Safety evaluation of main alkaloids from Rhizoma Coptidis

Journal of Ethnopharmacology

Volumn 145, Issue 1, 2013, Pages 303-310

  Yi, Jun ^a   Ye, Xiaoli ^a   Wang, Dezhen ^a   He, Kai ^b   Yang, Yong ^b   Liu, Xujing ^a   Li, Xuegang ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b HUAIHUA MEDICAL COLLEGE   (China)

Author keywords

Acute toxicity; Cytotoxicity; Rhizoma Coptidis alkaloids; Safety; Sub chronic toxicity

Indexed keywords

ALKALOID; BERBERINE; COPTISINE; EPIBERBERINE; PALMATINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD ANALYSIS; CONTROLLED STUDY; COPTIS CHINENSIS; DRUG SAFETY; DRUG SCREENING; FEMALE; HISTOPATHOLOGY; IC 50; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; RAT; TOXICITY; URINALYSIS;

3T3-L1 CELLS; ALKALOIDS; ANIMALS; BERBERINE; BERBERINE ALKALOIDS; BLOOD PROTEINS; BODY WEIGHT; COPTIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FEMALE; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LETHAL DOSE 50; MALE; MICE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; RHIZOME;

ANIMALIA; MUS; RATTUS;

EID: 84871319911     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.10.062     Document Type: Article

References (31)

