Increased serum gamma-glutamyltransferase levels are associated with ventricular instability in type 2 diabetes

Endocrine

Volumn 52, Issue 1, 2016, Pages 63-72

  Wang, Kun ^a   Li, Ling ^b   Wu, Yang ^c   Yang, Yu ^a   Chen, Jie ^a   Zhang, Danyu ^a   Liu, Zhoujun ^a   Xu, Juan ^a   Cao, Meng ^a   Mao, Xiaodong ^a   Liu, Chao ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^c THE THIRD AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Corrected QT interval (QTc); Gamma glutamyltransferase (GGT); QT dispersion (QTd); Type 2 diabetes mellitus (T2DM); Ventricular instability

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGE DISTRIBUTION; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CARDIOVASCULAR RISK; CHINESE; CHOLESTEROL BLOOD LEVEL; COMMUNITY ASSESSMENT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE DURATION; DRINKING BEHAVIOR; ECHOCARDIOGRAPHY; FEMALE; HEART RATE; HEART REPOLARIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QT DISPERSION; QT INTERVAL; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; COHORT ANALYSIS; COMPLICATION; ELECTROCARDIOGRAPHY; ENZYMOLOGY; ETIOLOGY; HEART VENTRICLE FUNCTION; IMPAIRED GLUCOSE TOLERANCE; MIDDLE AGED; PATHOPHYSIOLOGY; RISK FACTOR;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; ELECTROCARDIOGRAPHY; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HEART RATE; HUMANS; MALE; MIDDLE AGED; PREDIABETIC STATE; RISK FACTORS; VENTRICULAR DYSFUNCTION;

EID: 84944710684     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-015-0760-1     Document Type: Article

References (37)

