Clinicopathologic characteristics of microsatellite instable gastric carcinomas revisited: Urgent need for standardization

Applied Immunohistochemistry and Molecular Morphology

Volumn 25, Issue 1, 2017, Pages 12-24

  Mathiak, Micaela ^a   Warneke, Viktoria S ^a   Behrens, Hans Michael ^a   Haag, Jochen ^a   Böger, Christine ^a   Krüger, Sandra ^a   Röcken, Christoph ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

EBV; gastric cancer; MLH1; MSH2; MSH6; MSI; PMS2

Indexed keywords

MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

AGED; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; OVERALL SURVIVAL; PATHOLOGY; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEPLETION; REVIEW; STOMACH CARCINOMA; GENETICS; STOMACH TUMOR;

AGED; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE INSTABILITY; STOMACH NEOPLASMS;

EID: 84944339904     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0000000000000264     Document Type: Review

References (54)

1. Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014; 513: 202-209
2. Wang K, Yuen ST, Xu J, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat Genet. 2014; 46: 573-582
3. Lee YS, Cho YS, Lee GK, et al. Genomic profile analysis of diffusetype gastric cancers. Genome Biol. 2014; 15: R55
4. Lauwers GY, Carneiro F, Graham DY, et al. Tumours of the stomach. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, eds. WHO Classification of Tumours of the Digestive System, 4th ed. Lyon: International Agency for Research on Cancer; 2010: 48-80
5. Lauren T. The two histologic main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand. 1965; 64: 31-49
6. Sobin LH, Gospodarowicz M, Wittekind C. TNM Classification of Malignant Tumours, 7th ed. Oxford, England: Wiley-Blackwell; 2009
7. Weichert W, Röske A, Gekeler V, et al. Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol. 2008; 9: 139-148
8. Behrens HM, Warneke VS, Böger C, et al. Reproducibility of Her2/neu scoring in gastric cancer and assessment of the 10% cut-off rule. Cancer Med. 2014; 4: 235-244
9. van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003; 17: 2257-2317
10. Buhard O, Cattaneo F, Wong YF, et al. Multipopulation analysis of polymorphisms in five mononucleotide repeats used to determine the microsatellite instability status of human tumors. J Clin Oncol. 2006; 24: 241-251
11. Warneke V, Behrens HM, Haag J, et al. Prognostic and putative predictive biomarkers of gastric cancer for personalized medicine. Diagn Mol Pathol. 2013; 22: 127-137
12. Rüschoff J, Dietmaier W, Luttges J, et al. Poorly differentiated colonic adenocarcinoma, medullary type: clinical, phenotypic, and molecular characteristics. Am J Pathol. 1997; 150: 1815-1825
13. An C, Choi IS, Yao JC, et al. Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma. Clin Cancer Res. 2005; 11: 656-663
14. An JY, Kim H, Cheong JH, et al. Microsatellite instability in sporadic gastric cancer: its prognostic role and guidance for 5-FU based chemotherapy after RO resection. Int J Cancer. 2012; 131: 505-511
15. Arai T, Sakurai U, Sawabe M, et al. Frequent microsatellite instability in papillary and solid-type, poorly differentiated adenocarcinomas of the stomach. Gastric Cancer. 2013; 16: 505-512
16. Bacani J, Zwingerman R, Di Nicola N, et al. Tumor microsatellite instability in early onset gastric cancer. J Mol Diagn. 2005; 7: 465-477
17. Beghelli S, de Manzoni G, Barbi S, et al. Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers. Surgery. 2006; 139: 347-356
18. Carvalho R, Milne AN, van Rees BP, et al. Early-onset gastric carcinomas display molecular characteristics distinct from gastric carcinomas occurring at a later age. J Pathol. 2004; 204: 75-83
19. Chang MS, Kim HS, Kim CW, et al. Epstein-Barr virus, p53 protein, and microsatellite instability in the adenoma-carcinoma sequence of the stomach. Hum Pathol. 2002; 33: 415-420
20. Chang MS, Lee HS, Kim HS, et al. Epstein-Barr virus and microsatellite instability in gastric carcinogenesis. J Pathol. 2003; 199: 447-452
21. Chiaravalli AM, Cornaggia M, Furlan D, et al. The role of histological investigation in prognostic evaluation of advanced gastric cancer. Analysis of histological structure and molecular changes compared with invasive pattern and stage. Virchows Arch. 2001; 439: 158-169
22. Chiaravalli AM, Klersy C, Vanoli A, et al. Histotype-based prognostic classification of gastric cancer. World J Gastroenterol. 2012; 18: 896-904
23. Choe WH, Lee SY, Lee JH, et al. High frequency of microsatellite instability in intestinal-type gastric cancer in Korean patients. Korean J Intern Med. 2005; 20: 116-122
24. Corso G, Pedrazzani C, Marrelli D, et al. Correlation of microsatellite instability at multiple loci with long-term survival in advanced gastric carcinoma. Arch Surg. 2009; 144: 722-727
25. Corso G, Velho S, Paredes J, et al. Oncogenic mutations in gastric cancer with microsatellite instability. Eur J Cancer. 2011; 47: 443-451
