메뉴 건너뛰기




Volumn 22, Issue 12, 2015, Pages 581-590

HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration and invasion in lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CHEMOKINE RECEPTOR CXCR4; ELAV LIKE PROTEIN 1; FOLATE RECEPTOR 1; GELATINASE A; GELATINASE B; NANOPARTICLE; PLERIXAFOR; PROTEIN KINASE B; PROTEIN P27; SMALL INTERFERING RNA; ANTINEOPLASTIC AGENT; CXCR4 PROTEIN, HUMAN; ELAVL1 PROTEIN, HUMAN; HETEROCYCLIC COMPOUND;

EID: 84945162440     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2015.55     Document Type: Article
Times cited : (45)

References (44)
  • 2
    • 84872152304 scopus 로고    scopus 로고
    • TRIM28, a new molecular marker predicting metastasis and survival in early-stage non-small cell lung cancer
    • Liu L, Zhao E, Li C, Huang L, Xiao L, Cheng L et al. TRIM28, a new molecular marker predicting metastasis and survival in early-stage non-small cell lung cancer. Cancer Epidemiol 2013; 37: 71-78.
    • (2013) Cancer Epidemiol , vol.37 , pp. 71-78
    • Liu, L.1    Zhao, E.2    Li, C.3    Huang, L.4    Xiao, L.5    Cheng, L.6
  • 3
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 2011; 331: 1559-1564.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 4
    • 0038206771 scopus 로고    scopus 로고
    • The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases
    • Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP, Streiter RM et al. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med 2003; 167: 1676-1686.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1676-1686
    • Phillips, R.J.1    Burdick, M.D.2    Lutz, M.3    Belperio, J.A.4    Keane, M.P.5    Streiter, R.M.6
  • 5
    • 47749109823 scopus 로고    scopus 로고
    • The role of CXC chemokines and their receptors in cancer
    • Vandercappellen J, Van Damme J, Struyf S. The role of CXC chemokines and their receptors in cancer. Cancer Lett 2008; 267: 226-244.
    • (2008) Cancer Lett , vol.267 , pp. 226-244
    • Vandercappellen, J.1    Van Damme, J.2    Struyf, S.3
  • 6
    • 28544440733 scopus 로고    scopus 로고
    • Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells
    • Su L, Zhang J, Xu H, Wang Y, Chu Y, Liu R et al. Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells. Clin Cancer Res 2005; 11: 8273-8280.
    • (2005) Clin Cancer Res , vol.11 , pp. 8273-8280
    • Su, L.1    Zhang, J.2    Xu, H.3    Wang, Y.4    Chu, Y.5    Liu, R.6
  • 7
    • 2342451359 scopus 로고    scopus 로고
    • Stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space
    • Oonakahara K, Matsuyama W, Higashimoto I, Kawabata M, Arimura K, Osame M et al. Stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space. Am J Respir Cell Mol Biol 2004; 30: 671-677.
    • (2004) Am J Respir Cell Mol Biol , vol.30 , pp. 671-677
    • Oonakahara, K.1    Matsuyama, W.2    Higashimoto, I.3    Kawabata, M.4    Arimura, K.5    Osame, M.6
  • 8
    • 77952553533 scopus 로고    scopus 로고
    • Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung
    • Minamiya Y, Saito H, Takahashi N, Ito M, Imai K, Ono T et al. Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung. Lung Cancer 2010; 68: 466-471.
    • (2010) Lung Cancer , vol.68 , pp. 466-471
    • Minamiya, Y.1    Saito, H.2    Takahashi, N.3    Ito, M.4    Imai, K.5    Ono, T.6
  • 10
    • 56149118023 scopus 로고    scopus 로고
    • Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis
    • Na IK, Scheibenbogen C, Adam C, Stroux A, Ghadjar P, Thiel E et al. Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis. Hum Pathol 2008; 39: 1751-1755.
