H, et al. CD11c+ DCs Accelerate the Rejection of Older Cardiac Transplants via IL-17A. Circulation. doi:10.1161/CIRCULATIONAHA.114.014917. May 8, 2015 [Epub ahead of print].
    • Circulation
    • Oberhuber, R.1    Heinbokel, T.2    Rodriguez Cetina Biefer, H.3
  • 36
    • 0042844680 scopus 로고    scopus 로고
    • Long-term resultsof heart transplantation in patients older than 60 years
    • Demers P, Moffatt S, Oyer PE, et al. Long-term resultsof heart transplantation in patients older than 60 years. J Thorac Cardiovasc Surg. 2003; 126:224-231.
    • (2003) J Thorac Cardiovasc Surg. , vol.126 , pp. 224-231
    • Demers, P.1    Moffatt, S.2    Oyer, P.E.3
  • 37
    • 77958004592 scopus 로고    scopus 로고
    • The combinationof donor and recipient age is critical in determining host immunoresponsiveness and renal transplant outcome
    • Tullius SG, Tran H, Guleria I, et al. The combinationof donor and recipient age is critical in determining host immunoresponsiveness and renal transplant outcome. Ann Surg. 2010;252:662-674.
    • (2010) Ann Surg. , vol.252 , pp. 662-674
    • Tullius, S.G.1    Tran, H.2    Guleria, I.3
  • 38
    • 37549010765 scopus 로고    scopus 로고
    • Prospective age-matching in elderly kidney transplant recipients-A 5-year analysis of the Eurotransplant Senior Program
    • Frei U, Noeldeke J, Machold-Fabrizii V, et al. Prospective age-matching in elderly kidney transplant recipients-a 5-year analysis of the Eurotransplant Senior Program. Am J Transplant. 2008;8:50-57.
    • (2008) Am J Transplant. , vol.8 , pp. 50-57
    • Frei, U.1    Noeldeke, J.2    Machold-Fabrizii, V.3
  • 39
    • 0141923913 scopus 로고    scopus 로고
    • Physiological featuresof aging persons
    • Aalami OO, Fang TD, Song HM, et al. Physiological featuresof aging persons. Arch Surg. 2003;138:1068-1076.
    • (2003) Arch Surg. , vol.138 , pp. 1068-1076
    • Aalami, O.O.1    Fang, T.D.2    Song, H.M.3
  • 40
    • 77950674133 scopus 로고    scopus 로고
    • Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions
    • Corsonello A, Pedone C, Incalzi RA. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem. 2010;17:571-584.
    • (2010) Curr Med Chem. , vol.17 , pp. 571-584
    • Corsonello, A.1    Pedone, C.2    Incalzi, R.A.3
  • 41
    • 84864865440 scopus 로고    scopus 로고
    • Pharmacotherapy considerations in elderly adults
    • Wooten JM. Pharmacotherapy considerations in elderly adults. South Med J. 2012;105:437-445.
    • (2012) South Med J. , vol.105 , pp. 437-445
    • Wooten, J.M.1
  • 42
    • 80051544511 scopus 로고    scopus 로고
    • Examining the evidence: A systematic review of the inclusion and analysis of older adults in randomized controlled trials
    • Zulman DM, Sussman JB, Chen X, et al. Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials. J Gen Intern Med. 2011;26:783-790.
    • (2011) J Gen Intern Med. , vol.26 , pp. 783-790
    • Zulman, D.M.1    Sussman, J.B.2    Chen, X.3
  • 44
    • 77951021284 scopus 로고    scopus 로고
    • Cautionary tales in the interpretation of clinical studies involving older persons
    • Scott IA, Guyatt GH. Cautionary tales in the interpretation of clinical studies involving older persons. Arch Intern Med. 2010;170:587-595.
    • (2010) Arch Intern Med. , vol.170 , pp. 587-595
    • Scott, I.A.1    Guyatt, G.H.2
  • 45
    • 79954911256 scopus 로고    scopus 로고
    • Age, exclusion criteria, and generalizability of randomized trials enrolling kidney transplant recipients
    • Blosser CD, Huverserian A, Bloom RD, et al. Age, exclusion criteria, and generalizability of randomized trials enrolling kidney transplant recipients. Transplantation. 2011;91:858-863.
    • (2011) Transplantation. , vol.91 , pp. 858-863
    • Blosser, C.D.1    Huverserian, A.2    Bloom, R.D.3
  • 46
    • 0027418815 scopus 로고
    • Human P-glycoprotein transports cyclosporin A and FK506
    • Saeki T, Ueda K, Tanigawara Y, et al. Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem. 1993;268:6077-6080.
    • (1993) J Biol Chem. , vol.268 , pp. 6077-6080
    • Saeki, T.1    Ueda, K.2    Tanigawara, Y.3
  • 47
    • 0033608087 scopus 로고    scopus 로고
    • Low bioavailability of cyclosporine microemulsion and tacrolimus in a small bowel transplant recipient: Possible relationship to intestinal P-glycoprotein activity
    • Kaplan B, Lown K, Craig R, et al. Low bioavailability of cyclosporine microemulsion and tacrolimus in a small bowel transplant recipient: possible relationship to intestinal P-glycoprotein activity. Transplantation. 1999;67:333-335.
    • (1999) Transplantation. , vol.67 , pp. 333-335
    • Kaplan, B.1    Lown, K.2    Craig, R.3
  • 48
    • 11144221888 scopus 로고    scopus 로고
    • Transport proteins and intestinal metabolism: P-glycoprotein and cytochrome P4503A
    • Christians U. Transport proteins and intestinal metabolism: P-glycoprotein and cytochrome P4503A. Ther Drug Monit. 2004;26:104-106.
    • (2004) Ther Drug Monit. , vol.26 , pp. 104-106
    • Christians, U.1
  • 49
    • 0029128788 scopus 로고
    • Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
    • George J, Byth K, Farrell GC. Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver. Biochem Pharmacol. 1995;50:727-730.
