Head circumference and brain size in autism spectrum disorder: A systematic review and meta-analysis

Psychiatry Research - Neuroimaging

Volumn 234, Issue 2, 2015, Pages 239-251

  Sacco, Roberto ^a   Gabriele, Stefano ^a   Persico, Antonio M ^a,b  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b Mafalda Luce Center for Pervasive Developmental Disorders   (Italy)

Author keywords

Autistic disorder; Brain volume; Head circumference; Macrocephaly; Meta analysis; Structural brain imaging

Indexed keywords

ARTICLE; ASPERGER SYNDROME; AUTISM; BRAIN SIZE; CHILDHOOD; EFFECT SIZE; ENDOPHENOTYPE; HEAD CIRCUMFERENCE; HUMAN; MACROCEPHALY; MEDICAL LITERATURE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PUBLICATION; SYSTEMATIC REVIEW; AUTISM SPECTRUM DISORDER; BRAIN; CEPHALOMETRY; FEMALE; HEAD; MALE; META ANALYSIS; PATHOLOGY; PRESCHOOL CHILD; PREVALENCE;

AUTISM SPECTRUM DISORDER; BRAIN; CEPHALOMETRY; CHILD, PRESCHOOL; ENDOPHENOTYPES; FEMALE; HEAD; HUMANS; MALE; PREVALENCE;

EID: 84945952689     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2015.08.016     Document Type: Article

References (106)

