Loss of keratin 19 favours the development of cholestatic liver disease through decreased ductular reaction

Journal of Pathology

Volumn 237, Issue 3, 2015, Pages 343-354

  Chen, Yu ^a,b   Guldiken, Nurdan ^a,b   Spurny, Manuela ^b   Mohammed, Hawraman H A ^a   Haybaeck, Johannes ^c   Pollheimer, Marion J ^c   Fickert, Peter ^c   Gassler, Nikolaus ^d   Jeon, Min Kyung ^d   Trautwein, Christian ^a   Strnad, Pavel ^a,b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

cholangitis; DDC; ductular reaction; intermediate filament; stem cell

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; BICARBONATE; BILE ACID; CHOLIC ACID; CHOLINE; CYTOKERATIN 19; ETHIONINE; NOTCH2 RECEPTOR; 3,5-DIETHOXYCARBONYL-1,4-DIHYDROCOLLIDINE; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE COMPOSITION; BILE SECRETION; CELL PROLIFERATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE COURSE; FEMALE; HEPATIC PROGENITOR CELL; INTRAHEPATIC CHOLESTASIS; KNOCKOUT MOUSE; LIVER FIBROSIS; LIVER INJURY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION; ANIMAL; BILIARY CIRRHOSIS; CHEMICALLY INDUCED; CHOLESTASIS, EXTRAHEPATIC; COMMON BILE DUCT; COMPLICATION; DEFICIENCY; DISEASE MODEL; DRUG-INDUCED LIVER INJURY; EPITHELIUM CELL; GENETICS; LIGATION; LIVER; LIVER REGENERATION; MALE; METABOLISM; PATHOLOGY; SCLEROSING CHOLANGITIS; STEM CELL; SURGERY; TIME FACTOR; VITAMIN DEFICIENCY;

ANIMALS; CELL PROLIFERATION; CHOLANGITIS, SCLEROSING; CHOLESTASIS, EXTRAHEPATIC; CHOLIC ACID; CHOLINE DEFICIENCY; COMMON BILE DUCT; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; EPITHELIAL CELLS; ETHIONINE; KERATIN-19; LIGATION; LIVER; LIVER CIRRHOSIS, BILIARY; LIVER REGENERATION; MALE; MICE, KNOCKOUT; PHENOTYPE; PYRIDINES; SIGNAL TRANSDUCTION; STEM CELLS; TIME FACTORS;

EID: 84945464484     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4580     Document Type: Article

References (43)

