Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung

Lung Cancer

Volumn 68, Issue 3, 2010, Pages 466-471

  Minamiya Yoshihiro, Y ^a   Saito, Hajime ^a   Takahashi, Naoko ^a   Ito, Manabu ^a   Imai, Kazuhiro ^a   Ono, Takashi ^a   Motoyama, Satoru ^a   Ogawa, Junichi ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chemokine; Clinicopathological factor; CXCR4; Non small cell lung cancer; Prognosis; RT PCR

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; PLATINUM DERIVATIVE; UFT; BIOLOGICAL MARKER; CXCR4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG SURGERY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SURVIVAL RATE; SURVIVAL TIME; TUMOR CELL; ADENOCARCINOMA; CANCER STAGING; DISEASE COURSE; LUNG NEOPLASMS; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN TRANSPORT; SURVIVAL;

ADENOCARCINOMA; AGED; BIOLOGICAL MARKERS; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROTEIN TRANSPORT; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX FACTORS; SURVIVAL ANALYSIS;

EID: 77952553533     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2009.07.015     Document Type: Article

References (18)

1. Mareel M., Leroy A. Clinical, cellular, and molecular aspects of cancer invasion. Physiol Rev 2003, 83:337-376.
2. Campbell D.J., Kim C.H., Butcher E.C. Chemokines in the systemic organization of immunity. Immunol Rev 2003, 195:58-71.
3. Salvucci O., Bouchard A., Baccarelli A., Deschênes J., Sauter G., Simon R., et al. The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study. Breast Cancer Res Treat 2006, 97:275-283.
4. Sasaki K., Natsugoe S., Ishigami S., Matsumoto M., Okumura H., Setoyama T., et al. Expression of CXCL12 and its receptor CXCR4 in esophageal squamous cell carcinoma. Oncol Rep 2009, 21:65-71.
5. Lee H.J., Kim S.W., Kim H.Y., Li S., Yun H.J., Song K.S., et al. Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. Int J Oncol 2009, 34:473-480.
6. Schimanski C.C., Bahre R., Gockel I., Müller A., Frerichs K., Hörner V., et al. Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4. Br J Cancer 2006, 95:210-217.
7. Brand S., Dambacher J., Beigel F., Olszak T., Diebold J., Otte J.M., et al. CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation. Exp Cell Res 2005, 310:117-130.
8. Darash-Yahana M., Pikarsky E., Abramovitch R., Zeira E., Pal B., Karplus R., et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J 2004, 18:1222-1240.
9. Kim S.Y., Lee C.H., Midura B.V., Yeung C., Mendoza A., Hong S.H., et al. Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases. Clin Exp Metastasis 2008, 25:201-211.
10. Wagner P.L., Hyjek E., Vazquez M.F., Meherally D., Liu Y.F., Chadwick P.A., et al. CXCL12 and CXCR4 in adenocarcinoma of the lung: association with metastasis and survival. J Thorac Cardiovasc Surg 2009, 137:615-621.
11. Spano J.P., Andre F., Morat L., Sabatier L., Besse B., Combadiere C., et al. Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome. Ann Oncol 2004, 15:613-617.
12. Na I.K., Scheibenbogen C., Adam C., Stroux A., Ghadjar P., Thiel E., et al. Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis. Hum Pathol 2008, 39:1751-1755.
13. Woo S.U., Bae J.W., Kim C.H., Lee J.B., Koo B.W. A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer. Ann Surg Oncol 2008, 15:281-285.
14. Blot E., Laberge-Le Couteulx S., Jamali H., Cornic M., Guillemet C., Duval C., et al. CXCR4 membrane expression in node-negative breast cancer. Breast J 2008, 14:268-274.
15. Naruke T., Suemasu K., Ishikawa S. Lymph node mapping and curability at various levels of metastasis in resected lung cancer. J Thorac Cardiovasc Surg 1978, 76:832-839.
16. Ptasznik A., Urbanowska E., Chinta S., Costa M.A., Katz B.A., Stanislaus M.A., et al. Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells. J Exp Med 2002, 196:667-678.
17. Yoshitake N., Fukui H., Yamagishi H., Sekikawa A., Fujii S., Tomita S., et al. Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer. Br J Cancer 2008, 98:1682-1689.
18. Zeelenberg I.S., Ruuls-Van Stalle L., Roos E. Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma. J Clin Invest 2001, 108:269-277.