Frequency and clinical implications of development of donor-specific and non-donor-specific HLA antibodies after kidney transplantation

Journal of the American Society of Nephrology

Volumn 16, Issue 9, 2005, Pages 2804-2812

  Hourmant, Maryvonne ^a   Cesbron Gautier, Anne ^b   Terasaki, Paul I ^c   Mizutani, Kazuo ^c   Moreau, Anne ^a   Meurette, Aurélie ^a   Dantal, Jacques ^a   Giral, Magali ^a   Blancho, Gilles ^a   Cantarovich, Diego ^a   Karam, Georges ^a   Follea, Gilles ^b   Soulillou, Jean Paul ^a   Bignon, Jean Denis ^b  

^a HÔTEL DIEU   (France)

^b National Blood Bank   (France)

^c TERASAKI FOUNDATION LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIBODY; ALLOANTIBODY; HLA ANTIGEN;

ADULT; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNIZATION; KIDNEY DONOR; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; ANTIBODY SPECIFICITY; BLOOD; DONOR; FOLLOW UP; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOLOGY; MIDDLE AGED; TIME;

ADULT; ANTIBODY SPECIFICITY; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; GRAFT SURVIVAL; HLA ANTIGENS; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; TIME FACTORS; TISSUE DONORS;

EID: 32844463757     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2004121130     Document Type: Article

References (20)

1. Soulillou JP, Peyrat MA, Guenel J: Association between treatment-resistant kidney allograft rejection and post-transplant appearance of antibodies to donor B lymphocyte alloantigens. Lancet 1: 354-356, 1978
2. Mc Kenna RM, Takemoto S, Terasaki PI: Anti-HLA antibodies after solid organ transplantation. Transplantation 69: 319-326, 2000
3. Lee PC, Terasaki PI, Takemoto SK, Lee PH, Hung CJ, Chen YL, Tsai A, Lei HY: All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies. Transplantation 74: 1192-1194, 2002
4. Worthington JE, Martin S, Al-Husseini DM, Dyer PA, Johnson RWG: Post-transplantation production of donor HLA-specific antibodies is a predictor of renal transplant outcome. Transplantation 75: 1034-1040, 2003
5. Pelletier R, Hennessy PK, Adams PW, Van Buskirk AM, Ferguson RM, Orosz CG: Clinical significance of MHC-reactive alloantibodies that develop after kidney or kidney-pancreas transplantation. Am J Transplant 2: 134-141, 2002
6. Terasaki PI: The humoral theory of transplantation. Am J Transplant 3: 665-673, 2003
7. Feucht HE: Complement C4d in graft capillaries-The missing link in the recognition of humoral alloreactivity. Am J Transplant 3: 646-652, 2003
8. Nickelheit V, Zeiler M, Gudat F, Thiel G, Mihatsch MJ: Detection of the complement product C4d in the renal allografts: Diagnostic and therapeutic implications. J Am Soc Nephrol 13: 242-251, 2002
9. Regele H, Böhmig GA, Habicht A, Gollowitzer D, Schillinger M, Rockenschaub S, Watschinger B, Kerjaschki D, Exner M: Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: A contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol 13: 2371-2380, 2002
10. Christiaans MHL, Overhof-de-Roos R, Nieman F, van Hooff JP, van den Berg-Loonen EM: Donor-specific antibodies after transplantation by flow cytometry. Transplantation 65: 427-433, 1998
11. Terasaki PI, Ozawa M: Predicting kidney graft failure by HLA antibodies: A prospective trial. Am J Transplant 4: 438-443, 2004
12. Wang G, Tarsitani C, Denham S, Chen M, Lee JH: A new micro-ELISA for anti class I and class II antibody detection. Hum Immunol 59: 133-138, 1998
13. Pei R, Lee JH, Shih NJ, Chen M, Terasaki PI: Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation 75: 43-49, 2003
14. Terasaki PI, Mc Clelland JD: Microdroplet assay serum cytotoxins. Nature 204: 998-1003, 1964
15. Uboldi de Capei M, Pratico L, Curtoni ES: Comparison of different techniques for detection of anti-HLA antibodies in sera from patients awaiting kidney transplantation. Eur J Immunogenet 29: 379-382, 2002
16. Rentenaar RJ, van Diepen FNJ, Meijer RT, Surachno S, Wilmink JM, Schellekens PTA, Pals ST, van Lier RAW, Ten Berge IJM: Immune responsiveness in renal transplant recipients: Mycophenolic acid severely depresses humoral immunity in vivo. Kidney Int 62: 319-328, 2002
17. Zachary AA, Montgomery RA, Ratner LE, Samaniego-Picota M, Haas M, Kopchaliska D, Leffell MS: Specific and durable elimination of antibody to donor HLA-antigens in renal-transplant recipients. Transplantation 76: 1519-1525, 2003
18. Abraham KA, Brown C, Conlon PJ, Donohoe J, Hickey DP, O'Neill D, Keogan MT, Dorman AM, Walshe J: Plasmapheresis as rescue therapy in accelerated acute humoral rejection. J Clin Apheresis 18: 103-110, 2003
19. Rocha PN, Butterly DW, Greenberg A, Reddan DN, Tuttle-Newhall J, Collins BH, Kuo PC, Reinsmoen N, Fields T, Howell DN, Smith SR: Beneficial effects of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection. Transplantation 75: 1490-1495, 2003
20. Jordan SC, Quartel AW, Czer LSC, Jordan SC, Quartel AW, Czer LS, Admon D, Chen G, Fishbein MC, Schwieger J, Steiner RW, Davis C, Tyan DB: Posttransplantation therapy using high-dose human immunoglobulin (intravenous gammaglobulin) to control acute humoral rejection in renal and cardiac allograft recipients and potential mechanism of action. Transplantation 66: 800-806, 1998