Diet-induced changes in iron and n-3 fatty acid status and associations with cognitive performance in 8-11-year-old Danish children: Secondary analyses of the Optimal Well-Being, Development and Health for Danish Children through a Healthy New Nordic Diet School Meal Study

British Journal of Nutrition

Volumn 114, Issue 10, 2015, Pages 1623-1637

  Sorensen, Louise Bergmann ^a   Damsgaard, Camilla Trab ^a   Dalskov, Stine Mathilde ^a   Petersen, Rikke Agnete ^a   Egelund, Niels ^b   Dyssegaard, Camilla Brorup ^a   Stark, Ken D ^b   Andersen, Rikke ^c   Tetens, Inge ^d   Astrup, Arne ^d   Michaelsen, Kim Fleisher ^a   Lauritzen, Lotte ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF WATERLOO   (Canada)

^d TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Cognitive performance; Iron; n 3 PUFA; School meals; School performance

Indexed keywords

DOCOSAPENTAENOIC ACID; FERRITIN; HEMOGLOBIN; ICOSAPENTAENOIC ACID; IRON; OMEGA 3 FATTY ACID; IRON INTAKE;

ACADEMIC ACHIEVEMENT; ARTICLE; ATTENTION; CHILD; CHILD NUTRITION; CLUSTER ANALYSIS; COGNITION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DANISH CITIZEN; DIET; FEMALE; FERRITIN BLOOD LEVEL; FISH; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; IRON STORAGE; MALE; MATHEMATICS; MEAL; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; READING; SEX DIFFERENCE; ADMINISTRATION AND DOSAGE; ANIMAL; BLOOD; CATERING SERVICE; DENMARK; EDUCATION; IRON INTAKE; METABOLISM; NUTRITIONAL STATUS; PHYSIOLOGY; SCHOOL;

ANIMALS; CHILD; COGNITION; CROSS-OVER STUDIES; DENMARK; DIET; EDUCATIONAL MEASUREMENT; FATTY ACIDS, OMEGA-3; FEMALE; FERRITINS; FISHES; FOOD SERVICES; HEMOGLOBINS; HUMANS; IRON; IRON, DIETARY; LUNCH; MALE; MATHEMATICS; NUTRITIONAL STATUS; READING; SCHOOLS;

EID: 84945465566     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515003323     Document Type: Article

References (68)