    • (2008) Hum Pathol , vol.39 , pp. 1751-1755
    • Na, I.K.1    Scheibenbogen, C.2    Adam, C.3    Stroux, A.4    Ghadjar, P.5    Thiel, E.6
  • 11
    • 79959906050 scopus 로고    scopus 로고
    • CXCR4 overexpression is associated with poor outcome in females diagnosed with stage IV non-small cell lung cancer
    • Otsuka S, Klimowicz AC, Kopciuk K, Petrillo SK, Konno M, Hao D et al. CXCR4 overexpression is associated with poor outcome in females diagnosed with stage IV non-small cell lung cancer. J Thorac Oncol 2011; 6: 1169-1178.
    • (2011) J Thorac Oncol , vol.6 , pp. 1169-1178
    • Otsuka, S.1    Klimowicz, A.C.2    Kopciuk, K.3    Petrillo, S.K.4    Konno, M.5    Hao, D.6
  • 12
    • 77953090345 scopus 로고    scopus 로고
    • CXCL12 (SDF-1)/CXCR4 pathway in cancer
    • Teicher BA, Fricker SP. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010; 16: 2927-2931.
    • (2010) Clin Cancer Res , vol.16 , pp. 2927-2931
    • Teicher, B.A.1    Fricker, S.P.2
  • 14
    • 79251599039 scopus 로고    scopus 로고
    • Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases
    • Uchida D, Onoue T, Kuribayashi N, Tomizuka Y, Tamatani T, Nagai H et al. Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases. Eur J Cancer 2011; 147: 452-459.
    • (2011) Eur J Cancer , vol.147 , pp. 452-459
    • Uchida, D.1    Onoue, T.2    Kuribayashi, N.3    Tomizuka, Y.4    Tamatani, T.5    Nagai, H.6
  • 15
    • 84871015161 scopus 로고    scopus 로고
    • Halting metastasis through CXCR4 inhibition
    • Ramsey DM, McAlpine SR. Halting metastasis through CXCR4 inhibition. Bioorg Med Chem Lett 2013; 23: 20-25.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 20-25
    • Ramsey, D.M.1    McAlpine, S.R.2
  • 16
    • 84860349448 scopus 로고    scopus 로고
    • A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
    • Uy GL, Rettig MP, Motabi IH, McFarland K, Trinkaus KM, Hladnik LM et al. A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood 2012; 119: 3917-3924.
    • (2012) Blood , vol.119 , pp. 3917-3924
    • Uy, G.L.1    Rettig, M.P.2    Motabi, I.H.3    McFarland, K.4    Trinkaus, K.M.5    Hladnik, L.M.6
  • 17
    • 67650410440 scopus 로고    scopus 로고
    • Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
    • Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK et al. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood 2009; 113: 6206-6214.
    • (2009) Blood , vol.113 , pp. 6206-6214
    • Nervi, B.1    Ramirez, P.2    Rettig, M.P.3    Uy, G.L.4    Holt, M.S.5    Ritchey, J.K.6
  • 20
    • 79952759375 scopus 로고    scopus 로고
    • Post transcriptional regulation of cancer traits by HuR
    • Abdelmohsen K, Gorospe M. Post transcriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA 2010; 1: 214-229.
    • (2010) Wiley Interdiscip Rev RNA , vol.1 , pp. 214-229
    • Abdelmohsen, K.1    Gorospe, M.2
  • 21
    • 84877821108 scopus 로고    scopus 로고
    • Multiple functions of the RNAbinding protein HuR in cancer progression, treatment responses and prognosis
    • Wang J, Guo Y, Chu H, Guan Y, Ji Bi, Wang B. Multiple functions of the RNAbinding protein HuR in cancer progression, treatment responses and prognosis. Int J Mol Sci 2013; 14: 10015-10041.
    • (2013) Int J Mol Sci , vol.14 , pp. 10015-10041
    • Wang, J.1    Guo, Y.2    Chu, H.3    Guan, Y.4    Bi, J.5    Wang, B.6
  • 22
    • 27744520451 scopus 로고    scopus 로고
    • HuR: Post-transcriptional paths to malignancy
    • López de Silanes I, Lal A, Gorospe M. HuR: post-transcriptional paths to malignancy. RNA Biol 2005; 2: 11-13.
