Effects of Berberine on Cell Cycle, DNA, Reactive Oxygen Species, and Apoptosis in L929 Murine Fibroblast Cells

Evidence-based Complementary and Alternative Medicine

Volumn 2015, Issue , 2015, Pages

  Gu, Manman ^a   Xu, Jing ^a   Han, Chunyang ^a   Kang, Youxi ^a   Liu, Tengfei ^a   He, Yanfei ^a   Huang, Yanfei ^a   Liu, Cuiyan ^a  

^a ANHUI AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BERBERINE; DNA; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL STRUCTURE; CELL VIABILITY; CHEMICAL STRUCTURE; CYTOTOXICITY; DNA DAMAGE; FIBROBLAST; G2 PHASE CELL CYCLE CHECKPOINT; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 84945589326     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2015/796306     Document Type: Article

References (53)

1. M. He, X. Zhang, and S. Y. Yang, "In vitro effect of berberine induced apoptosis in PC3 cells," Chinese Journal of Gerontology, vol. 32, no. 2, pp. 341-342, 2012.
2. A. Shirwaikar, A. Shirwaikar, K. Rajendran, and I. S.R. Punitha, "In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine," Biological and Pharmaceutical Bulletin, vol. 29, no. 9, pp. 1906-1910, 2006.
3. Y.-B. Feng, W.-Q. Luo, and S.-Q. Zhu, "Explore new clinical application of Huanglian and corresponding compound prescriptions fromtheir traditional use," Journal of ChineseMateria Medica, vol. 33, no. 10, pp. 1221-1225, 2008.
4. D. Q. Li and M. J. Wu, "Protective effect of berberine on CCl4 induced acute liver injury in mice," China Pharmacy, vol. 20, no. 21, pp. 1618-1619, 2009.
5. T.-C. Yang, H.-F. Chao, L.-S. Shi, T.-C. Chang, H.-C. Lin, and W.-L. Chang, "Alkaloids from Coptis chinensis root promote glucose uptake in C2C12 myotubes," Fitoterapia, vol. 93, pp. 239-244, 2014.
6. H.-Y. Chen, X.-L. Ye, X.-L. Cui et al., "Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells," Fitoterapia, vol. 83, no. 1, pp. 67-73, 2012.
7. J. J. Yue, P. Li, and Q. He, "The improvement mechanism of berberine on insulin resistance," Journal of Tianjin University of Traditional Chinese Medicine, vol. 32, no. 3, pp. 186-188, 2013.
8. Y. Zhou, S. J. Cao, Y. Wang et al., "Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells," Fitoterapia, vol. 92, pp. 230-237, 2014.
9. J. Tang, Y. B. Feng, S. Tsao, N. Wang, R. Curtain, and Y. Wang, "Berberine and Coptidis Rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations," Journal of Ethnopharmacology, vol. 126, no. 1, pp. 5-17, 2009.
10. Y. H. Tan, W. W. Chen, Y. Y. Wu et al., "Effect of berberine, evodiamine and indirubin on gastric cancer cell," World Chinese Journal of Digestology, vol. 15, no. 13, p. 472, 2005.
11. C. Y. Bai, The protective effects of berberine on acute and chronicmyocardial ischemia in rats [M.S. thesis], JilinUniversity, Changchun, China, 2011.
12. Z. Y. Lei, "Medicinal safety of Rhizome copitis and berberine," China Pharmaceuticals, vol. 19, no. 9, pp. 84-86, 2009.
13. N. P. Singh, M. T. McCoy, R. R. Tice, and E. L. Schneider, "A simple technique for quantitation of low levels of DNA damage in individual cells," Experimental Cell Research, vol. 175, no. 1, pp. 184-191, 1988.
14. J.-J. Gao, S.-M. Feng, and W.-F. Jin, "Improvement of gel preparation on alkali single cell gel electrophoresis," Fudan University Journal of Medical Sciences, vol. 31, no. 3, pp. 311-312, 2004.
15. S. Nandhakumar, S. Parasuraman, M. M. Shanmugam, K. Ramachandra Rao, P. Chand, and B. Vishnu Bhat, "Evaluation of DNA damage using single-cell gel electrophoresis (Comet Assay)," Journal of Pharmacology and Pharmacotherapeutics, vol. 2, no. 2, pp. 107-111, 2011.
