Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction

Cardiovascular Research

Volumn 100, Issue 1, 2013, Pages 84-94

  Chen, Han ^a,b   Wang, Jing ^b   Xiang, Mei Xiang ^a   Lin, Yan ^a   He, Aina ^a,c   Jin, Chun Na ^a   Guan, Jian ^b   Sukhova, Galina K ^b   Libby, Peter ^b   Wang, Jian An ^a   Shi, Guo Ping ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Cathepsin S; Collagen; Fibronectin; Myocardial infarction; Myofibroblast; Trans differentiation

Indexed keywords

ALOXISTATIN; ALPHA SMOOTH MUSCLE ACTIN; CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CD4 ANTIGEN; CD8 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CYSTATIN C; FIBRONECTIN; FIBRONECTIN EXTRA DOMAIN A; MESSENGER RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TROPONIN T; UNCLASSIFIED DRUG; VIMENTIN;

ALTERNATIVE RNA SPLICING; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOVASCULAR INFLAMMATION; CARDIOVASCULAR PARAMETERS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL TRANSDIFFERENTIATION; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CORONARY ARTERY LIGATION; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; FUNCTIONAL DISEASE; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE REMODELLING; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HYPOTHESIS; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATORY CELL; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MYOFIBROBLAST; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; SCAR FORMATION; SHAM PROCEDURE;

CATHEPSIN S; COLLAGEN; FIBRONECTIN; MYOCARDIAL INFARCTION; MYOFIBROBLAST; TRANS-DIFFERENTIATION;

ACTINS; ANIMALS; CATHEPSINS; CELL TRANSDIFFERENTIATION; COLLAGEN; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOFIBROBLASTS; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84887345613     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt158     Document Type: Article

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