Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation

Circulation: Arrhythmia and Electrophysiology

Volumn 8, Issue 5, 2015, Pages 1255-1264

  Chowdhury, Rajib ^a   Ashraf, Hassan ^a   Melanson, Michelle ^a   Tanada, Yohei ^a   Nguyen, Minh ^a   Silberbach, Michael ^b   Wakimoto, Hiroko ^c   Benson, D Woodrow ^d   Anderson, Robert H ^e   Kasahara, Hideko ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b Department of Pediatrics Oregon Health Science School   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

animal models; atrioventricular block; congenital heart defects; genetics; human

Indexed keywords

TRANSCRIPTION FACTOR NKX2.5; HOMEOBOX PROTEIN NKX-2.5; HOMEODOMAIN PROTEIN; NKX2-5 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR CONDUCTION; CONGENITAL HEART DISEASE; CONTROLLED STUDY; DISEASE COURSE; ELECTROCARDIOGRAM; ELECTROPHYSIOLOGY; FEMALE; FIRST DEGREE ATRIOVENTRICULAR BLOCK; HEART ATRIOVENTRICULAR NODE; HEART CONDUCTION; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE REFRACTORY PERIOD; MALE; MISSENSE MUTATION; MOUSE; NONHUMAN; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; TELEMETRY; ANIMAL; CONGENITAL HEART MALFORMATION; DISEASE MODEL; ELECTROCARDIOGRAPHY; GENETICS; HEART FUNCTION TEST; HETEROZYGOTE; HUMAN; PATHOPHYSIOLOGY;

ANIMALS; ATRIOVENTRICULAR BLOCK; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; HEART DEFECTS, CONGENITAL; HETEROZYGOTE; HOMEOBOX PROTEIN NKX-2.5; HOMEODOMAIN PROTEINS; HUMANS; MICE; MUTATION, MISSENSE; PHENOTYPE; TRANSCRIPTION FACTORS;

EID: 84944676794     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.115.002720     Document Type: Article

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