    • (1995) Biochem Pharmacol. , vol.50 , pp. 727-730
    • George, J.1    Byth, K.2    Farrell, G.C.3
  • 50
    • 2142639394 scopus 로고    scopus 로고
    • Age-related differences in CYP3A expression and activity in the rat liver, intestine, and kidney
    • Warrington JS, Greenblatt DJ, von Moltke LL, et al. Age-related differences in CYP3A expression and activity in the rat liver, intestine, and kidney. J Pharmacol Exp Ther. 2004;309:720-729.
    • (2004) J Pharmacol Exp Ther. , vol.309 , pp. 720-729
    • Warrington, J.S.1    Greenblatt, D.J.2    Von Moltke, L.L.3
  • 51
    • 4644280019 scopus 로고    scopus 로고
    • In vitro metabolism of cyclosporine A by human kidney CYP3A5
    • Dai Y, Iwanaga K, Lin YS, et al. In vitro metabolism of cyclosporine A by human kidney CYP3A5. Biochem Pharmacol. 2004;68:1889-1902.
    • (2004) Biochem Pharmacol. , vol.68 , pp. 1889-1902
    • Dai, Y.1    Iwanaga, K.2    Lin, Y.S.3
  • 52
    • 80855131391 scopus 로고    scopus 로고
    • Dosing equation for tacro-limus using genetic variants and clinical factors
    • Passey C, Birnbaum AK, Brundage RC, et al. Dosing equation for tacro-limus using genetic variants and clinical factors. Br J Clin Pharmacol. 2011;72:948-957.
    • (2011) Br J Clin Pharmacol. , vol.72 , pp. 948-957
    • Passey, C.1    Birnbaum, A.K.2    Brundage, R.C.3
  • 53
    • 70349243452 scopus 로고    scopus 로고
    • No impact of age on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone 1 month after renal transplantation
    • Miura M, Satoh S, Kagaya H, et al. No impact of age on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone 1 month after renal transplantation. Eur J Clin Pharmacol. 2009;65: 1047-1053.
    • (2009) Eur J Clin Pharmacol. , vol.65 , pp. 1047-1053
    • Miura, M.1    Satoh, S.2    Kagaya, H.3
  • 54
    • 22344450724 scopus 로고    scopus 로고
    • CYP3A5 genetic polymorphisms in different ethnic populations
    • Roy J, Lajoie J, Zijenah LS, et al. CYP3A5 genetic polymorphisms in different ethnic populations. Drug Metab Dispos. 2005;33:884-887.
    • (2005) Drug Metab Dispos. , vol.33 , pp. 884-887
    • Roy, J.1    Lajoie, J.2    Zijenah, L.S.3
  • 55
    • 80054897494 scopus 로고    scopus 로고
    • P-glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expression during aging
    • Vilas-Boas V, Silva R, Gaio AR, et al. P-glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expression during aging. Cytometry A. 2011;79:912-919.
    • (2011) Cytometry A. , vol.79 , pp. 912-919
    • Vilas-Boas, V.1    Silva, R.2    Gaio, A.R.3
  • 56
    • 2442543344 scopus 로고    scopus 로고
    • P-glycoprotein function in the elderly
    • Brenner SS, Klotz U. P-glycoprotein function in the elderly. Eur J Clin Pharmacol. 2004;60:97-102.
    • (2004) Eur J Clin Pharmacol. , vol.60 , pp. 97-102
    • Brenner, S.S.1    Klotz, U.2
  • 57
    • 58149354277 scopus 로고    scopus 로고
    • Reduced elimination of cyclosporine A in elderly (65 years) kidney transplant recipients
    • Falck P, Asberg A, Byberg K, et al. Reduced elimination of cyclosporine A in elderly (65 years) kidney transplant recipients. Transplantation. 2008; 86:1379-1383.
    • (2008) Transplantation. , vol.86 , pp. 1379-1383
    • Falck, P.1    Asberg, A.2    Byberg, K.3
  • 58
    • 1542329748 scopus 로고    scopus 로고
    • Factors affecting variability in distribution of tacrolimus in liver transplant recipients
    • Zahir H, McCaughan G, Gleeson M, et al. Factors affecting variability in distribution of tacrolimus in liver transplant recipients. Br J Clin Pharmacol. 2004;57:298-309.
    • (2004) Br J Clin Pharmacol. , vol.57 , pp. 298-309
    • Zahir, H.1    McCaughan, G.2    Gleeson, M.3
  • 59
    • 84891867528 scopus 로고    scopus 로고
    • Importance of hematocrit for a ta-crolimus target concentration strategy
    • Størset E, Holford N, Midtvedt K, et al. Importance of hematocrit for a ta-crolimus target concentration strategy. Eur J Clin Pharmacol. 2014;70: 65-77.
    • (2014) Eur J Clin Pharmacol. , vol.70 , pp. 65-77
    • Størset, E.1    Holford, N.2    Midtvedt, K.3
  • 60
    • 84928194880 scopus 로고    scopus 로고
    • Use of generic tacrolimus in elderly renal transplant recipients: Precaution is needed
    • Robertsen I, Åsberg A, Ingerø AO, et al. Use of generic tacrolimus in elderly renal transplant recipients: precaution is needed. Transplantation. 2015;99:528-532.
    • (2015) Transplantation. , vol.99 , pp. 528-532
    • Robertsen, I.1    Åsberg, A.2    Ingerø, A.O.3
  • 61
    • 33748929299 scopus 로고    scopus 로고
    • Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function
    • Heit JJ, Apelqvist AA, Gu X, et al. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature. 2006;443:345-349.
    • (2006) Nature. , vol.443 , pp. 345-349
    • Heit, J.J.1    Apelqvist, A.A.2    Gu, X.3
  • 62
    • 33845935691 scopus 로고    scopus 로고
    • Risk factors for development of new-onset diabetes mellitus after kidney transplantation
    • Shah T, Kasravi A, Huang E, et al. Risk factors for development of new-onset diabetes mellitus after kidney transplantation. Transplantation. 2006;82:1673-1676.
    • (2006) Transplantation. , vol.82 , pp. 1673-1676
    • Shah, T.1    Kasravi, A.2    Huang, E.3
  • 63
    • 1942502245 scopus 로고    scopus 로고
    • New onset diabetes mellitus in patients receiving calcineurin inhibitors: A systematic review and meta-analysis
    • Heisel O, Heisel R, Balshaw R, et al. New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and meta-analysis. Am J Transplant. 2004;4:583-595.
