Hsa-miR-146a-5p modulates androgen-independent prostate cancer cells apoptosis by targeting ROCK1

Prostate

Volumn 75, Issue 16, 2015, Pages 1896-1903

  Xu, Bin ^a   Huang, Yeqing ^a   Niu, Xiaobing ^b   Tao, Tao ^a   Jiang, Liang ^a   Tong, Na ^b,c   Chen, Shuqiu ^a   Liu, Ning ^a   Zhu, Weidong ^a   Chen, Ming ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c Nanjing Medical University   (China)

Author keywords

apoptosis; miR 146a; prostate cancer; ROCK1

Indexed keywords

ANDROGEN; CASPASE 3; MICRORNA 146A; RHO ASSOCIATED COILED COIL CONTAINING PROTEIN KINASE 1; RHO KINASE; UNCLASSIFIED DRUG; MICRORNA; MIRN146 MICRORNA, HUMAN; ROCK1 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANDROGEN DEPENDENT PROSTATE CANCER; ANDROGEN INDEPENDENT PROSTATE CANCER; APOPTOSIS; ARTICLE; CANCER CELL; CANCER RECURRENCE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FUNCTIONAL ASSESSMENT; GENE CONTROL; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GLEASON SCORE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METASTASIS POTENTIAL; PREDICTION; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROSTATECTOMY; PROTEIN EXPRESSION; PROTEIN RNA BINDING; PROTEIN TARGETING; RECURRENCE RISK; TRANSURETHRAL RESECTION; ADENOCARCINOMA; CANCER GRADING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROSTATE; PROSTATE TUMOR; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; TUMOR CELL LINE;

ADENOCARCINOMA; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; NEOPLASM GRADING; PROSTATE; PROSTATIC NEOPLASMS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; TISSUE ARRAY ANALYSIS;

EID: 84944441675     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.23068     Document Type: Article

References (17)

1. Siegel R, Ma J, Zou Z, Jemal A,. Cancer statistics, 2014. CA Cancer J Clin 2014; 64 (1): 9-29.
2. Bartel DP,. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004; 116 (2): 281-297.
3. Bartel DP,. MicroRNAs: Target recognition and regulatory functions. Cell 2009; 136 (2): 215-233.
4. Lin SL, Chiang A, Chang D, Ying SY,. Loss of mir-146a function in hormone-refractory prostate cancer. Rna 2008; 14 (3): 417-424.
5. Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE, Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino PT, Sander C, Sawyers CL, Gerald WL,. Integrative genomic profiling of human prostate cancer. Cancer Cell 2010; 18 (1): 11-22.
6. Vergoulis T, Vlachos IS, Alexiou P, Georgakilas G, Maragkakis M, Reczko M, Gerangelos S, Koziris N, Dalamagas T, Hatzigeorgiou AG,. TarBase 6.0: Capturing the exponential growth of miRNA targets with experimental support. Nucleic Acids Res 2012; 40 (Database issue): D222-D229.
7. Xu B, Niu X, Zhang X, Tao J, Wu D, Wang Z, Li P, Zhang W, Wu H, Feng N, Wang Z, Hua L, Wang X,. MiR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS. Mol Cell Biochem 2011; 350 (1-2): 207-213.
8. Zhang C, Zhang S, Zhang Z, He J, Xu Y, Liu S,. ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc. Oncogene 2014.
9. Betel D, Koppal A, Agius P, Sander C, Leslie C,. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol 2010; 11 (8): R90.
10. Li GB, Cheng Q, Liu L, Zhou T, Shan CY, Hu XY, Zhou J, Liu EH, Li P, Gao N,. Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway. Cell Commun Signal 2013; 11: 50.
11. Majid S, Dar AA, Saini S, Shahryari V, Arora S, Zaman MS, Chang I, Yamamura S, Chiyomaru T, Fukuhara S, Tanaka Y, Deng G, Tabatabai ZL, Dahiya R,. MicroRNA-1280 inhibits invasion and metastasis by targeting ROCK1 in bladder cancer. PLoS ONE 2012; 7 (10): e46743.
12. Danial NN, Korsmeyer SJ,. Cell death: critical control points. Cell 2004; 116 (2): 205-219.
13. Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ,. Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci USA 2006; 103 (39): 14495-14500.
14. Sebbagh M, Renvoize C, Hamelin J, Riche N, Bertoglio J, Breard J,. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol 2001; 3 (4): 346-352.
15. Zheng B, Liang L, Wang C, Huang S, Cao X, Zha R, Liu L, Jia D, Tian Q, Wu J, Ye Y, Wang Q, Long Z, Zhou Y, Du C, He X, Shi Y,. MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res 2012; 17 (24): 7574-7583.
16. Xu X, Li S, Lin Y, Chen H, Hu Z, Mao Y, Xu X, Wu J, Zhu Y, Zheng X, Luo J, Xie L,. MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1. J Transl Med 2013; 11: 276.
17. Lei P, Xie J, Wang L, Yang X, Dai Z, Hu Y,. MicroRNA-145 inhibits osteosarcoma cell proliferation and invasion by targeting ROCK1. Mol Med Rep 2014; 10 (1): 155-160.