Experimental approaches for elucidating co-agonist regulation of NMDA receptor in motor neurons: Therapeutic implications for amyotrophic lateral sclerosis (ALS)

Journal of Pharmaceutical and Biomedical Analysis

Volumn 116, Issue , 2015, Pages 2-6

  Paul, Praveen ^a   de Belleroche, Jackie ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Amyotrophic lateral sclerosis (ALS); D Amino acid oxidase (DAO); D Serine; Glycine; Motor neurons

Indexed keywords

DEXTRO AMINO ACID OXIDASE; DEXTRO SERINE; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UBIQUITINATED PROTEIN; AMINO ACID RECEPTOR STIMULATING AGENT; SERINE;

AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CULTURE; EXCITOTOXICITY; FOREBRAIN; GENE MUTATION; GLIA CELL; HUMAN; IN VIVO STUDY; MAMMAL; MOTONEURON; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; SPINAL CORD; AGONISTS; ANIMAL; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; D-AMINO-ACID OXIDASE; EXCITATORY AMINO ACID AGONISTS; HUMANS; MOTOR NEURONS; RECEPTORS, N-METHYL-D-ASPARTATE; SERINE;

EID: 84945471407     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.12.040     Document Type: Article

References (38)

1. Tovar K.R., McGinley M.J., Westbrook G.L. Triheteromeric NMDA receptors at hippocampal synapses. J. Neurosci. 2013, 33:9150-9160.
2. Mothet J.P., Parent A.T., Wolosker H., Brady R.O., Linden D.J., Ferris C.D., Rogawski M.A., Snyder S.H. d-Serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:4926-4931.
3. Panatier A., Theodosis D.T., Mothet J.P., Touquet B., Pollegioni L., Poulain D.A., Oliet S.H. Glia-derived d-serine controls NMDA receptor activity and synaptic memory. Cell 2006, 125:775-784.
4. Fossat P., Turpin F.R., Sacchi S., Dulong J., Shi T., Rivet J.M., Sweedler J.V., Pollegioni L., Millan M.J., Oliet S.H., Mothet J.P. Glial d-serine gates NMDA receptors at excitatory synapses in prefrontal cortex. Cereb. Cortex 2012, 22:595-606.
5. Li Y., Sacchi, Pollegioni L., Basu A.C., Coyle J.T., Bolshakov V.Y. Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level. Nat. Commun. 2013, 4:1760-1766.
6. Papouin T., Ladépêche L., Ruel J., Sacchi S., Labasque M., Hanini M., Groc L., Pollegioni L., Mothet J.P., Oliet S.H. Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell 2012, 150:633-646.
7. Lisman J., Yasuda R., Raghavachari S. Mechanisms of CaMKII action in long-term potentiation. Nat. Rev. Neurosci. 2012, 13:169-182.
8. Barria A., Malinow R. NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. Neuron 2005, 48:289-301.
9. Mitchell J., Paul P., Chen H.J., Morris A., Payling M., Falchi M., Habgood J., Panoutsou S., Winkler S., Tisato V., Hajitou A., Smith B., Vance C., Shaw C., Mazarakis N.D., de Belleroche J. Familial amyotrophic lateral sclerosis is associated with a mutation in d-amino acid oxidase. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:7556-7561.
10. Paul P., de Belleroche J. The role of d-amino acids in amyotrophic lateral sclerosis pathogenesis: a review. Amino Acids 2012, 43:1823-1831.
11. Horiike K., Tojo H., Arai R., Nozaki M., Maeda T. d-Amino-acid oxidase is confined to the lower brain stem and cerebellum in rat brain: regional differentiation of astrocytes. Brain Res. 1994, 652:297-303.
12. Schell M.J., Molliver M.E., Snyder S.H. d-Serine an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:3948-3952.
13. Moreno S., Nardacci R., Cimini A., Cerù M.P. Immunocytochemical localization of d-aminoacid oxidase in rat brain. J. Neurocytol. 1999, 28:169-185.
14. Miya K., Inoue R., Takata Y., Abe M., Natsume R., Sakimura K., Hongou K., Miyawaki T., Mori H. Serine racemase is predominantly localized in neurons in mouse brain. J. Comp. Neurol. 2008, 510:641-654.
15. Wolosker H., Blackshaw S., Snyder S.H. Serine racemase: a glial enzyme synthesizing d-serine to regulate glutamate-N-methyl-d-aspartate neurotransmission. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:13409-13414.
16. Neumann M., Sampathu D.M., Kwong L.K., Truax A.C., Micsenyi M.C., Chou T.T., Bruce J., Schuck T., Grossman M., Clark C.M., McCluskey L.F., Miller B.L., Masliah E., Mackenzie I.R., Feldman H., Feiden W., Kretzschmar H.A., Trojanowski J.Q., Lee V.M. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006, 314:130-133.