    • (2004) Am J Transplant. , vol.4 , pp. 583-595
    • Heisel, O.1    Heisel, R.2    Balshaw, R.3
  • 64
    • 84897023826 scopus 로고    scopus 로고
    • Long-term follow-up of a phase III clinical trial comparing tacrolimus extended-release/MMF tacrolimus/MMF and cyclosporine/MMF in de novo kidney transplant recipients
    • Silva HT, Yang HC, Meier-Kriesche H, et al. Long-term follow-up of a phase III clinical trial comparing tacrolimus extended-release/MMF, tacrolimus/MMF, and cyclosporine/MMF in de novo kidney transplant recipients. Transplantation. 2014;97:636-641.
    • (2014) Transplantation. , vol.97 , pp. 636-641
    • Silva, H.T.1    Yang, H.C.2    Meier-Kriesche, H.3
  • 66
    • 0034079487 scopus 로고    scopus 로고
    • Influence of aging and caloric restriction on activation of Ras/MAPK, calcineurin, and CaMK-IV activities in rat Tcells
    • Pahlavani MA, Vargas DM. Influence of aging and caloric restriction on activation of Ras/MAPK, calcineurin, and CaMK-IV activities in rat Tcells. Proc Soc Exp Biol Med. 2000;223:163-169.
    • (2000) Proc Soc Exp Biol Med. , vol.223 , pp. 163-169
    • Ma, P.1    Vargas, D.M.2
  • 67
    • 0029935914 scopus 로고    scopus 로고
    • Age-related decreases in IL-2 production by human Tcells are associated with impaired activation of nuclear tran-scriptional factors AP-1 and NF-AT
    • Whisler RL, Beiqing L, Chen M. Age-related decreases in IL-2 production by human Tcells are associated with impaired activation of nuclear tran-scriptional factors AP-1 and NF-AT. Cell Immunol. 1996;169:185-195.
    • (1996) Cell Immunol. , vol.169 , pp. 185-195
    • Whisler, R.L.1    Beiqing, L.2    Chen, M.3
  • 68
    • 0025887582 scopus 로고
    • Factors influencing the pharmacokinetics of cyclosporine in man
    • Lindholm A. Factors influencing the pharmacokinetics of cyclosporine in man. Ther Drug Monit. 1991;13:465-477.
    • (1991) Ther Drug Monit. , vol.13 , pp. 465-477
    • Lindholm, A.1
  • 69
    • 27644436740 scopus 로고    scopus 로고
    • Maintenance immunosup-pression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
    • Kauffman HM, Cherikh WS, Cheng Y, et al. Maintenance immunosup-pression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation. 2005;80:883-889.
    • (2005) Transplantation. , vol.80 , pp. 883-889
    • Kauffman, H.M.1    Cherikh, W.S.2    Cheng, Y.3
  • 70
    • 84863226512 scopus 로고    scopus 로고
    • A randomized, controlled study to assess the conversion from calcineurin-inhibitors to everolimus after liver transplantation-PROTECT
    • Fischer L, Klempnauer J, Beckebaum S, et al. A randomized, controlled study to assess the conversion from calcineurin-inhibitors to everolimus after liver transplantation-PROTECT. Am J Transplant. 2012;12: 1855-1865.
    • (2012) Am J Transplant. , vol.12 , pp. 1855-1865
    • Fischer, L.1    Klempnauer, J.2    Beckebaum, S.3
  • 71
    • 0031452340 scopus 로고    scopus 로고
    • A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy
    • Tateishi T, Nakura H, Asoh M, et al. A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy. Life Sci. 1997;61:2567-2574.
    • (1997) Life Sci. , vol.61 , pp. 2567-2574
    • Tateishi, T.1    Nakura, H.2    Asoh, M.3
  • 72
    • 27844596265 scopus 로고    scopus 로고
    • Pharmacokinetics of sirolimus (rapamycin) in subjects with mild to moderate hepatic impairment
    • Zimmerman JJ, Lasseter KC, Lim H, et al. Pharmacokinetics of sirolimus (rapamycin) in subjects with mild to moderate hepatic impairment. J Clin Pharmacol. 2005;45:1368-1372.
    • (2005) J Clin Pharmacol. , vol.45 , pp. 1368-1372
    • Zimmerman, J.J.1    Lasseter, K.C.2    Lim, H.3
  • 73
    • 0035215119 scopus 로고    scopus 로고
    • Influence of hepatic impairment on everolimus pharmacokinetics: Implications for dose adjustment
    • Kovarik JM, Sabia HD, Figueiredo J, et al. Influence of hepatic impairment on everolimus pharmacokinetics: implications for dose adjustment. Clin Pharmacol Ther. 2001;70:425-430.
    • (2001) Clin Pharmacol Ther. , vol.70 , pp. 425-430
    • Kovarik, J.M.1    Sabia, H.D.2    Figueiredo, J.3
  • 74
    • 48149112155 scopus 로고    scopus 로고
    • Sirolimus is associated with new-onset diabetes in kidney transplant recipients
    • Johnston O, Rose CL, Webster AC, et al. Sirolimus is associated with new-onset diabetes in kidney transplant recipients. J Am Soc Nephrol. 2008;19:1411-1418.
    • (2008) J Am Soc Nephrol. , vol.19 , pp. 1411-1418
    • Johnston, O.1    Rose, C.L.2    Webster, A.C.3
  • 75
    • 79961032806 scopus 로고    scopus 로고
    • The ORION study: Comparison of two sirolimus-based regimens versus tacrolimus and mycophenolate mofetil in renal allograft recipients
    • Flechner SM, Glyda M, Cockfield S, et al. The ORION study: comparison of two sirolimus-based regimens versus tacrolimus and mycophenolate mofetil in renal allograft recipients. Am J Transplant. 2011;11: 1633-1644.
    • (2011) Am J Transplant. , vol.11 , pp. 1633-1644
    • Flechner, S.M.1    Glyda, M.2    Cockfield, S.3
  • 76
    • 2642572647 scopus 로고    scopus 로고
    • Aging biology and geriatric clinical pharmacology
    • McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004;56:163-184.