1. Akshoomoff N., Lord C., Lincoln A.J., Courchesne R.Y., Carper R.A., Townsend J., Courchesne E. Outcome classification of preschool children with autism spectrum disorders using MRI brain measures. J. Am. Acad. Child Adolesc. Psychiatry 2004, 43:349-357.
2. Amaral D.G., Schumann C.M., Nordahl C.W. Neuroanatomy of autism. Trends Neurosci. 2008, 31:137-145.
3. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2013, American Psychiatric Publishing, Arlington, VA. 5th ed.
4. Aylward E.H., Minshew N.J., Field K., Sparks B.F., Singh N. Effects of age on brain volume and head circumference in autism. Neurology 2002, 59:175-183.
5. Aylward E.H., Minshew N.J., Goldstein G., Honeycutt N.A., Augustine A.M., Yates K.O., Barta P.E., Pearlson G.D. MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology 1999, 53:2145-2150.
6. Bailey A., Le Couteur A., Gottesman I., Bolton P., Simonoff E., Yuzda E., Rutter M. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol. Med. 1995, 25:63-77.
7. Ben-Itzchak E., Ben-Shachar S., Zachor D.A. Specific neurological phenotypes in autism spectrum disorders are associated with sex representation. Autism Res. 2013, 6:596-604.
8. Bigler E.D., Abildskov T.J., Petrie J.A., Johnson M., Lange N., Chipman J., Lu J., McMahon W., Lainhart J.E. Volumetric and voxel-based morphometry findings in autism subjects with and without macrocephaly. Dev. Neuropsychol. 2010, 35:278-295.
9. Bloss C.S., Courchesne E. MRI neuroanatomy in young girls with autism: a preliminary study. J. Am. Acad. Child Adolesc. Psychiatry 2007, 46:515-523.
10. Bolton P., Macdonald H., Pickles A., Rios P., Goode S., Crowson M., Bailey A., Rutter M. A case-control family history study of autism. J. Child Psychol. Psychiatry 1994, 35:877-900.
11. Buxbaum J.D., Cai G., Chaste P., Nygren G., Goldsmith J., Reichert J., Anckarsäter H., Rastam M., Smith C.J., Silverman J.M., Hollander E., Leboyer M., Gillberg C., Verloes A., Betancur C. Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2007, 144B:484-491.
12. Calderoni S., Retico A., Biagi L., Tancredi R., Muratori F., Tosetti M. Female children with autism spectrum disorder: an insight from mass-univariate and pattern classification analyses. Neuroimage 2012, 59:1013-1022.
13. Carper R.A., Moses P., Tigue Z.D., Courchesne E. Cerebral lobes in autism: early hyperplasia and abnormal age effects. Neuroimage 2002, 16:1038-1051.
14. Cederlund M., Miniscalco C., Gillberg C. Pre-school children with autism spectrum disorders are rarely macrocephalic: a population study. Res. Dev. Disabil. 2014, 35:992-998.
15. Chaste P., Klei L., Sanders S.J., Murtha M.T., Hus V., Lowe J.K., Willsey A.J., Moreno-De-Luca D., Yu T.W., Fombonne E., Geschwind D., Grice D.E., Ledbetter D.H., Lord C., Mane S.M., Lese Martin C., Martin D.M., Morrow E.M., Walsh C.A., Sutcliffe J.S., State M.W., Devlin B., Cook E.H., Kim S.J. Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait. Biol. Psychiatry 2013, 74:576-584.
16. Chawarska K., Campbell D., Chen L., Shic F., Klin A., Chang J. Early generalized overgrowth in boys with autism. Arch. Gen. Psychiatry 2011, 68:1021-1031.
17. Cheung C., McAlonan G.M., Fung Y.Y., Fung G., Yu K.K., Tai K.S., Sham P.C., Chua S.E. MRI study of minor physical anomaly in childhood autism implicates aberrant neurodevelopment in infancy. PLoS One 2011, 6:e20246.
18. Chugani D.C. Neuroimaging and neurochemistry of autism. Pediatr. Clin. N. Am. 2012, 59:63-73.
19. Cleavinger H.B., Bigler E.D., Johnson J.L., Lu J., McMahon W., Lainhart J.E. Quantitative magnetic resonance image analysis of the cerebellum in macrocephalicand normocephalic children and adults with autism. J. Int. Neuropsychol. Soc. 2008, 14:401-413.
20. Constantino J.N., Majmudar P., Bottini A., Arvin M., Virkud Y., Simons P., Spitznagel E. Infant head growth in male siblings of children with and without autism spectrum disorders. J. Neurodev. Disord. 2010, 2:39-46.
21. Courchesne E., Carper R., Akshoomoff N. Evidence of brain overgrowth in the first year of life in autism. J. Am. Med. Assoc. 2003, 290:337-344.
22. Courchesne E., Karns C.M., Davis H.R., Ziccardi R., Carper R.A., Tigue Z.D., Chisum H.J., Moses P., Pierce K., Lord C., Lincoln A.J., Pizzo S., Schreibman L., Haas R.H., Akshoomoff N.A., Courchesne R.Y. Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology 2001, 57:245-254.
