Ebselen reduces autophagic activation and cell death in the ipsilateral thalamus following focal cerebral infarction

Neuroscience Letters

Volumn 600, Issue , 2015, Pages 206-212

  Li, Yiliang ^a,b   Zhang, Jian ^a   Chen, Li ^a   Xing, Shihui ^a   Li, Jingjing ^a   Zhang, Yusheng ^c   Li, Chuo ^d   Pei, Zhong ^a   Zeng, Jinsheng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH CHINA   (China)

^c JINAN UNIVERSITY   (China)

^d GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Cerebral infarction; Ebselen; Oxidative stress; Rats

Indexed keywords

BECLIN 1; EBSELEN; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN P62; ANTIOXIDANT; ORGANOSELENIUM DERIVATIVE; PYRROLE DERIVATIVE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN SIZE; CELL ACTIVATION; CELL DEATH; CONTROLLED STUDY; GLIOSIS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; THALAMUS; ANIMAL; CEREBRAL ARTERY DISEASE; CEREBRAL INFARCTION; COMPLICATION; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; AUTOPHAGY; AZOLES; CELL DEATH; CEREBRAL INFARCTION; GLIOSIS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEURONS; ORGANOSELENIUM COMPOUNDS; OXIDATIVE STRESS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; THALAMUS;

EID: 84944682836     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.06.024     Document Type: Article

References (29)

1. Iizuka H., Sakatani K., Young W. Neural damage in the rat thalamus after cortical infarcts. Stroke 1990, 21:790-794.
2. Dihne M., Grommes C., Lutzenburg M., Witte O.W., Block F. Different mechanisms of secondary neuronal damage in thalamic nuclei after focal cerebral ischemia in rats. Stroke 2002, 33:3006-3011.
3. Zhang J., Zhang Y., Xing S., Liang Z., Zeng J. Secondary neurodegeneration in remote regions after focal cerebral infarction: a new target for stroke management. Stroke 2012, 43:1700-1705.
4. Levine B., Klionsky D.J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 2004, 6:463-477.
5. Shintani T., Klionsky D.J. Autophagy in health and disease: a double-edged sword. Science 2004, 306:990-995.
6. Mizushima N. A(beta) generation in autophagic vacuoles. J. Cell. Biol. 2005, 171:15-17.
7. Xing S., Zhang Y., Li J., Zhang J., Li Y., Dang C., Li C., Fan Y., Yu J., Pei Z., Zeng J. Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction. Autophagy 2012, 8:63-76.
8. Zhang J., Zhang Y., Li J., Xing S., Li C., Li Y., Dang C., Fan Y., Yu J., Pei Z., Zeng J. Autophagosomes accumulation is associated with β-amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats. J. Neurochem. 2012, 120:564-573.
9. Kiffin R., Bandyopadhyay U., Cuervo A.M. Oxidative stress and autophagy. Antioxid. Redox. Signal. 2006, 8:152-162.
10. Scherz-Shouval R., Shvets E., Fass E., Shorer H., Gil L., Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007, 26:1749-1760.
11. Chen Y., Azad M.B., Gibson S.B. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ. 2009, 16:1040-1052.
12. Lai Y., Hickey R.W., Chen Y., Bayir H., Sullivan M.L., Chu C.T., Kochanek P.M., Dixon C.E., Jenkins L.W., Graham S.H., Watkins S.C., Clark R.S. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J. Cereb. Blood Flow Metabol. 2008, 28:540-550.
13. Noh H.S., Shin I.W., Ha J.H., Hah Y.S., Baek S.M., Kim D.R. Propofol protects the autophagic cell death induced by the ischemia/reperfusion injury in rats. Mol. Cells 2010, 30:455-460.
14. Hariharan N., Zhai P., Sadoshima J. Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid. Redox. Signal. 2011, 14:2179-2190.
15. He M., Xing S., Yang B., Zhao L., Hua H., Liang Z., Zhou W., Zeng J., Pei Z. Ebselen attenuates oxidative DNA damage and enhances its repair activity in the thalamus after focal cortical infarction in hypertensive rats. Brain Res. 2007, 1181:83-92.
16. Bidmon H.J., Kato K., Schleicher A., Witte O.W., Zilles K. Transient increase of manganese-superoxide dismutase in remote brain areas after focal photothrombotic cortical lesion. Stroke 1998, 29:203-210.
17. Zeng J., Zhang Y., Mo J., Su Z., Huang R. Two-kidney, two clip renovascular hypertensive rats can be used as stroke-prone rats. Stroke 1998, 29:1708-1713.
18. Brint S., Jacewicz M., Kiessling M., Tanabe J., Pulsinelli W. Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of thedistal middle cerebral and ipsilateral common carotid arteries. J. Cereb. Blood Flow Metabol. 1988, 8:474-485.
19. Swanson R.A., Morton M.T., Tsao-Wu G., Savalos R.A., Davidson C., Sharp F.R. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metabol. 1990, 10:290-293.
20. Ohba N., Kiryu-Seo S., Maeda M., Muraoka M., Ishii M., Kiyama H. Expression of damage-induced neuronal endopeptidase (DINE) mRNA in peri-infarct cortical and thalamic neurons following middle cerebral artery occlusion. J. Neurochem. 2004, 91:956-964.
21. Komatsu M., Kuroda M., Wang Y., St Clair D., Urano M., Akaki S., Asaumi J., Kawasaki S., Hiraki Y., Kanazawa S. Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line. Int. J. Oncol. 2005, 26:853-862.
22. Bémeur C., Ste-Marie L., Desjardins P., Butterworth R.F., Vachon L., Montgomery J., Hazell A.S. Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat. Neurochem. Int. 2004, 45:1167-1174.
23. Dawson D.A., Masayasu H., Graham D.I., Macrae I.M. The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat. Neurosci. Lett. 1995, 185:65-69.
24. Nascimento-Ferreira I., Santos-Ferreira T., Sousa-Ferreira L., Auregan G., Onofre I., Alves S., Dufour N., Colomer Gould V.F., Koeppen A., Déglon N., Pereira de Almeida L. Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Brain 2011, 134:1400-1415.
25. Pickford F., Masliah E., Britschgi M., Lucin K., Narasimhan R., Jaeger P.A., Small S., Spencer B., Rockenstein E., Levine B., Wyss-Coray T. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Invest. 2008, 118:2190-2199.
26. Bjørkøy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., Stenmark H., Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-inducedcell death. J. Cell. Biol. 2005, 171:603-614.
27. Jiang P., Mizushima N. LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells. Methods 2015, 75:13-18.
28. Mäkinen S., van Groen T., Clarke J., Thornell A., Corbett D., Hiltunen M., Soininen M., Jolkkonen J. Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats. J. Cereb. Blood Flow Metabol. 2008, 28:263-268.
29. Yu W.H., Cuervo A.M., Kumar A., Peterhoff C.M., Schmidt S.D., Lee J.H., Mohan P.S., Mercken M., Farmery M.R., Tjernberg L.O., Jiang Y., Duff K., Uchiyama Y., Näslund J., Mathews P.M., Cataldo A.M., Nixon R.A. Macroautophagy-a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J. Cell. Biol. 2005, 171:87-98.