-
1
-
-
47949116252
-
SHARP Investigators Study Group: Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Haüssinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J, SHARP Investigators Study Group: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-390.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
De Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Haüssinger, D.19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
-
2
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, Xu J, Sun Y, Liang H, Liu J, Wang J, Tak WY, Pan H, Burock K, Zou J, Voliotis D, Guan Z: Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009;10:25-34.
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
Tsao, C.J.4
Qin, S.5
Kim, J.S.6
Luo, R.7
Feng, J.8
Ye, S.9
Yang, T.S.10
Xu, J.11
Sun, Y.12
Liang, H.13
Liu, J.14
Wang, J.15
Tak, W.Y.16
Pan, H.17
Burock, K.18
Zou, J.19
Voliotis, D.20
Guan, Z.21
more..
-
3
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O'Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA, BRIM-3 Study Group: Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-2516.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
Dummer, R.7
Garbe, C.8
Testori, A.9
Maio, M.10
Hogg, D.11
Lorigan, P.12
Lebbe, C.13
Jouary, T.14
Schadendorf, D.15
Ribas, A.16
O'Day, S.J.17
Sosman, J.A.18
Kirkwood, J.M.19
Eggermont, A.M.20
Dreno, B.21
Nolop, K.22
Li, J.23
Nelson, B.24
Hou, J.25
Lee, R.J.26
Flaherty, K.T.27
McArthur, G.A.28
Study Group, B.29
more..
-
4
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-566.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
Fujiwara, S.7
Watanabe, H.8
Kurashina, K.9
Hatanaka, H.10
Bando, M.11
Ohno, S.12
Ishikawa, Y.13
Aburatani, H.14
Niki, T.15
Sohara, Y.16
Sugiyama, Y.17
Mano, H.18
-
6
-
-
11144236505
-
MTOR and P70 S6 kinase expression in primary liver neoplasms
-
Sahin F, Kannangai R, Adegbola O, Wang J, Su G, Torbenson M: mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res 2004;10:8421-8425.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8421-8425
-
-
Sahin, F.1
Kannangai, R.2
Adegbola, O.3
Wang, J.4
Su, G.5
Torbenson, M.6
-
7
-
-
0027954225
-
C-met mRNA overexpression in human hepatocellular carcinoma
-
Boix L, Rosa JL, Ventura F, Castells A, Bruix J, Rodés J, Bartrons R: c-met mRNA overexpression in human hepatocellular carcinoma. Hepatology 1994;19:88-91.
-
(1994)
Hepatology
, vol.19
, pp. 88-91
-
-
Boix, L.1
Rosa, J.L.2
Ventura, F.3
Castells, A.4
Bruix, J.5
Rodés, J.6
Bartrons, R.7
-
8
-
-
0346725866
-
The role of the IGF axis in hepatocarcinogenesis
-
Scharf JG, Braulke T: The role of the IGF axis in hepatocarcinogenesis. Horm Metab Res 2003;35:685-693.
-
(2003)
Horm Metab Res
, vol.35
, pp. 685-693
-
-
Scharf, J.G.1
Braulke, T.2
-
9
-
-
0345006147
-
Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas
-
de La Coste A, Romagnolo B, Billuart P, Renard CA, Buendia MA, Soubrane O, Fabre M, Chelly J, Beldjord C, Kahn A, Perret C: Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 1998;95:8847-8851.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8847-8851
-
-
De La Coste, A.1
Romagnolo, B.2
Billuart, P.3
Renard, C.A.4
Buendia, M.A.5
Soubrane, O.6
Fabre, M.7
Chelly, J.8
Beldjord, C.9
Kahn, A.10
Perret, C.11
-
10
-
-
42549164807
-
Wnt signalling and its impact on development and cancer
-
Klaus A, Birchmeier W: Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008;8:387-398.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 387-398
-
-
Klaus, A.1
Birchmeier, W.2
-
11
-
-
32544437230
-
Hedgehog signaling in human hepatocellular carcinoma
-
Patil MA, Zhang J, Ho C, Cheung ST, Fan ST, Chen X: Hedgehog signaling in human hepatocellular carcinoma. Cancer Biol Ther 2006;5:111-117.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 111-117
-
-
Patil, M.A.1
Zhang, J.2
Ho, C.3
Cheung, S.T.4
Fan, S.T.5
Chen, X.6
-
12
-
-
0035132143
-
Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: A prospective study
-
Poon RT, Ng IO, Lau C, Zhu LX, Yu WC, Lo CM, Fan ST, Wong J: Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: a prospective study. Ann Surg 2001;233:227-235.