17. DeJesus-Hernandez M., Mackenzie I.R., Boeve B.F., Boxer A.L., Baker M., Rutherford N.J., Nicholson A.M., Finch N.A., Flynn H., Adamson J., Kouri N., Wojtas A., Sengdy P., Hsiung G.Y., Karydas A., Seeley W.W., Josephs K.A., Coppola G., Geschwind D.H., Wszolek Z.K., Feldman H., Knopman D.S., Petersen R.C., Miller B.L., Dickson D.W., Boylan K.B., Graff-Radford N.R., Rademakers R. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 2011, 72:245-256.
18. Renton A.E., Majounie E., Waite A., Simón-Sánchez J., Rollinson S., Gibbs J.R., Schymick J.C., et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 2011, 72:257-268.
19. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J.P., Deng H.X., et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993, 362:59-62.
20. Sreedharan J., Blair I.P., Tripathi V.B., Hu X., Vance C., Rogelj B., Ackerley S., Durnall J.C., Williams K.L., Buratti E., Baralle F., de Belleroche J., Mitchell J.D., Leigh P.N., Al-Chalabi A., Miller C.C., Nicholson G., Shaw C.E. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 2008, 319:1668-1672.
21. Vance C., Rogelj B., Hortobagyi T., De Vos K.J., Nishimura A.L., Sreedharan J., Hu X., Smith B., Ruddy D., Wright P., Ganesalingam J., Williams K.L., Tripathi V., Al-Saraj S., Al-Chalabi A., Leigh P.N., Blair I.P., Nicholson G., de Belleroche J., Gallo J.M., Miller C.C., Shaw C.E. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 2009, 323:1208-1211.
22. Chen H.J., de Belleroche J. Endoplasmic reticulum (ER) stress in amyotrophic lateral sclerosis (ALS). Endoplasmic Reticulum Stress in Health and Disease 2012, 323-337. Springer, Dordrecht/Heidelberg/New York/London. P. Agostinis, A. Samali (Eds.).
23. Anagnostou G., Akbar M.T., Paul P., Angelinetta C., Steiner T.J., de Belleroche J. Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord. Neurobiol. Aging 2010, 31:969-985.
24. Chen H.J., Anagnostou G., Chai A., Withers J., Morris A., Adhikaree J., Pennetta G., de Belleroche J. Characterisation of the properties of a novel mutation in VAPB in familial ALS. J. Biol. Chem. 2010, 1-29.
25. Paul P., Murphy T., Oseni Z., Sivalokanathan S., de Belleroche J. Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in d-amino acid oxidase are mediated by d-serine. Neurobiol. Aging 2014, 35:876-885.
26. Konno R., Yasumura Y. Mouse mutant deficient in d-amino acid oxidase activity. Genetics 1983, 103:277-285.
27. Sasabe J., Miyoshi Y., Suzuki M., Mita M., Konno R., Matsuoka M., Hamase K., Aiso S. d-Amino acid oxidase controls motoneuron degeneration through d-serine. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:627-632.
28. Sasabe J., Chiba T., Yamada M., Okamoto K., Nishimoto I., Matsuoja M., Aiso S. d-Serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis. EMBO J. 2007, 26:4149-4159.
29. Katsuki H., Nonaka M., Shirakawa H., Kume T., Akaike A. Endogenous d-serine is involved in induction of neuronal death by N-methyl-d-aspartate and simulated ischemia in rat cerebrocortical slices. J. Pharmacol. Exp. Ther. 2004, 311:836-844.
30. Wu S., Barger S.W. Induction of serine racemase by inflammatory stimuli is dependent on AP-1. Ann. N. Y. Acad. Sci. 2004, 1035:133-146.
31. Bence N.F., Sampat R.M., Kopito R.R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001, 292:1552-1555.
32. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
33. Zhang X., Li L., Chen S., Yang D., Wang Y., Zhang X., Wang Z., Le W. Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy 2011, 7:412-425.
34. Sasaki S. Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 2011, 70:349-359.
35. Xie X., Dumas T., Tang L., Brennan T., Reeder T., Thomas W., Klein R.D., Flores J., O'Hara B.F., Heller H.C., Franken P. Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Res. 2005, 1052:212-221.
36. de Belleroche J., Recordati A., Rose F.C. Elevated levels of amino acids in the CSF of motor neuron disease patients. Neurochem. Pathol. 1984, 2:1-6.
37. Lane R.J., Bandopadhyay R., de Belleroche J. Abnormal glycine metabolism in motor neurone disease: studies on plasma and cerebrospinal fluid. J. R. Soc. Med. 1993, 86:501-505.
38. Liu Q.-R., Lopez-Corcuera B., Mandiyan S., Nelson H., Nelson N. Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structural features. J. Biol. Chem. 1993, 268:22802-22808.