23. Courchesne E., Pierce K. Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. Curr. Opin. Neurobiol. 2005, 15:225-230.
24. Courchesne E., Press G.A., Yeung-Courchesne R. Parietal lobe abnormalities detected with MR in patients with infantile autism. Am. J. Roentgenol. 1993, 160:387-393.
25. Courchesne E., Yeung-Courchesne R., Press G.A., Hesselink J.R., Jernigan T.L. Hypoplasia of cerebellar vermal lobules VI and VII in autism. N. Engl. J. Med. 1988, 318:1349-1354.
26. Davidovitch M., Golan D., Vardi O., Lev D., Lerman-Sagie T. Israeli children with autism spectrum disorder are not macrocephalic. J. Child Neurol. 2011, 26:580-585.
27. Davidovitch M., Patterson B., Gartside P. Head circumference measurements in children with autism. J. Child Neurol. 1996, 11:389-393.
28. Dementieva Y.A., Vance D.D., Donnelly S.L., Elston L.A., Wolpert C.M., Ravan S.A., DeLong G.R., Abramson R.K., Wright H.H., Cuccaro M.L. Accelerated head growth in early development of individuals with autism. Pediatr. Neurol. 2005, 32:102-108.
29. Deutsch C.K., Joseph R.M. Brief report: cognitive correlates of enlarged head circumference in children with autism. J. Autism Dev. Disord. 2003, 33:209-215.
30. Dissanayake C., Bui Q.M., Huggins R., Loesch D.Z. Growth in stature and head circumference in high-functioning autism and Asperger disorder during the first 3 years of life. Dev. Psychopathol. 2006, 18:381-393.
31. Ecker C., Ginestet C., Feng Y., Johnston P., Lombardo M.V., Lai M.C., Suckling J., Palaniyappan L., Daly E., Murphy C.M., Williams S.C., Bullmore E.T., Baron-Cohen S., Brammer M., Murphy D.G. Brain surface anatomy in adults with autism: the relationship between surface area, cortical thickness, and autistic symptoms. JAMA Psychiatry 2013, 70:59-70.
32. Ecker C., Marquand A., Mourão-Miranda J., Johnston P., Daly E.M., Brammer M.J., Maltezos S., Murphy C.M., Robertson D., Williams S.C., Murphy D.G. Describing the brain in autism in five dimensions--magnetic resonance imaging-assisted diagnosis of autism spectrum disorder using a multiparameter classification approach. J. Neurosci. 2010, 30:10612-10623.
33. Egger M., Smith G.D., Phillips A.N. Meta-analysis: principles and procedures. Br. Med. J. 1997, 315:1533-1537.
34. Fidler D.J., Bailey J.N., Smalley S.L. Macrocephaly in autism and other pervasive developmental disorders. Dev. Med. Child Neurol. 2000, 42:737-740.
35. Fombonne E., Rogé B., Claverie J., Courty S., Frémolle J. Microcephaly and macrocephaly in autism. J. Autism Dev. Disord. 1999, 29:113-119.
36. Freitag C.M., Luders E., Hulst H.E., Narr K.L., Thompson P.M., Toga A.W., Krick C., Konrad C. Total brain volume and corpus callosum size in medication-naïve adolescents and young adults with autism spectrum disorder. Biol. Psychiatry 2009, 66:316-319.
37. Freitas B.C., Trujillo C.A., Carromeu C., Yusupova M., Herai R.H., Muotri A.R. Stem cells and modeling of autism spectrum disorders. Exp. Neurol. 2012, 260:33-43.
38. Froehlich W., Cleveland S., Torres A., Phillips J., Cohen B., Torigoe T., Miller J., Fedele A., Collins J., Smith K., Lotspeich L., Croen L.A., Ozonoff S., Lajonchere C., Grether J.K., Hallmayer J. Head Circumferences in Twins With and Without Autism Spectrum Disorders. J. Autism Dev. Disord. 2013, 43:2026-2037.
39. Gabriele S., Sacco R., Persico A.M. Blood serotonin levels in autism spectrum disorder: a systematic review and meta-analysis. Eur. Neuropsychopharmacol. 2014, 24:919-929.
40. Ghaziuddin M., Zaccagnini J., Tsai L., Elardo S. Is megalencephaly specific to autism?. J. Intellect. Disabil. Res. 1999, 43:279-282.
41. Gillberg C., de Souza L. Head circumference in autism, asperger syndrome, and ADHD: comparative study. Dev. Med. Child Neurol. 2002, 44:296-300.
42. Girgis R.R., Minshew N.J., Melhem N.M., Nutche J.J., Keshavan M.S., Hardan A.Y. Volumetric alterations of the orbitofrontal cortex in autism. Prog. Neuropsychopharmacol. Biol. Psychiatry 2007, 31:41-45.
43. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 2003, 160:636-645.
44. Gottesman I.I., Shields J. Genetic theorizing and schizophrenia. Br. J. Psychiatry 1973, 122:15-30.