1. Haines RL, Lane EB,. Keratins and disease at a glance. J Cell Sci 2012; 125: 3923-3928.
2. Pan X, Hobbs RP, Coulombe PA,. The expanding significance of keratin intermediate filaments in normal and diseased epithelia. Curr Opin Cell Biol 2013; 25: 47-56.
3. Omary MB, Ku NO, Strnad P, et al., Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest 2009; 119: 1794-1805.
4. Szeverenyi I, Cassidy AJ, Chung CW, et al., The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases. Hum Mutat 2008; 29: 351-360.
5. Toivola DM, Strnad P, Habtezion A, et al., Intermediate filaments take the heat as stress proteins. Trends Cell Biol 2010; 20: 79-91.
6. Strnad P, Paschke S, Jang KH, et al., Keratins: markers and modulators of liver disease. Curr Opin Gastroenterol 2012; 28: 209-216.
7. Moll R, Divo M, Langbein L,. The human keratins: biology and pathology. Histochem Cell Biol 2008; 129: 705-733.
8. Iyer A, Robert ME, Bifulco CB, et al., Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance. Hum Pathol 2008; 39: 1370-1377.
9. Strnad P, Stumptner C, Zatloukal K, et al., Intermediate filament cytoskeleton of the liver in health and disease. Histochem Cell Biol 2008; 129: 735-749.
10. Gouw AS, Clouston AD, Theise ND,. Ductular reactions in human liver: diversity at the interface. Hepatology 2011; 54: 1853-1863.
11. Williams MJ, Clouston AD, Forbes SJ,. Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology 2014; 146: 349-356.
12. Meriden Z, Forde KA, Pasha TL, et al., Histologic predictors of fibrosis progression in liver allografts in patients with hepatitis C virus infection. Clin Gastroenterol Hepatol 2010; 8: 289-296, e281-288.
13. Guldiken N, Usachov V, Levada K, et al., Keratins 8 and 18 are type II acute-phase responsive genes overexpressed in human liver disease. Liver Int 2015; 35: 1203-1212.
14. Govaere O, Komuta M, Berkers J, et al., Keratin 19: a key role player in the invasion of human hepatocellular carcinomas. Gut 2014; 63: 674-685.
15. Tao GZ, Toivola DM, Zhong B, et al., Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury. J Cell Sci 2003; 116: 4629-4638.
16. Stone MR, O'Neill A, Lovering RM, et al., Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization. J Cell Sci 2007; 120: 3999-4008.
17. Zhong B, Strnad P, Selmi C, et al., Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity. Hepatology 2009; 50: 546-554.
18. Tabibian JH, Masyuk AI, Masyuk TV, et al., Physiology of cholangiocytes. Compr Physiol 2013; 3: 541-565.
19. Glaser SS, Gaudio E, Miller T, et al., Cholangiocyte proliferation and liver fibrosis. Expert Rev Mol Med 2009; 11: e7.
20. Duncan AW, Dorrell C, Grompe M,. Stem cells and liver regeneration. Gastroenterology 2009; 137: 466-481.
21. Khan FM, Komarla AR, Mendoza PG, et al., Keratin 19 demonstration of canal of Hering loss in primary biliary cirrhosis: 'minimal change PBC'? Hepatology 2013; 57: 700-707.
22. Preisegger KH, Factor VM, Fuchsbichler A, et al., Atypical ductular proliferation and its inhibition by transforming growth factor β1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease. Lab Invest 1999; 79: 103-109.
23. Wang X, Foster M, Al-Dhalimy M, et al., The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci USA 2003; 100 (suppl 1): 11881-11888.
24. Akhurst B, Croager EJ, Farley-Roche CA, et al., A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver. Hepatology 2001; 34: 519-522.
25. Fickert P, Stoger U, Fuchsbichler A, et al., A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis. Am J Pathol 2007; 171: 525-536.
26. Fickert P, Fuchsbichler A, Wagner M, et al., The role of the hepatocyte cytokeratin network in bile formation and resistance to bile acid challenge and cholestasis in mice. Hepatology 2009; 50: 893-899.
27. Alpini G, Glaser SS, Ueno Y, et al., Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. Am J Physiol 1998; 274: G767-775.
28. Tamai Y, Ishikawa T, Bosl MR, et al., Cytokeratins 8 and 19 in the mouse placental development. J Cell Biol 2000; 151: 563-572.
29. Boulter L, Govaere O, Bird TG, et al., Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med 2012; 18: 572-579.
30. Hanada S, Snider NT, Brunt EM, et al., Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress. Gastroenterology 2010; 138: 1607-1617.
31. Strnad P, Tao GZ, Zhou Q, et al., Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models. Gastroenterology 2008; 134: 1169-1179.
32. Fickert P, Wagner M, Marschall HU, et al., 24-norursodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 2006; 130: 465-481.
33. Molnar A, Haybaeck J, Lackner C, et al., The cytoskeleton in nonalcoholic steatohepatitis: 100 years old but still youthful. Expert Rev Gastroenterol Hepatol 2011; 5: 167-177.
34. Wilhelmsson U, Faiz M, de Pablo Y, et al., Astrocytes negatively regulate neurogenesis through the Jagged1-mediated Notch pathway. Stem Cells 2012; 30: 2320-2329.
35. Toivola DM, Nakamichi I, Strnad P, et al., Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury. Am J Pathol 2008; 172: 882-892.
36. Haybaeck J, Stumptner C, Thueringer A, et al., Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model. Lab Invest 2012; 92: 857-867.
37. - umbrella: experimental evidence revisited. Curr Opin Gastroenterol 2012; 28: 253-257.
38. Depianto D, Kerns ML, Dlugosz AA, et al., Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet 2010; 42: 910-914.
39. Alam H, Sehgal L, Kundu ST, et al., Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells. Mol Biol Cell 2011; 22: 4068-4078.
40. Spee B, Carpino G, Schotanus BA, et al., Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. Gut 2010; 59: 247-257.
41. Hyder CL, Isoniemi KO, Torvaldson ES, et al., Insights into intermediate filament regulation from development to ageing. J Cell Sci 2011; 124: 1363-1372.
42. Fabris L, Strazzabosco M,. Epithelial-mesenchymal interactions in biliary diseases. Semin Liver Dis 2011; 31: 11-32.
43. Osterreicher CH, Trauner M,. Animal models of biliary tract injury. Curr Opin Gastroenterol 2012; 28: 239-243.