1. McLean E, Cogswell M, Egli I, et al. (2009) Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutr 12, 444-454.
2. Ratnayake WMN & Galli C (2009) Fat and fatty acid terminology, methods of analysis and fat digestion and metabolism: a background review paper. Ann Nutr Metab 55, 8-43.
3. Uauy R & Dangour AD (2009) Fat and fatty acid requirements and recommendations for infants of 0-2 years and children of 2-18 years. Ann Nutr Metab 55, 76-96.
4. Bryan J, Osendarp S, Hughes D, et al. (2004) Nutrients for cognitive development in school-aged children. Nutr Rev 62, 295-306.
5. Chalon S (2006) Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins Leukot Essent Fatty Acids 75, 259-269.
6. McNamara RK & Carlson SE (2006) Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot Essent Fatty Acids 75, 329-349.
7. Hibbeln JR, Davis JM, Steer C, et al. (2007) Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 369, 578-585.
8. Daniels JL, Longnecker MP, Rowland AS, et al. (2004) Fish intake during pregnancy and early cognitive development of offspring. Epidemiology 15, 394-402.
9. Helland IB, Smith L, Blomen B, et al. (2008) Effect of supplementing pregnant and lactating mothers with n-3 verylong-chain fatty acids on children's IQ and body mass index at 7 years of age. Pediatrics 122, e472-e479.
10. Colombo J, Kannass KN, Shaddy DJ, et al. (2004) Maternal DHA and the development of attention in infancy and toddlerhood. Child Dev 75, 1254-1267.
11. Karr JE, Alexander JE & Winningham RG (2011) Omega-3 polyunsaturated fatty acids and cognition throughout the lifespan: a review. Nutr Neurosci 14, 216-225.
12. Kim J-L, Winkvist A, Aberg MAI, et al. (2010) Fish consumption and school grades in Swedish adolescents: a study of the large general population. Acta Paediatr 1992 99, 72-77.
13. De Groot RHM, Ouwehand C & Jolles J (2012) Eating the right amount of fish: inverted U-shape association between fish consumption and cognitive performance and academic achievement in Dutch adolescents. Prostaglandins Leukot Essent Fatty Acids 86, 113-117.
14. Koletzko B, Uauy R, Palou A, et al. (2010) Dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in children - A workshop report. Br J Nutr 103, 923-928.
15. Beard JL & Connor JR (2003) Iron status and neural functioning. Annu Rev Nutr 23, 41-58.
16. Beard JL (2008) Why iron deficiency is important in infant development. J Nutr 138, 2534-2536.
17. Benton D (2008) Micronutrient status, cognition and behavioral problems in childhood. Eur J Nutr 47, Suppl. 3, 38-50.
18. Grantham-McGregor S & Ani C (2001) A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr 131, 649S-666S; discussion 666S-668S.
19. Falkingham M, Abdelhamid A, Curtis P, et al. (2010) The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutr J 9, 4.
20. Andersen R, Biltoft-Jensen A, Christensen T, et al. (2014) Dietary effects of introducing school meals based on the New Nordic Diet - A randomised controlled trial in Danish children. The OPUS School Meal Study. Br J Nutr 111, 1967-1976.
21. Sørensen LB, Dyssegaard CB, Damsgaard CT, et al. (2015) The effects of Nordic school meals on concentration and school performance in 8-to 11-year-old children in the OPUS School Meal Study: a cluster-randomised, controlled, cross-over trial. Br J Nutr 113, 1280-1291.
22. Damsgaard CT, Dalskov S-M, Petersen RA, et al. (2012) Design of the OPUS School Meal Study: a randomised controlled trial assessing the impact of serving school meals based on the New Nordic Diet. Scand J Public Health 40, 693-703.
23. Nordic Council of Ministers (2004) Nordic Nutrition Recommendations 2004: NNR: Integrating Nutrition and Physical Activity, 4th ed., Copenhagen: Nordic Council of Ministers.
24. Mithril C, Dragsted LO, Meyer C, et al. (2012) Guidelines for the New Nordic Diet. Public Health Nutr 15, 1941-1947.
25. Morris NM & Udry JR (1980) Validation of a self-administered instrument to assess stage of adolescent development. J Youth Adolesc 9, 271-280.
26. Hjorth MF, Chaput J-P, Michaelsen K, et al. (2013) Seasonal variation in objectively measured physical activity, sedentary time, cardio-respiratory fitness and sleep duration among 8-11-year-old Danish children: a repeated-measures study. BMC Public Health 13, 808.
27. Biltoft-Jensen A, Hjorth MF, Trolle E, et al. (2013) Comparison of estimated energy intake using Web-based Dietary Assessment Software with accelerometer-determined energy expenditure in children. Food Nutr Res 57 (epublication 17 December 2013).
28. Henry CJK (2005) Basal metabolic rate studies in humans: measurement and development of new equations. Public Health Nutr 8, 1133-1152.
29. Black AE (2000) The sensitivity and specificity of the Goldberg cut-off for EI:BMR for identifying diet reports of poor validity. Eur J Clin Nutr 54, 395-404.
30. Cole TJ, Flegal KM, Nicholls D, et al. (2007) Body mass index cut offs to define thinness in children and adolescents: international survey. BMJ 335, 194.
31. Cole TJ, Bellizzi MC, Flegal KM, et al. (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320, 1240-1243.
32. World Health Organization, United Nations International Children's Emergency Fund & United Nations University (2001) Iron Deficiency Anaemia: Assessment, Prevention, and Control. A Guide for Programme Managers. Geneva: WHO.
33. Metherel AH, Aristizabal Henao JJ & Stark KD (2013) EPA and DHA levels in whole blood decrease more rapidly when stored at 20C as compared with room temperature, 4 and 75C. Lipids 48, 1079-1091.
34. Bates ME & Lemay EP Jr (2004) The d2 Test of attention: construct validity and extensions in scoring techniques. J Int Neuropsychol Soc 10, 392-400.
