Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3

Circulation Research

Volumn 111, Issue 2, 2012, Pages

  Risebro, Catherine A ^a   Petchey, Louisa K ^a   Smart, Nicola ^b   Gomes, John ^c   Clark, James ^d   Vieira, Joaquim M ^b   Yanni, Joseph ^e   Dobrzynski, Halina ^e   Davidson, Sean ^c   Zuberi, Zia ^c   Tinker, Andrew ^f   Shui, Bo ^g   Tallini, Yvonne I ^g   Kotlikoff, Michael I ^g   Miquerol, Lucile ^h   Schwartz, Robert J ⁱ   Riley, Paul R ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g Department of Obstetrics Gynecology   (United States)

^h AIX MARSEILLE UNIVERSITY   (France)

ⁱ TEXAS HEART INSTITUTE   (United States)

Author keywords

atrioventricular node; Nkx2.5; Prox1; Purkinje fiber

Indexed keywords

CALCIUM ION; CRE RECOMBINASE; HISTONE DEACETYLASE 3; HOMEODOMAIN PROTEIN; PROSPERO RELATED HOMEBOX PROTEIN 1; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONGENITAL HEART DISEASE; CONTROLLED STUDY; DNA MODIFICATION; DOWN REGULATION; ELECTROCARDIOGRAPHY; EMBRYO; GAIN OF FUNCTION MUTATION; GENE EXPRESSION REGULATION; GENETIC EPISTASIS; HAPLOINSUFFICIENCY; HEART ATRIOVENTRICULAR NODE; HEART CONTRACTION; HEART EXCITATION; HEART FUNCTION; HEART HEMODYNAMICS; HEART MUSCLE CONDUCTION DISTURBANCE; HETEROZYGOTE; IN VITRO STUDY; LOSS OF FUNCTION MUTATION; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PURKINJE FIBER; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; STEADY STATE; UPREGULATION;

ANIMALS; EPISTASIS, GENETIC; HEART CONDUCTION SYSTEM; HEART DISEASES; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; MICE; MICE, TRANSGENIC; NIH 3T3 CELLS; PHENOTYPE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84863720716     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.260695     Document Type: Article

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