Thymic function, anti-thymocytes globulins, and cancer after renal transplantation

Transplant Immunology

Volumn 25, Issue 1, 2011, Pages 56-60

  Ducloux, Didier ^a,b,c,d,e   Bamoulid, Jamal ^a,b,c,d   Courivaud, Cécile ^a,b,c,d   Gaugler, Béatrice ^a,b,c   Rebibou, Jean Michel ^a,b,f   Ferrand, Christophe ^a,b,c   Chalopin, Jean Marc ^a,b,c,d,e   Borg, Christophe ^a,b,c,d   Tiberghien, Pierre ^a,b,c,e   Saas, Philippe ^a,b,c  

^a INSERM   (France)

^b ETABLISSEMENT FRANÇAIS DU SANG   (France)

^c UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^d UNIVERSITY HOSPITAL OF BESANÇON   (France)

^e HÔPITAL SAINT JACQUES   (France)

^f DIJON UNIVERSITY HOSPITAL   (France)

Author keywords

Kidney transplantation; Polyclonal antithymocyte globulins; Thymus; TREC: TCR rearrangement excision circles

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; INTERLEUKIN 7 RECEPTOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; T LYMPHOCYTE RECEPTOR; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR FOXP3;

ACUTE GRAFT REJECTION; ACUTE PYELONEPHRITIS; ADULT; ARTICLE; BREAST CANCER; CANCER INCIDENCE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELLULITIS; COLON CANCER; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; GENE REARRANGEMENT; HUMAN; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY CANCER; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVER CANCER; LUNG CANCER; LYMPHOCYTE COUNT; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; PNEUMOCYSTOSIS; PNEUMONIA; PREDICTION; PRIORITY JOURNAL; PROSTATE CANCER; SKIN CANCER; T LYMPHOCYTE RECEPTOR GENE; T LYMPHOCYTE SUBPOPULATION; THYMUS FUNCTION;

ADULT; ANTILYMPHOCYTE SERUM; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; NEOPLASMS; RETROSPECTIVE STUDIES; THYMUS GLAND; TRANSPLANTATION, HOMOLOGOUS;

EID: 79959674114     PISSN: 09663274     EISSN: 18785492     Source Type: Journal    
DOI: 10.1016/j.trim.2011.05.003     Document Type: Article

References (19)

1. Bonnefoy-Berard N., Vincent C., Revillard J.P. Antibodies against functional leukocyte surface molecules in polyclonal antilymphocyte and antithymocyte globulins. Transplantation 1991, 51:669-673.
2. Rebellato L.M., Gross U., Verbanac K.M., Thomas J.M. A comprehensive definition of the major antibody specificities in polyclonal rabbit antithymocyte globulin. Transplantation 1994, 57:685-694.
3. Genestier L., Fournel S., Flacher M., Assossou O., Revillard J.P., Bonnefoy-Berard N. Induction of Fas (Apo-1, CD95)-mediated apoptosis of activated lymphocytes by polyclonal antithymocyte globulins. Blood 1998, 91:2360-2368.
4. Preville X., Flacher M., LeMauff B., Beauchard S., Davelu P., Tiollier J., et al. Mechanisms involved in antithymocyte globulin immunosuppressive activity in a nonhuman primate model. Transplantation 2001, 71:460-468.
5. Muller T.F., Grebe S.O., Neumann M.C., Heymanns J., Radsak K., Sprenger H., et al. Persistent long-term changes in lymphocyte subsets induced by polyclonal antibodies. Transplantation 1997, 64:1432-1437.
6. Ducloux D., Carron P.L., Motte G., Ab A., Rebibou J.M., Bresson-Vautrin C., et al. Lymphocyte subsets and assessment of cancer risk in renal transplant recipients. Transpl. Int. 2002, 15:393-396.
7. Ducloux D., Carron P.L., Rebibou J.M., Aubin F., Fournier V., Bresson-Vautrin C., et al. CD4 lymphocytopenia as a risk factor for skin cancers in renal transplant recipients. Transplantation 1998, 65:1270-1272.
8. Ducloux D., Courivaud C., Bamoulid J., Vivet B., Chabroux A., Deschamps M., et al. Prolonged CD4 T cell lymphopenia increases morbidity and mortality after renal transplantation. J. Am. Soc. Nephrol. 2010, 21:868-875.
9. Ducloux D., Challier B., Saas P., Tiberghien P., Chalopin J.M. CD4 cell lymphopenia and atherosclerosis in renal transplant recipients. J. Am. Soc. Nephrol. 2003, 14:767-772.
10. Racusen L.C., Colvin R.B., Solez K., Mihatsch M.J., Halloran P.F., Campbell P.M., et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am. J. Transplant. 2003, 3:708-714.
11. Steinmann G.G., Klaus B., Muller-Hermelink H.K. The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol 1985, 22:563-575.
12. Strobel P., Moritz R., Leite M.I., Willcox N., Chuang W.Y., Gold R., et al. The ageing and myasthenic thymus: a morphometric study validating a standard procedure in the histological workup of thymic specimens. J. Neuroimmunol. 2008, 201-202:64-73.
13. George A.J., Ritter M.A. Thymic involution with ageing: obsolescence or good housekeeping?. Immunol Today 1996, 17:267-272.
14. Zhang H.G., Grizzle W.E. Aging, immunity, and tumor susceptibility. Immunol Allergy Clin North Am 2003, 23:83-102.
15. Dunn G.P., Bruce A.T., Ikeda H., Old L.J., Schreiber R.D. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 2002, 3:991-998.
16. Koebel C.M., Vermi W., Swann J.B., Zerafa N., Rodig S.J., Old L.J., et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 2007, 450:903-907.
17. Perez-Diez A., Joncker N.T., Choi K., Chan W.F., Anderson C.C., Lantz O., et al. CD4 cells can be more efficient at tumor rejection than CD8 cells. Blood 2007, 109(12):5346-5354.
18. Martinez O.M., de Gruijl F.R. Molecular and immunological mechanisms of cancer pathogenesis in solid organ transplant recipients. Am. J. Transplant. 2008, 8:2205-2211.
19. Mohty M. Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond. Leukemia 2007, 21:1387-1394.