CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Oncotarget

Volumn 6, Issue 30, 2015, Pages 29725-29739

  Wilkinson, Richard D A ^a   Magorrian, Sinead M ^a   Williams, Rich ^a   Young, Andrew ^a   Small, Donna M ^a   Scott, Christopher J ^a   Burden, Roberta E ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Cancer; Chemokine; Inflammation; Microenvironment; Protease

Indexed keywords

CATHEPSIN S; CD74 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; SHORT HAIRPIN RNA; B LYMPHOCYTE ANTIGEN; CATHEPSIN; HLA ANTIGEN CLASS 2; INVARIANT CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; BRAIN TUMOR; BREAST TUMOR; CELL MIGRATION; COLON TUMOR; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE MIGRATION; MOUSE; NONHUMAN; PHARMACODYNAMICS; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TUMOR MICROENVIRONMENT; 3T3 CELL LINE; ANIMAL; C57BL MOUSE; CELL LINE; CELL MOTION; CELL PROLIFERATION; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; NEOPLASM; PATHOLOGY; RNA INTERFERENCE; TRANSCRIPTION INITIATION; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; BLOTTING, WESTERN; CATHEPSINS; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CCL2; HEK293 CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS; NIH 3T3 CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTIONAL ACTIVATION;

EID: 84945152144     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5065     Document Type: Article

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