Epstein-Barr virus modulates host cell microRNA-194 to promote IL-10 production and B lymphoma cell survival

American Journal of Transplantation

Volumn 15, Issue 11, 2015, Pages 2814-2824

  Harris Arnold, A ^a   Arnold, C P ^a   Schaffert, S ^a   Hatton, O ^a   Krams, S M ^a   Esquivel, C O ^a   Martinez, O M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; LATENT MEMBRANE PROTEIN 1; MICRORNA; MICRORNA 194; UNCLASSIFIED DRUG; IL10 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; B-CELL LYMPHOMA CELL LINE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; GENE OVEREXPRESSION; HOST CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOBLASTOID CELL LINE; LYMPHOPROLIFERATIVE DISEASE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADVERSE EFFECTS; B CELL LYMPHOMA; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; ORGAN TRANSPLANTATION; PATHOLOGY; PROCEDURES; REAL TIME POLYMERASE CHAIN REACTION; REFERENCE VALUE; TUMOR CELL CULTURE; VIROLOGY;

B-LYMPHOCYTES; CELL SURVIVAL; EPSTEIN-BARR VIRUS INFECTIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HERPESVIRUS 4, HUMAN; HUMANS; INTERLEUKIN-10; LYMPHOMA, B-CELL; LYMPHOPROLIFERATIVE DISORDERS; MICRORNAS; ORGAN TRANSPLANTATION; REAL-TIME POLYMERASE CHAIN REACTION; REFERENCE VALUES; TUMOR CELLS, CULTURED;

EID: 84945452672     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13375     Document Type: Article

References (36)

1. Cohen JI., Epstein Barr virus infection. N Engl J Med 2000; 343: 481-492.
2. Thorley-Lawson DA., Epstein-Barr virus: Exploiting the immune system. Nature Rev Immunol 2001; 1: 75-82.
3. Hatton O, Schaffert S, Harris-Arnold A, Krams SM, Martinez OM., The interplay between Epstein Barr Virus and B lymphocytes: Implications for infection, immunity, and disease. Immunol Res 2014; 58: 268-276.
4. Beatty PR, Krams SM, Martinez OM., Involvement of IL-10 in the autonomous growth of EBV-transformed B cell lines. J Immunol 1997; 158: 4045-4051.
5. Johannessen I, Perera SM, Gallagher A, Hopwood PA, Thomas JA, Crawford DH., Expansion in scid mice of Epstein-Barr virus-associated post-transplantation lymphoproliferative disease biopsy material. J Gen Virol 2002; 83: 173-178.
6. Birkeland SA, Bendtzen K, Moller B, Hamilton-Dutoit S, Andersen HK., Interleukin-10 and posttransplant lymphoproliferative disorder after kidney transplantation. Transplantation 1999; 67: 876-881.
7. Muti G, Klersy C, Baldanti F, et al., Epstein-Barr virus (EBV) load and interleukin-10 in EBV-positive and EBV-negative post-transplant lymphoproliferative disorders. Br J Haematol 2003; 122: 927-933.
8. Baiocchi OC, Colleoni GW, Caballero OL, et al., Epstein-Barr viral load, interleukin-6 and interleukin-10 levels in post-transplant lymphoproliferative disease: A nested case-control study in a renal transplant cohort. Leuk Lymphoma 2005; 46: 533-539.
9. Hinrichs C, Wendland S, Zimmermann H, et al., IL-6 and IL-10 in post-transplant lymphoproliferative disorders development and maintenance: A longitudinal study of cytokine plasma levels and T-cell subsets in 38 patients undergoing treatment. Transpl Int 2011; 24: 892-903.
10. Harris A, Krams SM, Martinez OM., MicroRNAs as immune regulators: Implications for transplantation. Am J Transplant 2010; 10: 713-719.
11. Sharma A, Kumar M, Aich J, et al., Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a. Proc Natl Acad Sci USA 2009; 106: 5761-5766.
12. Sheedy FJ, Palsson-McDermott E, Hennessy EJ, et al., Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol 2010; 11: 141-147.
13. Lambert SL, Martinez OM., Latent membrane protein 1 of EBV activates phosphatidylinositol 3-kinase to induce production of IL-10. J Immunol 2007; 179: 8225-8234.
14. Vaysberg M, Hatton O, Lambert SL, et al., Tumor-derived variants of Epstein-Barr virus latent membrane protein 1 induce sustained Erk activation and c-Fos. J Biol Chem 2008; 283: 36573-36585.
15. Arnold CP, Tan R, Zhou B, et al., MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Res 2011; 21: 798-810.
16. Linnstaedt SD, Gottwein E, Skalsky RL, Luftig MA, Cullen BR., Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. J Virol 2010; 84: 11670-11678.
17. Godshalk SE, Bhaduri-McIntosh S, Slack FJ., Epstein-Barr virus-mediated dysregulation of human microRNA expression. Cell Cycle 2008; 7: 3595-3600.
18. Lewis BP, Burge CB, Bartel DP., Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.
19. John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS., Human MicroRNA targets. PLoS Biol 2004; 2: e363.
20. Trujillo RD, Yue SB, Tang Y, O'Gorman WE, Chen CZ., The potential functions of primary microRNAs in target recognition and repression. Embo J 2010; 29: 3272-3285.
21. Miller G, Lipman M., Release of infectious Epstein-Barr virus by transformed marmoset leukocytes. Proc Natl Acad Sci U SA 1973; 70: 190-194.
22. Thorley-Lawson DA, Gross A., Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Engl J Med 2004; 350: 1328-1337.
23. Cameron JE, Fewell C, Yin Q, et al., Epstein-Barr virus growth/latency III program alters cellular microRNA expression. Virology 2008; 382: 257-266.
24. Forte E, Salinas RE, Chang C, et al., The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells. J Virol 2012; 86: 6889-6898.
25. Motsch N, Pfuhl T, Mrazek J, Barth S, Grasser FA., Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a. RNA Biol 2007; 4: 131-137.
26. Kluiver J, Poppema S, de Jong D, et al., BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol 2005; 207: 243-249.
27. Chai LE, Loh SK, Low ST, Mohamad MS, Deris S, Zakaria Z., A review on the computational approaches for gene regulatory network construction. Comput Biol Med 2014; 48C: 55-65.
28. Barthlemy M., Betweenness centrality in large complex networks. Eur Phys J B 2004; 38: 163-168.
29. Eis PS, Tam W, Sun L, et al., Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U SA 2005; 102: 3627-3632.
30. Thai TH, Calado DP, Casola S, et al., Regulation of the germinal center response by microRNA-155. Science 2007; 316: 604-608.
31. Dorsett Y, McBride KM, Jankovic M, et al., MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 2008; 28: 630-638.
32. Santpere G, Darre F, Blanco S, et al., Genome- wide analysis of wild-type Epstein-Barr virus genomes derived from healthy individuals of the 1000 Genomes Project. Genome Biol Evol 2014; 6: 846-860.
33. Ikeda T, Kobayashi R, Kogashiwa Y, Matsuda T, Kohno N., Epstein-barr virus diversity in immunocompetent healthy persons: Reassessment of the distribution of genetic variants. J Med Virol 2014; 86: 301-305.
34. Walling DM, Brown AL, Etienne W, Keitel WA, Ling PD., Multiple Epstein-Barr virus infections in healthy individuals. J Virol 2003; 77: 6546-6550.
35. Rubtsov YP, Rasmussen JP, Chi EY, et al., Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008; 28: 546-558.
36. Mauri C, Bosma A., Immune regulatory function of B cells. Annu Rev Immunol 2012; 30: 221-241.