-
(2001)
Ann Surg
, vol.233
, pp. 227-235
-
-
Poon, R.T.1
Ng, I.O.2
Lau, C.3
Zhu, L.X.4
Yu, W.C.5
Lo, C.M.6
Fan, S.T.7
Wong, J.8
-
13
-
-
75649116842
-
Early skin toxicity as a predictive factor for tumor control in hepatocellular carcinoma patients treated with sorafenib
-
Vincenzi B, Santini D, Russo A, Addeo R, Giuliani F, Montella L, Rizzo S, Venditti O, Frezza AM, Caraglia M, Colucci G, Del Prete S, Tonini G: Early skin toxicity as a predictive factor for tumor control in hepatocellular carcinoma patients treated with sorafenib. Oncologist 2010;15:85-92.
-
(2010)
Oncologist
, vol.15
, pp. 85-92
-
-
Vincenzi, B.1
Santini, D.2
Russo, A.3
Addeo, R.4
Giuliani, F.5
Montella, L.6
Rizzo, S.7
Venditti, O.8
Frezza, A.M.9
Caraglia, M.10
Colucci, G.11
Del Prete, S.12
Tonini, G.13
-
14
-
-
84881031034
-
Sorafenib in advanced hepatocellular carcinoma: Hypertension as a potential surrogate marker for efficacy
-
Estfan B, Byrne M, Kim R: Sorafenib in advanced hepatocellular carcinoma: hypertension as a potential surrogate marker for efficacy. Am J Clin Oncol 2013;36:319-324.
-
(2013)
Am J Clin Oncol
, vol.36
, pp. 319-324
-
-
Estfan, B.1
Byrne, M.2
Kim, R.3
-
15
-
-
80053212846
-
The significance of early alpha-fetoprotein level changes in predicting clinical and survival benefits in advanced hepatocellular carcinoma patients receiving sorafenib
-
Yau T, Yao TJ, Chan P, Wong H, Pang R, Fan ST, Poon RT: The significance of early alpha-fetoprotein level changes in predicting clinical and survival benefits in advanced hepatocellular carcinoma patients receiving sorafenib. Oncologist 2011;16:1270-1279.
-
(2011)
Oncologist
, vol.16
, pp. 1270-1279
-
-
Yau, T.1
Yao, T.J.2
Chan, P.3
Wong, H.4
Pang, R.5
Fan, S.T.6
Poon, R.T.7
-
16
-
-
81555231534
-
Early decrease in ?-fetoprotein, but not des-?-carboxy prothrombin, predicts sorafenib efficacy in patients with advanced hepatocellular carcinoma
-
Kuzuya T, Asahina Y, Tsuchiya K, Tanaka K, Suzuki Y, Hoshioka T, Tamaki S, Kato T, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Izumi N: Early decrease in ?-fetoprotein, but not des-?-carboxy prothrombin, predicts sorafenib efficacy in patients with advanced hepatocellular carcinoma. Oncology 2011;81:251-258.
-
(2011)
Oncology
, vol.81
, pp. 251-258
-
-
Kuzuya, T.1
Asahina, Y.2
Tsuchiya, K.3
Tanaka, K.4
Suzuki, Y.5
Hoshioka, T.6
Tamaki, S.7
Kato, T.8
Yasui, Y.9
Hosokawa, T.10
Ueda, K.11
Nakanishi, H.12
Itakura, J.13
Takahashi, Y.14
Kurosaki, M.15
Izumi, N.16
-
17
-
-
80051745537
-
Des-?-carboxyprothrombin may be a promising biomarker to determine the therapeutic efficacy of sorafenib for hepatocellular carcinoma
-
Ueshima K, Kudo M, Takita M, Nagai T, Tatsumi C, Ueda T, Kitai S, Ishikawa E, Yada N, Inoue T, Hagiwara S, Minami Y, Chung H, Sakurai T: Des-?-carboxyprothrombin may be a promising biomarker to determine the therapeutic efficacy of sorafenib for hepatocellular carcinoma. Dig Dis 2011;29:321-325.