45. Grandgeorge M., Lemonnier E., Jallot N. Autism spectrum disorders: head circumference and body length at birth are both relative. Acta Paediatr. 2013, 102:901-907.
46. Greimel E., Nehrkorn B., Schulte-Rüther M., Fink G.R., Nickl-Jockschat T., Herpertz-Dahlmann B., Konrad K., Eickoff S.B. Changes in grey matter development in autism spectrum disorder. Brain Struct. Funct. 2013, 218:929-942.
47. Griebling J., Minshew N.J., Bodner K., Libove R., Bansal R., Konasale P., Keshavan M.S., Hardan A. Dorsolateral prefrontal cortex magnetic resonance imaging measurements and cognitive performance in autism. J. Child Neurol. 2010, 25:856-863.
48. Hallahan B., Daly E.M., McAlonan G., Loth E., Toal F., O'Brien F., Robertson D., Hales S., Murphy C., Murphy K.C., Murphy D.G. Brain morphometry volume in autistic spectrum disorder: a magnetic resonance imaging study of adults. Psychol. Med. 2009, 39:337-346.
49. Hardan A.Y., Girgis R.R., Adams J., Gilbert A.R., Melhem N.M., Keshavan M.S., Minshew N.J. Brief report: abnormal association between the thalamus and brain size in Asperger's disorder. J. Autism Dev. Disord. 2008, 38:390-394.
50. Hardan A.Y., Kilpatrick M., Keshavan M.S., Minshew N.J. Motor performance and anatomic magnetic resonance imaging (MRI) of the basal ganglia in autism. J. Child Neurol. 2003, 18:317-324.
51. Hardan A.Y., Libove R.A., Keshavan M.S., Melhem N.M., Minshew N.J. A preliminary longitudinal magnetic resonance imaging study of brain volume and cortical thickness in autism. Biol. Psychiatry 2009, 66:320-326.
52. Hardan A.Y., Minshew N.J., Harenski K., Keshavan M.S. Posterior fossa magnetic resonance imaging in autism. J. Am. Acad. Child Adolesc. Psychiatry 2000, 40:666-672.
53. Hardan A.Y., Pabalan M., Gupta N., Bansal R., Melhem N.M., Fedorov S., Keshavan M.S., Minshew N.J. Corpus callosum volume in children with autism. Psychiatry Res. 2007, 174:57-61.
54. Hazlett H.C., Poe M., Gerig G., Smith R.G., Provenzale J., Ross A., Gilmore J., Piven J. Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years. Arch. Gen. Psychiatry 2005, 62:1366-1376.
55. Hazlett H.C., Poe M.D., Gerig G., Styner M., Chappell C., Smith R.G., Vachet C., Piven J. Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years. Arch. Gen. Psychiatry 2011, 68:467-476.
56. Haznedar M.M., Buchsbaum M.S., Wei T.C., Hof P.R., Cartwright C., Bienstock C.A., Hollander E. Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. Am. J. Psychiatry 2000, 157:1994-2001.
57. Herbert M.R., Ziegler D.A., Deutsch C.K., O'Brien L.M., Lange N., Bakardjiev A., Hodgson J., Adrien K.T., Steele S., Makris N., Kennedy D., Harris G.J., Caviness V.S.Jr Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain 2003, 126:1182-1192.
58. Hollander E., Soorya L., Wasserman S., Esposito K., Chaplin W., Anagnostou E. Divalproex sodium vs. placebo in the treatment of repetitive behaviours in autism spectrum disorder. Int. J. Neuropsychopharmacol. 2006, 9:209-213.
59. Hong S., Ke X., Tang T., Hang Y., Chu K., Huang H., Ruan Z., Lu Z., Tao G., Liu Y. Detecting abnormalities of corpus callosum connectivity in autism using magnetic resonance imaging and diffusion tensor tractography. Psychiatry Res. 2011, 194:333-339.
60. Jou R.J., Minshew N.J., Keshavan M.S., Hardan A.Y. Cortical gyrification in autistic and Asperger disorders: a preliminary magnetic resonance imaging study. J. Child Neurol. 2010, 25:1462-1467.
61. Jou R.J., Minshew N.J., Keshavan M.S., Vitale M.P., Hardan A.Y. Enlarged right superior superior temporal gyrus in children and adolescents with autism. Brain Res. 2010, 1360:205-212.
62. Kates W.R., Burnette C.P., Eliez S., Strunge L.A., Kaplan D., Landa R., Reiss A.L., Pearlson G.D. Neuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autism. Am. J. Psychiatry 2004, 161:539-546.
63. Lainhart J.E., Bigler E.D., Bocian M., Coon H., Dinh E., Dawson G., Deutsch C.K., Dunn M., Estes A., Tager-Flusberg H., Folstein S., Hepburn S., Hyman S., McMahon W., Minshew N., Munson J., Osann K., Ozonoff S., Rodier P., Rogers S., Sigman M., Spence M.A., Stodgell C.J., Volkmar F. Head circumference and height in autism: a study by the Collaborative Program of Excellence in Autism. Am. J. Med. Genet. 2006, 140:2257-2274.