    • (2004) Pharmacol Rev. , vol.56 , pp. 163-184
    • McLean, A.J.1    Le Couteur, D.G.2
  • 77
    • 0028124656 scopus 로고
    • Effect of age and disease on two drug binding proteins: Albumin and alpha-1-acid glycoprotein
    • Woo J, Chan HS, Or KH, et al. Effect of age and disease on two drug binding proteins: albumin and alpha-1-acid glycoprotein. Clin Biochem. 1994;27:289-292.
    • (1994) Clin Biochem. , vol.27 , pp. 289-292
    • Woo, J.1    Chan, H.S.2    Or, K.H.3
  • 78
    • 1842477100 scopus 로고    scopus 로고
    • Monitoring mycophenolate in liver transplant recipients: Toward a therapeutic range
    • Tredger JM, Brown NW, Adams J, et al. Monitoring mycophenolate in liver transplant recipients: toward a therapeutic range. Liver Transpl. 2004;10:492-502.
    • (2004) Liver Transpl. , vol.10 , pp. 492-502
    • Tredger, J.M.1    Brown, N.W.2    Adams, J.3
  • 79
    • 33645450634 scopus 로고    scopus 로고
    • Explaining variability in mycophenolic acid exposure to optimize mycophenolate mofetil dosing: A population pharmacokinetic meta-analysis of mycophenolic acid in renal transplant recipients
    • van Hest RM, Mathot RA, Pescovitz MD, et al. Explaining variability in mycophenolic acid exposure to optimize mycophenolate mofetil dosing: a population pharmacokinetic meta-analysis of mycophenolic acid in renal transplant recipients. J Am Soc Nephrol. 2006;17: 871-880.
    • (2006) J Am Soc Nephrol. , vol.17 , pp. 871-880
    • Van Hest, R.M.1    Mathot, R.A.2    Pescovitz, M.D.3
  • 80
    • 84864397182 scopus 로고    scopus 로고
    • Omeprazole impairs the absorption of mycophenolate mofetil but not of enteric-coated mycopheno-late sodium in healthy volunteers
    • Kees MG, Steinke T, Moritz S, et al. Omeprazole impairs the absorption of mycophenolate mofetil but not of enteric-coated mycopheno-late sodium in healthy volunteers. J Clin Pharmacol. 2012;52: 1265-1272.
    • (2012) J Clin Pharmacol. , vol.52 , pp. 1265-1272
    • Kees, M.G.1    Steinke, T.2    Moritz, S.3
  • 81
    • 33846230492 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients
    • Staatz CE, Tett SE. Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients. Clin Pharmacokinet. 2007;46:13-58.
    • (2007) Clin Pharmacokinet. , vol.46 , pp. 13-58
    • Staatz, C.E.1    Tett, S.E.2
  • 82
    • 11844269814 scopus 로고    scopus 로고
    • Pharmacokinetics and phar-macodynamics of systemically administered glucocorticoids
    • Czock D, Keller F, Rasche FM, et al. Pharmacokinetics and phar-macodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44:61-98.
    • (2005) Clin Pharmacokinet. , vol.44 , pp. 61-98
    • Czock, D.1    Keller, F.2    Rasche, F.M.3
  • 83
    • 84863827190 scopus 로고    scopus 로고
    • The pharmacokinetics of prednisolone and prednisone in adult liver transplant recipients early after transplantation
    • Sæves I, Line P, Bergan S. The pharmacokinetics of prednisolone and prednisone in adult liver transplant recipients early after transplantation. Ther Drug Monit. 2012;34:452-459.
    • (2012) Ther Drug Monit. , vol.34 , pp. 452-459
    • Sæves, I.1    Line, P.2    Bergan, S.3
  • 84
    • 0021811807 scopus 로고
    • Differences in metabolic properties among cortisol, prednisolone, and dexamethasone in liver and renal diseases: Accelerated metabolism of dexamethasone in renal failure
    • Kawai S, Ichikawa Y, Homma M. Differences in metabolic properties among cortisol, prednisolone, and dexamethasone in liver and renal diseases: accelerated metabolism of dexamethasone in renal failure. J Clin Endocrinol Metab. 1985;60:848-854.
    • (1985) J Clin Endocrinol Metab. , vol.60 , pp. 848-854
    • Kawai, S.1    Ichikawa, Y.2    Homma, M.3
  • 85
    • 0036796047 scopus 로고    scopus 로고
    • Pharmacokinetic and pharma-codynamic interactions between diltiazem and methylprednisolone in healthy volunteers
    • Booker BM, Magee MH, Blum RA, et al. Pharmacokinetic and pharma-codynamic interactions between diltiazem and methylprednisolone in healthy volunteers. Clin Pharmacol Ther. 2002;72:370-382.
    • (2002) Clin Pharmacol Ther. , vol.72 , pp. 370-382
    • Booker, B.M.1    Magee, M.H.2    Blum, R.A.3
  • 86
    • 0034856667 scopus 로고    scopus 로고
    • Effect of itraconazole onthe pharmacokinetics of prednisolone and methylprednisolone and cortisol secretion in healthy subjects
    • Lebrun-Vignes B, Archer VC, Diquet B, et al. Effect of itraconazole onthe pharmacokinetics of prednisolone and methylprednisolone and cortisol secretion in healthy subjects. Br J Clin Pharmacol. 2001;51:443-450.
    • (2001) Br J Clin Pharmacol. , vol.51 , pp. 443-450
    • Lebrun-Vignes, B.1    Archer, V.C.2    Diquet, B.3
  • 87
    • 0036851317 scopus 로고    scopus 로고
    • Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy
    • Shimada T, Terada A, Yokogawa K, et al. Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy. Transplantation. 2002;74:1419-1424.
    • (2002) Transplantation. , vol.74 , pp. 1419-1424
    • Shimada, T.1    Terada, A.2    Yokogawa, K.3
  • 88
    • 84873464631 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation
    • Bergmann TK, Barraclough KA, Lee KJ, et al. Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation. Clin Pharmacokinet. 2012;51:711-741.