-
(2011)
Dig Dis
, vol.29
, pp. 321-325
-
-
Ueshima, K.1
Kudo, M.2
Takita, M.3
Nagai, T.4
Tatsumi, C.5
Ueda, T.6
Kitai, S.7
Ishikawa, E.8
Yada, N.9
Inoue, T.10
Hagiwara, S.11
Minami, Y.12
Chung, H.13
Sakurai, T.14
-
18
-
-
84885025687
-
Okayama Liver Cancer Group: Evaluation of the effect of sorafenib using serum NX-des-?-carboxyprothrombin in patients with hepatocellular carcinoma
-
Miyahara K, Nouso K, Morimoto Y, Tomoda T, Kobayashi S, Takeuchi Y, Hagihara H, Kuwaki K, Ohnishi H, Ikeda F, Miyake Y, Nakamura S, Shiraha H, Takaki A, Yamamoto K, Okayama Liver Cancer Group: Evaluation of the effect of sorafenib using serum NX-des-?-carboxyprothrombin in patients with hepatocellular carcinoma. Hepatol Res 2013;43:1064-1070.
-
(2013)
Hepatol Res
, vol.43
, pp. 1064-1070
-
-
Miyahara, K.1
Nouso, K.2
Morimoto, Y.3
Tomoda, T.4
Kobayashi, S.5
Takeuchi, Y.6
Hagihara, H.7
Kuwaki, K.8
Ohnishi, H.9
Ikeda, F.10
Miyake, Y.11
Nakamura, S.12
Shiraha, H.13
Takaki, A.14
Yamamoto, K.15
-
19
-
-
84891887901
-
Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma
-
Tsuchiya K, Asahina Y, Matsuda S, Muraoka M, Nakata T, Suzuki Y, Tamaki N, Yasui Y, Suzuki S, Hosokawa T, Nishimura T, Ueda K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Izumi N: Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma. Cancer 2014;120:229-237.
-
(2014)
Cancer
, vol.120
, pp. 229-237
-
-
Tsuchiya, K.1
Asahina, Y.2
Matsuda, S.3
Muraoka, M.4
Nakata, T.5
Suzuki, Y.6
Tamaki, N.7
Yasui, Y.8
Suzuki, S.9
Hosokawa, T.10
Nishimura, T.11
Ueda, K.12
Kuzuya, T.13
Nakanishi, H.14
Itakura, J.15
Takahashi, Y.16
Kurosaki, M.17
Enomoto, N.18
Izumi, N.19
-
20
-
-
80054954581
-
Predicting the treatment effect of sorafenib using serum angiogenesis markers in patients with hepatocellular carcinoma
-
Miyahara K, Nouso K, Tomoda T, Kobayashi S, Hagihara H, Kuwaki K, Toshimori J, Onishi H, Ikeda F, Miyake Y, Nakamura S, Shiraha H, Takaki A, Yamamoto K: Predicting the treatment effect of sorafenib using serum angiogenesis markers in patients with hepatocellular carcinoma. J Gastroenterol Hepatol 2011;26:1604-1611.
-
(2011)
J Gastroenterol Hepatol
, vol.26
, pp. 1604-1611
-
-
Miyahara, K.1
Nouso, K.2
Tomoda, T.3
Kobayashi, S.4
Hagihara, H.5
Kuwaki, K.6
Toshimori, J.7
Onishi, H.8
Ikeda, F.9
Miyake, Y.10
Nakamura, S.11
Shiraha, H.12
Takaki, A.13
Yamamoto, K.14
-
21
-
-
59449089100
-
Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: Presence of lung metastasis predicts poor response
-
Yau T, Chan P, Ng KK, Chok SH, Cheung TT, Fan ST, Poon RT: Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: presence of lung metastasis predicts poor response. Cancer 2009;115:428-436.
