Many private mutations originate from the first few divisions of a human colorectal adenoma

Journal of Pathology

Volumn 237, Issue 3, 2015, Pages 355-362

  Kang, Haeyoun ^a   Salomon, Matthew P ^b   Sottoriva, Andrea ^c   Zhao, Junsong ^b   Toy, Morgan ^b   Press, Michael F ^b   Curtis, Christina ^d   Marjoram, Paul ^b   Siegmund, Kimberly ^b   Shibata, Darryl ^b  

^a CHA University   (South Korea)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

adenoma; Big Bang tumourigenesis; colorectal; intratumoural heterogeneity; mutation topography

Indexed keywords

ADULT; ARTICLE; CASE REPORT; COLORECTAL ADENOMA; DNA METHYLATION; FLUORESCENCE IN SITU HYBRIDIZATION; HETEROZYGOSITY LOSS; HUMAN; INTRATUMOURAL MUTATIONAL HETEROGENEITY; MALE; MUTANT; MUTATION; POINT MUTATION; POLYPLOIDY; PRIORITY JOURNAL; TUMOR MICROENVIRONMENT; ADENOMA; CELL DIVISION; CLONAL EVOLUTION; COLORECTAL TUMOR; DNA MICROARRAY; DNA MUTATIONAL ANALYSIS; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; PATHOLOGY; PHENOTYPE; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM;

TUMOR MARKER;

ADENOMA; BIOMARKERS, TUMOR; CELL DIVISION; CLONAL EVOLUTION; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; EPIGENESIS, GENETIC; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; POINT MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84945457918     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4581     Document Type: Article

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