    • (2012) Clin Pharmacokinet. , vol.51 , pp. 711-741
    • Bergmann, T.K.1    Barraclough, K.A.2    Lee, K.J.3
  • 89
    • 0023911363 scopus 로고
    • Kinetics of prednisolone and endogenous cortisol suppression in the elderly
    • Stuck AE, Frey BM, Frey FJ. Kinetics of prednisolone and endogenous cortisol suppression in the elderly. Clin Pharmacol Ther. 1988;43: 354-362.
    • (1988) Clin Pharmacol Ther. , vol.43 , pp. 354-362
    • Stuck, A.E.1    Frey, B.M.2    Frey, F.J.3
  • 90
    • 0030980564 scopus 로고    scopus 로고
    • Cortisol pharmacodynamics after methylprednisolone administration in young and elderly males
    • Tornatore KM, Logue G, Venuto RC, et al. Cortisol pharmacodynamics after methylprednisolone administration in young and elderly males. J Clin Pharmacol. 1997;37:304-311.
    • (1997) J Clin Pharmacol. , vol.37 , pp. 304-311
    • Tornatore, K.M.1    Logue, G.2    Venuto, R.C.3
  • 91
    • 33751536048 scopus 로고    scopus 로고
    • Immunosuppressive drug-induced diabetes
    • Penfornis A, Kury-Paulin S. Immunosuppressive drug-induced diabetes. Diabetes Metab. 2006;32(5 Pt 2):539-546.
    • (2006) Diabetes Metab. , vol.32 , Issue.5 , pp. 539-546
    • Penfornis, A.1    Kury-Paulin, S.2
  • 92
    • 9644262466 scopus 로고    scopus 로고
    • Insulin resistance after renal transplantation: The effect of steroid dose reduction and withdrawal
    • Midtvedt K, Hjelmesaeth J, Hartmann A, et al. Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal. J Am Soc Nephrol. 2004;15:3233-3239.
    • (2004) J Am Soc Nephrol. , vol.15 , pp. 3233-3239
    • Midtvedt, K.1    Hjelmesaeth, J.2    Hartmann, A.3
  • 93
    • 84864127871 scopus 로고    scopus 로고
    • Time-varying belatacept exposure and its relationship to efficacy/safety responses in kidney-transplant recipients
    • Zhou Z, Shen J, Hong Y, et al. Time-varying belatacept exposure and its relationship to efficacy/safety responses in kidney-transplant recipients. Clin Pharmacol Ther. 2012;92:251-257.
    • (2012) Clin Pharmacol Ther. , vol.92 , pp. 251-257
    • Zhou, Z.1    Shen, J.2    Hong, Y.3
  • 94
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: A role of phosphoinositide 3-kinase-signaling pathway
    • Agrawal A, Agrawal S, Cao J, et al. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol. 2007;178:6912-6922.
    • (2007) J Immunol. , vol.178 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.3
  • 97
    • 4243159775 scopus 로고    scopus 로고
    • In vitro internalization, intracellu-lar transport, and clearance of an anti-CD11a antibody (Raptiva) by human T-cells
    • Coffey GP, Stefanich E, Palmieri S, et al. In vitro internalization, intracellu-lar transport, and clearance of an anti-CD11a antibody (Raptiva) by human T-cells. J Pharmacol Exp Ther. 2004;310:896-904.
    • (2004) J Pharmacol Exp Ther. , vol.310 , pp. 896-904
    • Coffey, G.P.1    Stefanich, E.2    Palmieri, S.3
  • 98
    • 33747876762 scopus 로고    scopus 로고
    • Effect of target dynamics on pharmacokinetics of a novel therapeutic antibody against the epidermal growth factor receptor: Implications for the mechanisms of action
    • van Bueren Lammerts, Jeroen J, Bleeker WK, et al. Effect of target dynamics on pharmacokinetics of a novel therapeutic antibody against the epidermal growth factor receptor: implications for the mechanisms of action. Cancer Res. 2006;66:7630-7638.
    • (2006) Cancer Res. , vol.66 , pp. 7630-7638
    • Van Bueren Lammerts1    Jeroen, J.2    Bleeker, W.K.3
  • 100
    • 0033571215 scopus 로고    scopus 로고
    • Population pharmacoki-netics and exposure-response relationships for basiliximab in kidney transplantation. The U.S. Simulect Renal Transplant Study Group
    • Kovarik JM, Kahan BD, Rajagopalan PR, et al. Population pharmacoki-netics and exposure-response relationships for basiliximab in kidney transplantation. The U.S. Simulect Renal Transplant Study Group. Transplantation. 1999;68:1288-1294.
    • (1999) Transplantation. , vol.68 , pp. 1288-1294
    • Kovarik, J.M.1    Kahan, B.D.2    Rajagopalan, P.R.3
  • 101
    • 79960592783 scopus 로고    scopus 로고
    • Biomarkers of over-immunosuppression
    • Budde K, Matz M, Dürr M, et al. Biomarkers of over-immunosuppression. Clin Pharmacol Ther. 2011;90:316-322.
    • (2011) Clin Pharmacol Ther. , vol.90 , pp. 316-322
    • Budde, K.1    Matz, M.2    Dürr, M.3
  • 102
    • 84893417691 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of nuclear factor of activated T cell-regulated gene expression in liver allograft recipients on immunosuppressive therapy with calcineurin inhibitors in the course of time and correlation with acute rejection episodes-A prospective study
    • Steinebrunner N, Sandig C, Sommerer C, et al. Pharmacodynamic monitoring of nuclear factor of activated T cell-regulated gene expression in liver allograft recipients on immunosuppressive therapy with calcineurin inhibitors in the course of time and correlation with acute rejection episodes-a prospective study. Ann Transplant. 2014;19:32-40.
    • (2014) Ann Transplant. , vol.19 , pp. 32-40
    • Steinebrunner, N.1    Sandig, C.2    Sommerer, C.3
  • 103
    • 34447622296 scopus 로고    scopus 로고
    • Monitoring biological action of rapamycin in renal transplantation
    • Leogrande D, Teutonico A, Ranieri E, et al. Monitoring biological action of rapamycin in renal transplantation. Am J Kidney Dis. 2007;50: 314-325.
