Breath testing as potential colorectal cancer screening tool

International Journal of Cancer

Volumn 138, Issue 1, 2016, Pages 229-236

  Amal, Haitham ^a   Leja, Marcis ^b,c,d   Funka, Konrads ^b,c,d   Lasina, Ieva ^b,c   Skapars, Roberts ^b,c   Sivins, Armands ^b,c   Ancans, Guntis ^b,d   Kikuste, Ilze ^b   Vanags, Aigars ^d   Tolmanis, Ivars ^d   Kirsners, Arnis ^b   Kupcinskas, Limas ^e   Haick, Hossam ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b UNIVERSITY OF LATVIA   (Latvia)

^c RIGA EAST UNIVERSITY HOSPITAL   (Latvia)

^d Digestive Diseases Centre GASTRO   (Latvia)

^e LITHUANIAN UNIVERSITY OF HEALTH SCIENCES   (Lithuania)

Author keywords

breath; colorectal cancer; diagnosis; sensor; spectrometry

Indexed keywords

4 METHYL OCTANE; ACETIC ACID ETHYL ESTER; ACETONE; ALCOHOL; OCTANE; UNCLASSIFIED DRUG; VOLATILE ORGANIC COMPOUND; TUMOR MARKER;

ADVANCED CANCER; AGED; ARTICLE; BREATH ANALYSIS; CANCER SCREENING; COLONOSCOPY; COLORECTAL ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE MARKER; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SENSOR; SYNDROME DELINEATION; CANCER STAGING; CASE CONTROL STUDY; CHEMISTRY; COLORECTAL NEOPLASMS; EARLY CANCER DIAGNOSIS; MIDDLE AGED; REPRODUCIBILITY; RISK FACTOR;

AGED; BIOMARKERS, TUMOR; BREATH TESTS; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; EARLY DETECTION OF CANCER; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; REPRODUCIBILITY OF RESULTS; RISK FACTORS; SENSITIVITY AND SPECIFICITY; VOLATILE ORGANIC COMPOUNDS;

EID: 84944274524     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29701     Document Type: Article

References (50)

