IFN-γ-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 306, Issue 5, 2014, Pages

  Manzanares, Dahis ^a   Srinivasan, Maria ^a   Salathe, Samuel T ^a   Ivonnet, Pedro ^a   Baumlin, Nathalie ^a   Dennis, John S ^a   Conner, Gregory E ^a,b   Salathe, Matthias ^a  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Airway surface liquid; BK channel; Ciliary activity; Dual oxidase; IFN

Indexed keywords

ADENOSINE TRIPHOSPHATE; DUAL OXIDASE 2; GAMMA INTERFERON; HYDROGEN PEROXIDE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA1 SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA2 SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA4 SUBUNIT; LEUCINE RICH REPEAT CONTAINING PROTEIN; MALLOTOXIN; MESSENGER RNA; OXIDOREDUCTASE; POTASSIUM CHANNEL STIMULATING AGENT; PROTEIN; UNCLASSIFIED DRUG; ARABIDOPSIS PROTEIN; CHLORIDE; DUOX2 PROTEIN, HUMAN; KCNMA1 PROTEIN, HUMAN; KCNMB2 PROTEIN, HUMAN; KCNMB4 PROTEIN, HUMAN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT; LRRC26 PROTEIN, HUMAN; MARNERAL SYNTHASE, ARABIDOPSIS; MUTASE; NERVE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR PROTEIN;

AIRWAY SURFACE LIQUID; ARTICLE; BRONCHUS CHARACTERISTICS AND FUNCTIONS; BRONCHUS MUCOSA; CILIARY BEATING FREQUENCY; CONTROLLED STUDY; CYSTIC FIBROSIS; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; ION TRANSPORT; LUNG FLUID; MUCOCILIARY CLEARANCE; MUCOCILIARY DYSFUNCTION; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT DISEASE; UPREGULATION; BRONCHUS; CELL CULTURE; CILIARY MOTILITY; CYTOLOGY; DRUG EFFECT; DUAL OXIDASE; GENETICS; IFN-Γ; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; TRACHEA;

AIRWAY SURFACE LIQUID; BK CHANNEL; CILIARY ACTIVITY; DUAL OXIDASE; H2O2; IFN-Γ;

ARABIDOPSIS PROTEINS; BRONCHI; CELLS, CULTURED; CHLORIDES; CYSTIC FIBROSIS; HUMANS; HYDROGEN PEROXIDE; INTERFERON-GAMMA; INTRAMOLECULAR TRANSFERASES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; MUCOCILIARY CLEARANCE; NADPH OXIDASE; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; RESPIRATORY MUCOSA; TRACHEA;

EID: 84900536302     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00247.2013     Document Type: Article

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