4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 5727-5736

  Gao, Feng ^a   Du, Wen ^a,d   Zafar, Mohammad Ishraq ^a   Shafqat, Raja Adeel ^b   Jian, Liumeng ^a   Cai, Qin ^a   Lu, Furong ^c  

^a UNION HOSPITAL   (China)

^b Tongji Hospital   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d CHENGDU FIRST PEOPLE S HOSPITAL   (China)

Author keywords

4 hydroxyisoleucine; Fenugreek seed; Glucose uptake; Insulin signaling; Obesity related insulin resistance; Soluble TNF ; TACE; TIMP3

Indexed keywords

4 HYDROXYISOLEUCINE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PIOGLITAZONE; PROTEIN KINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 4-HYDROXYISOLEUCINE; ADAM PROTEIN; ADAM17 PROTEIN, MOUSE; DEOXYGLUCOSE; ISOLEUCINE; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE-4;

3T3 CELL LINE; ADIPOCYTE; ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; GLUCOSE TRANSPORT; IN VITRO STUDY; INSULIN RESISTANCE; OBESITY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MOUSE; TIME FACTOR;

3T3-L1 CELLS; ADAM PROTEINS; ADAM17 PROTEIN; ADIPOCYTES; ANIMALS; DEOXYGLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; INSULIN; INSULIN RESISTANCE; ISOLEUCINE; MICE; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES; TIME FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASES;

EID: 84944930541     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S92355     Document Type: Article

References (36)

1. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840-846.
2. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11:85-97.
3. Tilg H, Moschen AR. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med. 2008;14:222-231.
4. Yang J, Park Y, Zhang H, et al. Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 2009;296:H1850-H1858.
5. Sethi J, Hotamisligil G. The role of TNFα in adipocyte metabolism1. Semin Cell Dev Biol. 1999;10:19-29.
6. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415-445.
7. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87-91.
8. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860-867.
9. Black RA, Rauch CT, Kozlosky CJ, et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997;385:729-733.
10. Glass CK, Olefsky JM. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 2012;15:635-645.
11. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444:847-853.
12. Stephens JM, Lee J, Pilch PF. Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem. 1997;272:971-976.
13. Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS. Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology. 2002;143:1502-1511.
14. Voros G, Maquoi E, Collen D, Lijnen HR. Influence of membrane-bound tumor necrosis factor (TNF)-alpha on obesity and glucose metabolism. J Thromb Haemost. 2004;2:507-513.
15. Mezyk R, Bzowska M, Bereta J. Structure and functions of tumor necrosis factor-alpha converting enzyme. Acta Biochim Pol. 2003;50:625-645.
16. Fiorentino L, Vivanti A, Cavalera M, Marzano V, Ronci M, Fabrizi M, et al. Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice. Hepatology. 2010;51:103-110.
17. Broca C, Breil V, Cruciani-Guglielmacci C, et al. Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat. Am J Physiol Endocrinol Metab. 2004;287:E463-E471.
18. Broca C, Gross R, Petit P, et al. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties. Am J Physiol. 1999;277:E617-E623.
19. Singh AB, Tamarkar AK, Narender T, Srivastava AK. Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice. Nat Prod Res. 2010;24:258-265.
20. Narender T, Puri A, Khaliq T, Saxena R, Bhatia G, Chandra R. 4-Hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent. Bioorg Med Chem Lett. 2006;16:293-296.
21. Yu H, Wu M, Lu F-R, et al. [Effect of Trigonella foenum-graecum 4-hydroxyisoleucine on high-glucose induced insulin resistance in 3T3-L1 adipocytes of mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013;33:1394-1399.
22. Joo JI, Kim DH, Yun JW. Extract of Chaga mushroom (Inonotus obliquus) stimulates 3T3-L1 adipocyte differentiation. Phytother Res. 2010;24:1592-1599.
23. Tordjman KM, Leingang KA, James DE, Mueckler MM. Differential regulation of two distinct glucose transporter species expressed in 3T3-L1 adipocytes: effect of chronic insulin and tolbutamide treatment. Proc Natl Acad Sci U S A. 1989;86:7761-7765.
24. Susanti D, Amiroudine MZAM, Rezali MF, Taher M. Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes. Nat Prod Res. 2013;27:417-424.
25. Yi P, Lu F-E, Xu L-J, Chen G, Dong H, Wang K-F. Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. World J Gastroenterol. 2008;14:876-883.
26. Li J, Shen L, Lu F, et al. Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway. Acta Pharmacol Sin. 2012;33:242-249.
27. Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Mol Cell Endocrinol. 2010;316:129-139.
28. Von Maltzan K, Tan W, Pruett SB. Investigation of the role of TNF-α converting enzyme (TACE) in the inhibition of cell surface and soluble TNF-α production by acute ethanol exposure. PLoS One. 2012;7:e29890.
29. Peraldi P, Xu M, Spiegelman BM. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. J Clin Invest. 1997;100:1863-1869.
30. Iwata M, Haruta T, Usui I, et al. Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator-activated receptor-gamma. Diabetes. 2001;50:1083-1092.
31. Chawla A, Nguyen KD, Goh YPS. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol. 2011;11:738-749.
32. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006;116:1793-1801.
33. Serino M, Menghini R, Fiorentino L, et al. Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes. Diabetes. 2007;56:2541-2546.
34. Monroy A, Kamath S, Chavez AO, et al. Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. Diabetologia. 2009;52:2169-2181.
35. Jaiswal N, Maurya CK, Venkateswarlu K, et al. 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway. Eur J Nutr. 2012;51:893-898.
36. Minematsu T, Huang L, Ibuki A, et al. Altered expression of matrix metalloproteinases and their tissue inhibitors in matured rat adipocytes in vitro. Biol Res Nurs. 2012;14:242-249.