HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibodydependent cell-mediated cytotoxicity

Oncotarget

Volumn 6, Issue 31, 2015, Pages 32075-32088

  Peipp, Matthias ^a   Derer, Stefanie ^a   Lohse, Stefan ^a   Staudinger, Matthias ^a   Klausz, Katja ^a   Valerius, Thomas ^a   Gramatzki, Martin ^a   Kellner, Christian ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

ADCC; B7 H6; NK cells; NKp30; NKp80

Indexed keywords

ACTIVATION INDUCED C TYPE LECTIN EPIDERMAL GROWTH FACTOR RECEPTOR 2 SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; ANTINEOPLASTIC AGENT; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL P80 RELATED PROTEIN; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR B7 H6 EPIDERMAL GROWTH FACTOR RECEPTOR 2 SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; POLIOVIRUS RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR 2 SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; RITUXIMAB; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TRASTUZUMAB; ULBP2 EPIDERMAL GROWTH FACTOR RECEPTOR 2 SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; ERBB2 PROTEIN, HUMAN; KLRF1 PROTEIN, HUMAN; LECTIN; LIGAND; NCR3 PROTEIN, HUMAN;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; BREAST CANCER CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOLYSIS; DRUG BINDING; DRUG EFFICACY; DRUG POTENTIATION; DRUG TARGETING; HUMAN; HUMAN CELL; LYMPHOCYTOTOXICITY; NATURAL KILLER CELL; TUMOR CELL; ADENOCARCINOMA; BREAST NEOPLASMS; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; IMMUNOLOGY; IMMUNOTHERAPY; PATHOLOGY; TUMOR CELL CULTURE; WESTERN BLOTTING;

ADENOCARCINOMA; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; BLOTTING, WESTERN; BREAST NEOPLASMS; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOTHERAPY; KILLER CELLS, NATURAL; LECTINS, C-TYPE; LIGANDS; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; RECEPTOR, ERBB-2; RECEPTORS, NATURAL KILLER CELL; TUMOR CELLS, CULTURED;

EID: 84945565376     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5135     Document Type: Article

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