    • (2007) Am J Kidney Dis. , vol.50 , pp. 314-325
    • Leogrande, D.1    Teutonico, A.2    Ranieri, E.3
  • 104
    • 85027954875 scopus 로고    scopus 로고
    • Simultaneous quantification of IMPDH activity and purine bases in lymphocytes using LC-MS/MS: Assessment of biomarker responses to mycophenolic acid
    • Vethe NT, Ali AM, Reine PA, et al. Simultaneous quantification of IMPDH activity and purine bases in lymphocytes using LC-MS/MS: assessment of biomarker responses to mycophenolic acid. Ther Drug Monit. 2014;36:108-118.
    • (2014) Ther Drug Monit. , vol.36 , pp. 108-118
    • Vethe, N.T.1    Ali, A.M.2    Reine, P.A.3
  • 105
    • 77952574304 scopus 로고    scopus 로고
    • Prolonged CD4 T cell lym-phopenia increases morbidity and mortality after renal transplantation
    • Ducloux D, Courivaud C, Bamoulid J, et al. Prolonged CD4 T cell lym-phopenia increases morbidity and mortality after renal transplantation. J Am Soc Nephrol. 2010;21:868-875.
    • (2010) J Am Soc Nephrol. , vol.21 , pp. 868-875
    • Ducloux, D.1    Courivaud, C.2    Bamoulid, J.3
  • 106
    • 79959674114 scopus 로고    scopus 로고
    • Thymic function, anti-thymocytes globulins, and cancer after renal transplantation
    • Ducloux D, Bamoulid J, Courivaud C, et al. Thymic function, anti-thymocytes globulins, and cancer after renal transplantation. Transpl Immunol. 2011;25:56-60.
    • (2011) Transpl Immunol. , vol.25 , pp. 56-60
    • Ducloux, D.1    Bamoulid, J.2    Courivaud, C.3
  • 107
    • 84884907939 scopus 로고    scopus 로고
    • Multicenter validationofurinary CXCL9 as a risk-stratifying biomarker for kidney transplant injury
    • Hricik DE, Nickerson P, Formica RN, et al. Multicenter validationofurinary CXCL9 as a risk-stratifying biomarker for kidney transplant injury. Am J Transplant. 2013;13:2634-2644.
    • (2013) Am J Transplant. , vol.13 , pp. 2634-2644
    • De, H.1    Nickerson, P.2    Formica, R.N.3
  • 108
    • 80053328081 scopus 로고    scopus 로고
    • Urinary chemokines CXCL9 and CXCL10 are noninvasive markers of renal allograft rejection and BK viral infection
    • Jackson JA, Kim EJ, Begley B, et al. Urinary chemokines CXCL9 and CXCL10 are noninvasive markers of renal allograft rejection and BK viral infection. Am J Transplant. 2011;11:2228-2234.
    • (2011) Am J Transplant. , vol.11 , pp. 2228-2234
    • Jackson, J.A.1    Kim, E.J.2    Begley, B.3
  • 109
    • 84869509306 scopus 로고    scopus 로고
    • Pretransplantation soluble CD30 level as a predictor of acute rejection in kidney transplantation: A meta-analysis
    • Chen Y, Tai Q, Hong S, et al. Pretransplantation soluble CD30 level as a predictor of acute rejection in kidney transplantation: a meta-analysis. Transplantation. 2012;94:911-918.
    • (2012) Transplantation. , vol.94 , pp. 911-918
    • Chen, Y.1    Tai, Q.2    Hong, S.3
  • 110
    • 33748690103 scopus 로고    scopus 로고
    • Assessing relative risks of infection and rejection: A meta-analysis using an immune function assay
    • Kowalski RJ, Post DR, Mannon RB, et al. Assessing relative risks of infection and rejection: a meta-analysis using an immune function assay. Transplantation. 2006;82:663-668.
    • (2006) Transplantation. , vol.82 , pp. 663-668
    • Kowalski, R.J.1    Post, D.R.2    Mannon, R.B.3
  • 111
    • 84856100808 scopus 로고    scopus 로고
    • Intracellular ATP production in CD4+ Tcells as a predictor for infection and allograft rejection in trough-level guided pediatric liver transplant recipients under calcineurin-inhibitor therapy
    • Schulz-Juergensen S, Burdelski MM, Oellerich M, et al. Intracellular ATP production in CD4+ Tcells as a predictor for infection and allograft rejection in trough-level guided pediatric liver transplant recipients under calcineurin-inhibitor therapy. Ther Drug Monit. 2012;34:4-10.
    • (2012) Ther Drug Monit. , vol.34 , pp. 4-10
    • Schulz-Juergensen, S.1    Burdelski, M.M.2    Oellerich, M.3
  • 112
    • 74949094555 scopus 로고    scopus 로고
    • KDIGO clinical practice guideline for the care of kidney transplant recipients
    • Kasiske BL, Zeier MG, Craig JC, et al. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant. 2009; (9 Suppl 3):S1-S155.
    • (2009) Am J Transplant. , Issue.9 , pp. S1-S155
    • Kasiske, B.L.1    Zeier, M.G.2    Craig, J.C.3
  • 113
    • 79957843431 scopus 로고    scopus 로고
    • Induction immunosuppressive therapy in the elderly kidney transplant recipient in the United States
    • Gill J, Sampaio M, Gill JS, et al. Induction immunosuppressive therapy in the elderly kidney transplant recipient in the United States. Clin J Am Soc Nephrol. 2011;6:1168-1178.
    • (2011) Clin J Am Soc Nephrol. , vol.6 , pp. 1168-1178
    • Gill, J.1    Sampaio, M.2    Gill, J.S.3
  • 114
    • 84880070494 scopus 로고    scopus 로고
    • Evaluating safety and efficacy of rabbit antithymocyte globulin induction in elderly kidney transplant recipients
    • Khanmoradi K, Knorr JP, Feyssa EL, et al. Evaluating safety and efficacy of rabbit antithymocyte globulin induction in elderly kidney transplant recipients. Exp Clin Transplant. 2013;11:222-228.
