Diabetes and the QT interval: Time for debate

British Journal of Diabetes and Vascular Disease

Volumn 4, Issue 3, 2004, Pages 146-150

  Kumar, Rajeev ^a   Fisher, Miles ^b   Macfarlane, Peter W ^c  

^a QUEEN ELIZABETH II HOSPITAL   (United Kingdom)

^b GLASGOW ROYAL INFIRMARY   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Diabetes mellitus; QT dispersion; QT prolongation

Indexed keywords

AUTONOMIC NEUROPATHY; COST EFFECTIVENESS ANALYSIS; DIABETES MELLITUS; DISEASE ASSOCIATION; ELECTROCARDIOGRAM; HEART DEATH; HEART MUSCLE ISCHEMIA; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; ISCHEMIC HEART DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PREDICTION; QT DISPERSION; QT INTERVAL; QT PROLONGATION; REVIEW; TREATMENT OUTCOME;

EID: 3242777157     PISSN: 14746514     EISSN: None     Source Type: Journal    
DOI: 10.1177/14746514040040030201     Document Type: Review

References (43)

1. Bazett HC. An Analysis of the time relations of electrocardiograms. Heart 1920;7:353-70.
2. Hodges M, Salerno Q, Erlien D. Bazett's QT correction reviewed. Evidence that a linear QT correction for heart rate is better. J Am Coll Cardiol 1983;1:694
3. Macfarlane PW, Lawrie TDV. The normal electrocardiogram and vectorcardiogram. In: Macfarlane PW, Lawrie TDV, eds. Comprehensive Electrocardiology. Oxford, UK. Pergamon Press; 1989;1:407-57.
4. Algra A, Tijssen JG, Roelandt JR, Pool J, Lubsen J. QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation 1991;83:1888-94.
5. Ahnve S, Gilpin E, Madsen EB etal. Prognostic importance of QTc interval at discharge after acute myocardial infarction: a multicenter study of 865 patients. Am Heart J 1984;108:395-400.
6. Jackman WM, Friday KJ, Anderson JL et al. The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis 1988;31:115-72.
7. Day CP, McComb JM, Campbell RW. QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990;63: 342-4.
8. Macfarlane PW, McLaughlin SC, Rodger JC. Influence of lead selection and population on automated measurement of QT dispersion. Circulation 1998;98:2160-7.
9. Barr CS, Nass A, Freeman M, Lang CC, Struthers AD. QT dispersion and sudden unexpected death in chronic heart failure. Lancet 1994; 343:327-9.
10. Darbar D, Luck J, Davidson N, Pringle T, Main G, McNeill G, Struthers AD. Sensitivity and specificity of QTc dispersion for identification of risk of cardiac death in patients with peripheral vascular disease. BMJ 1996;312:874-9.
11. Clarkson PB, Naas AA, McMahon A, MacLeod C, Struthers AD, MacDonald TM. QT dispersion in essential hypertension. QJM 1995; 88:327-32.
12. Bujag G, Miorelli M, Turrini P, Melacini P, Nova A. Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. Am J Cardiol 1993; 72:973-6.
13. Glancy JM, Garratt CJ, Woods KL. QT dispersion and mortality after myocardial infarction. Lancet 1995;345:945-8.
14. Elming H, Holm E, Jun L et al. The prognostic value of the QT interval and QT interval dispersion in all-cause and cardiac mortality and morbidity in a population of Danish citizens. Eur Heart J 1998;19:139-400.
15. Moreno FL, Villanueva MT, Karagounis LA for the TEAM-2 Investigators. A reduction in QT interval dispersion by successful thrombolytic therapy in acute MI. Circulation 1994;90:94-100.
16. Zabel M, Portnoy S, Franz MR. Electrocardiographic indexes of dispersion of ventricular repolarization; an isolated heart validation study. J Am Coll Cardiol 1995;25:746-52.
17. Malik M, Batchvarov VN. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol 2000;36:1749-66.
18. Veglio M, Giunti S, Stevens LK et al. Prevalence of Q-T Interval Dispersion in Type 1 Diabetes and Its Relation with Cardiac Ischaemia: the EURODIAB IDDM Complications Study Group. Diabetes Care 2002;25:702-07.
19. Veglio M, Bruno G, Borra M et al. Prevalence of increased QT interval duration and dispersion in type 2 diabetic patients and its relationship with coronary heart disease: a population-based cohort. J Inter Med 2002;25:317-24.