-
(2009)
Cancer
, vol.115
, pp. 428-436
-
-
Yau, T.1
Chan, P.2
Ng, K.K.3
Chok, S.H.4
Cheung, T.T.5
Fan, S.T.6
Poon, R.T.7
-
22
-
-
70049099306
-
Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma: Evidence from an in vitro study
-
Zhang Z, Zhou X, Shen H, Wang D, Wang Y: Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma: evidence from an in vitro study. BMC Med 2009;7:41-52.
-
(2009)
BMC Med
, vol.7
, pp. 41-52
-
-
Zhang, Z.1
Zhou, X.2
Shen, H.3
Wang, D.4
Wang, Y.5
-
23
-
-
84862027112
-
Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma
-
Hagiwara S, Kudo M, Nagai T, Inoue T, Ueshima K, Nishida N, Watanabe T, Sakurai T: Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma. Br J Cancer 2012;106:1997-2003.
-
(2012)
Br J Cancer
, vol.106
, pp. 1997-2003
-
-
Hagiwara, S.1
Kudo, M.2
Nagai, T.3
Inoue, T.4
Ueshima, K.5
Nishida, N.6
Watanabe, T.7
Sakurai, T.8
-
24
-
-
84876107646
-
FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma
-
Arao T, Ueshima K, Matsumoto K, Nagai T, Kimura H, Hagiwara S, Sakurai T, Haji S, Kanazawa A, Hidaka H, Iso Y, Kubota K, Shimada M, Utsunomiya T, Hirooka M, Hiasa Y, Toyoki Y, Hakamada K, Yasui K, Kumada T, Toyoda H, Sato S, Hisai H, Kuzuya T, Tsuchiya K, Izumi N, Arii S, Nishio K, Kudo M: FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma. Hepatology 2013;57:1407-1415.
-
(2013)
Hepatology
, vol.57
, pp. 1407-1415
-
-
Arao, T.1
Ueshima, K.2
Matsumoto, K.3
Nagai, T.4
Kimura, H.5
Hagiwara, S.6
Sakurai, T.7
Haji, S.8
Kanazawa, A.9
Hidaka, H.10
Iso, Y.11
Kubota, K.12
Shimada, M.13
Utsunomiya, T.14
Hirooka, M.15
Hiasa, Y.16
Toyoki, Y.17
Hakamada, K.18
Yasui, K.19
Kumada, T.20
Toyoda, H.21
Sato, S.22
Hisai, H.23
Kuzuya, T.24
Tsuchiya, K.25
Izumi, N.26
Arii, S.27
Nishio, K.28
Kudo, M.29
more..
-
25
-
-
77954509572
-
Positioning of a molecular-targeted agent, sorafenib, in the treatment algorithm for hepatocellular carcinoma and implication of many complete remission cases in Japan
-
Kudo M, Ueshima K: Positioning of a molecular-targeted agent, sorafenib, in the treatment algorithm for hepatocellular carcinoma and implication of many complete remission cases in Japan. Oncology 2010;78(Suppl 1):154-166.
-
(2010)
Oncology
, vol.78
, pp. 154-166
-
-
Kudo, M.1
Ueshima, K.2
-
26
-
-
84916244854
-
Comparison of systems for assessment of post-therapeutic response to sorafenib for hepatocellular carcinoma
-
epub ahead of print
-
Arizumi T, Ueshima K, Takeda H, Osaki Y, Takita M, Inoue T, Kitai S, Yada N, Hagiwara S, Minami Y, Sakurai T, Nishida N, Kudo M: Comparison of systems for assessment of post-therapeutic response to sorafenib for hepatocellular carcinoma. J Gastroenterol 2014; epub ahead of print.
-
(2014)
J Gastroenterol
-
-
Arizumi, T.1
Ueshima, K.2
Takeda, H.3
Osaki, Y.4
Takita, M.5
Inoue, T.6
Kitai, S.7
Yada, N.8
Hagiwara, S.9
Minami, Y.10
Sakurai, T.11
Nishida, N.12
Kudo, M.13
|