1. B.S. Rana, P.O. Lim, A.A. Naas, S.A. Ogston, R.W. Newton, R.T. Jung, A.D. Morris, A.D. Struthers, QT interval abnormalities are often present at diagnosis in diabetes and are better predictors of cardiac death than ankle brachial pressure index and autonomic function tests. Heart 91, 44–50 (2005)
2. R. Marfella, F. Rossi, D. Giugliano, Hyperglycaemia and QT interval: time for re-evaluation. Diabetes Nutr. Metab. 14, 63–65 (2001)
3. S. Giunti, G. Bruno, E. Lillaz, G. Gruden, V. Lolli, N. Chaturvedi, J.H. Fuller, M. Veglio, P. Cavallo-Perin, EURODIAB IDDM Complications Study Group: incidence and risk factors of prolonged QTc interval in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care 30, 2057–2063 (2007)
4. A.A. Naas, N.C. Davidson, C. Thompson, R.T. Jung, R.W. Newton, A.D. Struthers, QT and QTc dispersion are accurate predictors of cardiac death in newly diagnosed non-insulin-dependent diabetes: cohort study. BMJ 316, 745–746 (1998)
5. C. Cardoso, G. Salles, K. Bloch, W. Deccache, A.G. Siqueira-Filho, Clinical determinants of increased QT dispersion in patients with diabetes mellitus. Int. J. Cardiol. 79, 253–262 (2001)
6. M. Odermarsky, J. Lykkesfeldt, P. Liuba, Poor vitamin C status is associated with increased carotid intima-media thickness, decreased microvascular function, and delayed myocardial repolarization in young patients with type 1 diabetes. Am. J. Clin. Nutr. 90, 447–452 (2009)
7. A.P. Kellogg, K. Converso, T. Wiggin, M. Stevens, R. Pop-Busui, Effects of cyclooxygenase-2 gene inactivation on cardiac autonomic and left ventricular function in experimental diabetes. Am. J. Physiol. Heart Circ. Physiol. 296, H453–H461 (2009)
8. G. Perseghin, F. De Cobelli, A. Esposito, E. Belloni, G. Lattuada, T. Canu, P.L. Invernizzi, F. Ragogna, A. La Torre, P. Scifo, G. Alberti, A. Del Maschio, L. Luzi, Left ventricular function and energy metabolism in middle-aged men undergoing long-lasting sustained aerobic oxidative training. Heart 95, 630–635 (2009)
9. + channel activity. Circ. Res. 103, 269–278 (2008)
10. A. Pannaccione, P. Castaldo, E. Ficker, L. Annunziato, M. Taglialatela, Histidines 578 and 587 in the S5-S6 linker of the human Ether-a-gogo related Gene-1K channels confer sensitivity to reactive oxygen species. J. Biol. Chem. 277, 8912–8919 (2002)
11. W.H. Tang, W.T. Cheng, G.M. Kravtsov, X.Y. Tong, X.Y. Hou, S.K. Chung, S.S. Chung, Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress. Am. J. Physiol. Cell. Physiol. 299, C643–C653 (2010)
12. A. Fraser, R. Harris, N. Sattar, S. Ebrahim, D.G. Smith, D.A. Lawlor, Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women’s Heart and Health Study and meta-analysis. Diabetes Care 32, 741–750 (2009)
13. N. Nakanishi, K. Suzuki, K. Tatara, Serum gamma-glutamyltransferase and risk of metabolic syndrome and type 2 diabetes in middle-aged Japanese men. Diabetes Care 27, 1427–1432 (2004)
14. S.G. Wannamethee, P.H. Whincup, A.G. Shaper, L. Lennon, N. Sattar, γ-glutamyltransferase, hepatic enzymes, and risk of incident heart failure in older men. Arterioscler. Thromb. Vasc. Biol. 32, 830–835 (2012)
15. A.M. Strasak, C.C. Kelleher, J. Klenk, L.J. Brant, E. Ruttmann, K. Rapp, H. Concin, G. Diem, K.P. Pfeiffer, H. Ulmer, Vorarlberg Health Monitoring and Promotion Program Study Group, Longitudinal change in serum gamma-glutamyltransferase and cardiovascular disease mortality: a prospective population-based study in 76,113 Austrian adults. Arterioscler. Thromb. Vasc. Biol. 28, 1857–1865 (2008)
16. M. Emdin, A. Pompella, A. Paolicchi, Gamma-glutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque. Circulation 112, 2078–2080 (2005)
17. A. Paolicchi, M. Emdin, E. Ghliozeni, E. Ciancia, C. Passino, G. Popoff, A. Pompella, Images in cardiovascular medicine. Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity. Circulation 109, 1440 (2004)
18. C. Lengyel, L. Virág, T. Bíró, N. Jost, J. Magyar, P. Biliczki, E. Kocsis, R. Skoumal, P.P. Nánási, M. Tóth, V. Kecskeméti, J.G. Papp, A. Varró, Diabetes mellitus attenuates the repolarization reserve in mammalian heart. Cardiovasc. Res. 73, 512–520 (2007)
19. G. Ning, Reaction study group. Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudial (REACTION) study. J. Diabetes 4, 172–173 (2012)
20. K. Wang, Y. Yang, Y. Wu, J. Chen, D. Zhang, X. Mao, X. Wu, X. Long, C. Liu, The association between insulin resistance and vascularization of thyroid nodules. J. Clin. Endocrinol. Metab. 100, 184–192 (2015)
21. D.H. Lee, D.R. Jacobs Jr, M. Gross, C.I. Kiefe, J. Roseman, C.E. Lewis, M. Steffes, Gammaglutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin. Chem. 49, 1358–1366 (2003)
22. P.M. Okin, R.B. Devereux, E.T. Lee, J.M. Galloway, B.V. Howard, Strong Heart Study, Electrocardiographic repolarization complexity and abnormality predict all-cause and cardiovascular mortality in diabetes: the strong heart study. Diabetes 53, 434–440 (2004)
23. M. Veglio, G. Bruno, M. Borra, G. Macchia, G. Bargero, N. D’Errico, G.F. Pagano, P. Cavallo-Perin, Prevalence of increased QT interval duration and dispersion in type 2 diabetic patients and its relationship with coronary heart disease: a population-based cohort. J. Int. Med 25, 317–324 (2002)
24. J.S. Lim, J.H. Yang, B.Y. Chun, S. Kam, D.R. Jacobs Jr, D.H. Lee, Is serum gamma-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress? Free Radic. Biol. Med. 37, 1018–1023 (2004)
25. D.H. Lee, M.D. Gross, M.W. Steffes, D.R. Jacobs Jr, Is serum gammaglutamyltransferase a biomarker of xenobiotics, which are conjugated by glutathione? Arterioscler. Thromb. Vasc. Biol. 28, e26–e28 (2008)
26. K. Kolbe, R. Schonherr, G. Gessner, N. Sahoo, T. Hoshi, S.H. Heinemann, Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels. J. Physiol. 588, 2999–3009 (2010)
27. M. Schönauer, A. Thomas, S. Morbach, J. Niebauer, U. Schönauer, H. Thiele, Cardiac autonomic diabetic neuropathy. Diabetes Vasc. Dis. Res. 5, 336–344 (2008)
28. S. Matsushima, S. Kinugawa, T. Ide, H. Matsusaka, N. Inoue, Y. Ohta, T. Yokota, K. Sunagawa, H. Tsutsui, Overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart. Am. J. Physiol.-Heart. C 291, H2237–H2245 (2006)
29. J. Chen, J. Sroubek, Y. Krishnan, Y. Li, J. Bian, T.V. McDonald, PKA phosphorylation of HERG protein regulates the rate of channel synthesis. Am. J. Physiol. Heart Circ. Physiol. 296, H1244–H1254 (2009)
30. + current during cardiac ischemia and hypoxia. J. Cardiovasc. Electrophysiol. 17, S96–S103 (2006)
31. Report and Recommendations of the San Antonio Conference on Diabetic Neuropathy: American Diabetes Association and American Academy of Neurology (Consensus Statement). Diabetes Care 11, 592–597 (1988)
32. F.M. Brown, M. Watts, S.L. Rabinowe, Aggregation of subclinical autonomic nervous system dysfunction and autoantibodies in families with type I diabetes. Diabetes 40, 1611–1614 (1991)
33. J. Fleischer, Diabetic autonomic imbalance and glycemic variability. J. Mech. Sci. Technol. 6, 1207–1215 (2012)
34. G. Bujag, M. Miorelli, P. Turrini, P. Melacini, A. Nova, Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. Am. J. Cardiol. 72, 973–976 (1993)
35. R. Kumar, M. Fisher, P.W. Macfarlane, Diabetes and the QT interval: time for debate. Br. J. Diabetes Vasc. Dis. 4, 146–150 (2004)
36. J.B. Whitfield, Serum γ-glutamyltransferase and risk of disease. Clin. Chem. 53, 1–2 (2007)
37. G. Targher, L. Bertolini, F. Poli, S. Rodella, L. Scala, R. Tessari, L. Zenari, G. Falezza, Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. Diabetes 54, 354–3546 (2005)