Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection

Science

Volumn 350, Issue 6260, 2015, Pages 563-567

  Sewald, Xaver ^a,f   Ladinsky, Mark S ^b   Uchil, Pradeep D ^a   Beloor, Jagadish ^a   Pi, Ruoxi ^a   Herrmann, Christin ^a   Motamedi, Nasim ^a,f   Murooka, Thomas T ^c   Brehm, Michael A ^d   Greiner, Dale L ^d   Shultz, Leonard D ^e   Mempel, Thorsten R ^c   Bjorkman, Pamela J ^b   Kumar, Priti ^a   Mothes, Walther ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b California Institute of Technology   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e JACKSON LABORATORY   (United States)

^f UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD5 ANTIGEN; CD9 ANTIGEN; IMMUNOGLOBULIN D; LEUKOSIALIN; SIALOADHESIN; SIGLEC1 PROTEIN, MOUSE;

CELLS AND CELL COMPONENTS; DISEASE TRANSMISSION; RODENT; VIRAL DISEASE; VIRUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL CONTACT; CELL MIGRATION; CELL POPULATION; CONTROLLED STUDY; DENDRITIC CELL; ELECTRON TOMOGRAPHY; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LASER MICROSCOPY; LYMPHOCYTE; LYMPHOCYTE MIGRATION; LYMPHOID TISSUE; MACROPHAGE; MOUSE; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS INFECTION; SPLEEN CELL; SYNAPSE; T LYMPHOCYTE; VIRUS CELL INTERACTION; VIRUS PARTICLE; VIRUS TRANSMISSION; ANIMAL; C57BL MOUSE; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPH NODE; PHYSIOLOGY; SPLEEN; VIROLOGY; VIRUS ENTRY;

HUMAN IMMUNODEFICIENCY VIRUS; MURINE LEUKEMIA VIRUS; MUS;

ANIMALS; DENDRITIC CELLS; HIV INFECTIONS; HIV-1; HUMANS; LEUKEMIA VIRUS, MURINE; LYMPH NODES; LYMPHOCYTES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RETROVIRIDAE INFECTIONS; SIALIC ACID BINDING IG-LIKE LECTIN 1; SPLEEN; VIRUS INTERNALIZATION;

EID: 84945566054     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aab2749     Document Type: Article

References (30)

1. T. G. Phan, I. Grigorova, T. Okada, J. G. Cyster, Nat. Immunol. 8, 992-1000 (2007).
2. T. G. Phan, J. A. Green, E. E. Gray, Y. Xu, J. G. Cyster, Nat. Immunol. 10, 786-793 (2009).
3. Y. R. Carrasco, F. D. Batista, Immunity 27, 160-171 (2007).
4. As pLN sample preparation leads to cross-contamination, particularly of CD169+ macrophages markers on to other cells (5), we flanked all flow cytometry data with immune histochemistry.
5. E. E. Gray, S. Friend, K. Suzuki, T. G. Phan, J. G. Cyster, PLOS ONE 7, e38258 (2012).
6. P. U. Cameron et al., Science 257, 383-387 (1992).
7. T. B. Geijtenbeek et al., Cell 100, 587-597 (2000).
8. S. G. Turville et al., Nat. Immunol. 3, 975-983 (2002).
9. N. Izquierdo-Useros et al., PLOS Biol. 10, e1001315 (2012).
10. W. B. Puryear, X. Yu, N. P. Ramirez, B. M. Reinhard, S. Gummuluru, Proc. Natl. Acad. Sci. U.S.A. 109, 7475-7480 (2012).
11. W. B. Puryear et al., PLOS Pathog. 9, e1003291 (2013).
12. N. Izquierdo-Useros et al., PLOS Biol. 10, e1001448 (2012).
13. Materials and Methods are available as supplementary materials on Science Online.
14. C. Oetke, M. C. Vinson, C. Jones, P. R. Crocker, Mol. Cell. Biol. 26, 1549-1557 (2006).
15. MLV Gag-GFP produced in mouse embryonic fibroblasts rather than human HEK293 cells, was similarly captured at the pLN in a CD169-dependent manner (fig. S7D). Future in vivo studies should address the CD169-dependence for endogenously produced MLV.
16. Y. S. Kang et al., Proc. Natl. Acad. Sci. U.S.A. 101, 215-220 (2004).
17. L. Martinez-Pomares, S. Gordon, Trends Immunol. 33, 66-70 (2012).
18. M. W. Melkus et al., Nat. Med. 12, 1316-1322 (2006).
19. X. Sewald, D. G. Gonzalez, A. M. Haberman, W. Mothes, Nat. Commun. 3, 1320 (2012).
20. N. Baumgarth, Nat. Rev. Immunol. 11, 34-46 (2011).
21. T. Roe, T. C. Reynolds, G. Yu, P. O. Brown, EMBO J. 12, 2099-2108 (1993).
22. P. R. Crocker et al., EMBO J. 10, 1661-1669 (1991).
23. K. Gousset et al., PLOS Pathog. 4, e1000015 (2008).
24. A. E. Bennett et al., PLOS Pathog. 5, e1000591 (2009).
25. R. L. Felts et al., Proc. Natl. Acad. Sci. U.S.A. 107, 13336-13341 (2010).
26. W. Hübner et al., Science 323, 1743-1747 (2009).
27. M. S. Ladinsky et al., PLOS Pathog. 10, e1003899 (2014).
28. F. Li, X. Sewald, J. Jin, N. M. Sherer, W. Mothes, J. Virol. 88, 10541-10555 (2014).
29. G. N. Llewellyn, I. B. Hogue, J. R. Grover, A. Ono, PLOS Pathog. 6, e1001167 (2010).
30. T. T. Murooka et al., Nature 490, 283-287 (2012).