Airway surface dehydration by transforming growth factor β (TGF-β) in cystic fibrosis is due to decreased function of a voltage-dependent potassium channel and can be rescued by the drug pirfenidone

Journal of Biological Chemistry

Volumn 290, Issue 42, 2015, Pages 25710-25716

  Manzanares, Dahis ^a   Krick, Stefanie ^a   Baumlin, Nathalie ^a   Dennis, John S ^a   Tyrrell, Jean ^b   Tarran, Robert ^b   Salathe, Matthias ^a,c  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

AIRWAY SURFACE LIQUID; CILIARY BEAT FREQUENCIES; LEUCINE-RICH REPEATS; MUCOCILIARY CLEARANCE; POTASSIUM CHANNELS; SIGNALING INHIBITORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTORS;

AMINO ACIDS;

CARRIER PROTEINS AND BINDING PROTEINS; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LEUCINE RICH REPEAT CONTAINING PROTEIN 26; MESSENGER RNA; PIRFENIDONE; POTASSIUM ION; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; LRRC26 PROTEIN, HUMAN; PYRIDONE DERIVATIVE; TUMOR PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL;

AIRWAY SURFACE DEHYDRATION; AIRWAY SURFACE LIQUID; ARTICLE; BRONCHUS MUCOSA; CILIARY MOTILITY; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG EFFECT; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MUCOCILIARY CLEARANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY TRACT PARAMETERS; ANTAGONISTS AND INHIBITORS; BRONCHUS; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; BRONCHI; CYSTIC FIBROSIS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MUCOCILIARY CLEARANCE; NEOPLASM PROTEINS; POTASSIUM CHANNELS, VOLTAGE-GATED; PYRIDONES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84944400951     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.670885     Document Type: Article

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