Pressure overload by transverse aortic constriction induces maladaptive hypertrophy in a titin-truncated mouse model

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Zhou, Qifeng ^a   Kesteven, Scott ^b   Wu, Jianxin ^b   Aidery, Parwez ^a   Gawaz, Meinrad ^a   Gramlich, Michael ^a,b   Feneley, Michael P ^b,c,d   Harvey, Richard P ^b,c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIN; PROTEIN KINASE; TITIN PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; GENE MUTATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE OVERLOAD; MECHANICAL STRESS; MOUSE; NONHUMAN; TRANSVERSE AORTIC CONSTRICTION; ANIMAL; AORTA VALVE STENOSIS; C57BL MOUSE; CARDIOMYOPATHY, DILATED; COMPLICATION; DIAGNOSTIC IMAGING; DISEASE MODEL; ECHOGRAPHY; GENE TARGETING; GENETICS; HYPERTROPHY, LEFT VENTRICULAR; PATHOPHYSIOLOGY; PROCEDURES; TRANSGENIC MOUSE;

ANIMALS; AORTIC VALVE STENOSIS; CARDIOMYOPATHY, DILATED; DISEASE MODELS, ANIMAL; GENE KNOCK-IN TECHNIQUES; HYPERTROPHY, LEFT VENTRICULAR; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN KINASES; ULTRASONOGRAPHY;

EID: 84945345247     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/163564     Document Type: Article

References (21)

1. M. Nichols, N. Townsend, P. Scarborough, and M. Rayner, "Cardiovascular disease in Europe 2014: epidemiological update," European Heart Journal, vol. 35, no. 42, pp. 2950-2959, 2014.
2. H. Morita, J. Seidman, and C. E. Seidman, "Genetic causes of human heart failure," The Journal of Clinical Investigation, vol. 115, no. 3, pp. 518-526, 2005.
3. H. L. Granzier and S. Labeit, "The giant protein titin. A major player in myocardial mechanics, signaling, and disease," Circulation Research, vol. 94, no. 3, pp. 284-295, 2004.
4. S. Labeit and B. Kolmerer, "Titins: giant proteins in charge of muscle ultrastructure and elasticity," Science, vol. 270, no. 5234, pp. 293-296, 1995.
5. W. A. Linke, "Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction," Cardiovascular Research, vol. 77, no. 4, pp. 637-648, 2008.
6. B. Gerull, M. Gramlich, J. Atherton et al., "Mutations of TTN, encoding the giant muscle flament titin, cause familial dilated cardiomyopathy," Nature Genetics, vol. 30, no. 2, pp. 201-204, 2002.
7. D. S. Herman, L. Lam, M. R. G. Taylor et al., "Truncations of titin causing dilated cardiomyopathy," The New England Journal of Medicine, vol. 366, no. 7, pp. 619-628, 2012.
8. A. M. Roberts, J. S. Ware, D. S. Herman et al., "Integrated allelic, transcriptional, and phenomic dissection of the cardiac efects of titin truncations in health and disease," Science Translational Medicine, vol. 7, no. 270, 2015.
9. M. Gramlich, B. Michely, C. Krohne et al., "Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease," Journal of Molecular and Cellular Cardiology, vol. 47, no. 3, pp. 352-358, 2009.
10. J. N. Cohn, R. Ferrari, and N. Sharpe, "Cardiac remodeling- concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling," Journal of the American College of Cardiology, vol. 35, no. 3, pp. 569-582, 2000.
11. I. Kehat and J. D. Molkentin, "Molecular pathways underlying cardiac remodeling during pathophysiological stimulation," Circulation, vol. 122, no. 25, pp. 2727-2735, 2010.
12. M. Yoshimura, H. Yasue, K. Okumura et al., "Diferent secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure," Circulation, vol. 87, no. 2, pp. 464-469, 1993.
13. M. Gotthardt, R. E. Hammer, N. Hübner et al., "Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure," Journal of Biological Chemistry, vol. 278, no. 8, pp. 6059-6065, 2003.
14. M. Hoshijima, "Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures," The American Journal of Physiology-Heart and Circulatory Physiology, vol. 290, no. 4, pp. H1313-H1325, 2006.
15. S. Lange, D. Auerbach, P. McLoughlin et al., "Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2," Journal of Cell Science, vol. 115, no. 24, pp. 4925-4936, 2002.
16. S. H. Witt, H. Granzier, C. C. Witt, and S. Labeit, "MURF-1 and MURF-2 target a specifc subset of myofbrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination," Journal of Molecular Biology, vol. 350, no. 4, pp. 713-722, 2005.
17. T. Lamark, V. Kirkin, I. Dikic, and T. Johansen, "NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets," Cell Cycle, vol. 8, no. 13, pp. 1986-1990, 2009.
18. M. Gramlich, L. S. Pane, Q. F. Zhou et al., "Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy," EMBO Molecular Medicine, vol. 7, pp. 562-576, 2015.
19. H. Granzier and S. Labeit, "Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells," Muscle and Nerve, vol. 36, no. 6, pp. 740-755, 2007.
20. M. K. Miller, H. Granzier, E. Ehler, and C. C. Gregorio, "The sensitive giant: the role of titin-based stretch sensing complexes in the heart," Trends in Cell Biology, vol. 14, no. 3, pp. 119-126, 2004.
21. S. Lange, F. Xiang, A. Yakovenko et al., "The kinase domain of titin controls muscle gene expression and protein turnover," Science, vol. 308, no. 5728, pp. 1599-1603, 2005.