16. C. H. Xin, G. L. Li, Z. Y. Ji et al., "Comparison of image analysis program for the comet assay," Journal of Health Toxicology, vol. 19, no. 2, pp. 141-143, 2005.
17. J. L. Li, "Treatment of atrial fibrillation new strategy: preventive effect of berberine on atrial fibrillation," Health Essentials, vol. 2, no. 2, p. 332, 2012.
18. Z. G. Qiao, "Worsening of atrioventricular block with oral berberine," Adverse Drug Reactions Journal, vol. 14, no. 2, pp. 131-132, 2012.
19. Z. L. He, "Analysis of berberine adverse reactions," Modern Health, vol. 20, p. 103, 2014.
20. M. S. Pasqual, C. P. Lauer, P. Moyna, and J. A. P. Henriques, "Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organisms," Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 286, no. 2, pp. 243-252, 1993.
21. D. Shaw, "Toxicological risks of Chinese herbs," Planta Medica, vol. 76, no. 17, pp. 2012-2018, 2010.
22. B.-L. Ma, Y.-M. Ma, R. Shi et al., "Identification of the toxic constituents in Rhizoma Coptidis," Journal of Ethnopharmacology, vol. 128, no. 2, pp. 357-364, 2010.
23. G.D. Jahnke, C. J. Price, and M.C. Marr, "Development toxicity evaluation of berberine in rats and mice," Birth Defects Research Part B: Dvelopmental and Reproductive Toxicology, vol. 77, no. 3, pp. 195-206, 2006.
24. J. Yi, X. L. Ye, D. Z. Wang et al., "Safety evaluation of main alkaloids from Rhizoma Coptidis," Journal of Ethnopharmacology, vol. 145, no. 1, pp. 303-310, 2013.
25. H. I. Cheong, J. Johnson, M. Cormier, and K. Hosseini, "In vitro cytotoxicity of eight beta-blockers in human corneal epithelial and retinal pigment epithelial cell lines: comparison with epidermal keratinocytes and dermal fibroblasts," Toxicology in Vitro, vol. 22, no. 4, pp. 1070-1076, 2008.
26. J. Han, S. H. Back, J. Hur et al., "ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death," Nature Cell Biology, vol. 15, no. 5, pp. 481-490, 2013.
27. M. J. Stoddart, "WST-8 analysis of cell viability during osteogenesis of human mesenchymal stem cells," in Mammalian Cell Viability: Methods and Protocols, vol. 740 of Methods in Molecular Biology, pp. 21-25, Humana Press, Totowa, NJ, USA, 2011.
28. T. Weinert, "DNA damage and checkpoint pathways: molecular anatomy and interactions with repair," Cell, vol. 94, no. 5, pp. 555-558, 1998.
29. P. Ghosh, M. Banerjee, A. K. Giri, and K. Ray, "Toxicogenomics of arsenic: classical ideas and recent advances," Mutation Research - Reviews in Mutation Research, vol. 659, no. 3, pp. 293-301, 2008.
30. L. H. Hartwell and M. B. Kastan, "Cell cycle control and cancer," Science, vol. 266, no. 5192, pp. 1821-1828, 1994.
31. L. F. He, Z. H. Zou, Y. F. Zhong et al., "Effects of fluoride on formation of dental fluorosis in rat incisor and DNA damage in ameloblasts," Journal of Clinical Stomatology, vol. 26, no. 7, pp. 403-405, 2010.
32. J. Han, S. H. Back, J. Hur et al., "ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death," Nature Cell Biology, vol. 15, no. 5, pp. 481-490, 2013.
33. M. J. Stoddart, "WST-8 analysis of cell viability during osteogenesis of human mesenchymal stem cells," Methods in Molecular Biology, vol. 740, pp. 21-25, 2011.
34. T. Weinert, "DNA damage and checkpoint pathways: molecular anatomy and interactions with repair," Cell, vol. 94, no. 5, pp. 555-558, 1998.
35. P. Ghosh, M. Banerjee, A. K. Giri, and K. Ray, "Toxicogenomics of arsenic: classical ideas and recent advances," Mutation Research, vol. 659, no. 3, pp. 293-301, 2008.