64. Lainhart J.E., Piven J., Wzorek M., Landa R., Santangelo S.L., Coon H., Folstein S.E. Macrocephaly in children and adults with autism. J. Am. Acad. Child Adolesc. Psychiatry 1997, 36:282-290.
65. McAlonan G.M., Daly E., Kumari V., Critchley H.D., van Amelsvoort T., Suckling J., Simmons A., Sigmundsson T., Greenwood K., Russell A., Schmitz N., Happe F., Howlin P., Murphy D.G. Brain anatomy and sensorimotor gating in Asperger's syndrome. Brain 2002, 125:1594-1606.
66. McCaffery P., Deutsch C.K. Macrocephaly and the control of brain growth in autistic disorders. Prog. Neurobiol. 2005, 77:38-56.
67. Miles J.H., Hadden L.L., Takahashi T.N., Hillman R.E. Head circumference is an independent clinical finding associated with autism. Am. J. Med. Genet. 2000, 95:339-350.
68. Miles J.H., Takahashi T.N., Hong J., Munden N., Flournoy N., Braddock S.R., Martin R.A., Bocian M.E., Spence M.A., Hillman R.E., Farmer J.E. Development and validation of a measure of dysmorphology: useful for autism subgroup classification. Am. J. Med. Genet. 2008, 146:1101-1116.
69. Mostofsky S.H., Burgess M.P., Gidley Larson J.C. Increased motor cortex white matter volume predicts motor impairment in autism. Brain 2007, 130:2117-2122.
70. Nordahl C.W., Braunschweig D., Iosif A.M., Lee A., Rogers S., Ashwood P., Amaral D.G., Van de Water J. Maternal autoantibodies are associated with abnormal brain enlargement in subgroup of children with autism spectrum disorder. Brain Behav. Immun. 2013, 30:61-65.
71. Palmen S.J., Hulshoff Pol H.E., Kemner C., Schnack H.G., Durston S., Lahuis B.E., Kahn R.S., Van Engeland H. Increased gray-matter volume in medication-naïve high-functioning children with autism spectrum disorder. Psychol. Med. 2005, 35:561-570.
72. Palmen S.J., Hulshoff Pol H.E., Kemner C., Schnack H.G., Janssen J., Kahn R.S., Van Engeland H. Larger brains in medication naive high-functioning subjects with pervasive developmental disorder. J. Autism Dev. Disord. 2004, 34:603-613.
73. Philip R.C., Dauvermann M.R., Whalley H.C., Baynham K., Lawrie S.M., Stanfield A.C. A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders. Neurosci. Biobehav. Rev. 2012, 36:901-942.
74. Pierce K., Courchesne E. Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biol. Psychiatry 2001, 49:655-664.
75. Piven J., Arndt S., Bailey J., Havercamp S., Andreasen N.C., Palmer P. An MRI study of brain size in autism. Am. J. Psychiatry 1995, 152:1145-1149.
76. Raznahan A., Gregory L.W., Antezana L., Greenstein D., Lenroot R., Thurm A., Gozzi M., Spence S., Martin A., Swedo S.E., Giedd J.N. Compared to what? Early brain overgrowth in autism and the perils of population norms. Biol. Psychiatry 2013, 74:563-575.
77. Redcay E., Courchesne E. When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biol. Psychiatry 2005, 58:1-9.
78. Rodier P.M. Converging evidence for brainstem injury in autism. Dev. Psychopathol. 2002, 14:537-557.
79. Rojas D.C., Bawn S.D., Benkers T.L., Reite M.L., Rogers S.J. Smaller left hemisphere planum temporale in adults with autistic disorder. Neurosci. Lett. 2002, 328:237-240.
80. Rojas D.C., Camou S.L., Reite M.L., Rogers S.J. Planum temporale volume in children and adolescents with autism. J. Autism Dev. Disord. 2005, 35:479-486.
81. Ruggeri B., Sarkans U., Schumann G., Persico A.M. Biomarkers in autism spectrum disorder: the old and the new. Psychopharmacology 2014, 231:1201-1216.
82. Sacco R., Curatolo P., Manzi B., Militerni R., Bravaccio C., Frolli A., Lenti C., Saccani M., Elia M., Reichelt K.L., Pascucci T., Puglisi-Allegra S., Persico A.M. Principal pathogenetic components and biological endophenotypes in autism spectrum disorders. Autism Res. 2010, 3:237-252.
83. Sacco R., Militerni R., Frolli A., Bravaccio C., Gritti A., Elia M., Curatolo P., Manzi B., Trillo S., Lenti C., Saccani M., Schneider C., Melmed R., Reichelt K.L., Pascucci T., Puglisi-Allegra S., Persico A.M. Clinical, morphological, and biochemical correlates of head circumference in autism. Biol. Psychiatry 2007, 62:1038-1047.
84. Say G.N., Sahin B., Aslan K., Akbaş S., Lncesu L., Ceyhan M. Increased laterality of the thalamus in children and adolescents with asperger's disorder: an mri and proton spectroscopy study. Psychiatry Investig. 2014, 11:237-242.