35. Brickenkamp R & Zillmer E (1998) The d2 Test of Attention. Seattle, WA: Hogrefe & Huber.
36. Wassenberg R, Hendriksen JGM, Hurks PPM, et al. (2008) Development of inattention, impulsivity, and processing speed as measured by the d2 Test: results of a large crosssectional study in children aged 7-13. Child Neuropsychol 14, 195-210.
37. Hansen KF (2007) MG/FG3: matematik grundlæggende, færdigheder grundlæggende: vejledning (MG3/FG3 Mathematics Basic: Manual), 2nd ed. Virum, Denmark: Hogrefe Psykologisk Forlag; (in Danish).
38. Hansen KF (2007) MG/FG4: matematik grundlæggende, færdigheder grundlæggende: vejledning (MG4/FG4 Mathematics Basic: Manual), 2nd ed. Virum, Denmark: Hogrefe Psykologisk Forlag; (in Danish).
39. Damsgaard CT, Dalskov S-M, Laursen RP, et al. (2014) Provision of healthy school meals does not affect the metabolic syndrome score in 8-11-year-old children, but reduces cardiometabolic risk markers despite increasing waist circumference. Br J Nutr 112, 1826-1836.
40. Altman D (1991) Practical Statistics for Medical Research. London: Chapman & Hall/CRC.
41. Laursen RP, Dalskov S-M, Damsgaard CT, et al. (2014) Backtransformation of treatment differences-an approximate method. Eur J Clin Nutr 68, 277-280.
42. R Core Team (2012) R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing.
43. Soemantri AG, Pollitt E & Kim I (1985) Iron deficiency anemia and educational achievement. Am J Clin Nutr 42, 1221-1228.
44. Pollitt E, Hathirat P, Kotchabhakdi NJ, et al. (1989) Iron deficiency and educational achievement in Thailand. Am J Clin Nutr 50, 687-696 discussion 696-697.
45. Halterman JS, Kaczorowski JM, Aligne CA, et al. (2001) Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics 107, 1381-1386.
46. Bruner AB, Joffe A, Duggan AK, et al. (1996) Randomised study of cognitive effects of iron supplementation in nonanaemic iron-deficient adolescent girls. Lancet 348, 992-996.
47. Lambert A, Knaggs K, Scragg R, et al. (2002) Effects of iron treatment on cognitive performance and working memory in non-anaemic, iron-deficient girls. J Psychol 31, 19-28.
48. Sungthong R, Mo-suwan L & Chongsuvivatwong V (2002) Effects of haemoglobin and serum ferritin on cognitive function in school children. Asia Pac J Clin Nutr 11, 117-122.
49. Lassek WD & Gaulin SJC (2011) Sex differences in the relationship of dietary fatty acids to cognitive measures in American children. Front Evol Neurosci 3, 5.
50. Engel S, Tronhjem KMH, Hellgren LI, et al. (2013) Docosahexaenoic acid status at 9 months is inversely associated with communicative skills in 3-year-old girls. Matern Child Nutr 9, 499-510.
51. Lauritzen L, Jorgensen MH, Olsen SF, et al. (2005) Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. Reprod Nutr Dev 45, 535-547.
52. Makrides M, Gibson RA, McPhee AJ, et al. (2010) Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA 304, 1675-1683.
53. Dalton A, Wolmarans P, Witthuhn RC, et al. (2009) A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. Prostaglandins Leukot Essent Fatty Acids 80, 143-149.
54. Parletta N, Cooper P, Gent DN, et al. (2013) Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. Prostaglandins Leukot Essent Fatty Acids 89, 71-79.
55. Baumgartner J, Smuts CM, Malan L, et al. (2012) Effects of iron and n-3 fatty acid supplementation, alone and in combination, on cognition in school children: a randomized, double-blind, placebo-controlled intervention in South Africa. Am J Clin Nutr 96, 1327-1338.
56. Richardson AJ & Montgomery P (2005) The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115, 1360-1366.
57. Richardson AJ & Puri BK (2002) A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry 26, 233-239.
58. Sinn N & Bryan J (2007) Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD. J Dev Behav Pediatr 28, 82-91.
59. Osendarp SJM, Baghurst KI, Bryan J, et al. (2007) Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia. Am J Clin Nutr 86, 1082-1093.
60. Kennedy DO, Jackson PA, Elliott JM, et al. (2009) Cognitive and mood effects of 8 weeks' supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10-12 years. Nutr Neurosci 12, 48-56.
61. Kirby A, Woodward A, Jackson S, et al. (2010) A double-blind, placebo-controlled study investigating the effects of omega-3 supplementation in children aged 8-10 years from a mainstream school population. Res Dev Disabil 31, 718-730.
62. McNamara RK, Able J, Jandacek R, et al. (2010) Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. Am J Clin Nutr 91, 1060-1067.
63. Richardson AJ, Burton JR, Sewell RP, et al. (2012) Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). PLOS ONE 7, e43909.
64. Muthayya S, Eilander A, Transler C, et al. (2009) Effect of fortification with multiple micronutrients and n-3 fatty acids on growth and cognitive performance in Indian schoolchildren: The CHAMPION (Children's Health and Mental Performance Influenced by Optimal Nutrition) Study. Am J Clin Nutr 89, 1766-1775.
65. Jackson PA, Reay JL, Scholey AB, et al. (2012) Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. Biol Psychol 89, 183-190.
66. Boucher O, Burden MJ, Muckle G, et al. (2011) Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. Am J Clin Nutr 93, 1025-1037.
67. Laursen RP, Lauritzen L, Ritz C, et al. (2015) Do healthy school meals affect illness, allergies and school attendance in 8-to 11-year-old children? A cluster-randomised controlled study. Eur J Clin Nutr 69, 626-631.
68. Eilander A, Gera T, Sachdev HS, et al. (2010) Multiple micronutrient supplementation for improving cognitive performance in children: systematic review of randomized controlled trials. Am J Clin Nutr 91, 115-130.