Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell rna-seq

Development (Cambridge)

Volumn 142, Issue 20, 2015, Pages 3468-3477

  Shi, Junchao ^a,b   Chen, Qi ^a,c   Li, Xin ^a   Zheng, Xiudeng ^a   Zhang, Ying ^a   Qiao, Jie ^d   Tang, Fuchou ^d   Tao, Yi ^a   Zhou, Qi ^a   Duan, Enkui ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^d PEKING UNIVERSITY   (China)

Author keywords

Bistable model; Lineage divergence; Monostable model; Pre implantation embryo development; Transcriptional symmetry breaking

Indexed keywords

MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTOME; CDX2 PROTEIN, HUMAN; CDX2 PROTEIN, MOUSE; COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1; HOMEODOMAIN PROTEIN; PROTEIN ARGININE METHYLTRANSFERASE; RNA; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BINOMIAL DISTRIBUTION; BLASTOMA; CELL DIVISION; CELL FATE; CELL HETEROGENEITY; CELL LINEAGE; CELL RENEWAL; CONTROLLED STUDY; DAUGHTER CELL; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; MITOSIS; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; POSITIVE FEEDBACK; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; RNA SEQUENCE; SINGLE CELL ANALYSIS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ANIMAL; ANIMAL EMBRYO; BLASTOCYST; C57BL MOUSE; CLUSTER ANALYSIS; MORPHOGENESIS; NIDATION; PHYSIOLOGY; PROCEDURES; SEQUENCE ANALYSIS; TIME; ZYGOTE;

ANIMALS; BLASTOCYST; BLASTOMERES; BODY PATTERNING; CELL LINEAGE; CLUSTER ANALYSIS; EMBRYO IMPLANTATION; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, INBRED C57BL; PROTEIN-ARGININE N-METHYLTRANSFERASES; RNA; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; ZYGOTE;

EID: 84944732679     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.123950     Document Type: Article

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