    • (2013) Exp Clin Transplant. , vol.11 , pp. 222-228
    • Khanmoradi, K.1    Knorr, J.P.2    Feyssa, E.L.3
  • 115
    • 79958747834 scopus 로고    scopus 로고
    • Rabbit antithymocyte induction and dosing in deceased donor renal transplant recipients over 60 yr of age
    • Patel SJ, Knight RJ, Suki WN, et al. Rabbit antithymocyte induction and dosing in deceased donor renal transplant recipients over 60 yr of age. Clin Transplant. 2011;25:E250-E256.
    • (2011) Clin Transplant. , vol.25 , pp. E250-E256
    • Patel, S.J.1    Knight, R.J.2    Suki, W.N.3
  • 116
    • 33750713302 scopus 로고    scopus 로고
    • Rabbit antithymocyte globulin versus basiliximab in renal transplantation
    • Brennan DC, Daller JA, Lake KD, et al. Rabbit antithymocyte globulin versus basiliximab in renal transplantation. N Engl J Med. 2006;355:1967-1977.
    • (2006) N Engl J Med. , vol.355 , pp. 1967-1977
    • Brennan, D.C.1    Daller, J.A.2    Lake, K.D.3
  • 117
    • 77950882839 scopus 로고    scopus 로고
    • Interleukin 2 receptor antagonists for kidney transplant recipients
    • Webster AC, Ruster LP, McGee R, et al. Interleukin 2 receptor antagonists for kidney transplant recipients. Cochrane Database Syst Rev. 2010;1:CD003897.
    • (2010) Cochrane Database Syst Rev. , vol.1 , pp. CD003897
    • Webster, A.C.1    Ruster, L.P.2    McGee, R.3
  • 118
    • 84920877216 scopus 로고    scopus 로고
    • Alemtuzumab-based induction treatment versus basiliximab-based induction treatment in kidney transplantation (the 3C Study): A randomised trial
    • Haynes R, Harden P, Judge P, et al. Alemtuzumab-based induction treatment versus basiliximab-based induction treatment in kidney transplantation (the 3C Study): a randomised trial. Lancet. 2014;384:1684-1690.
    • (2014) Lancet. , vol.384 , pp. 1684-1690
    • Haynes, R.1    Harden, P.2    Judge, P.3
  • 119
    • 1642576127 scopus 로고    scopus 로고
    • Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer
    • Boffa DJ, Luan F, Thomas D, et al. Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer. Clin Cancer Res. 2004;10(1 Pt 1):293-300.
    • (2004) Clin Cancer Res. , vol.10 , Issue.1 , pp. 293-300
    • Boffa, D.J.1    Luan, F.2    Thomas, D.3
  • 120
    • 0037336853 scopus 로고    scopus 로고
    • Rapamycin is an effective inhibitor of human renal cancer metastasis
    • Luan FL, Ding R, Sharma VK, et al. Rapamycin is an effective inhibitor of human renal cancer metastasis. Kidney Int. 2003;63:917-926.
    • (2003) Kidney Int. , vol.63 , pp. 917-926
    • Luan, F.L.1    Ding, R.2    Sharma, V.K.3
  • 121
    • 79952931627 scopus 로고    scopus 로고
    • Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells
    • Gabryová L, Christensen JR, Wu X, et al. Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells. Eur J Immunol. 2011;41:1242-1248.
    • (2011) Eur J Immunol. , vol.41 , pp. 1242-1248
    • Gabryová, L.1    Christensen, J.R.2    Wu, X.3
  • 122
    • 84899561523 scopus 로고    scopus 로고
    • Foxp3+ Tcells inhibit antitumor immune memory modulated by mTOR inhibition
    • Wang Y, Sparwasser T, Figlin R, et al. Foxp3+ Tcells inhibit antitumor immune memory modulated by mTOR inhibition. Cancer Res. 2014;74: 2217-2228.
    • (2014) Cancer Res. , vol.74 , pp. 2217-2228
    • Wang, Y.1    Sparwasser, T.2    Figlin, R.3
  • 123
    • 84886804102 scopus 로고    scopus 로고
    • Long-term exposure to belatacept in recipients of extended criteria donor kidneys
    • Charpentier B, Medina Pestana JO, Del C, Rial M, et al. Long-term exposure to belatacept in recipients of extended criteria donor kidneys. Am J Transplant. 2013;13:2884-2891.
    • (2013) Am J Transplant. , vol.13 , pp. 2884-2891
    • Charpentier, B.1    Medina Pestana, J.O.2    Del Rial C, M.3
  • 124
    • 72949123426 scopus 로고    scopus 로고
    • A randomized trial comparing renal function in older kidney transplant patients following delayed versus immediate tacrolimus administration
    • Andrés A, Budde K, Clavien P, et al. A randomized trial comparing renal function in older kidney transplant patients following delayed versus immediate tacrolimus administration. Transplantation. 2009;88: 1101-1108.
    • (2009) Transplantation. , vol.88 , pp. 1101-1108
    • Andrés, A.1    Budde, K.2    Clavien, P.3
  • 125
    • 55449124588 scopus 로고    scopus 로고
    • A prospective, randomized, double-blind, placebo-controlled multicenter trial comparing early (7 day) corti-costeroid cessation versus long-term, low-dose corticosteroid therapy
    • Woodle ES, First MR, Pirsch J, et al. A prospective, randomized, double-blind, placebo-controlled multicenter trial comparing early (7 day) corti-costeroid cessation versus long-term, low-dose corticosteroid therapy. Ann Surg. 2008;248:564-577.
    • (2008) Ann Surg. , vol.248 , pp. 564-577
    • Woodle, E.S.1    First, M.R.2    Pirsch, J.3
  • 126
    • 71149120978 scopus 로고    scopus 로고
    • The impact of reduced im-munosuppression on graft outcomes in elderly renal transplant recipients
    • Badowski M, Gurk-Turner C, Cangro C, et al. The impact of reduced im-munosuppression on graft outcomes in elderly renal transplant recipients. Clin Transplant. 2009;23:930-937.
    • (2009) Clin Transplant. , vol.23 , pp. 930-937
    • Badowski, M.1    Gurk-Turner, C.2    Cangro, C.3
  • 127
    • 32844463757 scopus 로고    scopus 로고
    • Frequency and clinical implications of development of donor-specific and non-donor-specific HLA antibodies after kidney transplantation
    • Hourmant M, Cesbron-Gautier A, Terasaki PI, et al. Frequency and clinical implications of development of donor-specific and non-donor-specific HLA antibodies after kidney transplantation. J Am Soc Nephrol. 2005;16:2804-2812.