26. dos Santos NR, Seruca R, Constancia M, et al. Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. Gastroenterology. 1996; 110: 38-44
27. Falchetti M, Saieva C, Lupi R, et al. Gastric cancer with high-level microsatellite instability: target gene mutations, clinicopathologic features, and long-term survival. Hum Pathol. 2008; 39: 925-932
28. Fang WL, Chang SC, Lan YT, et al. Molecular and survival differences between familial and sporadic gastric cancers. Biomed Res Int. 2013. doi: 10.1155/2013/396272
29. Ferrasi AC, Pinheiro NA, Rabenhorst SH, et al. Helicobacter pylori and EBV in gastric carcinomas: methylation status and microsatellite instability. World J Gastroenterol. 2010; 16: 312-319
30. Grogg KL, Lohse CM, Pankratz VS, et al. Lymphocyte-rich gastric cancer: associations with Epstein-Barr virus, microsatellite instability, histology, and survival. Mod Pathol. 2003; 16: 641-651
31. Kim H, An JY, Noh SH, et al. High microsatellite instability predicts good prognosis in intestinal-type gastric cancers. J Gastroenterol Hepatol. 2011; 26: 585-592
32. Kim KJ, Lee TH, Cho NY, et al. Differential clinicopathologic features in microsatellite-unstable gastric cancers with and without MLH1 methylation. Hum Pathol. 2013; 44: 1055-1064
33. Kim KM, Kwon MS, Hong SJ, et al. Genetic classification of intestinal-type and diffuse-type gastric cancers based on chromosomal loss and microsatellite instability. Virchows Arch. 2003; 443: 491-500
34. Kulke MH, Thakore KS, Thomas G, et al. Microsatellite instability and hMLH1/hMSH2 expression in Barrett esophagus-associated adenocarcinoma. Cancer. 2001; 91: 1451-1457
35. Lee HJ, Jang YJ, Lee EJ, et al. The significance of mismatch repair genes in gastric cancer. J Cancer Res Ther. 2013; 9: 80-83
36. Lee HS, Choi SI, Lee HK, et al. Distinct clinical features and outcomes of gastric cancers with microsatellite instability. Mod Pathol. 2002; 15: 632-640
37. Leite M, Corso G, Sousa S, et al. MSI phenotype and MMR alterations in familial and sporadic gastric cancer. Int J Cancer. 2011; 128: 1606-1613
38. Leung SY, Yuen ST, Chung LP, et al. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res. 1999; 59: 159-164
39. Lu BJ, Lai M, Cheng L, et al. Gastric medullary carcinoma, a distinct entity associated with microsatellite instability-H, prominent intraepithelial lymphocytes and improved prognosis. Histopathology. 2004; 45: 485-492
40. Mizoshita T, Tsukamoto T, Cao X, et al. Microsatellite instability is linked to loss of hMLH1 expression in advanced gastric cancers: lack of a relationship with the histological type and phenotype. Gastric Cancer. 2005; 8: 164-172
41. Oki E, Kakeji Y, Zhao Y, et al. Chemosensitivity and survival in gastric cancer patients with microsatellite instability. Ann Surg Oncol. 2009; 16: 2510-2515
42. Ottini L, Palli D, Falchetti M, et al. Microsatellite instability in gastric cancer is associated with tumor location and family history in a highrisk population from Tuscany. Cancer Res. 1997; 57: 4523-4529
43. Sakurai M, Zhao Y, Oki E, et al. High-resolution fluorescent analysis of microsatellite instability in gastric cancer. Eur J Gastroenterol Hepatol. 2007; 19: 701-709
44. Seo HM, Chang YS, Joo SH, et al. Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype. J Surg Oncol. 2009; 99: 143-147
45. Solcia E, Klersy C, Mastracci L, et al. A combined histologic and molecular approach identifies three groups of gastric cancer with different prognosis. Virchows Arch. 2009; 455: 197-211
46. Sugai T, Habano W, Uesugi N, et al. Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers-a new concept of genetic carcinogenesis of early differentiated-type adenocarcinomas. Mod Pathol. 2004; 17: 1223-1234
47. Tay ST, Leong SH, Yu K, et al. A combined comparative genomic hybridization and expression microarray analysis of gastric cancer reveals novel molecular subtypes. Cancer Res. 2003; 63: 3309-3316
48. Wirtz HC, Muller W, Noguchi T, et al. Prognostic value and clinicopathological profile of microsatellite instability in gastric cancer. Clin Cancer Res. 1998; 4: 1749-1754
49. Wu M, Semba S, Oue N, et al. BRAF/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1/MGMT in human gastric carcinomas. Gastric Cancer. 2004; 7: 246-253
50. Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998; 58: 5248-5257
51. Capelle LG, Van Grieken NC, Lingsma HF, et al. Risk and epidemiological time trends of gastric cancer in Lynch syndrome carriers in the Netherlands. Gastroenterology. 2010; 138: 487-492
52. Watanabe H, Enjoji M, Imai T. Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations. Cancer. 1976; 38: 232-243
53. Camargo MC, Kim WH, Chiaravalli AM, et al. Improved survival of gastric cancer with tumour Epstein-Barr virus positivity: an international pooled analysis. Gut. 2014; 63: 236-243
54. Yashiro M, Inoue T, Nishioka N, et al. Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma. Ann Surg Oncol. 2009; 16: 2926-2935