85. Schumann C.M., Bloss C.S., Barnes C.C., Wideman G.M., Carper R.A., Akshoomoff N., Pierce K., Hagler D., Schork N., Lord C., Courchesne E. Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism. J. Neurosci. 2010, 30:4419-4427.
86. Schumann C.M., Hamstra J., Goodlin-Jones B.L., Lotspeich L.J., Kwon H., Buonocore M.H., Lammers C.R., Reiss A.L., Amaral D.G. The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. J. Neurosci. 2004, 24:6392-6401.
87. Scott J.A., Schumann C.M., Goodlin-Jones B.L., Amaral D.G. A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder. Autism Res. 2009, 2:246-257.
88. Skjeldal O.H., Sponheim E., Ganes T., Jellum E., Bakke S. Childhood autism: the need for physical investigations. Brain Dev. 1998, 20:227-233.
89. Sparks B.F., Friedman S.D., Shaw D.W., Aylward E.H., Echelard D., Artru A.A., Maravilla K.R., Giedd J.N., Munson J., Dawson G., Dager S.R. Brain structural abnormalities in young children with autism spectrum disorder. Neurology 2002, 59:184-192.
90. Stamova B.S., Tian Y., Nordahl C.W., Shen M.D., Rogers S., Amaral D.G., Sharp F.R. Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders. Mol. Autism 2013, 4(30):1-16.
91. State M.W., Levitt, P. The conundrums of understanding genetic risks for autism spectrum disorders. Nat. Neurosci. 2011, 14:1499-1506.
92. Stevenson R.E., Schroer R.J., Skinner C., Fender D., Simensen R.J. Autism and macrocephaly. Lancet 1997, 349:1744-1745.
93. Tamura R., Kitamura H., Endo T., Hasegawa N., Someya T. Reduced thalamic volume observed across different subgroups of autism spectrum disorders. Psychiatry Res. 2010, 184:186-188.
94. Tate D.F., Bigler E.D., McMahon W., Lainhart J. The relative contributions of brain, cerebrospinal fluid-filled structures and non-neural tissue volumes to occipital-frontal head circumference in subjects with autism. Neuropediatrics 2007, 38:18-24.
95. Tepest R., Jacobi E., Gawronski A., Krug B., Möller-Hartmann W., Lehnhardt F.G., Vogeley K. Corpus callosum size in adults with high-functioning autism and the relevance of gender. Psychiatry Res. 2010, 183:38-43.
96. Torrey E.F., Dhavale D., Lawlor J.P., Yolken R.H. Autism and head circumference in the first year of life. Biol. Psychiatry 2004, 56:892-894.
97. Travers B.G., Adluru N., Ennis C., Tromp do P.M., Destiche D., Doran S., Bigler E.D., Lange N., Lainhart J.E., Alexander A.L. Diffusion tensor imaging in autism spectrum disorder: a review. Autism Res. 2012, 5:289-313.
98. Tsatsanis K.D., Rourke B.P., Klin A., Volkmar F.R., Cicchetti D., Schultz R.T. Reduced thalamic volume in high-functioning individuals with autism. Biol. Psychiatry 2003, 53:121-129.
99. Van Daalen E., Swinkels S.H., Dietz C., van Engeland H., Buitelaar J.K. Body length and head growth in the first year of life in autism. Pediatr. Neurol. 2007, 37:324-330.
100. Varga E.A., Pastore M., Prior T., Herman G.E., McBride K.L. The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly. Genet. Med. 2009, 11:111-117.
101. Ververi A., Vargiami E., Papadopoulou V., Tryfonas D., Zafeiriou D.I. Clinical and laboratory data in a sample of Greek children with autism spectrum disorders. J. Autism Dev. Disord. 2012, 42:1470-1476.
102. Vidal C.N., Nicolson R., DeVito T.J., Hayashi K.M., Geaga J.A., Drost D.J., Williamson P.C., Rajakumar N., Sui Y., Dutton R.A., Toga A.W., Thompson P.M. Mapping corpus callosum deficits in autism: an index of aberrant cortical connectivity. Biol. Psychiatry 2006, 60:218-225.
103. Vorstman J.A., Spooren W., Persico A.M., Collier D.A., Aigner S., Jagasia R., Glennon J.C., Buitelaar J.K. Using genetic findings in autism for the development of new pharmaceutical compounds. Psychopharmacology 2014, 231:1063-1078.
104. Walsh P., Elsabbagh M., Bolton P., Singh I. In search of biomarkers for autism: scientific, social and ethical challenges. Nat. Rev. Neurosci. 2011, 12:603-612.
105. Webb S.J., Nalty T., Munson J., Brock C., Abbott R., Dawson G. Rate of head circumference growth as a function of autism diagnosis and history of autistic regression. J. Child Neurol. 2007, 22:1182-1190.
106. Woodhouse W., Bailey A., Rutter M., Bolton P., Baird G., Le Couteur A. Head circumference in autism and other pervasive developmental disorders. J. Child Psychol. Psychiatry 1996, 37:665-671.