1. Ferlay J, Soerjomataram I, Ervik M, et al., GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer, 2013. Available at: Http://globocaniarcfr, accessed on January 5, 2014.
2. Council of the European Union. Council Recommendation of 2 December 2003 on cancer screening. Official Journal L 327 of 16122003; 2003.
3. Maciosek MV, Solberg LI, Coffield AB, et al., Colorectal cancer screening: Health impact and cost effectiveness. Am J Prev Med 2006; 31: 80-9.
4. Segnan N, Patnick J, von Karsa L, (eds.). European guidelines for quality assurance in colorectal cancer screening and diagnosised. Office for Official Publications of the European Communities, Luxembourg, 2010. Available at: Http://bookshop.europa.eu/is-bin/INTERSHOP.enfinity/WFS/EU-Bookshop-Site/en-GB/-/EUR/ViewPublication-Start?PublicationKey=ND3210390. Last accessed December 15, 2014.
5. Atkin WS, Edwards R, Kralj-Hans I, et al., Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: A multicentre randomised controlled trial. Lancet 2010; 375: 1624-33.
6. Segnan N, Armaroli P, Bonelli L, et al., Once-only sigmoidoscopy in colorectal cancer screening: Follow-up findings of the Italian Randomized Controlled Trial-SCORE. J Natl Cancer Inst 2011; 103: 1310-22.
7. Holme O, Loberg M, Kalager M, et al., Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: A randomized clinical trial. JAMA 2014; 312: 606-15.
8. Brenner H, Stock C, Hoffmeister M., Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: Systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ 2014; 348: G2467.
9. Ghevariya V, Duddempudi S, Ghevariya N, et al., Barriers to screening colonoscopy in an urban population: A study to help focus further efforts to attain full compliance. Int J Colorectal Dis 2013; 28: 1497-503.
10. Khalid-de Bakker C, Jonkers D, Smits K, et al., Participation in colorectal cancer screening trials after first-time invitation: A systematic review. Endoscopy 2011; 43: 1059-86.
11. Adler A, Geiger S, Keil A, et al., Improving compliance to colorectal cancer screening using blood and stool based tests in patients refusing screening colonoscopy in Germany. BMC Gastroenterol 2014; 14: 183.
12. Haick H, Broza YY, Mochalski P, et al., Assessment, origin, and implementation of breath volatile cancer markers. Chem Soc Rev 2014; 43: 1423-49.
13. Konvalina G, Haick H., Sensors for breath testing: From nanomaterials to comprehensive disease detection. Acc Chem Res 2014; 47: 66-76.
14. Amann A, Mochalski P, Ruzsanyi V, et al., Assessment of the exhalation kinetics of volatile cancer biomarkers based on their physicochemical properties. J Breath Res 2014; 8: 016003.
15. Broza YY, Haick H., Nanomaterial-based sensors for detection of disease by volatile organic compounds. Nanomedicine 2013; 8: 785-806.
16. de Boer NK, de Meij TG, Oort FA, et al., The scent of colorectal cancer: Detection by volatile organic compound analysis. Clin Gastroenterol Hepatol 2014; 12: 1085-9.
17. Westenbrink E, Arasaradnam RP, O'Connell N, et al., Development and application of a new electronic nose instrument for the detection of colorectal Cancer. Biosens Bioelectron 2014; 67: 733-8.
18. Amal H, Leja M, Funka K, et al., Detection of Precancerous Gastric Lesions and Gastric Cancer through Exhaled Breath. GUT. doi: 10.1136/gutjnl-2014-308536.
19. Amal H, Shi DY, Ionescu R, et al., Assessment of ovarian cancer conditions from exhaled breath. Int J Cancer 2015; 136: E614-E22.
20. Amal H, Ding L, Liu BB, et al., The scent fingerprint of hepatocarcinoma: In-vitro metastasis prediction with volatile organic compounds (VOCs). Int J Nanomed 2012; 7: 4135-46.
21. Xu ZQ, Broza YY, Ionsecu R, et al., A nanomaterial-based breath test for distinguishing gastric cancer from benign gastric conditions. Br J Cancer 2013; 108: 941-50.
22. Peng G, Hakim M, Broza YY, et al., Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. Br J Cancer 2010; 103: 542-51.
23. Peng G, Tisch U, Adams O, et al., Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nat Nanotechnol 2009; 4: 669-73.
24. Qin T, Liu H, Song Q, et al., The screening of volatile markers for hepatocellular carcinoma. Cancer Epidemiol Biomarkers 2010; 19: 2247-53.
25. Davies MP, Barash O, Jeries R, et al., Unique volatolomic signatures of TP53 and KRAS in lung cells. Br J Cancer 2014; 111: 1213-21.