    • (2005) J Am Soc Nephrol. , vol.16 , pp. 2804-2812
    • Hourmant, M.1    Cesbron-Gautier, A.2    Terasaki, P.I.3
  • 128
    • 59849089691 scopus 로고    scopus 로고
    • De novo anti-HLA antibody responses after renal transplantation: Detection and clinical impact
    • Seveso M, Bosio E, Ancona E, et al. De novo anti-HLA antibody responses after renal transplantation: detection and clinical impact. Contrib Nephrol. 2009;162:87-98.
    • (2009) Contrib Nephrol. , vol.162 , pp. 87-98
    • Seveso, M.1    Bosio, E.2    Ancona, E.3
  • 129
    • 84860473178 scopus 로고    scopus 로고
    • Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant
    • Wiebe C, Gibson IW, Blydt-Hansen TD, et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant. 2012;12:1157-1167.
    • (2012) Am J Transplant. , vol.12 , pp. 1157-1167
    • Wiebe, C.1    Gibson, I.W.2    Blydt-Hansen, T.D.3
  • 130
    • 84873377509 scopus 로고    scopus 로고
    • Incidence and impact of de novo donor-specific alloantibody in primary renal allografts
    • Everly MJ, Rebellato LM, Haisch CE, et al. Incidence and impact of de novo donor-specific alloantibody in primary renal allografts. Transplantation. 2013;95:410-417.
    • (2013) Transplantation. , vol.95 , pp. 410-417
    • Everly, M.J.1    Rebellato, L.M.2    Haisch, C.E.3
  • 131
    • 84868191953 scopus 로고    scopus 로고
    • The treatment of acute antibody-mediated rejection in kidney transplant recipients-A systematic review
    • Roberts DM, Jiang SH, Chadban SJ. The treatment of acute antibody-mediated rejection in kidney transplant recipients-a systematic review. Transplantation. 2012;94:775-783.
    • (2012) Transplantation. , vol.94 , pp. 775-783
    • Roberts, D.M.1    Jiang, S.H.2    Chadban, S.J.3
  • 132
    • 84872057765 scopus 로고    scopus 로고
    • Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation
    • Tait BD, Süsal C, Gebel HM, et al. Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation. Transplantation. 2013;95:19-47.
    • (2013) Transplantation. , vol.95 , pp. 19-47
    • Tait, B.D.1    Süsal, C.2    Gebel, H.M.3
  • 133
    • 84909634392 scopus 로고    scopus 로고
    • Clinical mycophenolic acid monitoring in liver transplant recipients
    • Chen H, Chen B. Clinical mycophenolic acid monitoring in liver transplant recipients. World J Gastroenterol. 2014;20:10715-10728.
    • (2014) World J Gastroenterol. , vol.20 , pp. 10715-10728
    • Chen, H.1    Chen, B.2
  • 134
    • 68049148369 scopus 로고    scopus 로고
    • Presensitized kidney graft recipients with HLA class i and II antibodies are at increased risk for graft failure: A Collaborative Transplant Study report
    • Süsal C, Döhler B, Opelz G. Presensitized kidney graft recipients with HLA class I and II antibodies are at increased risk for graft failure: a Collaborative Transplant Study report. Hum Immunol. 2009;70:569-573.
    • (2009) Hum Immunol. , vol.70 , pp. 569-573
    • Süsal, C.1    Döhler, B.2    Opelz, G.3
  • 135
    • 0036487952 scopus 로고    scopus 로고
    • Blood tacrolimus levels and calcineurin phosphatase activity early after renal transplantation
    • Koefoed-Nielsen PB, Gesualdo MB, Poulsen JH, et al. Blood tacrolimus levels and calcineurin phosphatase activity early after renal transplantation. Am J Transplant. 2002;2:173-178.
    • (2002) Am J Transplant. , vol.2 , pp. 173-178
    • Koefoed-Nielsen, P.B.1    Gesualdo, M.B.2    Poulsen, J.H.3
  • 136
    • 10744226204 scopus 로고    scopus 로고
    • Pharmacodynamic approach to immunosuppressive therapies using calcineurin inhibitors and mycophe-nolate mofetil
    • Millán O, Brunet M, Campistol JM, et al. Pharmacodynamic approach to immunosuppressive therapies using calcineurin inhibitors and mycophe-nolate mofetil. Clin Chem. 2003;49:1891-1899.
    • (2003) Clin Chem. , vol.49 , pp. 1891-1899
    • Millán, O.1    Brunet, M.2    Campistol, J.M.3
  • 137
    • 84920286912 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of mammalian target of rapamycin inhibition by phosphoflow cytometric determination of p70S6 kinase activity
    • Hoerning A, Wilde B, Wang J, et al. Pharmacodynamic monitoring of mammalian target of rapamycin inhibition by phosphoflow cytometric determination of p70S6 kinase activity. Transplantation. 2014.
    • (2014) Transplantation.
    • Hoerning, A.1    Wilde, B.2    Wang, J.3
  • 138
    • 0033047817 scopus 로고    scopus 로고
    • Induction of inosine monophosphate dehydrogenase activity after long-term treatment with mycophenolate mofetil
    • Sanquer S, Breil M, Baron C, et al. Induction of inosine monophosphate dehydrogenase activity after long-term treatment with mycophenolate mofetil. Clin Pharmacol Ther. 1999;65:640-648.
    • (1999) Clin Pharmacol Ther. , vol.65 , pp. 640-648
    • Sanquer, S.1    Breil, M.2    Baron, C.3
  • 139
    • 84866337685 scopus 로고    scopus 로고
    • Pharmacodynamic analysis of tofacitinib and basiliximab in kidney allograft recipients
    • Vafadari R, Quaedackers ME, Kho MM, et al. Pharmacodynamic analysis of tofacitinib and basiliximab in kidney allograft recipients. Transplantation. 2012;94:465-472.
    • (2012) Transplantation. , vol.94 , pp. 465-472
    • Vafadari, R.1    Quaedackers, M.E.2    Kho, M.M.3


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