Application of multivariate analysis and mass transfer principles for refinement of a 3-L bioreactor scale-down model-when shake flasks mimic 15,000-L bioreactors better

Biotechnology Progress

Volumn 31, Issue 5, 2015, Pages 1370-1380

  Ahuja, Sanjeev ^a   Jain, Shilpa ^a   Ram, Kripa ^a  

^a MEDIMMUNE   (United States)

Author keywords

Mass transfer; Multivariate analysis; OPLS DA; Outlier analysis; Scale down model

Indexed keywords

ANIMAL CELL CULTURE; BIOCONVERSION; BIOREACTORS; BOTTLES; DISCRIMINANT ANALYSIS; MAMMALS; MASS TRANSFER; QUALITY CONTROL; SMALL SATELLITES; STATISTICS;

LARGE SCALE BIOREACTORS; MAMMALIAN CELL CULTURE; MULTI VARIATE ANALYSIS; OPLS-DA; OUTLIER ANALYSIS; PARTIAL LEAST SQUARE (PLS); SCALE DOWN MODEL; STATISTICAL TECHNIQUES;

MULTIVARIANT ANALYSIS;

ANIMAL; BIOREACTOR; CELL CULTURE TECHNIQUE; CHO CELL LINE; CRICETULUS; HAMSTER; MULTIVARIATE ANALYSIS; PH; PILOT STUDY; PRINCIPAL COMPONENT ANALYSIS; REGRESSION ANALYSIS; STATISTICAL MODEL; THEORETICAL MODEL;

ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; HYDROGEN-ION CONCENTRATION; LEAST-SQUARES ANALYSIS; LINEAR MODELS; MODELS, THEORETICAL; MULTIVARIATE ANALYSIS; PILOT PROJECTS; PRINCIPAL COMPONENT ANALYSIS;

EID: 84944908864     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.2134     Document Type: Article

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