36. L. H. Hartwell and M. B. Kastan, "Cell cycle control and cancer," Science, vol. 266, no. 5192, pp. 1821-1828, 1994.
37. L. F. He, Z. H. Zou, Y. F. Zhong et al., "Effects of fluoride on formation of dental fluorosis in rat incisor and DNA damage in ameloblasts," Journal of Clinical Stomatology, vol. 26, no. 7, pp. 403-405, 2010.
38. M. Zhang, A. Wang, T. Xia, and P. He, "Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-kappaB in primary cultured rat hippocampal neurons," Toxicology Letters, vol. 179, no. 1, pp. 1-5, 2008.
39. L.-F. He and J.-G. Chen, "DNA damage, apoptosis and cell cycle changes induced by fluoride in rat oral mucosal cells and hepatocytes," World Journal of Gastroenterology, vol. 12, no. 7, pp. 1144-1148, 2006.
40. Y. L. Zhao, B. Zhang, G. H. Song et al., "Injury and apoptosis in testis cells of in mice exposed to sodium fluoride," Chinese Journal of Comparative Medicine, vol. 22, no. 1, pp. 39-43, 2012.
41. J. Chen, X.M. Chen, K. D. Yang, T. Xia, and H. Xie, "Studies on DNA damage and apoptosis in rat brain induced by fluoride," Chinese Journal of Preventive Medicine, vol. 36, no. 4, pp. 222-224, 2002.
42. Y. L. Zhao, G. H. Song, B. Zhang et al., "Effects of sodium fluoride on cell apoptosis and Bcl-2 and Bax expression in mouse leydig cells in vitro," Journal of Health Toxicology, vol. 26, no. 1, pp. 17-20, 2012.
43. D.W. Fairbairn, P. L. Olive, and K. L. O'Neill, "The comet assay: a comprehensive review," Mutation Research, vol. 339, no. 1, pp. 37-59, 1995.
44. M. Kruszewski, T. Iwaneńko, E. K. MacHaj et al., "Direct use of the comet assay to study cell cycle distribution and its application to study cell cycle-dependent DNA damage formation," Mutagenesis, vol. 27, no. 5, pp. 551-558, 2012.
45. R. C. Zhu, W. W. Jiang, Z. L. Tan et al., "Progress of reactive oxygen species, oxidative stress, cell apoptosis and antioxidant in animals," Journal of Traditional Chinese Veterinary Medicine, no. 3, pp. 21-25, 2015.
46. M. L. Circu and T. Y. Aw, "Reactive oxygen species, cellular redox systems, and apoptosis," Free Radical Biology & Medicine, vol. 48, no. 6, pp. 749-762, 2010.
47. Y. Xu, J. L. Yin, and B. Wu, "Effect of Wuziyanzong compound recipe on oxidative stress injury and apoptosis of sertoli cells," Modern Journal of Integrated Traditional Chinese and Western Medicine, vol. 22, no. 15, pp. 1615-1626, 2013.
48. Q. Chang and X.-L. Wang, "Cytochrome C, mitochondria and apoptosis," Chinese Pharmacological Bulletin, vol. 19, no. 3, pp. 241-244, 2003.
49. T. Nakamura and X. L. Wang, "Cytochrome C, mitochondria and apoptosis," Chinese Pharmacological Bulletin, vol. 19, no. 3, pp. 241-244, 2003.
50. L.-J. Zhou and X.-Z. Zhu, "Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide," The Journal of Pharmacology and Experimental Therapeutics, vol. 293, no. 3, pp. 982-988, 2000.
51. Y. Y. Wang, Study on cytotoxicity, DNA damage and repair induced by phenol in vitro [M.S. thesis], Soochow University, Suzhou, China, 2011.
52. J. Su, H. Lai, J. Chen et al., "Natural borneol, a monoterpenoid compound, potentiates selenocystine-induced apoptosis in human hepatocellular carcinoma cells by enhancement of cellular uptake and activation of ROS-mediated DNA damage," PLoS ONE, vol. 8, no. 5, Article ID e63502, 2013.
53. X. Zou, Study on the mechanism of G2/Mphase arrest and apoptosis induced by sulforaphane in human hepatocarcinoma HepG cells [Ph.D. thesis], Beijing University of Chinese Medicine, Beijing, China, 2010.