20. Glancey MJ, Weston PJ, Bhullar HK et al. Reproducibility and automatic measurement of QT dispersion. Eur Heart J 1996;17:1035-9.
21. Rautaharju PM. QT and Dispersion of Ventricular Repolarization: The Greatest Fallacy in Electrocardiography in the 1990s. Circulation 1999; 99:2477-8.
22. Rautaharju PM. Why did QT dispersion die? Cardiac Electrophysiology Review 2002;6:295-301.
23. Veglio M, Borra M, Stevens LK et al. The relationship between QTc interval prolongation and diabetic complications: the EURODIAB IDDM Complication Study Group. Diabetologia 1999;42:68-75.
24. Sivieri R, Veglio M, Chinaglia A et al. Prevalence of QT prolongation in a type 1 diabetic population and its association with autonomic neuropathy. Diabetic Med 1993;10:920-4.
25. Cardoso C, Salles G, Bloch K et al. Clinical determinants of increased QT dispersion in patients with diabetes mellitus. Intern J Cardiol 2001;79:253-62.
26. Sawicki PT, Meinhold J, Kiwitt S et al. QT interval dispersion is an important predictor of mortality in NIDDM patients. Diabetes 1996;45:128.
27. Naas AA, Davidson NC, Thompson C, Jung RT, Newton RW, Struthers AD. QT and QTc dispersion are accurate predictors of cardiac death in newly diagnosed non-insulin-dependent diabetes: cohort study. BMJ 1998;316:745-6.
28. Dinneen SF, Gerstein HC. The Association of Microalbuminuria and Mortality in Non-Insulin-Dependent Diabetes Mellitus: A Systematic Overview of the Literature. Arch Intern Med 1997;157:1413-18.
29. Ewing DJ, Martyn CN, Young RJ, Clarke BF. The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care 1985;8:491-8.
30. Report and Recommendations of the San Antonio Conference on Diabetic Neuropathy: American Diabetes Association and American Academy of Neurology (Consensus Statement). Diabetes Care 1988;11:592-7.
31. Whitsel EA, Boyko EJ, Siscovick DS. Reassessing the role of QTc in the diagnosis of autonomic failure among patients with diabetes: a meta-analysis. Diabetes Care 2000;23:241-7.
32. Bravenboer B, Hendriksen PH, Oey LP et al. Is the corrected QT interval a reliable indicator of the severity of diabetic autonomic neuropathy? Diabetes Care 1993;16:1249-53.
33. Marfella R, Nappo F, DeAngelis L et al. The effect of acute hyperglycaemia on QTc duration in healthy men. Diabetologia 2000;43:571-5.
34. Lefrandt JD, Diercks GFH, van Boven AJ et al. High fasting glucose and QTc duration in a large healthy cohort. Diabetologia 2000;43:1332-4.
35. Brown DW, Giles WH, Greenlund KJ et al. Impaired fasting glucose, diabetes mellitus, and cardiovascular disease risk factors are associated with prolonged QTc duration. Results from the Third National Health and Nutrition Examination Survey. J Cardiovasc Risk 2001;8:227-33.
36. Marfella R, Rossi F, Giugliano D. Hyperglycaemia and QT interval: time for re-evaluation. Diabetes Nutri Metab 2001;14:63-5.
37. Julu P. Vagolytic effect of diabetes mellitus. Brain 1993;116:485-92.
38. UK Prospective Diabetes Study Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-53.
39. Stratton IM, Adler AI, Neil HA et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes [UKPDS 35]: prospective observational study. BMJ 2000;321:405-12.
40. Lawson ML, Gerstein HC, Tsui E et al. Effect of intensive therapy on early macrovascular disease in young individuals with type 1 diabetes. Diabetes Care 1999;22:B35-B39.
41. Day CP, McComb JM, Matthews J et al. Reduction in QT dispersion by sotalol following myocardial infarction. Eur Heart J 1991;12:423-7.
42. Rana BS, Band MM, Ogston S, Morris AD, Pringle SD, Struthers AD. Relation of QT interval dispersion to the number of different cardiac abnormalities in diabetes mellitus. Am J Cardiol 2002;90:483-7.
43. Najeed SA, Khan IA, Molnar J et al. Differential effect of glyburide (glibenclamide) and metformin on QT dispersion: a potential adenosine triphosphate sensitive K+ channel effect. Am J Cardiol 2002;90:1103-06.