Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish

Journal of Endocrinology

Volumn 227, Issue 2, 2015, Pages 93-103

  Li, Mingyu ^a   Danielle Dean, E ^b   Zhao, Liyuan ^a,c   Nicholson, Wendell E ^b   Powers, Alvin C ^a,b,d   Chen, Wenbiao ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c SOA Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources Key Laboratory of Marine Genetic   (China)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cell growth control; Fish; Glucagon; Mutations; Whole animal physiology

Indexed keywords

CAPPED RNA; CYCLIC AMP; GLUCAGON RECEPTOR; GLUCOSE; GLUCOSE 6 PHOSPHATASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE;

ADULT; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL PROLIFERATION; CHROMOSOME 1; CHROMOSOME 17; CHROMOSOME 3; CONTROLLED STUDY; GERMLINE MUTATION; GLUCOSE ASSAY; GLUCOSE BLOOD LEVEL; HYPERGLUCAGONEMIA; HYPOGLYCEMIA; NONHUMAN; OPEN READING FRAME; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET CELL HYPERPLASIA; PHYLOGENETIC TREE; PHYLOGENY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; SYNTENY; ZEBRA FISH; ANIMAL; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HYPERPLASIA; METABOLISM; MOLECULAR CLONING; NONMAMMALIAN EMBRYO; PATHOLOGY; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL PROLIFERATION; CLONING, MOLECULAR; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE SILENCING; GLUCAGON-SECRETING CELLS; HYPERPLASIA; RECEPTORS, GLUCAGON; ZEBRAFISH;

EID: 84945907813     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-15-0284     Document Type: Article

References (30)

