Chemoenzymatic synthesis of (R)- and (S)-propranolol using an engineered epoxide hydrolase with a high turnover number

Journal of Molecular Catalysis B: Enzymatic

Volumn 122, Issue , 2015, Pages 275-281

  Kong, Xu Dong ^a,b   Yu, Hui Lei ^a   Yang, Sheng ^c   Zhou, Jiahai ^b   Zeng, Bu Bing ^d   Xu, Jian He ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^c INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

^d EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bacillus megaterium epoxide hydrolase; Beta blocker; Biocatalytic resolution; Biphasic reaction; Chemoenzymatic synthesis; Naphthyl glycidyl ether; Propranolol

Indexed keywords

BACTERIOLOGY; ETHERS; HYDROLASES; NAPHTHALENE; ORGANOMETALLICS; SYNTHESIS (CHEMICAL);

BETA-BLOCKERS; BIPHASIC REACTION; CHEMO-ENZYMATIC SYNTHESIS; EPOXIDE HYDROLASES; NAPHTHYL GLYCIDYL ETHER; PROPRANOLOL;

ENZYME ACTIVITY;

CYCLOHEXANE; DIISOPROPYL ETHER; EPOXIDE HYDROLASE; PROPANE; PROPRANOLOL DERIVATIVE; TOLUENE;

ARTICLE; BACILLUS MEGATERIUM; BIOCATALYSIS; BIOCATALYST; CATALYST; CHEMOENZYMATIC SYNTHESIS; CONTROLLED STUDY; CRYSTALLIZATION; DRUG PURITY; DRUG SYNTHESIS; DRY WEIGHT; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STABILITY; ENZYME SYNTHESIS; MOLECULAR STABILITY; NONHUMAN; SOLUBILITY; SUBSTRATE CONCENTRATION; TURNOVER NUMBER;

EID: 84944746903     PISSN: 13811177     EISSN: 18733158     Source Type: Journal    
DOI: 10.1016/j.molcatb.2015.10.005     Document Type: Article

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