26. Dovgolevsky E, Tisch U, Haick H., Chemically sensitive resistors based on monolayer-capped cubic nanoparticles: Towards configurable nanoporous sensors. Small 2009; 5: 1158-61.
27. Nakhleh MK, Amal H, Awad H, et al., Sensor arrays based on nanoparticles for early detection of kidney injury by breath samples. Nanomedicine 2014; 10: 1767-76.
28. Nakhleh MK, Jeries R, Gharra A, et al., Detecting active pulmonary tuberculosis with a breath test using nanomaterial-based sensors. Eur Respir J 2014; 43: 1522.
29. Peled N, Barash O, Tisch U, et al., Volatile fingerprints of cancer specific genetic mutations. Nanomedicine 2013; 9: 758-66.
30. Peled N, Hakim M, Bunn PA, Jr., et al., Non-invasive breath analysis of pulmonary nodules. J Thorac Oncol 2012; 7: 1528-33.
31. Shuster G, Gallimidi Z, Heyman Reiss A, et al., Classification of breast cancer precursors through exhaled breath. Breast Cancer Res Treat 2011; 126: 791-196.
32. Tisch U, Haick H., Arrays of chemisensitive monolayer-capped metallic nanoparticles for diagnostic breath testing. Rev Chem Eng 2010; 26: 171-9.
33. Wang C, Li P, Lian A, et al., Blood volatile compounds as biomarkers for colorectal cancer. Cancer Biol Ther 2014; 15: 200-6.
34. de Meij TG, Larbi IB, van der Schee MP, et al., Electronic nose can discriminate colorectal carcinoma and advanced adenomas by fecal volatile biomarker analysis: Proof of principle study. Int J Cancer 2014; 134: 1132-8.
35. Arasaradnam RP, McFarlane MJ, Ryan-Fisher C, et al., Detection of colorectal cancer (CRC) by urinary volatile organic compound analysis. PLoS One 2014; 9: E108750.
36. Covington J, Westinbrink E, O'Connell N, et al., PTH-018 towards novel non invasive methods to diagnose colorectal cancer using an electronic noses (e-nose) and field asymmetric ion mobility spectrometry (faims). Gut 2013; 62: A218 A9.
37. Altomare DF, Di Lena M, Porcelli F, et al., Exhaled volatile organic compounds identify patients with colorectal cancer. Br J Surg 2013; 100: 144-50.
38. Wang C, Ke C, Wang X, et al., Noninvasive detection of colorectal cancer by analysis of exhaled breath. Anal Bioanal Chem 2014; 406: 4757-63.
39. Sonoda H, Kohnoe S, Yamazato T, et al., Colorectal cancer screening with odour material by canine scent detection. Gut 2011; 60: 814-9.
40. Amann A, Corradi M, Mazzone P, et al., Lung cancer biomarkers in exhaled breath. Expert Rev Mol Diagn 2011; 11: 207-17.
41. Broza YY, Kremer R, Tisch U, et al., A nanomaterial-based breath test for short-term follow-up after lung tumor resection. Nanomedicine 2013; 9: 15-21.
42. Quintero E, Castells A, Bujanda L, et al., Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening. N Engl J Med 2012; 366: 697-706.
43. Salas D, Vanaclocha M, Ibanez J, et al., Participation and detection rates by age and sex for colonoscopy versus fecal immunochemical testing in colorectal cancer screening. Cancer Causes Control 2014; 25: 985-97.
44. Chiu H-M, Lee YC, Tu CH, et al., Association between early stage colon neoplasms and false-negative results from the fecal immunochemical test. Clin Gastroenterol Hepatol 2013; 11: 832-8 e2.
45. Lo SH, Waller J, Wardle J, et al., Comparing barriers to colorectal cancer screening with barriers to breast and cervical screening: A population-based survey of screening-age women in Great Britain. J Med Screen 2013; 20: 73-9.
46. Pilz JB, Portmann S, Peter S, et al., Colon Capsule Endoscopy compared to Conventional Colonoscopy under routine screening conditions. BMC Gastroenterol 2010; 10: 66.
47. Hagel AF, Gabele E, Raithel M, et al., Colon capsule endoscopy: Detection of colonic polyps compared with conventional colonoscopy and visualization of extracolonic pathologies. Can J Gastroenterol Hepatol 2014; 28: 77-82.
48. Imperiale TF, Ransohoff DF, Itzkowitz SH, et al., Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med 2014; 370: 1287-97.
49. Lee JK, Liles EG, Bent S, et al., Accuracy of fecal immunochemical tests for colorectal cancer: Systematic review and meta-analysis. Ann Intern Med 2014; 160: 171
50. Hakim M, Broza YY, Barash O, et al., Volatile organic compounds of lung cancer and possible biochemical pathways. Chem Rev 2012; 112: 5949-66.