1. Abrahamsen N, Lundgren K & Nishimura E 1995 Regulation of glucagon receptor mRNA in cultured primary rat hepatocytes by glucose and cAMP. Journal of Biological Chemistry 270 15853-15857. (doi:10.1074/jbc.270.26.15853).
2. Ali S & Drucker DJ 2009 Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes. American Journal of Physiology. Endocrinology and Metabolism 296 E415-E421. (doi:10.1152/ajpendo.90887.2008).
3. Argenton F, Zecchin E & Bortolussi M 1999 Early appearance of pancreatic hormone-expressing cells in the zebrafish embryo. Mechanisms of Development 87 217-221. (doi:10.1016/S0925-4773(99)00151-3).
4. Biemar F, Argenton F, Schmidtke R, Epperlein S, Peers B & Driever W 2001 Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet. Developmental Biology 230 189-203. (doi:10.1006/dbio. 2000.0103).
5. Brubaker PL & Drucker DJ 2002 Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors. Receptors & Channels 8 179-188. (doi:10.1080/10606820213687).
6. Cermak T, Doyle EL, Christian M, Wang L, Zhang Y, Schmidt C, Baller JA, Somia NV, Bogdanove AJ & Voytas DF 2011 Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Research 39 e82. (doi:10.1093/nar/gkr218).
7. Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, Nackers L, Pack S, Jou W & Weinstein LS 2005 Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gsα deficiency. Journal of Clinical Investigation 115 3217-3227. (doi:10.1172/JCI24196).
8. Chow BK, Moon TW, Hoo RL, Yeung CM, Muller M, Christos PJ & Mojsov S 2004 Identification and characterization of a glucagon receptor from the goldfish Carassius auratus: implications for the evolution of the ligand specificity of glucagon receptors in vertebrates. Endocrinology 145 3273-3288. (doi:10.1210/en.2003-0597).
9. Conarello SL, Jiang G, Mu J, Li Z, Woods J, Zycband E, Ronan J, Liu F, Roy RS, Zhu L et al. 2007 Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated β cell loss and hyperglycaemia. Diabetologia 50 142-150. (doi:10.1007/s00125-006-0481-3).
10. Cruz SA, Tseng YC, Kaiya H & Hwang PP 2010 Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 156 190-200. (doi:10.1016/j.cbpa.2010.01.019).
11. Field HA, Dong PD, Beis D & Stainier DY 2003 Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology 261 197-208. (doi:10.1016/S0012-1606(03)00308-7).
12. Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C et al. 2003 Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice. PNAS 100 1438-1443. (doi:10.1073/pnas. 0237106100).
13. Hansen LH, Abrahamsen N & Nishimura E 1995 Glucagon receptor mRNA distribution in rat tissues. Peptides 16 1163-1166. (doi:10.1016/0196-9781(95)00078-X).
14. Hesselson D, Anderson RM & Stainier DY 2011 Suppression of Ptf1a activity induces acinar-to-endocrine conversion. Current Biology 21 712-717. (doi:10.1016/j.cub.2011.03.041).
15. Jiang G & Zhang BB 2003 Glucagon and regulation of glucose metabolism. American Journal of Physiology. Endocrinology and Metabolism 284 E671-E678. (doi:10.1152/ajpendo.00492.2002).
16. Kedees MH, Grigoryan M, Guz Y & Teitelman G 2009 Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic α and β cells in two models of α cell hyperplasia. Molecular and Cellular Endocrinology 311 69-76. (doi:10.1016/j.mce.2009.07.024).
17. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B & Schilling TF 1995 Stages of embryonic development of the zebrafish. Developmental Dynamics 203 253-310. (doi:10.1002/aja.1002030302).
18. Lee Y, Wang MY, Du XQ, Charron MJ & Unger RH 2011 Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Diabetes 60 391-397. (doi:10.2337/db10-0426).
19. Li M, Maddison LA, Crees Z & Chen W 2013 Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafish. Zebrafish 10 170-176. (doi:10.1089/zeb.2012.0816).
20. Li M, Maddison LA, Page-McCaw P & Chen W 2014 Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvae. American Journal of Physiology. Endocrinology and Metabolism 306 E799-E807. (doi:10.1152/ajpendo.00686.2013).
21. Lieschke GJ & Currie PD 2007 Animal models of human disease: zebrafish swim into view. Nature Reviews. Genetics 8 353-367. (doi:10.1038/nrg2091).
22. Livak KJ & Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(KDelta Delta C(T)) method. Methods 25 402-408. (doi:10.1006/meth.2001.1262).
23. Longuet C, Robledo AM, Dean ED, Dai C, Ali S, McGuinness I, de Chavez V, Vuguin PM, Charron MJ, Powers AC et al. 2013 Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for α circulating α-cell growth factor. Diabetes 62 1196-1205. (doi:10.2337/db11-1605).
24. Lund A, Bagger JI, Christensen M, Knop FK & Vilsboll T 2014 Glucagon and type 2 diabetes: the return of the α cell. Current Diabetes Reports 14 555. (doi:10.1007/s11892-014-0555-4).
25. Maddison LA & Chen W 2012 Nutrient excess stimulates β-cell neogenesis in zebrafish. Diabetes 61 2517-2524. (doi:10.2337/db11-1841).
26. Mayo KE, Miller LJ, Bataille D, Dalle S, Goke B, Thorens B & Drucker DJ 2003 International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacological Reviews 55 167-194. (doi:10.1124/pr. 55.1.6).
27. Ni TT, Lu J, Zhu M, Maddison LA, Boyd KL, Huskey L, Ju B, Hesselson D, Zhong TP, Page-McCaw PS et al. 2012 Conditional control of gene function by an invertible gene trap in zebrafish. PNAS 109 15389-15394. (doi:10.1073/pnas.1206131109).
28. Venkatesh B 2003 Evolution and diversity of fish genomes. Current Opinion in Genetics & Development 13 588-592. (doi:10.1016/j.gde.2003.09.001).
29. Vuguin PM, Kedees MH, Cui L, Guz Y, Gelling RW, Nejathaim M, Charron MJ & Teitelman G 2006 Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation. Endocrinology 147 3995-4006. (doi:10.1210/en.2005-1410).
30. Ye L, Robertson MA, Hesselson D, Stainier DY & Anderson RM 2015 Glucagon is essential for α cell transdifferentiation and β cell neogenesis. Development 142 1407-1417. (doi:10.1242/dev.117911).