Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates

BMC Genomics

Volumn 16, Issue 1, 2015, Pages

  Black, P A ^a   de Vos, M ^a   Louw, G E ^a   van der Merwe, R G ^a   Dippenaar, A ^a   Streicher, E M ^a   Abdallah, A M ^b   Sampson, S L ^a   Victor, T C ^a   Dolby, T ^c   Simpson, J A ^c   van Helden, P D ^a   Warren, R M ^a   Pain, A ^b  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

^c NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

Author keywords

Clinical isolates; Genetic complexity; Heterogeneity; Mycobacterium tuberculosis; Next generation sequencing; Relaxed variant filtering

Indexed keywords

ISONIAZID; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENOME; BACTERIUM COLONY; BACTERIUM ISOLATE; BOTTLENECK POPULATION; CONTROLLED STUDY; DNA ISOLATION; DNA SEQUENCE; EVOLUTION; FOLLOW UP; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NEXT GENERATION SEQUENCING; NONHUMAN; PRIMARY CULTURE; SANGER SEQUENCING; SEQUENCE ANALYSIS; STATISTICAL ANALYSIS; WHOLE GENOME SEQUENCING; DRUG EFFECTS; GENETIC VARIATION; GENETICS; GENOMICS; HIGH THROUGHPUT SEQUENCING; ISOLATION AND PURIFICATION; MICROBIOLOGY; MOLECULAR EVOLUTION; PROCEDURES; RECEIVER OPERATING CHARACTERISTIC; TUBERCULOSIS, PULMONARY;

ANTITUBERCULAR AGENTS; DRUG RESISTANCE, BACTERIAL; EVOLUTION, MOLECULAR; GENETIC HETEROGENEITY; GENETIC VARIATION; GENOME, BACTERIAL; GENOMICS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MYCOBACTERIUM TUBERCULOSIS; ROC CURVE; SEQUENCE ANALYSIS, DNA; TUBERCULOSIS, PULMONARY;

EID: 84945118021     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/s12864-015-2067-2     Document Type: Article

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