1. T. Baptista, E. Araujo de Baptista, N. Ying Kin, S. Beaulieu, D. Walker, R. Joober, J. Lalonde, and D. Richard Comparative effects of the antipsychotics sulpiride or risperidone in rats. l: bodyweight, food intake, body composition, hormones and glucose tolerance Brain Research 957 2002 144 151
2. H.-Y. Chen, X.-L. Ye, X.-L. Cui, K. He, Y.-N. Jin, Z. Chen, and X.-G. Li Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells Fitoterapia 83 2012 67 73
3. Y.-X. Chen, and X.-S. Gao The statistics of prescriptions containing Coptis and Coptis compatibility medicines Chinese Proprietary Medicines 19 1997 40 41
4. C.W. Cheng, Z.X. Bian, and T.X. Wu Systematic review of Chinese herbal medicine for functional constipation World Journal of Gastroenterology 15 2009 4886
5. U.K. Choi, M.H. Kim, and N.H. Lee Optimization of antibacterial activity by Gold-Thread (Coptidis Rhizoma Franch) against Streptococcus mutans using evolutionary operation-factorial design technique Journal of Microbiology and Biotechnology 17 2007 1880 1884
6. M.S. Coelho, M.D. Passadore, A.L. Gasparetti, T. Bibancos, P.O. Prada, L.L. Furukawa, L.N.S. Furukawa, R.T. Fukui, D.E. Casarini, and M.J.A. Saad High- or low-salt diet from weaning to adulthood: effect on body weight, food intake and energy balance in rats Nutrition, Metabolism and Cardiovascular Diseases 16 2006 148 155
7. M.L. Colombo, C. Bugatti, A. Mossa, N. Pescalli, L. Piazzoni, G. Pezzoni, E. Menta, S. Spinelli, F. Johnson, and R.C. Gupta Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine ll Farmaco 56 2001 403 409
8. Committee, C.P.; 2010. Chinese Pharmacopoeia. Beijing, China.
9. R.N. Cortright, M.P. Chandler, P.W.R. Lemon, and S.E. DiCarlo Daily exercise reduces fat, protein and body mass in male but not female rats Physiology & Behavior 62 1997 105 111
10. Y. Feng, N. Wang, X. Ye, H. Li, Y. Feng, F. Cheung, and T. Nagamatsu Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats Journal of Ethnopharmacology 138 2011 683 690
11. E.B. Geer, and W. Shen Gender differences in insulin resistance, body composition, and energy balance Gender Medicine 6 2009 60 75
12. C.L. Gray, P.M. Cinciripini, and L.G. Cinciripini The relationship of gender, diet patterns, and body type to weight change following smoking reduction: a multivariate approach Journal of Substance Abuse 7 1995 405 423
13. K.O. Hiller, M. Ghorbani, and H. Schilcher Antispasmodic and relaxant activity of chelidonine, protopine, coptisine, and Chelidonium majus extracts on isolated guinea-pig ileum Planta Medica 64 1998 758 759
14. Y.-S. Huang The standard implementation manual of inspection and evaluation technology in health food 2003 Tsinghua Tong Fang Electronic Press Beijing, China
15. Hyun Ah Jung, Byung-Sun Min, Takako Yokozawa, Je-Hyun Lee, Yeong Shik Kim, and Jae Sue Choi Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids Biological and Pharmaceutical Bulletin 32 2009 1433 1438
16. G.D. Jahnke, C.J. Price, M.C. Marr, C.B. Myers, and J.D. George Developmental toxicity evaluation of berberine in rats and mice Birth Defects Research Part B: Developmental and Reproductive Toxicology 77 2006 195 206
17. F. Jia, G. Zou, J. Fan, and Z. Yuan Identification of palmatine as an inhibitor of West Nile virus Archives of Virology 155 2010 1325 1329
18. M.M. Kheir, Y. Wang, L. Hua, J. Hu, L. Li, F. Lei, and L. Du Acute toxicity of berberine and its correlation with the blood concentration in mice Food and Chemical Toxicology 48 2010 1105 1110
19. S. Kulkarni, and A. Dhir Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders Phytotherapy Research 24 2010 317 324
20. H. Li, X. Cai, and X. Li New applications and the side effects of Rhizoma coptidis in clinic Medical Journal of Chinese People's Armed Police Forces 19 2008 661 663
21. Y.-Q. Liu, M.-C. Cheng, L.-X. Wang, and H.-B. Xiao Rhizoma coptidis and berberine-induced activation of murine microglia N9 cells Journal of Ethnopharmacology 129 2010 121 126
22. J. Lu, J.-S. Wang, and L.-Y. Kong Anti-inflammatory effects of Huang-Lian-Jie-Du decoction, its two fractions and four typical compounds Journal of Ethnopharmacology 134 2011 911 918
23. X. Lv, J. Wang, W.-Q. Jiang, and H.-Y. Zhang The research progress of Rhizoma Coptidis Shandong Pharmaceutical Industry 22 2003 33 34
24. B.-L. Ma, Y.-M. Ma, R. Shi, T.-M. Wang, N. Zhang, C.-H. Wang, and Y. Yang Identification of the toxic constituents in Rhizoma Coptidis Journal of Ethnopharmacology 128 2010 357 364
25. M.S. Pasqual, C.P. Lauer, P. Moyna, and J.A.P. Henriques Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organisms Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 286 1993 243 252
26. B. Roffey, A.S. Atwal, T. Johns, and S. Kubow Water extracts from Momordica charantia increase glucose uptake and adiponectin secretion in 3T3-L1 adipose cells Journal of Ethnopharmacology 112 2007 77
27. J. Tang, Y. Feng, S. Tsao, N. Wang, R. Curtain, and Y. Wang Berberine and Coptidis Rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations Journal of Ethnopharmacology 126 2009 5 17
28. Y. Tjong, S. Ip, L. Lao, H.H.S. Fong, J.J.Y. Sung, B. Berman, and C. Che Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome Journal of Ethnopharmacology 135 2011 754 761
29. X. Ye, Y. Feng, Y. Tong, K.-M. Ng, S. Tsao, G.K.K. Lau, C. Sze, Y. Zhang, J. Tang, J. Shen, and S. Kobayashi Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats Journal of Ethnopharmacology 124 2009 130 136
30. X.-k. Zheng, Y.-j. Li, L. Zhang, W.-s. Feng, and X. Zhang Antihyperglycemic activity of Selaginella tamariscina (Beauv.) Spring Journal of Ethnopharmacology 133 2011 531 537
31. G. Zhong, X. Huang, K. Ma, S. Chen, and S. Qin Quality assessment of Coptis chinensis in China China Journal of Chinese Materia Medica 30 2005 495