    • (2005) RNA Biol , vol.2 , pp. 11-13
    • López De Silanes, I.1    Lal, A.2    Gorospe, M.3
  • 23
    • 0034657686 scopus 로고    scopus 로고
    • HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation
    • Wang WG, Caldwell MC, Lin SK, Furneaux H, Gorospe M. HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J 2000; 19: 2340-2350.
    • (2000) EMBO J , vol.19 , pp. 2340-2350
    • Wang, W.G.1    Caldwell, M.C.2    Lin, S.K.3    Furneaux, H.4    Gorospe, M.5
  • 24
    • 84859331650 scopus 로고    scopus 로고
    • Expression of the RNAbinding protein HuR and its clinical significance in human stage i and II lung adenocarcinoma
    • Lauriola L, Granone P, Ramella S, Lanza P, Ranelletti FO. Expression of the RNAbinding protein HuR and its clinical significance in human stage I and II lung adenocarcinoma. Histol Histopathol 2012; 27: 617-626.
    • (2012) Histol Histopathol , vol.27 , pp. 617-626
    • Lauriola, L.1    Granone, P.2    Ramella, S.3    Lanza, P.4    Ranelletti, F.O.5
  • 25
    • 33747601610 scopus 로고    scopus 로고
    • Expression of the ELAV-like protein HuR in human colon cancer: Association with tumor stage and cyclooxygenase-2
    • Denkert C, Koch I, von Keyserlingk N, Noske A, Niesporek S, Dietel M et al. Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. Mod Pathol 2006; 19: 1261-1269.
    • (2006) Mod Pathol , vol.19 , pp. 1261-1269
    • Denkert, C.1    Koch, I.2    Von Keyserlingk, N.3    Noske, A.4    Niesporek, S.5    Dietel, M.6
  • 26
    • 38849112559 scopus 로고    scopus 로고
    • Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression
    • Niesporek S, Kristiansen G, Thoma A, Weichert W, Noske A, Buckendahl AC et al. Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression. Int J Oncol 2008; 32: 341-347.
    • (2008) Int J Oncol , vol.32 , pp. 341-347
    • Niesporek, S.1    Kristiansen, G.2    Thoma, A.3    Weichert, W.4    Noske, A.5    Buckendahl, A.C.6
  • 27
    • 84925286231 scopus 로고    scopus 로고
    • Expression of the ELAV-like protein HuR in the cytoplasm is associated with endometrial carcinoma progression
    • Wang D, Wang M, Hu C, Shuang T, Zhou Y, Yan X. Expression of the ELAV-like protein HuR in the cytoplasm is associated with endometrial carcinoma progression. Tumour Biol 2014; 35: 11939-11947.
    • (2014) Tumour Biol , vol.35 , pp. 11939-11947
    • Wang, D.1    Wang, M.2    Hu, C.3    Shuang, T.4    Zhou, Y.5    Yan, X.6
  • 28
    • 84906837700 scopus 로고    scopus 로고
    • Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells
    • Al-Souhibani N, Al-Ghamdi M, Al-Ahmadi W, Khabar KS. Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells. Carcinogenesis 2014; 35: 1983-1992.
    • (2014) Carcinogenesis , vol.35 , pp. 1983-1992
    • Al-Souhibani, N.1    Al-Ghamdi, M.2    Al-Ahmadi, W.3    Khabar, K.S.4
  • 29
    • 0034981225 scopus 로고    scopus 로고
    • Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector
    • Ramesh R, Saeki T, Templeton NS, Ji L, Stephens LC, Ito I et al. Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol Ther 2001; 3: 337-350.
    • (2001) Mol Ther , vol.3 , pp. 337-350
    • Ramesh, R.1    Saeki, T.2    Templeton, N.S.3    Ji, L.4    Stephens, L.C.5    Ito, I.6
  • 30
    • 11144301272 scopus 로고    scopus 로고
    • Nanoparticle based systemic gene therapy for lung cancer: Molecular mechanisms, and strategies to suppress nanoparticle-mediated inflammatory response
    • Began G, Ito I, Branch CD, Clifton Stephens L, Roth JA, Ramesh R. Nanoparticle based systemic gene therapy for lung cancer: molecular mechanisms, and strategies to suppress nanoparticle-mediated inflammatory response. Technol Cancer Res Treat 2004; 3: 647-657.
    • (2004) Technol Cancer Res Treat , vol.3 , pp. 647-657
    • Began, G.1    Ito, I.2    Branch, C.D.3    Clifton Stephens, L.4    Roth, J.A.5    Ramesh, R.6
  • 31
    • 84905485892 scopus 로고    scopus 로고
    • Chitosan coated poly(lactic acid) polymeric nanoparticle-mediated combinatorial delivery of cisplatin and siRNA/plasmid DNA chemosensitizes cisplatin-resistant human ovarian cancer cells
    • Babu A, Wang Q, Muralidharan R, Shanker M, Munshi A, Ramesh R. Chitosan coated poly(lactic acid) polymeric nanoparticle-mediated combinatorial delivery of cisplatin and siRNA/plasmid DNA chemosensitizes cisplatin-resistant human ovarian cancer cells. Mol Pharm 2014; 11: 2720-2733.
    • (2014) Mol Pharm , vol.11 , pp. 2720-2733
    • Babu, A.1    Wang, Q.2    Muralidharan, R.3    Shanker, M.4    Munshi, A.5    Ramesh, R.6
  • 32
    • 0034502591 scopus 로고    scopus 로고
    • Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro
    • Saeki T, Mhashilkar A, Chada S, Branch C, Roth JA, Ramesh R. Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro. Gene Ther 2000; 7: 2051-2057.
    • (2000) Gene Ther , vol.7 , pp. 2051-2057
    • Saeki, T.1    Mhashilkar, A.2    Chada, S.3    Branch, C.4    Roth, J.A.5    Ramesh, R.6
  • 33
    • 0041513362 scopus 로고    scopus 로고
    • Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor
    • Ramesh R, Mhashilkar AM, Tanaka F, Saito Y, Branch CD, Sieger K et al. Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor. Cancer Res 2003; 63: 5105-5113.
    • (2003) Cancer Res , vol.63 , pp. 5105-5113
    • Ramesh, R.1    Mhashilkar, A.M.2    Tanaka, F.3    Saito, Y.4    Branch, C.D.5    Sieger, K.6
  • 34
    • 84937850574 scopus 로고    scopus 로고
    • Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activity
    • Panneerselvam J, Shanker M, Jin J, Branch CD, Muralidharan R, Zhao DY et al. Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activity. Oncotarget 2015; 18: 16271-16286.
    • (2015) Oncotarget , vol.18 , pp. 16271-16286
    • Panneerselvam, J.1    Shanker, M.2    Jin, J.3    Branch, C.D.4    Muralidharan, R.5    Zhao, D.Y.6
  • 35
    • 2342623458 scopus 로고    scopus 로고
    • Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells
    • Ramesh R, Ito I, Gopalan B, Saito Y, Mhashilkar AM, Chada S. Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells. Mol Ther 2004; 9: 510-518.
    • (2004) Mol Ther , vol.9 , pp. 510-518
    • Ramesh, R.1    Ito, I.2    Gopalan, B.3    Saito, Y.4    Mhashilkar, A.M.5    Chada, S.6
  • 36
    • 84924975503 scopus 로고    scopus 로고
    • Disruption of the CXCR-4/SDF axis by interleukin (IL)-24 reduces tumor cell migration and invasion in lung cancer cells
    • Panneerselvam J, Jin J, Shanker M, Lauderdale J, Bates J, Wang Q et al. Disruption of the CXCR-4/SDF axis by interleukin (IL)-24 reduces tumor cell migration and invasion in lung cancer cells. PLoS One 2015; 10: e0122439.
    • (2015) PLoS One , vol.10 , pp. e0122439
    • Panneerselvam, J.1    Jin, J.2    Shanker, M.3    Lauderdale, J.4    Bates, J.5    Wang, Q.6
  • 37
    • 84911888437 scopus 로고    scopus 로고
    • Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer
    • Liu J, Ping W, Zu Y, Sun W. Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer. Int J Clin Exp Pathol 2014; 7: 6040-6047.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 6040-6047
    • Liu, J.1    Ping, W.2    Zu, Y.3    Sun, W.4
  • 38
    • 0035286224 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases 1, 2, 9 and their tissue inhibitors in stage II non-small cell lung cancer: Implications for MMP inhibition therapy
    • Pritchard SC, Nicolson MC, Lloret C, McKay JA, Ross VG, Kerr KM et al. Expression of matrix metalloproteinases 1, 2, 9 and their tissue inhibitors in stage II non-small cell lung cancer: implications for MMP inhibition therapy. Oncol Rep 2001; 8: 421-424.
    • (2001) Oncol Rep , vol.8 , pp. 421-424
    • Pritchard, S.C.1    Nicolson, M.C.2    Lloret, C.3    McKay, J.A.4    Ross, V.G.5    Kerr, K.M.6
  • 39
    • 9444239192 scopus 로고    scopus 로고
    • Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
    • Darash-Yahana M, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J 2004; 18: 1240-1242.
    • (2004) FASEB J , vol.18 , pp. 1240-1242
    • Darash-Yahana, M.1    Pikarsky, E.2    Abramovitch, R.3    Zeira, E.4    Pal, B.5    Karplus, R.6
  • 40
    • 29344451650 scopus 로고    scopus 로고
    • CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12
    • Chinni SR, Sivalogan S, Dong Z, Filho JC, Deng X, Bonfil RD et al. CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. Prostate 2006; 66: 32-48.
    • (2006) Prostate , vol.66 , pp. 32-48
    • Chinni, S.R.1    Sivalogan, S.2    Dong, Z.3    Filho, J.C.4    Deng, X.5    Bonfil, R.D.6
  • 41
    • 84975249460 scopus 로고    scopus 로고
    • Designing of tumor-targeted HuRsiRNA nanoparticle as a therapeutic for lung cancer
    • Gandhi V, Mehta K, Grover RK, Pathak S, Aggarwal BB (eds). Springer International Publishing: Switzerland
    • Muralidharan R, Babu A, Basalingappa K, Mehta M, Munshi A, Ramesh R. Designing of tumor-targeted HuRsiRNA nanoparticle as a therapeutic for lung cancer. In: Gandhi V, Mehta K, Grover RK, Pathak S, Aggarwal BB (eds). Multitargeted Approach to the Treatment of Cancer. Springer International Publishing: Switzerland, pp 277-294, 2015.
    • (2015) Multitargeted Approach to the Treatment of Cancer , pp. 277-294
    • Muralidharan, R.1    Babu, A.2    Basalingappa, K.3    Mehta, M.4    Munshi, A.5    Ramesh, R.6
  • 42
    • 84975249475 scopus 로고    scopus 로고
    • Nanoparticle-mediated siRNA delivery for lung cancer treatment
    • Naik J (ed). IAPC Publishing: Croatia
    • Babu A, Amreddy N, Muralidharan R, Munshi A, Ramesh R. Nanoparticle-mediated siRNA delivery for lung cancer treatment. In: Naik J (ed). Nano Based Drug Delivery. IAPC Publishing: Croatia, pp 195-215, 2015.
    • (2015) Nano Based Drug Delivery , pp. 195-215
    • Babu, A.1    Amreddy, N.2    Muralidharan, R.3    Munshi, A.4    Ramesh, R.5
  • 43
    • 0038788884 scopus 로고    scopus 로고
    • Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR
    • Akool El-S, Kleinert H, Hamada FM, Abdelwahab MH, Förstermann U, Pfeilschifter J et al. Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR. Mol Cell Biol 2003; 23: 4901-4916.
    • (2003) Mol Cell Biol , vol.23 , pp. 4901-4916
    • El-S, A.1    Kleinert, H.2    Hamada, F.M.3    Abdelwahab, M.H.4    Förstermann, U.5    Pfeilschifter, J.6
  • 44
    • 84938633467 scopus 로고    scopus 로고
    • CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1/2
    • Chen H, Xu X, Teng J, Cheng S, Bunjhoo H, Cao Y et al. CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1/2. Int J Clin Exp Pathol 2015; 8: 6700-6777.
    • (2015) Int J Clin Exp Pathol , vol.8 , pp. 6700-6777
    • Chen, H.1    Xu, X.2    Teng, J.3    Cheng, S.4    Bunjhoo, H.5    Cao, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.